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1. 发明申请

US20110301189A1 STABLE PHARMACEUTICAL COMPOSITIONS OF RAPAMYCIN ESTERS 审中-公开
标题翻译： RAPAMYCIN ESTER的稳定药用组合物
公开(公告)号：US20110301189A1
公开(公告)日：2011-12-08
申请号：US13151721
申请日：2011-06-02
申请人： Dhiraj Khattar , Rajesh Khanna , Poonam Singla , Abhilasha Yadav , Vinay Gupta , Rajesh Kini , Sushil Kumar Dubey
发明人： Dhiraj Khattar , Rajesh Khanna , Poonam Singla , Abhilasha Yadav , Vinay Gupta , Rajesh Kini , Sushil Kumar Dubey
IPC分类号： A61K31/436 , A61P35/00 , C07D491/153
CPC分类号： A61K9/0019 , A61K31/436 , A61K47/10 , A61K47/12
摘要： A stable pharmaceutical compositions of Rapamycin Esters, in particular Rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid that is free of antioxidants and a process of preparing the same.
摘要翻译：雷帕霉素酯的稳定药物组合物，特别是不含抗氧化剂的3-羟基-2-（羟甲基）-2-甲基丙酸的雷帕霉素42-酯及其制备方法。

2. 发明授权

US09872873B2 Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis 有权
公开(公告)号：US09872873B2
公开(公告)日：2018-01-23
申请号：US14377047
申请日：2012-03-29
申请人： Dhiraj Khattar , Rajesh Khanna , Sanjay Motwani , Minakshi Garg , Vikas Chandel , Mukti Yadav , Vijay Kumar Kyama , Vikas Bhandari
发明人： Dhiraj Khattar , Rajesh Khanna , Sanjay Motwani , Minakshi Garg , Vikas Chandel , Mukti Yadav , Vijay Kumar Kyama , Vikas Bhandari
IPC分类号： A61K31/706 , A61K47/02 , A61K47/26 , A61K31/4184 , A61K9/19 , A61K9/00
CPC分类号： A61K31/706 , A61K9/0019 , A61K9/19 , A61K31/4184 , A61K47/02 , A61K47/26
摘要： The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.

3. 发明申请

US20140378407A1 PROCESS FOR PREPARING STABLE PHARMACEUTICAL COMPOSITIONS OF COMPOUNDS SUSCEPTIBLE TO HYDROLYSIS 有权
标题翻译：制备易溶于水解的化合物的稳定的药物组合物的方法
公开(公告)号：US20140378407A1
公开(公告)日：2014-12-25
申请号：US14377047
申请日：2012-03-29
申请人： Dhiraj Khattar , Rajesh Khanna , Sanjay Motwani , Minakshi Garg , Vikas Chandel , Mukti Yadav , Vijay Kumar Kyama , Vikas Bhandari
发明人： Dhiraj Khattar , Rajesh Khanna , Sanjay Motwani , Minakshi Garg , Vikas Chandel , Mukti Yadav , Vijay Kumar Kyama , Vikas Bhandari
IPC分类号： A61K31/706 , A61K47/02 , A61K47/26 , A61K31/4184 , A61K9/19
CPC分类号： A61K31/706 , A61K9/0019 , A61K9/19 , A61K31/4184 , A61K47/02 , A61K47/26
摘要： The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.
摘要翻译：本发明涉及一种制备易于水解的化合物的稳定药物组合物的方法，其包括a。在配制容器中，任选地在注射用水中加入所需量的药学上可接受的冻干赋形剂; b。加入有机溶剂形成适当比例的水和有机溶剂; C。将制剂容器的温度保持在-5±1℃至-5±3℃的范围内。 d。加入所需量的易水解的化合物形成溶液并冻干该溶液。

