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1. 发明授权

US08932340B2 Bifurcated stent and delivery system 有权
标题翻译：分叉支架和分娩系统
公开(公告)号：US08932340B2
公开(公告)日：2015-01-13
申请号：US12129372
申请日：2008-05-29
申请人： Michael P. Meyer , Michael W. Davis , Benjamin Arcand , Jay Rassat , James Anderson , Derek Sutermeister
发明人： Michael P. Meyer , Michael W. Davis , Benjamin Arcand , Jay Rassat , James Anderson , Derek Sutermeister
IPC分类号： A61F2/06 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61M25/10
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61M2025/1013
摘要： A delivery system has a stent and a balloon. The stent has a first section made of a plurality of interconnected framework members which define a plurality of potential side branches. The balloon is a dual lumen balloon that can inflate from the proximal end to the distal end with a plurality of protrusions and/or herniations.
摘要翻译：输送系统具有支架和气囊。支架具有由多个互连的框架构件制成的第一部分，其限定多个潜在的侧分支。气囊是可以从多个突起和/或疝的近端膨胀到远端的双腔气囊。

2. 发明授权

US07919137B2 Medical devices having adherent polymeric layers with depth-dependent properties 有权
标题翻译：具有与深度相关性质的贴壁聚合物层的医疗装置
公开(公告)号：US07919137B2
公开(公告)日：2011-04-05
申请号：US11983952
申请日：2007-11-13
申请人： Derek Sutermeister , Jay Rassat , James Anderson
发明人： Derek Sutermeister , Jay Rassat , James Anderson
IPC分类号： A61L33/00 , C08J7/18
CPC分类号： A61L31/10 , A61L31/14 , Y10T428/31678
摘要： According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
摘要翻译：根据本发明的一个方面，提供了一种形成医疗装置的方法，其包括：（a）使基底与含有（i）一种或多种聚合物的溶液接触，（ii）含有一种或更多类型的溶剂物质，和（iii）一种或多种任选的试剂，例如一种或多种治疗剂等; 和（b）从溶液中除去溶剂，由此在基材上形成聚合物层。在形成聚合物层的过程中改变溶液的组成。在本发明的另一方面，提供了一种医疗装置，其包括衬底和在衬底上的聚合物层。聚合物层含有含有不同的第一和第二单体的共聚物。与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。

3. 发明申请

US20090299460A1 Bifurcated Stent and Delivery System 有权
标题翻译：分叉支架和分娩系统
公开(公告)号：US20090299460A1
公开(公告)日：2009-12-03
申请号：US12129372
申请日：2008-05-29
申请人： Michael P. Meyer , Michael W. Davis , Benjamin Arcand , Jay Rassat , James Anderson , Derek Sutermeister
发明人： Michael P. Meyer , Michael W. Davis , Benjamin Arcand , Jay Rassat , James Anderson , Derek Sutermeister
IPC分类号： A61F2/88
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61M2025/1013
摘要： A delivery system has a stent and a balloon The stent has a first section made of a plurality of interconnected framework members which define a plurality of potential side branches. The balloon is a dual lumen balloon that can inflate from the proximal end to the distal end with a plurality of protrusions and/or herniations.
摘要翻译：输送系统具有支架和气囊。支架具有由多个互连的框架构件制成的第一部分，其限定多个潜在的侧分支。气囊是可以从多个突起和/或疝的近端膨胀到远端的双腔气囊。

4. 发明申请

US20080113083A1 Medical devices having adherent polymeric layers with depth-dependent properties 有权
标题翻译：具有与深度相关性质的贴壁聚合物层的医疗装置
公开(公告)号：US20080113083A1
公开(公告)日：2008-05-15
申请号：US11983952
申请日：2007-11-13
申请人： Derek Sutermeister , Jay Rassat , James Anderson
发明人： Derek Sutermeister , Jay Rassat , James Anderson
IPC分类号： A61L33/00 , A61F2/01 , A61F2/24 , A61N1/00 , A61F2/82
CPC分类号： A61L31/10 , A61L31/14 , Y10T428/31678
摘要： According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
摘要翻译：根据本发明的一个方面，提供了一种形成医疗装置的方法，其包括：（a）使基底与包含（i）一种或多种聚合物的溶液接触，（ii）含有一种或更多类型的溶剂物质，和（iii）一种或多种任选的试剂，例如一种或多种治疗剂等; 和（b）从溶液中除去溶剂，由此在基材上形成聚合物层。在形成聚合物层的过程中改变溶液的组成。在本发明的另一方面，提供了一种医疗装置，其包括衬底和在衬底上的聚合物层。聚合物层含有含有不同的第一和第二单体的共聚物。接触基材的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。

