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1. 发明授权

US4413367A Confining frame for water bed 失效
标题翻译：封闭框架为水床
公开(公告)号：US4413367A
公开(公告)日：1983-11-08
申请号：US389095
申请日：1982-06-16
申请人： Paul S. Miller , Michael J. Rossi
发明人： Paul S. Miller , Michael J. Rossi
IPC分类号： A47C27/08 , A47C19/00
CPC分类号： A47C27/085 , Y10S5/915
摘要： Portions of the confining frame of a water bed are made so they can be tilted away from the water-filled mattress of that water bed to facilitate the positioning, and the smoothing, of a cover for that water-filled mattress adjacent the sides and end of that water-filled mattress.
摘要翻译：水床的限制框架的部分被制成使得它们可以从该水床的充水床垫倾斜，以便于邻近侧面和端部的充水床垫的定位和平滑化的充水床垫。

2. 发明授权

US5407801A Formation of oligonucleotide triplexes with selectively modified cytosines 失效
标题翻译：用选择性修饰的胞嘧啶形成寡核苷酸三链体
公开(公告)号：US5407801A
公开(公告)日：1995-04-18
申请号：US101094
申请日：1993-08-03
申请人： Paul S. Miller
发明人： Paul S. Miller
IPC分类号： C07H21/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , C07H21/00 , C12Q1/6839 , C12N2310/15 , C12N2310/152 , C12N2310/334 , C12N2310/3341
摘要： An oligonucleotide or analog thereof including a single cytidine residue at a selected position and having one or more cytidine residues which are 5-methyl substituted. The cytidine nucleus can be selectively transaminated to include an aminoalkyl or carboxyalkyl group as a linker for other functional groups which can be used to form DNA duplexes and triplexes.
摘要翻译：寡核苷酸或其类似物，其在选定位置包括单个胞苷残基并具有一个或多个5-甲基取代的胞苷残基。胞苷核可以选择性转氨基化以包括氨基烷基或羧基烷基作为可用于形成DNA双链体和三链体的其它官能团的连接体。

3. 发明授权

US5665541A Formation of triple helix complexes for the detection of double stranded DNA sequences using oligomers which comprise an 8-modified purine base 失效
标题翻译：用于使用包含8-修饰的嘌呤碱基的寡聚体检测双链DNA序列的三螺旋复合物的形成
公开(公告)号：US5665541A
公开(公告)日：1997-09-09
申请号：US194789
申请日：1994-02-10
申请人： Paul S. Miller , Purshotam Bhan
发明人： Paul S. Miller , Purshotam Bhan
IPC分类号： C07H21/00 , C12Q1/68 , C07H21/04
CPC分类号： C07H21/00 , C12Q1/6839
摘要： A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an Oligomer comprising an 8-modified purine base such as 8-oxo-adenine or 8-oxo-guanine to form a detectable triple helix complex. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel Oligomers comprising an 8-modified purine base are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.
摘要翻译：可以使用包含8-修饰的嘌呤碱（例如8-氧代 - 腺嘌呤或8-氧代 - 鸟嘌呤）的低聚物形成三螺旋结构来检测或识别双链DNA的特定区段，以形成可检测的三螺旋复合物。可以通过三螺旋形成来防止双链DNA片段的功能或表达。包含8-修饰的嘌呤碱基的新型低聚物可用于三螺旋形成，并且可以任选地用DNA修饰基团衍生化。

4. 发明授权

US5627951A Graphical display of chroma keyer controls 失效
标题翻译：色度键控器的图形显示
公开(公告)号：US5627951A
公开(公告)日：1997-05-06
申请号：US395233
申请日：1995-02-27
申请人： Daniel J. Chaplin , Paul M. Trethewey , Paul S. Miller
发明人： Daniel J. Chaplin , Paul M. Trethewey , Paul S. Miller
IPC分类号： G06T11/00
CPC分类号： G06T11/001
摘要： A graphic display for chroma keyer controls presents background hue as a radial spoke of an outer chroma vector circle, with selectivity being displayed as a wedge about the radial spoke. Foreground suppression may be added to the graphic display by providing a concentric inner chroma vector circle with the foreground suppression hue being a radial spoke of the inner circle and foreground selectivity being a wedge within the inner circle about such radial spoke. That portion of the outer circle that is overlapped by the inner circle is suppressed, or rendered invisible, so that the background chroma information appears as a torus about the inner chroma vector circle.
摘要翻译：色度键控器的图形显示器将背景色调呈现为外部色度矢量圆的径向辐条，其选择性以围绕径向辐条的楔形显示。前景抑制可以通过提供同心的内部色度矢量圆添加到图形显示器中，前景抑制色调是内圆的径向辐条，前景选择性是围绕这种径向辐条的内圆内的楔形物。被内圈重叠的外圆的部分被抑制或不可见，使得背景色度信息作为关于内部色度矢量圆的圆环表现出来。

5. 发明授权

US4757055A Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells 失效
标题翻译：用于选择性地控制动物或哺乳动物细胞中外来核酸不希望的表达或功能的方法
公开(公告)号：US4757055A
公开(公告)日：1988-07-12
申请号：US604919
申请日：1984-04-27
申请人： Paul S. Miller , Paul O. P. Ts'O
发明人： Paul S. Miller , Paul O. P. Ts'O
IPC分类号： C07H21/00 , A61K31/70 , A61K31/665
CPC分类号： C07H21/00
摘要： A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
摘要翻译：选择性地控制或干扰外源核酸在其它正常活细胞存在下的作用或功能的方法，其包括确定所述核酸的碱基序列并将所述核酸与适当制备的非离子寡核苷酸烷基或芳基膦酸盐类似物其与指定的外源核酸序列互补。

