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1. 发明申请

US20050042589A1 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US20050042589A1
公开(公告)日：2005-02-24
申请号：US10642998
申请日：2003-08-18
申请人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
发明人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/11 , A61N1/362 , G09B23/28
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an imlantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。睡眠质量可以使用收集的数据由不可变的或患者外部的睡眠质量处理器进行评估。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

2. 发明申请

US20050240236A1 Implantable medical device with voice responding and recording capacity 失效
标题翻译：具有语音响应和记录能力的植入式医疗设备
公开(公告)号：US20050240236A1
公开(公告)日：2005-10-27
申请号：US11071984
申请日：2005-03-04
申请人： Douglas Daum , Qingsheng Zhu , Bruce KenKnight
发明人： Douglas Daum , Qingsheng Zhu , Bruce KenKnight
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
摘要翻译：一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

3. 发明申请

US20060009812A1 Maximum pacing rate limiter implemented using the evoked response - T-wave interval 失效
标题翻译：使用诱发反应 - T波间隔实现最大起搏速率限制器
公开(公告)号：US20060009812A1
公开(公告)日：2006-01-12
申请号：US11225712
申请日：2005-09-13
申请人： Douglas Daum , Geng Zhang , Qingsheng Zhu , Gerrard Carlson , Julio Spinelli
发明人： Douglas Daum , Geng Zhang , Qingsheng Zhu , Gerrard Carlson , Julio Spinelli
IPC分类号： A61N1/37
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

4. 发明申请

US20070161873A1 Sleep detection using an adjustable threshold 有权
公开(公告)号：US20070161873A1
公开(公告)日：2007-07-12
申请号：US11717561
申请日：2007-03-13
申请人： Quan Ni , Zoe Hajenga , Douglas Daum , Jeff Stahmann , John Hatlestad , Kent Lee
发明人： Quan Ni , Zoe Hajenga , Douglas Daum , Jeff Stahmann , John Hatlestad , Kent Lee
IPC分类号： A61B5/00 , A61B5/08
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/085 , A61B5/1116 , A61B5/4809 , A61B5/686 , A61B5/7271 , A61B5/7282 , A61N1/362 , A61N1/365 , A61N1/36542 , G16H40/63 , G16H50/20
摘要： Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.

5. 发明申请

US20050288719A1 Far-field sensing channel for implantable cardiac device 有权
标题翻译：用于可植入心脏装置的远场感测通道
公开(公告)号：US20050288719A1
公开(公告)日：2005-12-29
申请号：US10858848
申请日：2004-06-02
申请人： Geng Zhang , Douglas Daum , James Gilkerson , Quan Ni
发明人： Geng Zhang , Douglas Daum , James Gilkerson , Quan Ni
IPC分类号： A61N1/362 , A61N1/37 , A61N1/375
CPC分类号： A61N1/371 , A61N1/3621 , A61N1/3756
摘要： An implantable pacemaker is provided with a far-field sensing channel which requires a reduced refractory period during the time when pacing pulses are delivered as compared with sensing channels using intra-cardiac electrodes. The far-field sensing channel may use the conductive housing of the implantable device or can and an indifferent electrode mounted on the device header as the electrodes for its differential inputs. Such a far-field sensing channel is able to sense activity occurring in either the atria or the ventricles for the purposes of arrhythmia detection and/or capture verification.
摘要翻译：植入式心脏起搏器设置有远场感测通道，与使用心脏内电极的感测通道相比，在进行起搏脉冲的时间期间需要减少的不应期。远场感测通道可以使用可植入装置的导电外壳或者可以将安装在设备头上的无关电极用作其差分输入的电极。为了心律失常检测和/或捕获验证的目的，这种远场感测通道能够感测在心房或心室中发生的活动。

