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1. 发明申请

US20080038822A1 Virus clearance of neoplastic cells from mixed cellular compositions 审中-公开
标题翻译：来自混合细胞组合物的肿瘤细胞的病毒清除
公开(公告)号：US20080038822A1
公开(公告)日：2008-02-14
申请号：US11807921
申请日：2007-05-30
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N5/00
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N15/86 , C12N2500/70 , C12N2720/12232 , C12N2720/12243
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

2. 发明申请

US20050214266A1 Combination of transplantation and oncolytic virus treatment 审中-公开
标题翻译：组合移植和溶瘤病毒治疗
公开(公告)号：US20050214266A1
公开(公告)日：2005-09-29
申请号：US11079008
申请日：2005-03-10
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： A61K35/14 , A61K35/15 , A61K35/23 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , A61K35/42 , A61K35/44 , A61K35/76 , A61K35/765 , A61K39/00 , A61K45/06 , A61K48/00 , C12N15/86
CPC分类号： A61K35/15 , A61K35/28 , A61K35/765 , A61K39/00 , A61K45/06 , C12N2720/12032
摘要： Oncolytic viruses can be used to purge cellular compositions to remove undesired neoplastic cells before the cellular compositions are used for transplantation. The present invention relates to the use of a virus to pre-treat a subject prior to delivery into the subject a transplant that has been purged with the same virus. This pre-treatment serves to elicit an immune response in the subject against the virus, thereby protecting the subject from infections by the virus after receiving the transplant, which likely contains infectious viruses.
摘要翻译：在将细胞组合物用于移植之前，溶瘤病毒可用于清除细胞组合物以除去不想要的肿瘤细胞。本发明涉及病毒在将相同病毒清除的移植物递送到受试者之前预处理对象的用途。该预处理用于在受试者中引起针对病毒的免疫应答，从而在接受可能含有感染性病毒的移植物之后保护受试者免受病毒感染。

3. 发明申请

US20080081032A1 Method for reducing pain using oncolytic viruses 审中-公开
标题翻译：使用溶瘤病毒减轻疼痛的方法
公开(公告)号：US20080081032A1
公开(公告)日：2008-04-03
申请号：US11809714
申请日：2007-06-01
申请人： Donald Morris , Matthew Coffey , Bradley Thompson
发明人： Donald Morris , Matthew Coffey , Bradley Thompson
IPC分类号： A61K48/00 , A61P25/04
CPC分类号： A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.
摘要翻译：本发明提供了减少与哺乳动物赘生物相关的疼痛的方法，包括施用有效量的一种或多种溶瘤病毒。优选地，哺乳动物还接受止痛剂，并且当施用溶瘤病毒时，哺乳动物所需的止痛剂的量减少。溶瘤病毒优选为呼肠孤病毒。哺乳动物可以另外进行其他治疗，例如化学疗法，免疫治疗，激素和/或放射治疗。

4. 发明申请

US20060029598A1 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US20060029598A1
公开(公告)日：2006-02-09
申请号：US11236059
申请日：2005-09-26
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： A61K39/395
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

5. 发明申请

US20080032279A1 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US20080032279A1
公开(公告)日：2008-02-07
申请号：US11807930
申请日：2007-05-30
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N7/01
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

6. 发明申请

US20050026289A1 Virus clearance of neoplastic cells from mixed cellular compositions 审中-公开
标题翻译：来自混合细胞组合物的肿瘤细胞的病毒清除
公开(公告)号：US20050026289A1
公开(公告)日：2005-02-03
申请号：US10931728
申请日：2004-08-31
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N7/00 , A61K35/12 , A61K35/14 , A61K35/23 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/52 , A61K35/54 , A61K35/76 , A61K35/765 , A61K48/00 , A61L2/00 , A61P43/00 , C12N5/00 , C12N5/09 , C12N15/861 , C12Q1/68 , C12N15/86
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N15/86 , C12N2500/70 , C12N2720/12232 , C12N2720/12243
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

7. 发明授权

US09708815B1 Operable ramp 有权
公开(公告)号：US09708815B1
公开(公告)日：2017-07-18
申请号：US15424687
申请日：2017-02-03
申请人： Donald Morris , George Franco
发明人： Donald Morris , George Franco
IPC分类号： E04F11/06 , E04F11/00
CPC分类号： E04F11/002 , E04F2011/005
摘要： An operable ramp is moveable between a stowed position and a deployed position to provide a sloped transition surface between upper and lower surfaces of an architectural setting. The operable ramp includes a housing disposed on the lower surface of the architectural setting and having a selectively adjustable height. A first ramp panel has a support element extending from a first end. The operable ramp also includes a drive assembly located within the housing. The drive assembly includes an endless loop coupled to an end of the support element to move the operable ramp between the stowed position and the deployed position. The endless loop has a linear portion located between first and second arcuate portions. The endless loop raises the end of the support element to deploy first ramp panel. The distance between the first and second arcuate portions is selectively adjustable.

