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1. 发明授权

US5147401A Artificial skin 失效
标题翻译：人造皮肤
公开(公告)号：US5147401A
公开(公告)日：1992-09-15
申请号：US574659
申请日：1990-08-29
申请人： Dirkjan Bakker , Maria Ponec-Waelsch
发明人： Dirkjan Bakker , Maria Ponec-Waelsch
IPC分类号： A61L27/00 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/60
CPC分类号： A61L27/60 , A61L27/18 , A61L27/56 , A61L27/58 , Y10T428/249953
摘要： The invention relates to an artificial skin which is made up of(1) a water vapor-permeable, non-porous top layer of a segmented thermoplastic copolyester with a thickness of 5-200 .mu.m, consisting essentially of a multiplicity of recurring long-chain-ester-units and short-chain-ester-units, the long-chain-ester-units making up 30-70% by weight of the copolyester and being represented by the formula--OLO--CO--R--CO-- and the short-chain-ester-units being represented by the formula--OEO--CO--R--CO-- whereinL in the long-chain-unit represents a divalent group which remains after removal of the terminal hydroxyl groups from a poly(oxyethylene) glycol with an average molecular weight of 500-3000;R is a divalent group which remains after removing the carboxyl groups from a dicarboxylic acid with a molecular weight of at most 300; andE in the abovementioned short-chain-unit represents an alkylene group having 2-6 carbon atoms, and(2) a macroporous underlayer of a degradable, biocompatible (co)polymer having a thickness of 30-300 .mu.m, the diameter of the pores having a value of 30-300 microns and the macroporosity being 30-80%.The artificial skin according to the invention can also be designed as a single-layer film, in which case the abovementioned top layer and underlayer gradually merge into one another. Furthermore, the top layer of the artificial skin can be provided with autologous epithelial cells such as keratinocytes and the underlayer can be provided with autologous fibroblasts.

2. 发明申请

US20080214936A1 Phantom Device 失效
标题翻译：幻影装置
公开(公告)号：US20080214936A1
公开(公告)日：2008-09-04
申请号：US11915548
申请日：2006-05-17
申请人： Fokko Pieter Wieringa , Dirkjan Bakker , Rene Gerardus Maria Melick
发明人： Fokko Pieter Wieringa , Dirkjan Bakker , Rene Gerardus Maria Melick
IPC分类号： A61B8/00
CPC分类号： G09B23/30 , A61B5/0059 , A61B5/1455 , A61B8/00 , A61B8/587 , A61B2560/0233
摘要： A phantom device for mimicking anatomical structures, comprising: at least one electronic device layer comprising segmented areas of liquid crystals for forming a graphic layout of an anatomical structure; the segments comprising dyes of various absorbing characteristics for mimicking anatomical structures such as blood vessels; the areas further comprising electrically controllable optical diffuser and/or absorber elements for varying the absorption in the segments so as to mimic dynamical properties of said anatomical structure.
摘要翻译：一种用于模拟解剖结构的幻影装置，包括：至少一个电子装置层，包括用于形成解剖结构的图形布局的液晶分割区域; 所述片段包含用于模拟诸如血管的解剖结构的各种吸收特性的染料; 所述区域还包括用于改变所述段中的吸收以便模拟所述解剖结构的动态特性的电可控光扩散器和/或吸收元件。

