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1. 发明申请

US20110200573A1 Methods of inhibiting retrovirus replication and infectivity 审中-公开
标题翻译：抑制逆转录病毒复制和感染的方法
公开(公告)号：US20110200573A1
公开(公告)日：2011-08-18
申请号：US12931608
申请日：2011-02-04
申请人： Derya Unutmaz , Vyacheslav Furtak
发明人： Derya Unutmaz , Vyacheslav Furtak
IPC分类号： A61K38/43 , C12N9/00 , A61P31/18 , C40B30/00
CPC分类号： A61K38/162
摘要： The present invention provides methods of inhibiting a retrovirus replication or infectivity by administering a therapeutically effective amount of MOV10 or a fragment, derivative or analog thereof or an inhibitor of MOV10 or a fragment, derivative or analog thereof or of inhibiting a retrovirus replication or infectivity by increasing or decreasing transcription, translation or biological activity of MOV10 or a fragment, derivative or analog thereof. In some instances the retrovirus is HIV or HIV-1. The present invention also features methods of treating a disease caused all or in part by a retrovirus, such as HIV or HIV-1, by administering a therapeutically effective amount of MOV10 or a fragment, derivative or analog thereof or an inhibitor thereof or by increasing or decreasing transcription, translation or biological activity of MOV10 or a fragment, derivative or analog thereof. Further, the present invention features methods to identify an agent that may inhibit a retrovirus comprising identifying an agent that is regulated by MOV10 or a fragment, derivative or analog thereof.
摘要翻译：本发明提供了通过施用治疗有效量的MOV10或其片段，衍生物或类似物或其片段，衍生物或类似物或其片段，衍生物或类似物或抑制逆转录病毒复制或感染性的方法来抑制逆转录病毒复制或感染性的方法增加或减少MOV10或其片段，衍生物或类似物的转录，翻译或生物活性。在某些情况下，逆转录病毒是HIV或HIV-1。本发明还涉及通过施用治疗有效量的MOV10或其片段，衍生物或类似物或其抑制剂或通过增加或增加抗体来治疗由全部或部分由逆转录病毒例如HIV或HIV-1引起的疾病的疾病的方法或降低MOV10或其片段，衍生物或类似物的转录，翻译或生物活性。此外，本发明的特征在于鉴定可能抑制逆转录病毒的试剂的方法，包括鉴定由MOV10调节的试剂或其片段，衍生物或类似物。

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