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1. 发明授权

US07582667B2 Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase 失效
标题翻译：用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物
公开(公告)号：US07582667B2
公开(公告)日：2009-09-01
申请号：US11710666
申请日：2007-02-23
申请人： Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
发明人： Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
IPC分类号： A01N43/50 , C07D233/00
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04
摘要： The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的10,11-二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑] -5'（1'H） - 酮化合物。还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结。

2. 发明申请

US20070203116A1 Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase 失效
标题翻译：用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物
公开(公告)号：US20070203116A1
公开(公告)日：2007-08-30
申请号：US11710666
申请日：2007-02-23
申请人： Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
发明人： Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
IPC分类号： A61K31/551 , A61K31/506 , A61K31/4188 , C07D487/10
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04
摘要： The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的10,11-二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑] -5'（1'H） - 酮化合物。还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结。

3. 发明申请

US20130100180A1 COLOR LCOS DISPLAY CHIP AND CONTROL METHOD 审中-公开
标题翻译：彩色LCOS显示芯片和控制方法
公开(公告)号：US20130100180A1
公开(公告)日：2013-04-25
申请号：US13320544
申请日：2010-08-13
申请人： Yongping Dai , Xuhuai Dong , Wei Fan , Yi Fan
发明人： Yongping Dai , Xuhuai Dong , Wei Fan , Yi Fan
IPC分类号： G09G3/36
CPC分类号： G09G3/36 , G09G3/3611 , G09G5/008 , G09G2310/0235 , G09G2320/0276 , G09G2330/00 , G09G2330/021 , G09G2370/08
摘要： The present invention relates to a color LCOS display chip and the drive and control method thereof. With new structure design and drive and control method, the video signal nonlinear correcting chip, display drive signal control chip and other high cost special chips which are used in conventional control and drive circuit are abandoned. Multiple systems are integrated in a single chip to save PCB required for combination of multi-system chips, which leads to a lower production cost. The weight and size of control and drive circuit are reduced due to fewer integrated circuit chips and save of PCB. Power consumption is reduced without nonlinear correcting chips and display drive signal control chips. With the finite state machine (FSM) Scheduler as the core of digital signal processing module, the voltage coding value could be adjusted as per nonlinear characteristics of different crystal materials so as to achieve an optimal nonlinear correcting performance, which enhances the universality of the chip.
摘要翻译：本发明涉及彩色LCOS显示芯片及其驱动和控制方法。采用新的结构设计和驱动控制方式，放弃了用于传统控制和驱动电路的视频信号非线性校正芯片，显示驱动信号控制芯片等高成本专用芯片。多个系统集成在单个芯片中，以节省多系统芯片组合所需的PCB，从而降低生产成本。控制和驱动电路的重量和尺寸由于集成电路芯片的减少和PCB的节省而减少。没有非线性校正芯片和显示驱动信号控制芯片，功耗降低。以有限状态机（FSM）调度器为核心的数字信号处理模块，电压编码值可根据不同晶体材料的非线性特性进行调整，实现最优非线性校正性能，提高芯片的通用性。

4. 发明申请

US20120065184A1 COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS 失效
标题翻译：作为TRK抑制剂的化合物和组合物
公开(公告)号：US20120065184A1
公开(公告)日：2012-03-15
申请号：US13227957
申请日：2011-09-08
申请人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
发明人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号： A61K31/5025 , A61K31/5377 , A61P11/06 , A61P25/00 , A61P17/00 , C07D487/04 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。

5. 发明授权

US08101608B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US08101608B2
公开(公告)日：2012-01-24
申请号：US11718886
申请日：2005-11-07
申请人： Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
发明人： Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
IPC分类号： A61K31/404 , A61K31/4025 , A61K31/4178 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61K31/496 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D471/04
CPC分类号： C07D403/14 , C07D403/06
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症，cSrc，TPR-Met，Tie2，MET，FGFR3，Aurora，Ax1，Bmx，BTK，c-kit，CHK2，Flt3，MST2，p70S6K，PDGFR，PKB，PKC，Raf，ROCK-II，Rsk1，SGK，TrkA ，TrkB和TrkC激酶。

