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1. 发明申请

US20100221195A1 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 有权
标题翻译：基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途
公开(公告)号：US20100221195A1
公开(公告)日：2010-09-02
申请号：US12778591
申请日：2010-05-12
申请人： Dov TAMARKIN , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
发明人： Dov TAMARKIN , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
IPC分类号： A61K9/12 , A61P31/00 , A61P33/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P35/00 , A01P1/00 , A01P3/00 , A01P7/00
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。

2. 发明申请

US20080260655A1 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途
公开(公告)号：US20080260655A1
公开(公告)日：2008-10-23
申请号：US12025547
申请日：2008-02-04
申请人： Dov TAMARKIN , Doron FRIEDMAN , Enbal ZIV , Meir EINI , Tal BERMAN , Jorge DANZIGER , Rita KEYNAN , David SCHUZ
发明人： Dov TAMARKIN , Doron FRIEDMAN , Enbal ZIV , Meir EINI , Tal BERMAN , Jorge DANZIGER , Rita KEYNAN , David SCHUZ
IPC分类号： A61K9/12 , A61K8/04 , A61P17/00 , A61Q19/00
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。

3. 发明申请

US20110212033A1 OIL AND LIQUID SILICONE FOAMABLE CARRIERS AND FORMULATIONS 有权
标题翻译：油和液体硅胶可发泡载体和配方
公开(公告)号：US20110212033A1
公开(公告)日：2011-09-01
申请号：US12795213
申请日：2010-06-07
申请人： Dov TAMARKIN , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
发明人： Dov TAMARKIN , Helena Shifrin , Rita Keynan , Enbal Ziv , Tal Berman , David Schuz , Elana Gazal
IPC分类号： A61K9/12
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译：公开了一种适用于外用的无水可发泡药物组合物。组合物包括可发泡载体至少一种液化或压缩气体推进剂。可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01％至约25％重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0％至约5％重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

4. 发明申请

US20120237453A1 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 有权
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：US20120237453A1
公开(公告)日：2012-09-20
申请号：US12350650
申请日：2009-01-08
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。

5. 发明申请

US20110097279A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20110097279A1
公开(公告)日：2011-04-28
申请号：US12974857
申请日：2010-12-21
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P17/00 , A61K8/06 , A61Q19/00
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

6. 发明申请

US20080206155A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20080206155A1
公开(公告)日：2008-08-28
申请号：US11940290
申请日：2007-11-14
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近所述油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

7. 发明申请

US20080253973A1 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 审中-公开
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：US20080253973A1
公开(公告)日：2008-10-16
申请号：US11971197
申请日：2008-01-08
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。

8. 发明申请

US20080206161A1 QUIESCENT FOAMABLE COMPOSITIONS, STEROIDS, KITS AND USES THEREOF 审中-公开
标题翻译：各种可泡沫组合物，STEROIDS，KITS及其用途
公开(公告)号：US20080206161A1
公开(公告)日：2008-08-28
申请号：US12020381
申请日：2008-01-25
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P29/00
CPC分类号： A61K9/122 , A01N25/16 , A61K9/0014 , A61K9/0034 , A01N53/00
摘要： The present invention relates to an emulsion steroid composition as a foamable vehicle in which the vehicle is stable or stabilized by the presence of at least one quiesence agent; therapeutical kit containing such composition; to methods of treatment using such composition; to methods of enhancing the stability of such composition.
摘要翻译：本发明涉及一种乳化类固醇组合物作为其中载体通过至少一种静止剂的存在而稳定或稳定的起泡载体; 含有该组合物的治疗试剂盒; 使用这种组合物的治疗方法; 涉及提高这种组合物的稳定性的方法。

9. 发明申请

US20080317679A1 FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES 审中-公开
标题翻译：包含一个或多个通道代理，化学试剂，氮氧化物和相关试剂及其用途的可燃组合物和试剂盒
公开(公告)号：US20080317679A1
公开(公告)日：2008-12-25
申请号：US11767442
申请日：2007-06-22
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Tal BERMAN , Alex BESONOV
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Tal BERMAN , Alex BESONOV
IPC分类号： A61K9/00 , A61P17/14 , A61P17/02 , A61P17/06
CPC分类号： A61K31/554 , A01N25/16 , A61K9/1075 , A61K9/12 , A61K31/4422 , A61K31/505 , A61K47/10
摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
摘要翻译：本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; ii。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，助溶剂，渗透增强剂及其混合物; iii。表面活性剂; iv。约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。

10. 发明申请

US20090041680A1 Wax Foamable Vehicle and Pharmaceutical Compositions Thereof 有权
标题翻译：蜡可发泡车辆及其药物组合物
公开(公告)号：US20090041680A1
公开(公告)日：2009-02-12
申请号：US12187840
申请日：2008-08-07
申请人： Dov TAMARKIN , Rita KEYNAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Rita KEYNAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P43/00 , A61Q90/00
CPC分类号： A61K9/124 , A61K8/046 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/4993 , A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/1075 , A61K9/122 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
摘要翻译：提供了包含至少一种蜡，蜡质物质，对应物或衍生物，稳定剂，水和推进剂的独特的可发泡车辆或载体。在一些实施方案中，蜡是液体蜡。在一些实施方式中，蜡包括固体蜡和液体蜡。组合物基本上不含晶体。选择组分以提供基本上耐老化和相分离的组合物和/或可以基本上溶解和/或稳定活性成分。还提供了具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。

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