6. 发明授权

US5912339A Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids 失效
标题翻译：能够与核酸交联或切割核酸的寡核苷酸烷基或芳基膦酸酯衍生物
公开(公告)号：US5912339A
公开(公告)日：1999-06-15
申请号：US342005
申请日：1994-11-16
申请人： Paul S. Miller , Paul O.P. Ts'o
发明人： Paul S. Miller , Paul O.P. Ts'o
IPC分类号： C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C12Q1/68
摘要： A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.
摘要翻译：用于灭活靶核酸的组合物，其包含与靶核酸序列互补的寡核苷酸烷基或芳基膦酸酯类似物，并且包括与靶核酸反应以使靶核酸无活性或非功能性的官能团。

7. 发明授权

US4591614A Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates 失效
标题翻译：寡脱氧核糖核苷烷基或芳基膦酸酯的制备
公开(公告)号：US4591614A
公开(公告)日：1986-05-27
申请号：US605451
申请日：1984-04-30
申请人： Paul S. Miller , Paul O. P. T'so
发明人： Paul S. Miller , Paul O. P. T'so
IPC分类号： C07H21/00 , C07H19/10 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00
摘要： Oligonucleoside-3'-alkyl or aryl phosphonates are prepared by condensing (i) a 5'-protected nucleoside 3'-alkyl or aryl phosphonic imidazolide with (ii) a nucleoside or oligomer which is attached through its 3'-position to a polymer support. The process is advantageously carried out in the presence of tetrazole.
摘要翻译：通过将（i）5'-保护的核苷3'-烷基或芳基膦酸咪唑与（ii）通过其3'-位连接的核苷或寡聚体缩合成聚合物来制备寡核苷-3'-烷基或芳基膦酸酯支持。该方法有利地在四唑的存在下进行。

8. 发明授权

US4507433A Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates 失效
标题翻译：寡脱氧核糖核苷烷基或芳基膦酸酯的制备
公开(公告)号：US4507433A
公开(公告)日：1985-03-26
申请号：US540185
申请日：1983-10-07
申请人： Paul S. Miller , Paul O. P. Ts'O
发明人： Paul S. Miller , Paul O. P. Ts'O
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00 , Y02P20/55
摘要： Process for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which involves condensing 5'-dimethoxytrityldeoxynucleoside 3'-methylphosphonates. The oligomers are removed from the support and the base protecting groups hydrolyzed by treatment with ethylenediamene in ethanol, which avoids hydrolysis of the methylphosphonate linkages. Two types of oligomers are synthesized: those containing only methylphosphonate linkages, d-Np(Np).sub.n N, and those which terminate with a 5' nucleotide residue, dNp(Np).sub.n N. The latter oligomers can be phosphorylated by polynucleotide kinase, and are separated by polyacrylamide gel electrophoresis according to their chain length. Piperidine randomly cleaves the oligomer methylphosphonate linkages and generates a series of shorter oligomers whose number corresponds to the length of the original oligomer. Apurinic sites introduced by acid treatment spontaneously hydrolyze to give oligomers which terminate with free 3' and 5'-OH groups. These reactions may be used to characterize the oligomers.
摘要翻译：在聚苯乙烯聚合物载体上合成脱氧核糖核苷甲基膦酸酯的方法，其涉及使5'-二甲氧基三脱氧核苷3'-甲基膦酸酯缩合。从载体中除去低聚物，碱性保护基团通过在乙醇中用乙二胺处理而水解，这避免了甲基膦酸酯键的水解。合成两种类型的低聚物：仅含甲基膦酸酯键，d-Np（Np）nN和终止于5'核苷酸残基dNp（Np）nN的低聚物。后者的寡聚体可以被多核苷酸激酶磷酸化，并根据其链长度通过聚丙烯酰胺凝胶电泳分离。哌啶随机切割低聚物甲基膦酸酯键，并产生一系列较短的低聚物，其数量对应于原始低聚物的长度。通过酸处理引入的无麸质位点自发水解，得到以游离的3'和5'-OH基团终止的低聚物。这些反应可用于表征低聚物。

9. 发明授权

US6005094A Oligonucleotide analogues having improved stability at acid pH 失效
标题翻译：在酸性pH下具有改善的稳定性的寡核苷酸类似物
公开(公告)号：US6005094A
公开(公告)日：1999-12-21
申请号：US364840
申请日：1994-12-27
申请人： Lionel N. Simon , Paul S. Miller , Paul O. P. Ts'o
发明人： Lionel N. Simon , Paul S. Miller , Paul O. P. Ts'o
IPC分类号： C07H21/00 , C07H21/02
CPC分类号： C07H21/00
摘要： Acid resistant Oligomers suitable for oral administration, orally acceptable formulations of such Oligomers and preparation of pharmaceutical formations of such Oligomers are provided.
摘要翻译：提供了适用于口服给药的耐酸低聚物，这种低聚物的口服可接受的制剂和这种低聚物的药物组合物的制备。

10. 发明授权

US4587044A Linkage of proteins to nucleic acids 失效
标题翻译：蛋白质与核酸的连接
公开(公告)号：US4587044A
公开(公告)日：1986-05-06
申请号：US528573
申请日：1983-09-01
申请人： Paul S. Miller , Paul O. P. Ts'O
发明人： Paul S. Miller , Paul O. P. Ts'O
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K1/107 , C07K14/42 , C12Q1/68 , C07K17/00 , C07H15/12 , C07H17/00
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07K1/1077 , C07K14/42 , C12Q1/68 , C12Q1/6816 , A61K38/00
摘要： A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
摘要翻译：通过将所述核酸与特定于所述活细胞的蛋白质连接来制备相对于所选活细胞特异的核酸 - 蛋白质结合物。

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