4. 发明授权

US08167932B2 Heart valve delivery system with valve catheter 有权
标题翻译：带阀导管的心脏瓣膜输送系统
公开(公告)号：US08167932B2
公开(公告)日：2012-05-01
申请号：US11252657
申请日：2005-10-18
申请人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario Iobbi , Rajesh Khanna , Dave J. Evans
发明人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario Iobbi , Rajesh Khanna , Dave J. Evans
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9583
摘要： A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.
摘要翻译：提供心脏瓣膜输送系统，其中人造瓣膜被携带在输送套筒内的阀导管上。步进气球从输送套筒突出并提供锥形表面，以便于通过身体血管进入。阶梯气球还有助于穿过天然瓣膜的小叶。在人工瓣膜定位在天然瓣膜内之后，输送套筒缩回以露出假体瓣膜。在一个实施例中，输送套筒通过使用导螺杆缩回，其实现了阀导管和输送套筒之间的相对运动。假体瓣膜优选是可自膨胀的。如果需要，可以扩展踏板气囊以将人工瓣膜牢固地安置在天然瓣膜的位置。假体瓣膜优选地通过多个柔性延伸臂联接到瓣膜导管，所述多个柔性延伸臂允许假肢瓣膜在初始部署之后被折叠，使得如果必要，可以重新定位假体瓣膜。

5. 发明申请

US20110319991A1 Low Profile Transcatheter Heart Valve 有权
标题翻译：薄型经导管心脏瓣膜
公开(公告)号：US20110319991A1
公开(公告)日：2011-12-29
申请号：US13167549
申请日：2011-06-23
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

6. 发明申请

US20070239254A1 System for percutaneous delivery and removal of a prosthetic valve 审中-公开
标题翻译：用于经皮输送和移除假体瓣膜的系统
公开(公告)号：US20070239254A1
公开(公告)日：2007-10-11
申请号：US11400063
申请日：2006-04-07
申请人： Chris Chia , Rajesh Khanna , Philippe Marchand , David Taylor
发明人： Chris Chia , Rajesh Khanna , Philippe Marchand , David Taylor
IPC分类号： A61F2/06
CPC分类号： A61F2/2436 , A61B2017/22035 , A61B2017/2215 , A61F2002/9528
摘要： A valve-retrieval device permits a non-deployed valve mounted on a balloon catheter to be retracted back into an introducer sheath for removal from a patient's body. In particular embodiments, the valve-retrieval device is adapted to be placed on a balloon catheter shaft and then advanced over the shaft into the blood vessel via the introducer sheath. The valve-retrieval device has an expandable distal end portion that assumes an expanded shape when advanced out of the introducer sheath. The valve is positioned within or adjacent the distal end portion of the retrieval device, and the retrieval device and the balloon catheter are retracted together back into the introducer sheath. The distal end portion of the retrieval device, rather than the outer surface portion of the valve covered thereby, contacts the distal end and inner surface of the introducer sheath to facilitate retraction of the valve into the introducer sheath.
摘要翻译：瓣膜取出装置允许安装在气囊导管上的未展开的瓣膜回缩到导引器护套中以从患者身体移除。在具体实施例中，瓣膜取出装置适于放置在球囊导管轴上，然后通过导引器鞘在轴上方进入血管。瓣膜取出装置具有可伸展的远端部分，当伸出引导器护套时，该顶端部呈展开形状。所述阀位于所述取出装置的远端部分内或邻近所述取出装置的远端部分，并且所述取出装置和所述气囊导管一起缩回到所述导引器鞘中。取出装置的远端部分而不是由其覆盖的阀的外表面部分接触引导器护套的远端和内表面，以便于将瓣膜收回到引导器护套中。

7. 发明申请

US20070088431A1 Heart valve delivery system with valve catheter 有权
标题翻译：带阀导管的心脏瓣膜输送系统
公开(公告)号：US20070088431A1
公开(公告)日：2007-04-19
申请号：US11252657
申请日：2005-10-18
申请人： Henry Bourang , Thanh Le , David Taylor , Sam Sok , Mario Iobbi , Rajesh Khanna , Dave Evans
发明人： Henry Bourang , Thanh Le , David Taylor , Sam Sok , Mario Iobbi , Rajesh Khanna , Dave Evans
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9583
摘要： A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.
摘要翻译：提供心脏瓣膜输送系统，其中人造瓣膜被携带在输送套筒内的阀导管上。步进气球从输送套筒突出并提供锥形表面，以便于通过身体血管进入。阶梯气球还有助于穿过天然瓣膜的小叶。在人工瓣膜定位在天然瓣膜内之后，输送套筒缩回以露出假体瓣膜。在一个实施例中，输送套筒通过使用导螺杆缩回，其实现了阀导管和输送套筒之间的相对运动。假体瓣膜优选是可自膨胀的。如果需要，可以扩展踏板气囊以将人工瓣膜牢固地安置在天然瓣膜的位置。假体瓣膜优选地通过多个柔性延伸臂联接到瓣膜导管，所述多个柔性延伸臂允许假肢瓣膜在初始部署之后被折叠，使得如果必要，可以重新定位假体瓣膜。