5. 发明申请

US20110150965A1 MEDICAL DEVICES HAVING ADHERENT POLYMERIC LAYERS WITH DEPTH-DEPENDENT PROPERTIES 审中-公开
标题翻译：具有深度依赖性的附加聚合物层的医疗装置
公开(公告)号：US20110150965A1
公开(公告)日：2011-06-23
申请号：US13036894
申请日：2011-02-28
申请人： Derek Sutermeister , Jay Rassat , James Anderson
发明人： Derek Sutermeister , Jay Rassat , James Anderson
IPC分类号： A61F2/00 , A61F2/01 , B32B15/08 , C08F299/00
CPC分类号： A61L31/10 , A61L31/14 , Y10T428/31678
摘要： According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
摘要翻译：根据本发明的一个方面，提供了一种形成医疗装置的方法，其包括：（a）使基底与含有（i）一种或多种聚合物的溶液接触，（ii）含有一种或更多类型的溶剂物质，和（iii）一种或多种任选的试剂，例如一种或多种治疗剂等; 和（b）从溶液中除去溶剂，由此在基材上形成聚合物层。在形成聚合物层的过程中改变溶液的组成。在本发明的另一方面，提供了一种医疗装置，其包括衬底和在衬底上的聚合物层。聚合物层含有含有不同的第一和第二单体的共聚物。与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。

6. 发明申请

US20100137973A1 Layered Bifurcation Stent 审中-公开
标题翻译：分层分叉支架
公开(公告)号：US20100137973A1
公开(公告)日：2010-06-03
申请号：US12615680
申请日：2009-11-10
申请人： Derek Sutermeister , James Anderson , Benjamin Arcand , Jay Rassat , Ryan Tschudi
发明人： Derek Sutermeister , James Anderson , Benjamin Arcand , Jay Rassat , Ryan Tschudi
IPC分类号： A61F2/82
CPC分类号： A61F2/856 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2002/91575 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/0063
摘要： An implantable medical device has an outer stent with a tubular body disposed about a longitudinal axis. The outer stent includes members defining openings which are in fluid communication with a flow path. At least one opening is larger than adjacent openings when the outer stent is in an expanded state, and is positioned between the ends of the outer stent. The at least one larger opening is a side branch opening having a perimeter. The device also has an inner stent with a tubular body disposed within the outer stent and about a longitudinal axis. The inner stent has a branch portion with deployable petals positioned adjacent to the side branch opening of the outer stent. The petals are biased against the perimeter of the side branch opening such that the petals are restrained from opening outward when the outer stent is in an unexpanded state.
摘要翻译：可植入医疗装置具有围绕纵向轴线设置的具有管状体的外部支架。外支架包括限定与流动路径流体连通的开口的构件。当外支架处于膨胀状态时，至少一个开口大于相邻开口，并且位于外支架的端部之间。至少一个更大的开口是具有周边的侧分支开口。该装置还具有内支架，其具有设置在外支架内且围绕纵向轴线的管状主体。内支架具有分支部分，其具有与外支架的侧分支开口相邻的可展开的瓣。花瓣偏向侧分支开口的周边，使得当外支架处于未膨胀状态时，花瓣被限制向外打开。