6. 发明授权

US07939519B2 Immunosuppresant compounds and compositions 有权
标题翻译：免疫抑制剂化合物和组合物
公开(公告)号：US07939519B2
公开(公告)日：2011-05-10
申请号：US12024992
申请日：2008-02-01
申请人： Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
发明人： Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
IPC分类号： A61K31/397 , C07D205/00
CPC分类号： C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译：本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。

7. 发明申请

US20090221547A1 Immunosuppressant Compounds and Compositions 审中-公开
标题翻译：免疫抑制剂化合物和组合物
公开(公告)号：US20090221547A1
公开(公告)日：2009-09-03
申请号：US12063804
申请日：2006-08-22
申请人： Wenqi Gao , Yongqin Wan , Jiqing Jiang , Yi Fan , Nathanael S. Gray , Shifeng Pan
发明人： Wenqi Gao , Yongqin Wan , Jiqing Jiang , Yi Fan , Nathanael S. Gray , Shifeng Pan
IPC分类号： A61K31/397 , C07D213/79 , A61K31/44 , C07D233/54 , A61K31/4164 , C07D213/02 , C07D401/02 , A61K31/4439 , C07D417/02 , A61K31/4436 , C07D239/02 , A61K31/505 , C07D241/10 , A61K31/4965 , A61P37/06 , A61P29/00 , A61P35/00
CPC分类号： C07D213/79 , C07D209/12 , C07D213/54 , C07D213/80 , C07D213/81 , C07D213/84 , C07D213/86 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/28 , C07D239/30 , C07D241/24 , C07D277/56 , C07D401/04 , C07D401/06 , C07D413/04 , C07D417/12
摘要： The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).
摘要翻译：本发明涉及免疫抑制剂，其制备方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。本申请涉及选自式（Ia），（Ib），（Ic）和（Id）的化合物。

8. 发明申请

US20080298338A1 METHOD FOR EFFICIENT TRANSMISSION AND RECEPTION OF AUDIO DIGITAL SIGNALS 审中-公开
标题翻译：有效传输和接收音频数字信号的方法
公开(公告)号：US20080298338A1
公开(公告)日：2008-12-04
申请号：US12060830
申请日：2008-04-01
申请人： Christopher Deng , Igor Elgorriaga , Yi Fan , Mau-Chung Frank Chang
发明人： Christopher Deng , Igor Elgorriaga , Yi Fan , Mau-Chung Frank Chang
IPC分类号： H04L29/02 , H04Q7/00
CPC分类号： H04L65/608 , H04L1/1607
摘要： The present invention relates to a method of wirelessly transmitting and receiving audio digital signals of the type having a first plurality of blocks with each block having a second plurality of frames, with each frame having a third plurality of subframes, with each subframe having a preamble and a binary data. The method efficiently transmits and recomposes the digital audio signals by searching for the preamble associated with a subframe, which is the first subframe of a frame, with the frame being the first frame of a block, and then transmitting wirelessly only the binary data of each subframe, in each frame, in each block thereafter. In a preferred embodiment, the protocol for the transmission of data calls for each data packet that is transmitted to consist of 512 bytes. The data packet transmitted by the transmitter must be acknowledged by the transmission of an acknowledgement (ACK) packet from the receiver. In the event, the data packet is not received and/or the ACK packet is not received, and transmission must recommence, synchronization is accomplished by the retransmission of data packet immediately after the preamble of the first subframe of the first frame of a block.
摘要翻译：本发明涉及无线发送和接收具有第一多个块的类型的音频数字信号的方法，每个块具有第二多个帧，每个帧具有第三多个子帧，每个帧具有前导码和二进制数据。该方法通过搜索与作为块的第一帧的帧的第一子帧相关联的前同步码来有效地发送和重构数字音频信号，然后仅传输每个帧的二进制数据在每个帧中，在每个块中。在优选实施例中，用于传输数据的协议针对被发送的512个字节的每个数据分组进行呼叫。发送器发送的数据包必须通过来自接收器的确认（ACK）包的传输来确认。在这种情况下，未接收到数据分组和/或没有接收到ACK分组，并且传输必须重新开始，通过在块的第一帧的第一子帧的前导码之后立即重新发送数据分组来实现同步。

