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1. 发明授权

US07220732B2 Compounds useful as photodynamic therapeutic agents 有权
标题翻译：可用作光动力治疗剂的化合物
公开(公告)号：US07220732B2
公开(公告)日：2007-05-22
申请号：US10508754
申请日：2003-03-24
申请人： Donal O'Shea , John Killoran , William Gallagher
发明人： Donal O'Shea , John Killoran , William Gallagher
IPC分类号： A61K31/69 , A61K31/53 , C07D251/72
CPC分类号： C07F5/022
摘要： The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent; R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: H; a substituted or unsubstituted, saturated or unsaturated, cyclic, moiety; a substituted or unsubstituted, saturated or unsaturated, heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl or acyl moiety; and R2and R5 may also be independently a heavy atom or a water-solubilizing group. The present invention also relates to use of these compounds in the therapy in vivo or in vitro of a photosensitive target biological cell by irradiation, as well as methods of treating a photosensitive target biological cell in vivo or in vitro. Finally, the present invention relates to pharmaceutical compositions, comprising these compounds, in association with a pharmaceutically acceptable diluent or carrier.
摘要翻译：本发明涉及下式的化合物或其盐，金属配合物或水合物或其它溶剂化物，其中：M为螯合剂; R 1，R 2，R 3，R 4，R 5和R 5， R 6独立地选自：H; 取代或未取代的饱和或不饱和的环状部分; 取代或未取代的饱和或不饱和的杂环部分; 或取代或未取代的饱和或不饱和的直链或支链烷基或酰基部分; R 2和R 5也可以独立地是重原子或水溶性基团。本发明还涉及这些化合物在体内或体外通过照射进行光敏靶生物细胞治疗的用途，以及在体内或体外治疗感光性靶生物细胞的方法。最后，本发明涉及与药学上可接受的稀释剂或载体结合的包含这些化合物的药物组合物。

2. 发明申请

US20050107335A1 Compounds useful as photodynamic therapeutic agents 有权
标题翻译：可用作光动力治疗剂的化合物
公开(公告)号：US20050107335A1
公开(公告)日：2005-05-19
申请号：US10508754
申请日：2003-03-24
申请人： Donal O'Shea , John Killoran , William Gallagher
发明人： Donal O'Shea , John Killoran , William Gallagher
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/022
摘要： The present invention relates to compounds of the formula or a salt, metal complex or hydrate or other solvate thereof, wherein: M is a chelating agent; R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: H; a substituted or unsubstituted, saturated or unsaturated, cyclic, moiety; a substituted or unsubstituted, saturated or unsaturated, heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl or acyl moiety; and R2 and R5 may also be independently a heavy atom or a water-solubilizing group. The present invention also relates to use of these compounds in the therapy in vivo or in vitro of a photosensitive target biological cell by irradiation, as well as methods of treating a photosensitive target biological cell in vivo or in vitro. Finally, the present invention relates to pharmaceutical compositions, comprising these compounds, in association with a pharmaceutically acceptable diluent or carrier.
摘要翻译：本发明涉及下式的化合物或其盐，金属配合物或水合物或其它溶剂化物，其中：M为螯合剂; R 1，R 2，R 3，R 4，R 5和R 5， R 6独立地选自：H; 取代或未取代的饱和或不饱和的环状部分; 取代或未取代的饱和或不饱和的杂环部分; 或取代或未取代的饱和或不饱和的直链或支链烷基或酰基部分; R 2和R 5也可以独立地是重原子或水溶性基团。本发明还涉及这些化合物在体内或体外通过照射进行光敏靶生物细胞治疗的用途，以及在体内或体外治疗感光性靶生物细胞的方法。最后，本发明涉及与药学上可接受的稀释剂或载体结合的包含这些化合物的药物组合物。

3. 发明授权

US09657120B1 Cyanoacrylate compositions 有权
公开(公告)号：US09657120B1
公开(公告)日：2017-05-23
申请号：US13226184
申请日：2011-09-06
申请人： Marisa Phelan , Cormac Duffy , John Killoran , Barry N. Burns , John Guthrie , Bernard Ryan , Ciara Goff
发明人： Marisa Phelan , Cormac Duffy , John Killoran , Barry N. Burns , John Guthrie , Bernard Ryan , Ciara Goff
IPC分类号： C09J4/00 , C08F20/34 , C08F120/34 , C08F20/00 , C08F222/34 , C08F22/32 , C09J11/06
CPC分类号： C09J133/14 , C08F20/00 , C08F20/34 , C08F22/32 , C08F120/34 , C08F222/32 , C08F222/34 , C09J4/00 , C09J5/00 , C09J5/06 , C09J11/06 , C09J2433/00 , C08F2222/322
摘要： This invention relates to cyanoacrylate-containing compositions, which when cured provide improved heat resistance.

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