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1. 发明授权

US07336994B2 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US07336994B2
公开(公告)日：2008-02-26
申请号：US10760155
申请日：2004-01-16
申请人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
发明人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
IPC分类号： A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

2. 发明授权

US07647107B2 Addressing recurrent atrial fibrillation 失效
标题翻译：解决复发性房颤
公开(公告)号：US07647107B2
公开(公告)日：2010-01-12
申请号：US11532741
申请日：2006-09-18
申请人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
发明人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：在AF事件终止后将超速起搏应用于一个或两个心房的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过速起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

3. 发明授权

US07127292B2 Addressing recurrent atrial fibrillation 有权
标题翻译：解决复发性房颤
公开(公告)号：US07127292B2
公开(公告)日：2006-10-24
申请号：US10284873
申请日：2002-10-31
申请人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
发明人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/3962 , A61N1/395
摘要： An implantable medical device is directed to techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. The implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：可植入式医疗装置涉及用于在AF发作终止后向一个或两个心房施加超速起搏的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过驱动起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

4. 发明授权

US09375578B2 Cardiac pacing methods and apparatus 有权
标题翻译：心脏起搏方法和装置
公开(公告)号：US09375578B2
公开(公告)日：2016-06-28
申请号：US12178534
申请日：2008-07-23
申请人： Douglas A. Hettrick , Todd Jon Sheldon , Paul D. Ziegler , David E. Euler
发明人： Douglas A. Hettrick , Todd Jon Sheldon , Paul D. Ziegler , David E. Euler
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译：提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。

5. 发明申请

US20100023079A1 Cardiac Pacing Methods and Apparatus 有权
标题翻译：心脏起搏方法与装置
公开(公告)号：US20100023079A1
公开(公告)日：2010-01-28
申请号：US12178534
申请日：2008-07-23
申请人： Douglas A. Hettrick , Todd Jon Sheldon , Paul D. Ziegler , David E. Euler
发明人： Douglas A. Hettrick , Todd Jon Sheldon , Paul D. Ziegler , David E. Euler
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译：提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。

6. 发明申请

US20120253207A1 HEART FAILURE MONITORING 审中-公开
标题翻译：心力衰竭监测
公开(公告)号：US20120253207A1
公开(公告)日：2012-10-04
申请号：US13436408
申请日：2012-03-30
申请人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
发明人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
IPC分类号： A61B5/0205
CPC分类号： A61B5/0006 , A61B5/0004 , A61B5/7275 , G06F19/3418 , G16H40/40 , G16H50/30
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.
摘要翻译：描述了基于患者住院时间传送存储在可植入医疗装置（IMD）中的诊断信息的技术。例如，IMD可以在住院期间向临床医师和/或外部设备传送更高分辨率的诊断信息，以帮助临床医师评价心力衰竭治疗以及放电是否合适。该更高分辨率的诊断信息可以包括由IMD自动生成和发送的至少每两小时一次的一个或多个患者度量。在住院后期间，IMD可以向临床医生传递较低分辨率的诊断信息，指示重新住院的风险水平。例如，较低分辨率诊断信息可以包括一天一次的风险水平和/或患者度量。以这种方式，IMD传输的诊断信息可以针对患者所需的特定心力衰竭监测。

7. 发明授权

US10542887B2 Heart failure monitoring 有权
公开(公告)号：US10542887B2
公开(公告)日：2020-01-28
申请号：US13436408
申请日：2012-03-30
申请人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
发明人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
IPC分类号： A61B5/02 , A61B5/00
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.

