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1. 发明授权

US07985424B2 Dendritic polymers with enhanced amplification and interior functionality 有权
标题翻译：具有增强的扩增和内部功能的树枝状聚合物
公开(公告)号：US07985424B2
公开(公告)日：2011-07-26
申请号：US11630044
申请日：2005-12-21
申请人： Donald A. Tomalia , Douglas R. Swanson , Baohua Huang , Veera Reddy Pulgam , Joseph R. Heinzelmann , Sonke Svenson , Lori A. Reyna , Michael A. Zhuravel , Abhay Singh Chauhan , Cordell R. DeMattei
发明人： Donald A. Tomalia , Douglas R. Swanson , Baohua Huang , Veera Reddy Pulgam , Joseph R. Heinzelmann , Sonke Svenson , Lori A. Reyna , Michael A. Zhuravel , Abhay Singh Chauhan , Cordell R. DeMattei
IPC分类号： A61K9/14
CPC分类号： C08G63/46 , A01N25/10 , A61K8/85 , A61K9/0019 , A61K9/5146 , A61Q15/00 , A61Q17/005 , C08G83/003 , H01M4/86 , H01M8/10 , Y02P70/56
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易缩放到商业尺寸，新的材料范围以及更低的成本。制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和较少的或没有反向的迈克尔反应），并且在较低的代次下达到包封表面密度。出乎意料的是，多官能分支细胞试剂与多官能核心的这些反应不产生交联材料。这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂作为油漆。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如用于药物递送，转染和诊断，这些树枝状聚合物具有携带材料的附加性质。

2. 发明申请

US20110230348A1 PEHAM Dendrimers for Use in Agriculture 审中-公开
标题翻译： PEHAM用于农业的树枝状大分子
公开(公告)号：US20110230348A1
公开(公告)日：2011-09-22
申请号：US13101098
申请日：2011-05-04
申请人： Ryan T. Hayes , David James Owen , Abhay Singh Chauhan , Veera Reddy Pulgam
发明人： Ryan T. Hayes , David James Owen , Abhay Singh Chauhan , Veera Reddy Pulgam
IPC分类号： A01N57/20 , A01N33/18 , A01N43/40 , A01P7/04 , A01P13/00
CPC分类号： A01N25/22 , A01N25/24 , A01N25/30 , C08L101/005 , A01N33/18 , A01N43/54 , A01N43/653 , A01N47/02 , A01N47/20 , A01N59/20
摘要： Specific PEHAM dendrimers are used in a formulation with an active agent for agricultural purposes, particularly for increasing the efficacy of the active agent in various ways, such as by improving solubility of the active agent in the formulation, by improving adhesion and penetration of the active agent to plant surfaces, by improving the water-fastness of the active agent to the plant or seed, by increasing soil penetration of the active agent to reach the plant roots or under soil parts, or by reducing soil adhesion of the active agent to reach the plant roots or under soil parts, or reducing enzymatic degradation of the active agent by the plant or seed or microorganisms in the soil.
摘要翻译：具体的PEHAM树枝状大分子用于具有用于农业目的的活性剂的制剂中，特别是用于以各种方式增加活性剂的功效，例如通过改善活性剂在制剂中的溶解度，通过改善活性物质的粘附性和渗透性通过增加活性剂到达植物根部或土壤部分的土壤渗透，或通过降低活性剂的土壤粘附达到达到，通过提高活性剂对植物或种子的耐水性，植物根系或土壤部分下降，或减少土壤中植物或种子或微生物对活性成分的酶降解。

