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1. 发明申请

US20050163914A1 Deposition method for endoprostheses provided for constantly administering medicaments 审中-公开
标题翻译：提供用于不断施用药物的内用假体的沉积方法
公开(公告)号：US20050163914A1
公开(公告)日：2005-07-28
申请号：US10507924
申请日：2003-03-17
申请人： Doris Klee , Norbert Weiss , Alexander Rubben , Arno Bucker
发明人： Doris Klee , Norbert Weiss , Alexander Rubben , Arno Bucker
IPC分类号： A61K47/48 , A61L31/16 , A61L2/00 , B05D3/00
CPC分类号： A61L31/16 , A61K47/6957 , A61L2300/428 , A61L2300/602 , A61L2300/608
摘要： The present invention describes a deposition method for applying an active ingredient onto an endoprosthesis with a thin polymer coating. By means of the inventive deposition method which can be carried out in a technically easy way it is possible to bring about a slow and largely constant active ingredient release, as shown in III. 1 using tretinoin as the example. Since further processing steps are not necessary after the application of the active ingredient(s), no destruction of the active ingredient by the application of a second polymer coating, for example, has to be feared. Thus, relatively unstable active ingredients, such as tretinoin, can also be applied onto the endoprosthesis without any problems.
摘要翻译：本发明描述了一种使用薄聚合物涂层将活性成分施用到内用假体上的沉积方法。通过本发明的沉积方法，其可以以技术上容易的方式进行，如III所示，可以产生缓慢且大部分恒定的活性成分释放。 1以维甲酸为例。由于在施用活性成分之后不需要进一步的加工步骤，所以不必担心例如通过施加第二聚合物涂层破坏活性成分。因此，相对不稳定的活性成分（如维甲酸）也可以应用于内用假体，没有任何问题。

2. 发明申请

US20080243244A1 Metallic Endoprosthesis Compatible with Magnetic Resonance 审中-公开
标题翻译：金属内置假体兼容磁共振
公开(公告)号：US20080243244A1
公开(公告)日：2008-10-02
申请号：US12035699
申请日：2008-02-22
申请人： Arno Bucker , Alexander Rubben
发明人： Arno Bucker , Alexander Rubben
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2220/005 , A61F2220/0058 , A61L31/022 , A61L31/18
摘要： A metallic endoprosthesis is provided and causes no significant artefacts on images taken by magnetic resonance tomography (MRT), as a result of the combination of the production materials with a special design, which permits an evaluation of the externally adjacent region and the lumen of the endoprosthesis by means of MRT. The endoprosthesis is made from a material with a magnetisability similar to human tissue. The design of the endoprosthesis is such that the members or wires of the endoprosthesis run extensively along the longitudinal axis of the endoprosthesis, without forming a closed circuit in a plane which is essentially perpendicular to the endoprosthesis longitudinal axis. Further variations of the endoprosthesis design are possible, which all offer a full compatibility with MR for the endoprosthesis
摘要翻译：由于生产材料与特殊设计的结合，提供了一种金属内置假体，并且不会对由磁共振断层扫描（MRT）拍摄的图像产生显着的伪像，这样可以评估外部相邻区域和通过MRT进行内假体。内置假体由具有类似于人体组织的可磁性的材料制成。内假体的设计使得内用假体的构件或电线沿着内置假体的纵向轴线延伸，而不在基本上垂直于内假体纵向轴线的平面中形成闭合电路。内置假体设计的进一步变化是可能的，所有这些都能为内置假体提供与MR的完全兼容性

3. 发明申请

US20110092900A1 Method for Producing a Bioactive Surface on an Endoprosthesis or on the Balloon of a Balloon Catheter 有权
标题翻译：生物活性表面在气道导管的内置假体或气球上的方法
公开(公告)号：US20110092900A1
公开(公告)日：2011-04-21
申请号：US12936952
申请日：2008-04-09
申请人： Alexander Rubben
发明人： Alexander Rubben
IPC分类号： A61M29/00 , B05D5/00
CPC分类号： A61L29/16 , A61F2/0077 , A61F2/82 , A61L29/06 , A61L29/08 , A61L31/16 , A61L2300/00 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/1086 , A61M2025/1088
摘要： A method for producing a bioactive surface on an endoprosthesis, or on the balloon (3) of a balloon catheter (1) is described, wherein the surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is softened. The surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is moistened with a solution (6) of an active ingredient (7), and the solvent (8) is separated from the active ingredient (7). In addition, a balloon (3) of a balloon catheter (1) is disclosed, which comprises an uncoated surface (4), wherein an unencapsulated active ingredient (7) is embedded at least partially into the material of the surface (4). Furthermore, a balloon catheter (1) is described, which comprises a balloon (3) according to the invention. In addition, an endoprosthesis, particularly a polymer stent is described, which comprises an uncoated surface (15), wherein an active ingredient (7) is embedded at least partially into the material of the surface (15).
摘要翻译：描述了一种用于在内置假体上或球囊导管（1）的球囊（3）上产生生物活性表面的方法，其中内置假体的表面（15）或球囊（3）的表面（4）软化了内用假体的表面（15）或球囊（3）的表面（4）用活性成分（7）的溶液（6）润湿，并且将溶剂（8）与活性成分（ 7）。此外，公开了一种气球导管（1）的气球（3），其包括未涂覆的表面（4），其中未包封的活性成分（7）至少部分地嵌入到表面（4）的材料中。此外，描述了包括根据本发明的气球（3）的气囊导管（1）。此外，描述了内置假体，特别是聚合物支架，其包括未涂覆的表面（15），其中活性成分（7）至少部分地嵌入到表面（15）的材料中。

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