8. 发明申请

US20100204716A1 METHODS AND DEVICES FOR OCCLUSION OF AN ATRIAL APPENDAGE 审中-公开
标题翻译：方法和装置用于消除ATRIAL附件
公开(公告)号：US20100204716A1
公开(公告)日：2010-08-12
申请号：US12768200
申请日：2010-04-27
申请人： Mark T. Stewart , Alison Lutterman , David E. Francischelli , Leonard H. Leuer , Daneil C. Haeg , Marie T. Steinbrink , Roderick E. Briscoe , Tom P. Daigel , Eduardo N. Warman , Paul T. Rothstein , Phillip C. Falkner , Douglas A. Hettrick , David J.S. Kim , Steven C. Christian
发明人： Mark T. Stewart , Alison Lutterman , David E. Francischelli , Leonard H. Leuer , Daneil C. Haeg , Marie T. Steinbrink , Roderick E. Briscoe , Tom P. Daigel , Eduardo N. Warman , Paul T. Rothstein , Phillip C. Falkner , Douglas A. Hettrick , David J.S. Kim , Steven C. Christian
IPC分类号： A61B17/128 , A61B17/122
CPC分类号： A61B17/12 , A61B17/0057 , A61B17/12009 , A61B17/12013 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B90/39 , A61B2017/00243 , A61B2017/00575 , A61B2017/12018 , A61B2017/306
摘要： Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.
摘要翻译：本发明的一些实施例提供一种用于闭塞患者左心耳的系统。该系统的一些实施例可以包括可以围绕左心耳定位的环封闭器和环施加器来相对于左心耳定位环封闭器。一个实施例公开了通过心房接近心脏心脏表面的方法。本发明的另外的实施例提供了可以围绕左心耳定位的夹子封堵器。夹子施放器可以相对于左心耳定位夹子封堵器。

9. 发明申请

US20090275854A1 SYSTEM AND METHOD OF MONITORING PHYSIOLOGIC PARAMETERS BASED ON COMPLEX IMPEDANCE WAVEFORM MORPHOLOGY 审中-公开
标题翻译：基于复杂阻抗波形形态监测生理参数的系统和方法
公开(公告)号：US20090275854A1
公开(公告)日：2009-11-05
申请号：US12112655
申请日：2008-04-30
申请人： Todd M. Zielinski , Douglas A. Hettrick , Eduardo N. Warman
发明人： Todd M. Zielinski , Douglas A. Hettrick , Eduardo N. Warman
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/029 , A61B5/0538 , A61N1/36521
摘要： Changes in physiologic parameters may be detected in a patient by measuring the impedance of a tissue segment located in a selected electrode vector field, storing baseline impedance information based on the measured impedance, detecting changes in impedance characteristics from the baseline impedance information, and providing alerts for changes in the physiologic parameters based on the detected changes in impedance characteristics. In some situations, detecting the changes in impedance characteristics involves detecting changes in morphology of an impedance waveform, such as a cardiac component of an impedance waveform, a respiratory component of an impedance waveform, and the phase angle of the complex impedance.
摘要翻译：可以通过测量位于所选择的电极向量场中的组织段的阻抗，基于所测量的阻抗存储基线阻抗信息，从基线阻抗信息检测阻抗特性的变化，并提供警报来检测患者生理参数的变化基于检测到的阻抗特性变化对生理参数进行变化。在某些情况下，检测阻抗特性的变化涉及检测阻抗波形的形态变化，例如阻抗波形的心脏分量，阻抗波形的呼吸成分和复阻抗的相位角。

10. 发明授权

US08369946B2 Time based arrhythmia therapy efficacy criteria 有权
标题翻译：基于时间的心律失常治疗功效标准
公开(公告)号：US08369946B2
公开(公告)日：2013-02-05
申请号：US12211254
申请日：2008-09-16
申请人： Anne M. Gillis , Katherine H. Anderson , Douglas A. Hettrick , David E. Ritscher
发明人： Anne M. Gillis , Katherine H. Anderson , Douglas A. Hettrick , David E. Ritscher
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/0215 , A61B5/0464 , A61B5/11 , A61B5/145 , A61B5/7264 , A61N1/3624 , A61N1/3962
摘要： An implantable medical device and associated method classify therapy outcomes and heart rhythms in association with therapy outcome. A therapy success time interval is started in response to delivering an arrhythmia therapy. If normal sinus rhythm is detected after the therapy success time interval expires, the delivered therapy is classified as unsuccessful and the detected arrhythmia is classified as a self-terminating rhythm.
摘要翻译：可植入医疗器械和相关方法将治疗结果和心律相结合的治疗结果进行分类。响应于递送心律失常疗法开始治疗成功时间间隔。如果治疗成功时间间隔到期后检测到正常的窦性心律，则将所传递的治疗分类为不成功，并将检测到的心律失常归类为自终止节律。

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