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1. 发明授权

US07985424B2 Dendritic polymers with enhanced amplification and interior functionality 有权
标题翻译：具有增强的扩增和内部功能的树枝状聚合物
公开(公告)号：US07985424B2
公开(公告)日：2011-07-26
申请号：US11630044
申请日：2005-12-21
申请人： Donald A. Tomalia , Douglas R. Swanson , Baohua Huang , Veera Reddy Pulgam , Joseph R. Heinzelmann , Sonke Svenson , Lori A. Reyna , Michael A. Zhuravel , Abhay Singh Chauhan , Cordell R. DeMattei
发明人： Donald A. Tomalia , Douglas R. Swanson , Baohua Huang , Veera Reddy Pulgam , Joseph R. Heinzelmann , Sonke Svenson , Lori A. Reyna , Michael A. Zhuravel , Abhay Singh Chauhan , Cordell R. DeMattei
IPC分类号： A61K9/14
CPC分类号： C08G63/46 , A01N25/10 , A61K8/85 , A61K9/0019 , A61K9/5146 , A61Q15/00 , A61Q17/005 , C08G83/003 , H01M4/86 , H01M8/10 , Y02P70/56
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易缩放到商业尺寸，新的材料范围以及更低的成本。制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和较少的或没有反向的迈克尔反应），并且在较低的代次下达到包封表面密度。出乎意料的是，多官能分支细胞试剂与多官能核心的这些反应不产生交联材料。这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂作为油漆。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如用于药物递送，转染和诊断，这些树枝状聚合物具有携带材料的附加性质。

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