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1. 发明授权

US08748624B2 Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists 有权
标题翻译：可用作胰高血糖素受体拮抗剂的吡啶酰胺 - 丙酸衍生物
公开(公告)号：US08748624B2
公开(公告)日：2014-06-10
申请号：US13478534
申请日：2012-05-23
申请人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
发明人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D213/81
摘要： The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及吡啶甲酰 - 丙酸衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体而改善的病症和病症的用途，包括例如代谢性疾病如II型糖尿病和肥胖。

2. 发明申请

US20120302610A1 PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权
标题翻译：作为GLUCAGON受体拮抗剂有用的PICOLINAMIDO-丙二酸衍生物
公开(公告)号：US20120302610A1
公开(公告)日：2012-11-29
申请号：US13478534
申请日：2012-05-23
申请人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
发明人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
IPC分类号： A61K31/4418 , A61P13/12 , A61P3/04 , C07D213/81 , A61P3/10
CPC分类号： C07D213/81
摘要： The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及吡啶甲酰 - 丙酸衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体而改善的病症和病症的用途，包括例如代谢性疾病如II型糖尿病和肥胖。

3. 发明授权

US09045389B2 Biphenyl derivatives useful as glucagon receptor antagonists 有权
标题翻译：可用作胰高血糖素受体拮抗剂的联苯衍生物
公开(公告)号：US09045389B2
公开(公告)日：2015-06-02
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/166 , C07C229/52 , C07C237/36
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

4. 发明申请

US20120302641A1 BIPHENYL DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权
标题翻译：二苯乙烯衍生物作为GLUCAGON受体拮抗剂有用
公开(公告)号：US20120302641A1
公开(公告)日：2012-11-29
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/197 , A61P13/12 , A61P3/04 , C07C237/36 , A61P3/10
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

5. 发明授权

US08328466B1 Buoyancy stabilized underwater plow and methods for use 有权
标题翻译：浮力稳定的水下犁和使用方法
公开(公告)号：US08328466B1
公开(公告)日：2012-12-11
申请号：US12880200
申请日：2010-09-13
申请人： Brian Shook , Steve Whiteside , Robert Lee , Ronald Skala , Paul Wade , Bret Thomson
发明人： Brian Shook , Steve Whiteside , Robert Lee , Ronald Skala , Paul Wade , Bret Thomson
IPC分类号： F16L1/16
CPC分类号： H02G1/10
摘要： An underwater plow can include a depressor cam and a chute cam that are pivotably attached to a blade portion. The blade portion can be formed with a trough and the depressor cam can be biased in the trough. The chute cam can be formed with a groove having a minimum thickness at its attached end and an increasing taper to a maximum thickness at its distal end. A sensor passing through the plow contacts the edge of the depressor cam, causing depressor cam rotation away from the trough. The sensor passes the depressor cam and pushes against the chute cam, which causes the chute cam to contra-rotate relative to the depressor cam until the sensor passes through the chute arm at is maximum thickness. Once the sensor passes through, the cams contra-rotate back to their respective biased positions.
摘要翻译：水下犁可以包括可枢转地附接到叶片部分的压下凸轮和滑槽凸轮。叶片部分可以形成有槽，并且压力凸轮可以偏置在槽中。滑槽凸轮可以在其附接端形成具有最小厚度的凹槽，并且在其远端处形成增加的锥度至最大厚度。穿过犁的传感器接触压力凸轮的边缘，使压力凸轮转动远离槽。传感器通过压力凸轮并推动斜槽凸轮，这导致滑槽凸轮相对于压力凸轮相反转动，直到传感器以最大厚度通过滑槽臂。一旦传感器通过，凸轮反向旋转回其各自的偏置位置。