8. 发明授权

US09580910B1 Operable ramp 有权
标题翻译：可操作坡道
公开(公告)号：US09580910B1
公开(公告)日：2017-02-28
申请号：US14852384
申请日：2015-09-11
申请人： Donald Morris , George Franco , David Johnson
发明人： Donald Morris , George Franco , David Johnson
IPC分类号： E04F11/00
CPC分类号： E04F11/002 , E04F2011/005
摘要： An operable ramp is moveable between a raised position, in which the ramp forms a pair of steps, and a lowered position, in which the operable ramp provides an inclined surface. The operable ramp includes a first panel rotatably coupled about a first axis that moves back and forth when the operable ramp moves between the lowered position and the raised position. A link is rotatably coupled to the first panel about a second axis and is itself rotatable about a fixed third axis. A second panel is rotatably coupled to the link between the second axis and the third axis, and a third panel is rotatably coupled to the second panel about a fourth axis. When the ramp moves between the raised and lowered positions, the fourth axis rotates about a fixed fifth axis. A linkage selectively rotates the first panel about the first axis.
摘要翻译：可操作的斜坡可在其中斜坡形成一对台阶的升高位置和降低位置之间移动，其中可操作斜坡提供倾斜表面。可操作斜坡包括可旋转地联接在第一轴线上的第一面板，该第一轴线在可操作斜坡在下降位置和升高位置之间移动时来回移动。连杆可围绕第二轴线可旋转地联接到第一面板，并且本身可绕固定的第三轴线旋转。第二面板可旋转地联接到第二轴线和第三轴线之间的连杆，并且第三面板围绕第四轴线可旋转地联接到第二面板。当斜坡在升高位置和下降位置之间移动时，第四轴线绕固定的第五轴线旋转。连杆选择性地围绕第一轴线旋转第一面板。

9. 发明授权

US08961139B2 Aircraft propeller balancing system 有权
标题翻译：飞机螺旋桨平衡系统
公开(公告)号：US08961139B2
公开(公告)日：2015-02-24
申请号：US12925138
申请日：2010-10-14
申请人： Askari Badre-Alam , David Boswell , Donald Morris , Wayne Winzenz
发明人： Askari Badre-Alam , David Boswell , Donald Morris , Wayne Winzenz
IPC分类号： B64C11/08 , F01D25/04 , B64C11/00
CPC分类号： B64C11/008 , F01D25/04 , Y10S416/50 , Y10T29/4902 , Y10T74/2127
摘要： An aircraft system/method for propeller balancing. The system includes an inboard driver with a first and second inboard electromagnetic coil, the inboard driver and the first counterweight balancing rotor and the second counterweight balancing rotor centered around the aircraft propeller shaft rotating machine member with the first inboard electromagnetic coil proximate the first inboard magnets of the first counterweight balancing rotor, with the inboard electromagnetic coil driver proximate the rotation axis of the aircraft propeller shaft rotating machine member and the first counterweight balancing rotor outboard of the inboard electromagnetic coil driver with the first inboard electromagnetic coil generating a electromagnetic field to electromagnetically step the first inboard magnets of the at least first counterweight balancing rotor to electromagnetically actuate rotational movement of the first counterweight balancing rotor around the rotating machine member and relative to the inboard electromagnetic coil driver to a first rotor held balancing position.
摘要翻译：一种用于螺旋桨平衡的飞机系统/方法。该系统包括内部驱动器，其具有第一和第二内侧电磁线圈，内侧驱动器和第一配重平衡转子和第二配重平衡转子以飞行器螺旋桨轴旋转机器构件为中心，第一内侧电磁线圈靠近第一内侧磁体第一配重平衡转子的内侧电磁线圈驱动器靠近飞机螺旋桨轴旋转机构的旋转轴线，并且内侧电磁线圈驱动器的第一配重平衡转子外侧与第一内侧电磁线圈产生电磁场以电磁将所述至少第一配重平衡转子的第一内侧磁体逐步地电磁致动所述第一配重平衡转子围绕所述旋转机械构件并相对于所述内侧电磁线圈驱动器到第一r otor保持平衡位置。

10. 发明授权

US08745800B1 Fold out ramp 有权
标题翻译：折叠斜坡
公开(公告)号：US08745800B1
公开(公告)日：2014-06-10
申请号：US13943603
申请日：2013-07-16
申请人： Donald Morris
发明人： Donald Morris
IPC分类号： B65G69/28
CPC分类号： B60P1/433
摘要： A ramp assembly includes a ramp portion coupled for rotational movement between a stowed position and a deployed position. A first panel is rotatably coupled to the ramp portion about a first axis so that movement of the ramp portion between the stowed position and the deployed position moves the axis along an arcuate path. The ramp assembly further includes a guide that maintains a fixed position relative to the stowed position of the ramp portion. A second panel is slidably associated with the guide and is rotatably coupled to the first panel about a second axis.
摘要翻译：斜坡组件包括连接用于在收起位置和展开位置之间旋转运动的斜坡部分。第一面板围绕第一轴线可旋转地联接到斜面部分，使得倾斜部分在收起位置和展开位置之间的移动沿着弓形路径移动轴线。斜坡组件还包括相对于斜坡部分的收起位置保持固定位置的引导件。第二面板与引导件可滑动地相关联，并且可围绕第二轴线可旋转地联接到第一面板。

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