6. 发明申请

US20080051672A1 WIRELESS ECG IN IMPLANTABLE DEVICES 有权
标题翻译：无线心电图在可植入的设备
公开(公告)号：US20080051672A1
公开(公告)日：2008-02-28
申请号：US11925657
申请日：2007-10-26
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas Daum
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas Daum
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

7. 发明申请

US20060271119A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US20060271119A1
公开(公告)日：2006-11-30
申请号：US11264941
申请日：2005-11-02
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

8. 发明申请

US20060200204A1 CALIBRATION OF ADAPTIVE-RATE PACING USING INTRINSIC CHRONOTROPIC RESPONSE 失效
标题翻译：使用内部反应的校正自适应速度
公开(公告)号：US20060200204A1
公开(公告)日：2006-09-07
申请号：US11276530
申请日：2006-03-03
申请人： Douglas Daum , Quan Ni
发明人： Douglas Daum , Quan Ni
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： Calibration of adaptive-rate pacing by a cardiac rhythm management system using an intrinsic chronotropic response. The cardiac rhythm management system may include an adaptive-rate pacing device. The adaptive-rate pacing device may include an adaptive-rate sensor module for measuring an activity level of the individual. A monitor module may be coupled to the adaptive-rate sensor module, the monitor module monitoring an intrinsic chronotropic response. A calculator module may be coupled to the monitor module, the calculator module calculating a calibrated parameter for the adaptive-rate pacing device based on the intrinsic chronotropic response. An adjuster module may be coupled to the calculator module, wherein the adjuster module adjusts the adaptive-rate pacing device based on the calibrated parameter. The parameters of the adaptive-rate pacing device adjusted by the adjuster module may include a sensor rate target, a maximum sensor rate, and a response factor.
摘要翻译：使用内在的时间延迟响应通过心律管理系统校准自适应起搏。心律管理系统可以包括自适应速率起搏装置。自适应速率起搏装置可以包括用于测量个人的活动水平的自适应速率传感器模块。监视器模块可以耦合到自适应速率传感器模块，监视器模块监视固有的时间变化响应。计算器模块可以耦合到监视器模块，计算器模块基于固有的时间变化响应来计算自适应速率起搏装置的校准参数。调节器模块可以耦合到计算器模块，其中调节器模块基于校准参数来调整自适应速率起搏装置。由调节器模块调整的自适应速率起搏装置的参数可以包括传感器速率目标，最大传感器速率和响应因子。

9. 发明申请

US20050251215A1 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US20050251215A1
公开(公告)日：2005-11-10
申请号：US11061315
申请日：2005-02-18
申请人： Richard Dujmovic , Phil Foshee , Richard Fogoros , Joseph Smith , Douglas Daum , Weimin Sun
发明人： Richard Dujmovic , Phil Foshee , Richard Fogoros , Joseph Smith , Douglas Daum , Weimin Sun
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

10. 发明申请

US20060036288A1 Pacer with combined defibrillator tailored for bradycardia patients 失效
标题翻译：步行者联合除颤器为心动过缓患者量身打造
公开(公告)号：US20060036288A1
公开(公告)日：2006-02-16
申请号：US10921777
申请日：2004-08-18
申请人： Joseph Bocek , Richard Dujmovic , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard Sanders , Douglas Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
发明人： Joseph Bocek , Richard Dujmovic , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard Sanders , Douglas Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： This document discusses, among other things, a combination pacer/defibrillator that is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value, but only if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as “avoiding at all costs” delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：本文件还讨论了针对心动过缓患者定制的组合起搏器/除颤器。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。灵敏度被编程为高期望的灵敏度值，但是只有在不降低低于所需特异性阈值的特异性的情况下才能进行。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括，当患者呼吸或不仰卧时，使用多个通道或高速率的VT / VF检测阈值来抑制冲击输送。本发明的起搏器/除颤器装置可能潜在地节省目前临床指示用于除颤器/止痛器但是由于一个或多个危险因素引起的心脏猝死风险增加的缓慢心律失常患者的生命。

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