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1. 发明授权

US07802569B2 Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery 有权
标题翻译：用于高剂量率气雾剂药物输送的气溶胶加工和吸入方法和系统
公开(公告)号：US07802569B2
公开(公告)日：2010-09-28
申请号：US11315951
申请日：2005-12-22
申请人： Donovan B. Yeates , Jinghai Yi , Guanglin Li
发明人： Donovan B. Yeates , Jinghai Yi , Guanglin Li
IPC分类号： A61M16/00
CPC分类号： A61M15/0086 , A61M11/042 , A61M11/06 , A61M15/008 , A61M2016/0036 , A61M2205/362 , A61M2205/368 , B01D45/08
摘要： A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
摘要翻译：公开了能够以高剂量率递送来自含有所需治疗剂的含水或非水性溶液的可呼吸固体气溶胶的方法和系统。该方法和系统包括气溶胶发生器，气溶胶蒸发器，气溶胶浓缩器和气溶胶流量调节器的集成。气溶胶发生器产生10-30微米的液滴，分布狭窄。气溶胶射流被同轴逆流加热的空气射流阻止，并通过环形旋转的加热空气迅速蒸发。在气溶胶浓缩过程中，大部分空气与不需要的溶剂蒸气一起从气溶胶流中除去。输出的气溶胶携带干燥的颗粒被患者吸入。呼吸控制的气溶胶液体发生系统在吸入过程中将含有感兴趣的测试剂（药物或毒素）的流体输送到气溶胶发生器。

2. 发明授权

US07933644B2 Instantaneous autonomic nervous function and cardiac predictability based on heart and pulse rate variability analysis 失效
标题翻译：基于心脏和脉搏变异性分析的瞬时自主神经功能和心脏可预测性
公开(公告)号：US07933644B2
公开(公告)日：2011-04-26
申请号：US10552009
申请日：2004-03-26
申请人： Lid B. Wong , Donovan B. Yeates , Guanglin Li , Tarun Chandra , Mahandas A. Kizhakayil
发明人： Lid B. Wong , Donovan B. Yeates , Guanglin Li , Tarun Chandra , Mahandas A. Kizhakayil
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/04014 , A61B5/0472 , A61B5/4035 , A61B5/7257
摘要： A system and method that can simultaneously acquire electrocardiogram or pulse rate data (42, 44, 46), dynamically perform time-frequency (70) and chaotic analysis (60) in real-time, visually display the results in a convenient graphical format (50) and store the results in a computer file format (50).
摘要翻译：可以同时获取心电图或脉搏数据（42,44,46），实时动态执行时间频率（70）和混沌分析（60）的系统和方法，以方便的图形格式可视化显示结果（ 50）并将结果存储为计算机文件格式（50）。

3. 发明申请

US20070144514A1 Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery 有权
标题翻译：用于高剂量率气雾剂药物输送的气溶胶加工和吸入方法和系统
公开(公告)号：US20070144514A1
公开(公告)日：2007-06-28
申请号：US11315951
申请日：2005-12-22
申请人： Donovan Yeates , Jinghai Yi , Guanglin Li
发明人： Donovan Yeates , Jinghai Yi , Guanglin Li
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0086 , A61M11/042 , A61M11/06 , A61M15/008 , A61M2016/0036 , A61M2205/362 , A61M2205/368 , B01D45/08
摘要： A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
摘要翻译：公开了能够以高剂量率递送来自含有所需治疗剂的含水或非水性溶液的可呼吸固体气溶胶的方法和系统。该方法和系统包括气溶胶发生器，气溶胶蒸发器，气溶胶浓缩器和气溶胶流量调节器的集成。气溶胶发生器产生10-30个液滴，尺寸分布窄。气溶胶射流被同轴逆流加热的空气射流阻止，并通过环形旋转的加热空气迅速蒸发。在气溶胶浓缩过程中，大部分空气与不需要的溶剂蒸气一起从气溶胶流中除去。输出的气溶胶携带干燥的颗粒被患者吸入。呼吸控制的气溶胶液体发生系统在吸入过程中将含有感兴趣的测试剂（药物或毒素）的流体输送到气溶胶发生器。

4. 发明申请

US20070219455A1 Instantaneous Autonomic Nervous Function and Cardiac Predictability Based on Heart and Pulse Rate Variability Analysis 失效
标题翻译：基于心脏和心率变异性分析的瞬时自主神经功能和心脏可预测性
公开(公告)号：US20070219455A1
公开(公告)日：2007-09-20
申请号：US10552009
申请日：2004-03-26
申请人： Lid Wong , Donovan Yeates , Guanglin Li , Tarun Chandra , Mahandas Kizhakayil
发明人： Lid Wong , Donovan Yeates , Guanglin Li , Tarun Chandra , Mahandas Kizhakayil
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/04014 , A61B5/0472 , A61B5/4035 , A61B5/7257
摘要： A system and method that can simultaneously acquire electrocardiogram or pulse rate data (42, 44, 46), dynamically perform time-frequency (70) and chaotic analysis (60) in real-time, visually display the results in a convenient graphical format (50) and store the results in a computer file format (50).
摘要翻译：可以同时获取心电图或脉搏数据（42,44,46），实时动态执行时间频率（70）和混沌分析（60）的系统和方法，以方便的图形格式可视化显示结果（ 50）并将结果存储为计算机文件格式（50）。

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