专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07925125B2 Microfluidic detection device having reduced dispersion and method for making same 有权
标题翻译：具有降低的色散的微流体检测装置及其制造方法
公开(公告)号：US07925125B2
公开(公告)日：2011-04-12
申请号：US12030078
申请日：2008-02-12
申请人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
发明人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
IPC分类号： G02B6/00
CPC分类号： G01N30/74 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/161 , G01N21/05 , G01N30/6086 , G01N30/6095 , G01N2021/0346 , G01N2030/746 , Y10T156/1052
摘要： A microfluidic detection device provides reduced dispersion of axial concentration gradients in a flowing sample. The microfluidic detection device includes a cell body and a flow path through the cell body. The flow path has an inlet segment, an outlet segment, and a central segment, which forms a detection cell. The central segment is located between and at an angle with both the inlet segment and the outlet segment. The central segment has a first junction with the inlet segment and a second junction with the outlet segment. The cell body contains two arms that can transmit light to and from the detection cell. At least a portion of a first arm is located in the first junction and at least a portion of a second arm is located in the second junction. The portions of the arms located in the junctions are situated so that fluid entering or exiting the central segment of the flow path flows around the outer surface of one of the portions. By ensuring that the flow velocity is high near the walls both at the beginning and at the end of the conduit, the configuration serves to counteract dispersion caused by the normal parabolic velocity profile of flow through a cylindrical conduit, where the fluid velocity is highest at the center. In addition, the configuration promotes efficient sweeping of the entire volume between the two arms. A method for manufacturing the microfluidic detection device is also provided.
摘要翻译：微流体检测装置在流动的样品中提供减小的轴向浓度梯度的分散。微流体检测装置包括细胞体和通过细胞体的流路。流路具有入口段，出口段和形成检测单元的中心段。中心段位于入口段和出口段之间并与之成一定角度。中心段具有与入口段的第一结和与出口段的第二结。电池体包含两个可以将光传输到检测电池和从检测电池传输光的臂。第一臂的至少一部分位于第一接合处，并且第二臂的至少一部分位于第二接合处。位于接合处的臂的部分被定位成使得进入或离开流动路径的中心段的流体围绕其中一个部分的外表面流动。通过确保在导管的开始和结束处的壁附近的流速高，该构造用于抵消由通过圆柱形导管的流动的正常抛物线速度分布引起的色散，其中流体速度最高在中心。此外，该配置促进了在两个臂之间的整个体积的有效扫描。还提供了一种用于制造微流体检测装置的方法。

2. 发明申请

US20080216951A1 Microfluidic Detection Device Having Reduced Dispersion And Method For Making Same 有权
标题翻译：具有降低色散的微流体检测装置及其制造方法
公开(公告)号：US20080216951A1
公开(公告)日：2008-09-11
申请号：US12030078
申请日：2008-02-12
申请人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
发明人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
IPC分类号： B32B38/04
CPC分类号： G01N30/74 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/161 , G01N21/05 , G01N30/6086 , G01N30/6095 , G01N2021/0346 , G01N2030/746 , Y10T156/1052
摘要： A microfluidic detection device provides reduced dispersion of axial concentration gradients in a flowing sample. The microfluidic detection device includes a cell body and a flow path through the cell body. The flow path has an inlet segment, an outlet segment, and a central segment, which forms a detection cell. The central segment is located between and at an angle with both the inlet segment and the outlet segment. The central segment has a first junction with the inlet segment and a second junction with the outlet segment. The cell body contains two arms that can transmit light to and from the detection cell. At least a portion of a first arm is located in the first junction and at least a portion of a second arm is located in the second junction. The portions of the arms located in the junctions are situated so that fluid entering or exiting the central segment of the flow path flows around the outer surface of one of the portions. By ensuring that the flow velocity is high near the walls both at the beginning and at the end of the conduit, the configuration serves to counteract dispersion caused by the normal parabolic velocity profile of flow through a cylindrical conduit, where the fluid velocity is highest at the center. In addition, the configuration promotes efficient sweeping of the entire volume between the two arms. A method for manufacturing the microfluidic detection device is also provided.
摘要翻译：微流体检测装置在流动的样品中提供减小的轴向浓度梯度的分散。微流体检测装置包括细胞体和通过细胞体的流路。流路具有入口段，出口段和形成检测单元的中心段。中心段位于入口段和出口段之间并与之成一定角度。中心段具有与入口段的第一结和与出口段的第二结。电池体包含两个可以将光传输到检测电池和从检测电池传输光的臂。第一臂的至少一部分位于第一接合处，并且第二臂的至少一部分位于第二接合处。位于接合处的臂的部分被定位成使得进入或离开流动路径的中心段的流体围绕其中一个部分的外表面流动。通过确保在导管的开始和结束处的壁附近的流速高，该构造用于抵消由通过圆柱形导管的流动的正常抛物线速度分布引起的色散，其中流体速度最高在中心。此外，该配置促进了在两个臂之间的整个体积的有效扫描。还提供了一种用于制造微流体检测装置的方法。