3. 发明申请

US20090324742A1 Peham dendrimers as excipients 审中-公开
标题翻译： Peham树枝状大分子作为赋形剂
公开(公告)号：US20090324742A1
公开(公告)日：2009-12-31
申请号：US12310748
申请日：2007-09-07
申请人： Sonke Svenson , Abhay Singh Chauhan
发明人： Sonke Svenson , Abhay Singh Chauhan
IPC分类号： A61K47/48 , A61K47/34 , A61K33/24 , A61K31/59 , A61K8/84
CPC分类号： A61K47/34 , A61K47/6949 , B82Y5/00
摘要： The present invention concerns poly(etherhydroxylamine) PEHAM dendritic polymers wherein they function as excipients for the enhancement of water solubility of poorly water soluble (hydrophobic) Active Materials or enhancement of oil solubility of poorly oil soluble (hydrophilic) Active Materials. These dendritic polymers can have Active Materials associated with them by one or more of the following: (a) by adsorption onto the surface or (b) encapsulation into the interior of the dendritic polymers or (c) a mixture of both where these interactions are driven by one or more of the following (i) electrostatic attraction, (ii) hydrogen bonding between dendritic polymers and Active Material and (iii) hydrophobic or hydrophilic interactions or mixtures of these interactions. Additionally, these associated Active Materials can be associated with dendritic polymers through chemical bonding to the surface or to internal functionalities (IF) of PEHAM dendritic polymers or both. Such bonding is done either directly between PEHAM dendritic polymers and Active Material molecules or via a linker that can have a hydrolysable bond to the Active Material. In addition, a chemical entity with strong interaction to the Active Material and dendritic polymers can be associated with the dendritic polymer prior to adsorption or encapsulation of the Active Material or together with the Active Material.
摘要翻译：本发明涉及聚（醚羟胺）PEHAM树枝状聚合物，其中它们用作增强水溶性差（疏水性）活性材料的水溶性的赋形剂，或提高油溶性（亲水性）活性物质的油溶性。这些树枝状聚合物可以通过一种或多种以下物质与其相关的活性材料：（a）通过吸附到表面上或（b）包封到树枝状聚合物的内部，或（c）两者的混合物，其中这些相互作用是由以下一个或多个（i）静电吸引，（ii）树枝状聚合物和活性材料之间的氢键和（iii）疏水或亲水相互作用或这些相互作用的混合物驱动。另外，这些相关的活性材料可以通过与表面的化学键合或PEHAM树枝状聚合物的内部功能（IF）或两者结合而与树枝状聚合物缔合。这种键合可以直接在PEHAM树枝状聚合物和活性材料分子之间进行，或者通过可以与活性材料具有可水解键的接头进行。此外，与活性物质和树枝状聚合物具有强相互作用的化学物质在活性物质的吸附或包封之前或与活性物质一起可与树枝状聚合物缔合。

4. 发明授权

US06989160B2 Therapeutic/edible compositions comprising herbal ingredients and methods for treating hyperglycemia 失效
公开(公告)号：US06989160B2
公开(公告)日：2006-01-24
申请号：US10101501
申请日：2002-03-19
申请人： Abhay Singh Chauhan , Kishore Babu Chalasani , Sridevi Surapanini , Sharath Kumar Yandrapu , Rajasekhar Kataram , Govardhana Maroju Chary , Prakash Vamanrao Diwan , Kondapuram Vijaya Raghavan
发明人： Abhay Singh Chauhan , Kishore Babu Chalasani , Sridevi Surapanini , Sharath Kumar Yandrapu , Rajasekhar Kataram , Govardhana Maroju Chary , Prakash Vamanrao Diwan , Kondapuram Vijaya Raghavan
IPC分类号： A61K35/78
CPC分类号： A61K36/75 , A61K36/53 , A61K36/58 , A61K36/87 , A61K2300/00
摘要： A therapeutic or an edible composition comprising at least three of the five herbs selected from Prunus amygdales, Ocimum sanctum, Azadirachta indica, Aegle marelose and Vitus vinefera, is provided for the treatment of hyperglycemia, especially for non-insulin dependent diabetic subjects, and the herbal composition has significantly reduced the blood glucose levels in both diabetic and non-diabetic experimental subjects having elevated blood glucose levels.

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