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    • 5. 发明授权
    • Conjugated biological molecules and their preparation
    • 共轭生物分子及其制备
    • US07595292B2
    • 2009-09-29
    • US10564340
    • 2004-07-12
    • Stephen James BrocchiniAntony Robert GodwinElisa PedoneJin-Won ChoiSunil Shaunak
    • Stephen James BrocchiniAntony Robert GodwinElisa PedoneJin-Won ChoiSunil Shaunak
    • A61K38/16A61K39/00
    • A61K47/48215A61K47/60
    • Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W- together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.
    • 通式(I)的新型生物活性化合物,其中X和X'之一表示聚合物,另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物,则X-Q-W一起可以代表吸电子基团; 此外,如果X表示聚合物,则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团,其各自经由亲核部分与A和B连接; 或Z 1和Z 2一起表示衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团,优选通过二硫桥将合适的聚合物与合适的生物活性分子缀合而形成。
    • 7. 发明授权
    • Function execution method and apparatus thereof
    • 功能执行方法及其装置
    • US09292199B2
    • 2016-03-22
    • US12557322
    • 2009-09-10
    • Jin-Won Choi
    • Jin-Won Choi
    • G06F3/0488
    • G06F3/04886G06F3/0488G06F3/04883
    • A function execution method and apparatus thereof for displaying one or more sub-functions included in a function selected by a first touch on a trace according to a second touch input based upon the first and the second touches inputted with a timing difference, and executing the relevant sub-function selected among the displayed one or more sub-functions. For this purpose, a function execution method according to the present invention is performed by comprising: detecting a first touch input touched on a display unit; detecting a drag created by a second touch inputted while maintaining the first touch; and displaying one or more sub-functions included in a function selected by the first touch along a trace of the detected drag on the display unit.
    • 一种功能执行方法及其装置,用于根据基于以定时差输入的第一触摸和第二触摸,根据第二触摸输入,在轨迹上由第一次触摸选择的功能中包含的一个或多个子功能,以及执行 在显示的一个或多个子功能中选择相关子功能。 为此,根据本发明的功能执行方法包括:检测在显示单元上触摸的第一触摸输入; 检测在保持第一次触摸的同时输入的第二触摸产生的拖动; 以及在所述显示单元上沿着所述检测到的拖动的迹线,显示包括在由所述第一触摸选择的功能中的一个或多个子功能。
    • 8. 发明申请
    • Conjugated biological molecules and their preparation
    • 共轭生物分子及其制备
    • US20060210526A1
    • 2006-09-21
    • US10564340
    • 2004-07-12
    • Stephen BrocchiniAntony GodwinElisa PedoneJin-Won ChoiSunil Shaunak
    • Stephen BrocchiniAntony GodwinElisa PedoneJin-Won ChoiSunil Shaunak
    • A61K38/16A61K31/785C08G63/91C08G63/48
    • A61K47/48215A61K47/60
    • Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W- together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.
    • 通式(I)的新型生物活性化合物,其中X和X'之一表示聚合物,另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物,则X-Q-W一起可以代表吸电子基团; 此外,如果X表示聚合物,则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团,其各自通过亲核部分连接到A和B; 或Z 1和Z 2一起代表衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团,优选通过二硫桥将合适的聚合物与合适的生物活性分子缀合而形成。