3. 发明授权

US07336860B2 Microfluidic detection device having reduced dispersion and method for making same 有权
标题翻译：具有降低的色散的微流体检测装置及其制造方法
公开(公告)号：US07336860B2
公开(公告)日：2008-02-26
申请号：US11379348
申请日：2006-04-19
申请人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
发明人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
IPC分类号： G02B6/00
CPC分类号： G01N30/74 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/161 , G01N21/05 , G01N30/6086 , G01N30/6095 , G01N2021/0346 , G01N2030/746 , Y10T156/1052
摘要： A microfluidic detection device provides reduced dispersion of axial concentration gradients in a flowing sample. The microfluidic detection device includes a cell body and a flow path through the cell body. The flow path has an inlet segment, an outlet segment, and a central segment, which forms a detection cell. The central segment is located between and at an angle with both the inlet segment and the outlet segment. The central segment has a first junction with the inlet segment and a second junction with the outlet segment. The cell body contains two arms that can transmit light to and from the detection cell. At least a portion of a first arm is located in the first junction and at least a portion of a second arm is located in the second junction. The portions of the arms located in the junctions are situated so that fluid entering or exiting the central segment of the flow path flows around the outer surface of one of the portions. By ensuring that the flow velocity is high near the walls both at the beginning and at the end of the conduit, the configuration serves to counteract dispersion caused by the normal parabolic velocity profile of flow through a cylindrical conduit, where the fluid velocity is highest at the center. In addition, the configuration promotes efficient sweeping of the entire volume between the two arms. A method for manufacturing the microfluidic detection device is also provided.
摘要翻译：微流体检测装置在流动的样品中提供减小的轴向浓度梯度的分散。微流体检测装置包括细胞体和通过细胞体的流路。流路具有入口段，出口段和形成检测单元的中心段。中心段位于入口段和出口段之间并与之成一定角度。中心段具有与入口段的第一结和与出口段的第二结。电池体包含两个可以将光传输到检测电池和从检测电池传输光的臂。第一臂的至少一部分位于第一接合处，并且第二臂的至少一部分位于第二接合处。位于接合处的臂的部分被定位成使得进入或离开流动路径的中心段的流体围绕其中一个部分的外表面流动。通过确保在导管的开始和结束处的壁附近的流速高，该构造用于抵消由通过圆柱形导管的流动的正常抛物线速度分布引起的色散，其中流体速度最高在中心。此外，该配置促进了在两个臂之间的整个体积的有效扫描。还提供了一种用于制造微流体检测装置的方法。

4. 发明授权

US07050660B2 Microfluidic detection device having reduced dispersion and method for making same 有权
标题翻译：具有降低的色散的微流体检测装置及其制造方法
公开(公告)号：US07050660B2
公开(公告)日：2006-05-23
申请号：US10410313
申请日：2003-04-07
申请人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
发明人： Douglas R. Cyr , Roger L. Farrow , Don W. Arnold
IPC分类号： G02B6/00
CPC分类号： G01N30/74 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/161 , G01N21/05 , G01N30/6086 , G01N30/6095 , G01N2021/0346 , G01N2030/746 , Y10T156/1052
摘要： A microfluidic detection device provides reduced dispersion of axial concentration gradients in a flowing sample. The microfluidic detection device includes a cell body and a flow path through the cell body. The flow path has an inlet segment, an outlet segment, and a central segment, which forms a detection cell. The central segment is located between and at an angle with both the inlet segment and the outlet segment. The central segment has a first junction with the inlet segment and a second junction with the outlet segment. The cell body contains two arms that can transmit light to and from the detection cell. At least a portion of a first arm is located in the first junction and at least a portion of a second arm is located in the second junction. The portions of the arms located in the junctions are situated so that fluid entering or exiting the central segment of the flow path flows around the outer surface of one of the portions. By ensuring that the flow velocity is high near the walls both at the beginning and at the end of the conduit, the configuration serves to counteract dispersion caused by the normal parabolic velocity profile of flow through a cylindrical conduit, where the fluid velocity is highest at the center. In addition, the configuration promotes efficient sweeping of the entire volume between the two arms. A method for manufacturing the microfluidic detection device is also provided.
摘要翻译：微流体检测装置在流动的样品中提供减小的轴向浓度梯度的分散。微流体检测装置包括细胞体和通过细胞体的流路。流路具有入口段，出口段和形成检测单元的中心段。中心段位于入口段和出口段之间并与之成一定角度。中心段具有与入口段的第一结和与出口段的第二结。电池体包含两个可以将光传输到检测电池和从检测电池传输光的臂。第一臂的至少一部分位于第一接合处，并且第二臂的至少一部分位于第二接合处。位于接合处的臂的部分被定位成使得进入或离开流动路径的中心段的流体围绕其中一个部分的外表面流动。通过确保在导管的开始和结束处的壁附近的流速高，该构造用于抵消由通过圆柱形导管的流动的正常抛物线速度分布引起的色散，其中流体速度最高在中心。此外，该配置促进了在两个臂之间的整个体积的有效扫描。还提供了一种用于制造微流体检测装置的方法。