7. 发明申请

US20100069837A1 Balloon Assembly and Method for Therapeutic Agent Delivery 审中-公开
标题翻译：气球装配和治疗剂递送方法
公开(公告)号：US20100069837A1
公开(公告)日：2010-03-18
申请号：US12211528
申请日：2008-09-16
申请人： Jay Rassat , Derek Sutermeister , James Anderson , Benjamin Arcand
发明人： Jay Rassat , Derek Sutermeister , James Anderson , Benjamin Arcand
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1086 , A61M2025/109
摘要： A balloon assembly includes an elongated balloon, one or more cutting elements engaged to the balloon, and one or more therapeutic agents disposed within an opening defined by the cutting blades. The balloon assembly converts energy into heat to enhance elution of the therapeutic agent at the treatment site
摘要翻译：球囊组件包括细长气囊，与球囊接合的一个或多个切割元件以及设置在由切割刀片限定的开口内的一个或多个治疗剂。气囊组件将能量转化为热量以增强治疗部位处理剂的洗脱

8. 发明申请

US20110160645A1 Cryo Activated Drug Delivery and Cutting Balloons 审中-公开
标题翻译：冷冻激活药物输送和切割气球
公开(公告)号：US20110160645A1
公开(公告)日：2011-06-30
申请号：US12939864
申请日：2010-11-04
申请人： Derek Sutermeister , James Anderson
发明人： Derek Sutermeister , James Anderson
IPC分类号： A61L29/16 , A61B18/02 , A61M25/10 , A61B17/32
CPC分类号： A61M25/104 , A61B17/320725 , A61B18/02 , A61B2017/00867 , A61B2017/22061 , A61B2017/22082 , A61B2018/0022 , A61B2018/0212 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/109
摘要： Physical property changes in materials between body temperature and a cryotreatment temperature are used to benefit auxiliary functional structures on a cryotherapy device. The auxiliary functional structures may be drug delivery coatings, cutting balloon blades, balloon stiffeners or force concentrators.
摘要翻译：使用身体温度和冷冻治疗温度之间的材料的物理性质变化有益于冷冻治疗装置上的辅助功能结构。辅助功能结构可以是药物递送涂层，切割球囊，球囊加强件或力集中器。

9. 发明申请

US20110190863A1 Therapeutic Balloon with Systemic Drug Loss Protection and Controlled Particle Size Release 审中-公开
标题翻译：具有系统药物损失保护和受控粒径释放的治疗气球
公开(公告)号：US20110190863A1
公开(公告)日：2011-08-04
申请号：US13014269
申请日：2011-01-26
申请人： Tim Ostroot , Derek Sutermeister , James Anderson
发明人： Tim Ostroot , Derek Sutermeister , James Anderson
IPC分类号： A61M25/10 , A61F2/84
CPC分类号： A61F2/013 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2310/0097
摘要： Systemic drug loss protection devices are disclosed. The drug loss protection device includes a balloon and a drug particulate filter. The drug particulate filter has a plurality of openings and is configured to selectively permit transmission of drug particulates through the filter. Consequently, the size of the openings in the filter regulates transmission of the drug particulates. The drug particulate filter can also be used as an embolic filter.
摘要翻译：公开了系统性药物损失保护装置。药物损失保护装置包括气囊和药物颗粒过滤器。药物颗粒过滤器具有多个开口并且被配置为选择性地允许药物颗粒通过过滤器的传播。因此，过滤器中的开口的尺寸调节药物颗粒的传播。药物颗粒过滤器也可用作栓塞过滤器。

10. 发明公开

US20240239570A1 WINE BOTTLE CORK HOLDER 审中-公开
公开(公告)号：US20240239570A1
公开(公告)日：2024-07-18
申请号：US18097126
申请日：2023-01-13
申请人： James Anderson
发明人： James Anderson
IPC分类号： B65D51/16 , B65D39/00 , B65D55/16
CPC分类号： B65D51/1611 , B65D39/0076 , B65D55/16 , B65D2539/003
摘要： A wine cork display and aerating system is disclosed. The wine cork system includes a plug with a corresponding sleeve operable to form a fluid tight seal inside the neck of a bottle, a holder operable to secure a wine cork and a plurality of aeration holes in communication with the bottle's contents to allow the wine to breathe and to prevent contamination of the wine.

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