9. 发明申请

US20080298232A1 Systems and methods for wireless transmission and reception of data including processing and buffering features 审中-公开
标题翻译：用于无线传输和接收数据的系统和方法，包括处理和缓冲功能
公开(公告)号：US20080298232A1
公开(公告)日：2008-12-04
申请号：US11809062
申请日：2007-05-30
申请人： Yi Fan , Christopher Deng , Igor Elgorriaga
发明人： Yi Fan , Christopher Deng , Igor Elgorriaga
IPC分类号： H04L12/26 , G06F17/00
CPC分类号： H04L47/10 , H04L47/14 , H04L47/30 , H04L47/35 , H04L47/41 , H04W28/12 , H04W28/22
摘要： The present invention relates to a wireless data system which has a transmitter including a transmission buffer. The transmitter is configured to transmit a plurality of packets of encoded data, wherein a level of the transmission buffer is encoded in one of the packets of encoded data. The system further has a wireless receiver for receiving the plurality of packets. The receiver has at least one receiving component that receives the plurality of packets to generate a plurality of decoded signals, wherein the at least one receiving component is configured to receive one of the packets of encoded data from the transmitter to determine the level of transmission buffer. The receiving component is further configured to store the plurality of packets received in a receive buffer, to determine the level of the receive buffer, and to calculate an aggregate buffer level from the transmission buffer and the receive buffer. The receiver controls a packet output rate from the receive buffer to maintain the aggregate buffer level at a desired level.
摘要翻译：本发明涉及一种具有发送器的无线数据系统，发送器包括发送缓冲器。发送器被配置为发送多个编码数据分组，其中传输缓冲器的级别被编码在编码数据的分组之一中。该系统还具有用于接收多个分组的无线接收机。所述接收机具有接收所述多个分组以生成多个解码信号的至少一个接收组件，其中所述至少一个接收组件被配置为从所述发射机接收编码数据分组中的一个以确定所述发射缓冲器的电平。接收组件还被配置为存储在接收缓冲器中接收的多个分组，以确定接收缓冲器的电平，并且从发送缓冲器和接收缓冲器计算聚合缓冲器电平。接收器控制来自接收缓冲器的分组输出速率，以将聚合缓冲器级别保持在期望的水平。

10. 发明申请

US20120050112A1 ANTENNA DESIGNING METHOD AND DATA CARD SINGLE BOARD OF WIRELESS TERMINAL 有权
标题翻译：天线设计方法和数据卡无线终端单板
公开(公告)号：US20120050112A1
公开(公告)日：2012-03-01
申请号：US13290485
申请日：2011-11-07
申请人： Yao LAN , Shuhui Sun , Ping Lei , Yi Fan , Zhitai Zheng , Yanping Xie , Yongling Ban
发明人： Yao LAN , Shuhui Sun , Ping Lei , Yi Fan , Zhitai Zheng , Yanping Xie , Yongling Ban
IPC分类号： H01Q1/38 , G06F17/50
CPC分类号： H01Q1/242 , H01Q5/328 , H01Q5/364
摘要： An antenna designing method and a data single board of a wireless terminal are disclosed. The method provided by the embodiments of the present invention includes: dividing a semi-closed area without other metal wirings on a data card single board of the wireless terminal; and arranging an antenna wiring and a metal coupling piece in the semi-closed area, where the antenna wiring and the metal coupling piece are parallel and overlap one another, a gap exists between the metal coupling piece and the data card single board, and the metal coupling piece is coupled with the data card single board via the gap. An embodiment of the present invention also provides a data card single board of a wireless terminal. According to the embodiments of the present invention, a Specific Absorption Rate (SAR) value of the antenna is reduced, and a working bandwidth of a broadband is realized.
摘要翻译：公开了一种无线终端的天线设计方法和数据单板。本发明实施例提供的方法包括：在无线终端的数据卡单板上划分没有其他金属布线的半封闭区域; 并且在天线和金属耦合片平行并重叠的半封闭区域中布置天线布线和金属耦合片，金属耦合片与数据卡单板之间存在间隙，金属耦合片通过间隙与数据卡单板耦合。本发明的实施例还提供了无线终端的数据卡单板。根据本发明的实施例，减小了天线的比吸收率（SAR）值，实现了宽带的工作带宽。

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