5. 发明授权

US06963062B2 Method for multiplexed optical detection including a multimode optical fiber in which propagation modes are coupled 有权
标题翻译：包括传播模式耦合的多模光纤的复用光检测方法
公开(公告)号：US06963062B2
公开(公告)日：2005-11-08
申请号：US10410314
申请日：2003-04-07
申请人： Douglas R. Cyr , Roger L. Farrow
发明人： Douglas R. Cyr , Roger L. Farrow
IPC分类号： G01N21/31 , G01N30/74 , G02B6/14 , G02B6/28 , G02B6/42
CPC分类号： G02B6/14 , G01N21/31 , G01N30/74 , G01N2030/746 , G02B6/2808 , G02B6/4298
摘要： A method for multiplexed optical detection includes: imaging light onto an input face of a first optical fiber, wherein the first optical fiber is a multimode optical fiber; inducing coupling among the propagation modes of the light in the first optical fiber; coupling an output face of the first optical fiber to input faces of multiple individual second optical fibers in a multi-fiber bundle, wherein each output face of the individual fibers emits substantially similar light; and detecting one or more properties of one or more fluids, including analytes that may be present, with the light emitted from at least one of the second optical fibers. The second optical fibers can be a part of an optical detector that is part of a high performance liquid chromatography system, which can be located in a substrate.
摘要翻译：一种复用光检测方法，包括：将光成像到第一光纤的输入面上，其中第一光纤为多模光纤; 在第一光纤中的光的传播模式之间引起耦合; 将第一光纤的输出面耦合到多纤维束中的多个单独的第二光纤的输入面，其中各个光纤的每个输出面发射基本相似的光; 以及检测一种或多种流体，包括可能存在的分析物的一种或多种性质与从至少一种第二光纤发射的光。第二光纤可以是作为可位于基板中的高效液相色谱系统的一部分的光学检测器的一部分。

6. 发明授权

US08021056B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US08021056B2
公开(公告)日：2011-09-20
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

7. 发明申请

US20110018259A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20110018259A1
公开(公告)日：2011-01-27
申请号：US12874055
申请日：2010-09-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： F16L25/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

8. 发明授权

US07802923B2 Microfluidic connections 有权
标题翻译：微流体连接
公开(公告)号：US07802923B2
公开(公告)日：2010-09-28
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

9. 发明申请

US20090129728A1 Microfluidic Connections 有权
标题翻译：微流体连接
公开(公告)号：US20090129728A1
公开(公告)日：2009-05-21
申请号：US10599591
申请日：2005-04-01
申请人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人： Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号： G02B6/00 , F16J15/02
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译：在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。每个基板具有一对对准特征，例如在基板相对侧的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。细长部件可以被可压缩垫片40）包围。基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

10. 发明授权

US07867694B2 Composite polymer microfluidic control device 有权
标题翻译：复合聚合物微流控制装置
公开(公告)号：US07867694B2
公开(公告)日：2011-01-11
申请号：US11874815
申请日：2007-10-18
申请人： Jason E. Rehm , Phillip H. Paul , Douglas R. Cyr
发明人： Jason E. Rehm , Phillip H. Paul , Douglas R. Cyr
IPC分类号： B81B5/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2200/143 , B01L2300/0816 , B01L2400/0487 , B01L2400/0605 , B01L2400/0616 , B01L2400/0633 , F16K99/0011 , F16K99/0021 , F16K99/0057 , F16K2099/0084 , G01F1/661 , G01F1/662 , G01F15/005 , G05D7/0186 , Y10T137/7904
摘要： A device for microfluidic control comprising a regulator that is moveable in a conduit where the regulator is a composite polymer formed from a composite mixture comprising a polymerizable precursor and a particulate filler.
摘要翻译：一种用于微流控制的装置，包括可在管道中移动的调节器，其中调节器是由包含可聚合前体和颗粒填料的复合混合物形成的复合聚合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式