6. 发明授权

US08360685B1 Autonomous underwater plow and method of use 有权
标题翻译：自主水下犁和使用方法
公开(公告)号：US08360685B1
公开(公告)日：2013-01-29
申请号：US12876323
申请日：2010-09-07
申请人： Steve Whiteside , Robert Lee , Ronald Skala , Brian Shook , Paul Wade , Bret Thomson
发明人： Steve Whiteside , Robert Lee , Ronald Skala , Brian Shook , Paul Wade , Bret Thomson
IPC分类号： F16L1/16
CPC分类号： B63C11/52 , E02F3/8866 , E02F5/105 , E02F5/106 , H02G1/10
摘要： An autonomous underwater plow can include a frame, a plow assembly and a propulsion assembly. The plow assembly is fixed to the one end of the frame, while the propulsion assembly is pivotably attached to the other end. The propulsion assembly includes thrusters that are rigidly coupled to a float, and that provide a propulsion force perpendicular to the float buoyancy force. The plow sinks when placed in the water, but the float provides sufficient buoyancy so that the float end floats while the plow end is in contact with the ocean floor. This establishes a rake angle of between the frame and ocean floor. The plow requires less propulsion force for motion because part of the plow is floating, and requires less force to overcome obstacles on the ocean floor because the thrusters provides a constant horizontal propulsion force while the frame tilts to overcome the obstacle.
摘要翻译：自主的水下犁可以包括框架，犁组件和推进组件。犁组件固定到框架的一端，而推进组件可枢转地附接到另一端。推进组件包括刚性地联接到浮子的推进器，并且提供垂直于浮子浮力的推进力。当放置在水中时，犁槽下沉，但是浮子提供足够的浮力，使得浮子端在犁端与海底接触时浮动。这确定了框架和海底之间的前角。由于犁的一部分是浮动的，所以犁需要更少的推进力，并且需要更少的力来克服海底上的障碍物，因为推进器在框架倾斜以克服障碍物时提供恒定的水平推进力。

7. 发明授权

US08333535B1 Underwater plow having an improved plow assembly 有权
标题翻译：水下犁具有改进的犁组件
公开(公告)号：US08333535B1
公开(公告)日：2012-12-18
申请号：US12876407
申请日：2010-09-07
申请人： Steve Whiteside , Robert Lee , Ronald Skala , Brian Shook , Paul Wade , Bret Thomson
发明人： Steve Whiteside , Robert Lee , Ronald Skala , Brian Shook , Paul Wade , Bret Thomson
IPC分类号： F16L1/16
CPC分类号： E02F5/101 , E02F5/105 , E02F5/106
摘要： An underwater plow includes a plow assembly that is attached to a frame. The plow assembly includes a blade portion, which defines a blade trough, and a sensor chute portion. The blade portion extends downwardly below a plane that is coincident with a longitudinal axis defined by the frame, while the chute portion extends upwardly above the same plane. A depressor arm is pivotably attached to the blade portion and biased to be in contact with the trough. The depressor arm has a groove that is sized to allow the cable, but not the sensors, to pass through the groove while the depressor arm is in contact with the trough. With this configuration, an array cable passes downward through the blade portion of the plow assembly and becomes buried in the ocean floor. Array sensors, however, are routed upward and pass through the chute portion of the plow assembly.
摘要翻译：水下犁包括附接到框架的犁组件。犁组件包括限定叶片槽的叶片部分和传感器滑槽部分。刀片部分向下延伸到与由框架限定的纵向轴线重合的平面上，而斜槽部分在相同的平面上方向上延伸。压力臂可枢转地连接到叶片部分并被偏压以与槽接触。压降臂具有凹槽，其尺寸允许电缆（而不是传感器）在压降臂与槽接触的同时通过凹槽。利用这种构造，阵列电缆向下通过犁组件的叶片部分并且被埋在海底。然而，阵列传感器被向上引导并穿过犁组件的斜槽部分。

8. 发明申请

US20110172193A1 PRO-DRUGS OF (E)-7-(3-(2-AMINO-1-FLUOROETHYLIDENE)PIPERIDIN-1-YL)-1-CYCLOPROPYL-6-FLUORO-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 审中-公开
标题翻译：（E）-7-（3-（2-氨基-1-氟代乙基）哌啶-1-基）-1-环丙基-6-氟-8-甲氧基-4-氧代-1,4-二氢喹啉的制剂 -3-羧酸
公开(公告)号：US20110172193A1
公开(公告)日：2011-07-14
申请号：US12983365
申请日：2011-01-03
申请人： Mark MACIELAG , Gary Eichenbaum , Tim Gaekens , Michel Guillaume , Brian Shook
发明人： Mark MACIELAG , Gary Eichenbaum , Tim Gaekens , Michel Guillaume , Brian Shook
IPC分类号： A61K31/675 , C07D401/02 , A61K31/4709 , C07D401/14 , C07D405/14 , C07F9/06 , A61P31/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07F9/65583
摘要： The present invention is directed to pro-drugs of (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pharmaceutical compositions containing them and the use of said pro-drugs and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes.
摘要翻译：本发明涉及（E）-7-（3-（2-氨基-1-氟亚乙基）哌啶-1-基）-1-环丙基-6-氟-8-甲氧基-4-氧代 -1,4-二氢喹啉-3-羧酸，含有它们的药物组合物以及所述前药和药物组合物作为抗病原微生物的抗微生物剂的用途，特别是抗耐药微生物。

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