3. 发明授权

US08630465B2 Imaging of buried structures 有权
标题翻译：埋藏结构成像
公开(公告)号：US08630465B2
公开(公告)日：2014-01-14
申请号：US10598077
申请日：2005-02-15
申请人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
发明人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
IPC分类号： G06K9/00
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/489 , A61B2562/0242 , G01N21/35 , G01N21/359 , G06T7/12 , G06T7/174 , G06T2207/10048 , G06T2207/20224 , G06T2207/30076 , G06T2207/30101
摘要： A method of obtaining an image of buried structures in an object, comprising: providing a camera for imaging visual and infrared-images; providing a bounded light source; partly irradiating said object by said bounded light source; imaging a non-irradiated area of said object by said camera to image said buried structure; and combining said buried structure image with a visual image of said object. Accordingly an image can be obtained while discarding specular reflections of the object. Additionally there is disclosed a method of enhancing imaging of buried structures in an object, comprising: aligning said infrared light source with a visual light source; providing a first edge analysis of said infrared image; providing a second edge analysis of said visual image; comparing said first and second edge analysis; and discarding edges in said infrared image that are also detected in said second image.
摘要翻译：一种在物体中获得掩埋结构的图像的方法，包括：提供用于对视觉和红外图像进行成像的照相机; 提供有界光源; 通过所述有界光源部分照射所述物体; 通过所述相机对所述物体的未照射区域成像以对所述掩埋结构进行成像; 以及将所述掩埋结构图像与所述物体的视觉图像组合。因此，可以在丢弃对象的镜面反射的同时获得图像。此外，公开了一种增强物体中埋藏结构的成像的方法，包括：将所述红外光源与视觉光源对准; 提供所述红外图像的第一边缘分析; 提供所述视觉图像的第二边缘分析; 比较所述第一和第二边缘分析; 并且丢弃也在所述第二图像中检测到的所述红外图像中的边缘。

4. 发明授权

US5508036A Devices for preventing tissue adhesion 失效
标题翻译：用于防止组织粘连的装置
公开(公告)号：US5508036A
公开(公告)日：1996-04-16
申请号：US78350
申请日：1993-06-21
申请人： Dirkjan Bakker , Erica A. Bakkum , Clemens A. van Blitterswijk
发明人： Dirkjan Bakker , Erica A. Bakkum , Clemens A. van Blitterswijk
IPC分类号： A61L31/00 , A61B19/00 , A61L31/06 , A61L31/14 , A61L33/00 , B32B7/02 , B32B3/26
CPC分类号： B32B7/02 , A61B90/00 , A61L31/06 , A61L31/146 , A61L31/148 , A61B2090/0816 , Y10S521/916 , Y10T428/249976 , Y10T428/249978 , Y10T428/249988 , Y10T428/249989 , Y10T428/249992
摘要： A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer. The first layer is selected from the group consisting of a non-porous layer and a porous layer having a pore size no greater than 3.mu.. The second layer has pores which have a pore size of from about 30.mu. to about 250.mu.. Such a composite device provides for tissue growth into the second layer, while the first layer acts as an adhesion-preventing barrier, and enables attachment of the device to tissue without suturing. Alternatively, the device comprises the first layer hereinabove mentioned and a second layer which is an adherence layer and which adheres to tissue and/or bone.
摘要翻译：一种用于防止组织粘附或粘合到组织或组织至骨的装置，其包括第一层和第二层的复合物，其中每一层包含可生物降解的聚合物。第一层选自无孔层和孔径不大于3μm的多孔层。第二层具有孔径为约30至约250μm的孔。这种复合装置提供组织生长进入第二层，而第一层起着防粘连的屏障的作用，并且能够使装置与组织连接而不缝合。或者，该装置包括上述第一层和作为粘附层并粘附于组织和/或骨的第二层。

5. 发明授权

US5480436A Method for preventing tissue adhesion 失效
标题翻译：防止组织粘连的方法
公开(公告)号：US5480436A
公开(公告)日：1996-01-02
申请号：US279811
申请日：1994-07-15
申请人： Dirkjan Bakker , Erica A. Bakkum , Clemens A. van Blitterswlijk
发明人： Dirkjan Bakker , Erica A. Bakkum , Clemens A. van Blitterswlijk
IPC分类号： A61L31/00 , A61B19/00 , A61L31/06 , A61L31/14 , A61L33/00 , B32B7/02 , A61F2/02
CPC分类号： B32B7/02 , A61B90/00 , A61L31/06 , A61L31/146 , A61L31/148 , A61B2090/0816 , Y10S521/916 , Y10T428/249976 , Y10T428/249978 , Y10T428/249988 , Y10T428/249989 , Y10T428/249992
摘要： A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer, such as, for example, a polyethylene glycol/polybutylene terephthalate copolymer. The first layer is selected from the group consisting of a non-porous layer and a porous layer having a pore size no greater than 3.mu.. The second layer has pores which have a pore size of from about 30.mu. to about 250.mu.. The device is placed between two tissues or between tissue and bone. Such a composite device provides for tissue growth into the second layer, while the first layer acts as an adhesion-preventing barrier, and enables attachment of the device to tissue without suturing. Alternatively, the device comprises the first layer hereinabove mentioned and a second layer which is an adherence layer and which adheres to tissue and/or bone.
摘要翻译：一种用于防止组织粘附或粘合到组织或组织至骨的装置，其包括第一层和第二层的复合物，每一层包含可生物降解的聚合物，例如聚乙二醇/聚对苯二甲酸丁二醇酯共聚物。第一层选自无孔层和孔径不大于3μm的多孔层。第二层具有孔径为约30至约250μm的孔。该装置放置在两个组织之间或组织和骨之间。这种复合装置提供组织生长进入第二层，而第一层起着防粘连的屏障的作用，并且能够使装置能够在没有缝合的情况下附着到组织。或者，该装置包括上述第一层和作为粘附层并粘附于组织和/或骨的第二层。

