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1. 发明授权

US08008317B2 Inhibitors of akt activtiy 有权
标题翻译：抑制剂的活性
公开(公告)号：US08008317B2
公开(公告)日：2011-08-30
申请号：US11921352
申请日：2006-06-07
申请人： Donna J. Armstrong , Essa H. Hu , Michael J. Kelly, III , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Michael J. Rossi , Philip E. Sanderson , Jiabing Wang
发明人： Donna J. Armstrong , Essa H. Hu , Michael J. Kelly, III , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Michael J. Rossi , Philip E. Sanderson , Jiabing Wang
IPC分类号： A61K31/437 , A61K31/4375 , C07D471/14 , C07D471/16
CPC分类号： C07D471/14 , C07D487/14
摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供抑制Akt活性的取代的萘啶化合物。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

2. 发明授权

US4413367A Confining frame for water bed 失效
标题翻译：封闭框架为水床
公开(公告)号：US4413367A
公开(公告)日：1983-11-08
申请号：US389095
申请日：1982-06-16
申请人： Paul S. Miller , Michael J. Rossi
发明人： Paul S. Miller , Michael J. Rossi
IPC分类号： A47C27/08 , A47C19/00
CPC分类号： A47C27/085 , Y10S5/915
摘要： Portions of the confining frame of a water bed are made so they can be tilted away from the water-filled mattress of that water bed to facilitate the positioning, and the smoothing, of a cover for that water-filled mattress adjacent the sides and end of that water-filled mattress.
摘要翻译：水床的限制框架的部分被制成使得它们可以从该水床的充水床垫倾斜，以便于邻近侧面和端部的充水床垫的定位和平滑化的充水床垫。

3. 发明授权

US5531407A Apparatus and method for controlling the shape of structures 失效
标题翻译：用于控制结构形状的装置和方法
公开(公告)号：US5531407A
公开(公告)日：1996-07-02
申请号：US277416
申请日：1994-07-18
申请人： Fred Austin , Gareth J. Knowles , Michael J. Rossi
发明人： Fred Austin , Gareth J. Knowles , Michael J. Rossi
IPC分类号： B64C3/38 , B64C3/48 , G06F19/00 , B64C3/44
CPC分类号： B64C3/48 , Y02T50/145
摘要： An apparatus and method control the shape of a structure with one or more surfaces and internal actuators. A plurality of translational actuators are capable of extending and contracting. The structure can have any number of controllable surfaces, including one. The shapes of the surfaces are controlled by computing the actuator strokes or loads required for achieving specified surface deflections. There are two methods for accomplishing this control. In the actuator stroke-control method, the surface deflections, or deflection errors for closed-loop control, are multiplied by a stroke-control gain matrix which is a function of the properties of the structure with the actuators absent. In the actuator load-control method, the surface deflections, or deflection errors for closed-loop control, are multiplied by a load-control gain matrix which is a function of the properties of the structure with the actuators absent. The control gain matrices minimize the surface shape errors. Ratios of stresses to allowable values are continuously monitored throughout the structure and corrective action is taken to prevent an overstressed condition.
摘要翻译：一种装置和方法用一个或多个表面和内部致动器控制结构的形状。多个平移致动器能够伸缩。该结构可以具有任意数量的可控表面，包括一个。通过计算实现特定表面挠曲所需的致动器行程或载荷来控制表面的形状。实现这种控制有两种方法。在执行器行程控制方法中，闭环控制的表面偏转或偏转误差乘以行程控制增益矩阵，该行程控制增益矩阵是不存在执行器的结构特性的函数。在执行器负载控制方法中，闭环控制的表面偏转或偏转误差乘以负载控制增益矩阵，该增益矩阵是不存在执行器的结构特性的函数。控制增益矩阵使表面形状误差最小化。在整个结构中不断地监测应力对允许值的比例，并采取纠正措施来防止过应力状态。

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