8. 发明授权

US6081136A Dynamic NOR gates for NAND decode 失效
标题翻译：用于NAND解码的动态NOR门
公开(公告)号：US6081136A
公开(公告)日：2000-06-27
申请号：US993335
申请日：1997-12-19
申请人： Rajesh Khanna , Hamid Partovi
发明人： Rajesh Khanna , Hamid Partovi
IPC分类号： H03K19/096 , H03K19/003
CPC分类号： H03K19/0963
摘要： A NOR gate pair includes a first and second NOR gate, each with a plurality of inputs and an output. A first NAND gate has a first input coupled to the output of the first NOR gate, a second input coupled to the output of the second NOR gate through a first input inverter, and an output. A second NAND gate has a first input coupled to the output of the second NOR gate, a second input coupled to the output of the first NOR gate through a second input inverter, and an output. A first output inverter is coupled to the output of the first NAND gate and a second output inverter is coupled to the output of the second NAND gate. This configuration assures that NOR gates used in a one-hot-decode decoder will all have logic-low outputs during a precharge phase.
摘要翻译： NOR门对包括第一和第二NOR门，每个具有多个输入和输出。第一NAND门具有耦合到第一或非门的输出的第一输入端，通过第一输入反相器耦合到第二或非门的输出的第二输入和输出。第二与非门具有耦合到第二或非门的输出的第一输入，通过第二输入反相器耦合到第一或非门的输出的第二输入和输出。第一输出反相器耦合到第一NAND门的输出，第二输出反相器耦合到第二NAND门的输出。该配置确保在一个热解码解码器中使用的或非门将在预充电阶段期间都具有逻辑低输出。

9. 发明授权

US08454685B2 Low profile transcatheter heart valve 有权
标题翻译：低调的经导管心脏瓣膜
公开(公告)号：US08454685B2
公开(公告)日：2013-06-04
申请号：US13167549
申请日：2011-06-23
申请人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh Khanna , Son Nguyen , Tamir Levi , Itai Pelled
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
摘要翻译：根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。框架可以具有由多个圆周支柱互连的多个轴向支柱。小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。小叶结构具有固定到框架的扇形下边缘部分。裙部构件可以设置在小叶结构和框架之间。

10. 发明申请

US20090108899A1 DYNAMIC VOLTAGE SCALING FOR SELF-TIMED OR RACING PATHS 有权
标题翻译：自动或赛车运动的动态电压调节
公开(公告)号：US20090108899A1
公开(公告)日：2009-04-30
申请号：US11932311
申请日：2007-10-31
申请人： Ajay Bhatia , Rajesh Khanna
发明人： Ajay Bhatia , Rajesh Khanna
IPC分类号： H03H11/26 , G06F17/50
CPC分类号： H03H11/265 , G11C7/04 , G11C7/08 , G11C7/22 , G11C11/4076 , H03K19/00384 , H03K19/018521 , H03K2005/00019
摘要： A timing-constrained circuit (e.g., a self-timed circuit) of optimal performance is achieved by allowing the delay of the circuit to be changed dynamically as a function of operating conditions (e.g., operating voltages or temperatures). The delay of timing signals in the timing-constrained circuit for a given operating condition may be selected to have the minimum margin for that operating condition among the available delays to maximize performance over the entire dynamic range of operating conditions.
摘要翻译：通过允许根据操作条件（例如，工作电压或温度）动态地改变电路的延迟来实现具有最佳性能的定时受限电路（例如，自定时电路）。可以选择给定操作条件的定时约束电路中的定时信号的延迟，以便在可用延迟之间具有该操作条件的最小余量，以在整个操作条件的动态范围内最大化性能。

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