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1. 发明授权

US5880105A Human galactokinase gene 失效
标题翻译：人类半乳糖激酶基因
公开(公告)号：US5880105A
公开(公告)日：1999-03-09
申请号：US998208
申请日：1997-12-24
申请人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
发明人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , A61K31/70
CPC分类号： C12N9/1205 , C12Y207/01006 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
摘要翻译：本发明涉及人半乳糖激酶和半乳糖激酶突变的识别，错义和废话，以及编码相同的分离的核酸，用编码这种蛋白质的DNA转化的重组宿主细胞，以及表达的蛋白质和核酸序列在治疗和/ 诊断应用。

2. 发明授权

US5789223A Human galactokinase gene 失效
公开(公告)号：US5789223A
公开(公告)日：1998-08-04
申请号：US451777
申请日：1995-05-26
申请人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
发明人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , C12N15/85
CPC分类号： C12N9/1205 , C12Y207/01006 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.

3. 发明授权

US08211439B2 Albumin fusion proteins comprising insulin polypeptides 有权
标题翻译：包含胰岛素多肽的白蛋白融合蛋白
公开(公告)号：US08211439B2
公开(公告)日：2012-07-03
申请号：US11929939
申请日：2007-10-30
申请人： Craig A. Rosen , Steven M. Ruben , Olivier Blondel
发明人： Craig A. Rosen , Steven M. Ruben , Olivier Blondel
IPC分类号： A61K39/00 , A61K38/28 , C07H21/04 , C12P21/02 , C07K14/76 , C12N15/17
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

4. 发明授权

US08106165B2 Antibodies to HNFIP24 polypeptides 失效
标题翻译： HNFIP24多肽的抗体
公开(公告)号：US08106165B2
公开(公告)日：2012-01-31
申请号：US11745580
申请日：2007-05-08
申请人： Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07K16/26 , C07K16/00 , C12N5/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

5. 发明申请

US20110081360A1 Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US20110081360A1
公开(公告)日：2011-04-07
申请号：US12943722
申请日：2010-11-10
申请人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
发明人： Viktor Roschke , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00 , A61P37/04 , A61P9/00 , A61P17/06 , A61P17/00 , A61P11/00
CPC分类号： C07K14/7158 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

6. 发明授权

US07906634B2 HEMCM42 nucleic acids 有权
标题翻译： HEMCM42核酸
公开(公告)号：US07906634B2
公开(公告)日：2011-03-15
申请号：US12324825
申请日：2008-11-26
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

7. 发明授权

US07838636B1 Antibodies to HWHGU54 polypeptides 有权
标题翻译： HWHGU54多肽的抗体
公开(公告)号：US07838636B1
公开(公告)日：2010-11-23
申请号：US11760578
申请日：2007-06-08
申请人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
发明人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
IPC分类号： C07K16/40 , C12P21/08 , C12P21/06 , C12N15/09
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

8. 发明申请

US20100093627A1 ALBUMIN FUSION PROTEINS 有权
公开(公告)号：US20100093627A1
公开(公告)日：2010-04-15
申请号：US12534585
申请日：2009-08-03
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
IPC分类号： A61K38/38 , C12N15/63 , C12N5/00 , C12N1/19 , C12N5/07 , C12P21/00 , C07K14/76 , A61P3/00 , A61P37/06
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

9. 发明申请

US20090247482A1 50 Human Secreted Proteins 审中-公开
标题翻译： 50人类分泌蛋白
公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/00 , C12N5/06 , C12N15/87 , C12P21/04
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

10. 发明授权

US07514079B2 Antibodies that specifically bind to neurokinin B 失效
标题翻译：特异性结合神经激肽B的抗体
公开(公告)号：US07514079B2
公开(公告)日：2009-04-07
申请号：US10981692
申请日：2004-11-05
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , G01N33/53 , C07K16/26
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/80 , Y10S424/804 , Y10S424/806 , Y10S424/809 , Y10S435/975
摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.
摘要翻译：本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘，胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。

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