6. 发明授权

US07748252B2 Phantom device 失效
标题翻译：幻影装置
公开(公告)号：US07748252B2
公开(公告)日：2010-07-06
申请号：US11915548
申请日：2006-05-17
申请人： Fokko Pieter Wieringa , Dirkjan Bakker , René Gerardus Maria Melick
发明人： Fokko Pieter Wieringa , Dirkjan Bakker , René Gerardus Maria Melick
IPC分类号： G01N29/00
CPC分类号： G09B23/30 , A61B5/0059 , A61B5/1455 , A61B8/00 , A61B8/587 , A61B2560/0233
摘要： A phantom device for mimicking anatomical structures, comprising: at least one electronic device layer comprising segmented areas of liquid crystals for forming a graphic layout of an anatomical structure; the segments comprising dyes of various absorbing characteristics for mimicking anatomical structures such as blood vessels; the areas further comprising electrically controllable optical diffuser and/or absorber elements for varying the absorption in the segments so as to mimic dynamical properties of said anatomical structure.
摘要翻译：一种用于模拟解剖结构的幻影装置，包括：至少一个电子装置层，包括用于形成解剖结构的图形布局的液晶分割区域; 所述片段包含用于模拟诸如血管的解剖结构的各种吸收特性的染料; 所述区域还包括用于改变所述段中的吸收以便模拟所述解剖结构的动态特性的电可控光扩散器和/或吸收元件。

7. 发明申请

US20090028461A1 IMAGING OF BURIED STRUCTURES 有权
标题翻译： BURIED结构的成像
公开(公告)号：US20090028461A1
公开(公告)日：2009-01-29
申请号：US10598077
申请日：2005-02-15
申请人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
发明人： Fokko Pieter Wieringa , Dirkjan Bakker , Antonius Franciscus Wilhelmus van der Steen , Frits Mastik , Rene Gerardus Maria van Melick
IPC分类号： G06K9/36 , G06K9/00 , A61B17/34
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/489 , A61B2562/0242 , G01N21/35 , G01N21/359 , G06T7/12 , G06T7/174 , G06T2207/10048 , G06T2207/20224 , G06T2207/30076 , G06T2207/30101
摘要： A method of obtaining an image of buried structures in an object, comprising partially irradiating said object by light of a wavelength that images said buried structure; and obtaining a complementary partial image of said buried structure by light diffused from a non-irradiated image area.According to the method, an image can be obtained while discarding specular reflections of the object. Thus, deeper structures will be better visible. In a further aspect, the invention offers a method of enhancing imaging of buried structures in an object, comprising: analysing said image as a first image in order to detect the edges of said buried structure; obtaining a second image by irradiating said object with a second light that visually images said object; and combining said first and second images for defining edges of said buried structure in said visual image.
摘要翻译：一种获得物体中埋藏结构的图像的方法，包括通过对所述掩埋结构进行成像的波长的光部分照射所述物体; 以及通过从非照射图像区域扩散的光获得所述掩埋结构的互补部分图像。根据该方法，可以在丢弃对象的镜面反射的同时获得图像。因此，更深层的结构将会更加明显。在另一方面，本发明提供了一种增强物体中掩埋结构的成像的方法，包括：分析所述图像作为第一图像，以便检测所述掩埋结构的边缘; 通过用视觉图像所述物体的第二光照射所述物体来获得第二图像; 以及将所述第一和第二图像组合用于在所述视觉图像中定义所述掩埋结构的边缘。

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