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1. 发明申请

US20110250630A1 Motif-grafted hybrid polypeptides and uses thereof 审中-公开
标题翻译：基质移植杂交多肽及其用途
公开(公告)号：US20110250630A1
公开(公告)日：2011-10-13
申请号：US13066088
申请日：2011-04-05
申请人： Dennis R. Burton , Gianluca Moroncini , R. Anthony Williamson
发明人： Dennis R. Burton , Gianluca Moroncini , R. Anthony Williamson
IPC分类号： C12Q1/02 , G01N33/68 , C12N15/63 , C12N5/10 , C07K16/46 , C07H21/04
CPC分类号： C12N15/62 , C07K14/47 , C07K16/1063 , C07K2317/21 , C07K2317/565 , C07K2318/10 , C07K2319/00 , G01N33/6896
摘要： Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious form of a prion (PrPSc) is provided.
摘要翻译：本文提供了特异性结合参与蛋白质聚集疾病的多肽的疾病相关同种型的杂合多肽。杂合多肽可用于诊断和治疗这些疾病。在一个具体实施方案中，提供了与朊病毒（PrPSc）的感染形式特异性结合的杂合蛋白质。

2. 发明授权

US07939641B2 Motif-grafted hybrid polypeptides and uses thereof 有权
公开(公告)号：US07939641B2
公开(公告)日：2011-05-10
申请号：US10410907
申请日：2003-04-08
申请人： Dennis R. Burton , Gianluca Moroncini , R. Anthony Williamson
发明人： Dennis R. Burton , Gianluca Moroncini , R. Anthony Williamson
IPC分类号： C07K16/00 , C12P21/08 , A61K38/395 , A61K39/395 , A61K39/42 , G01N33/53
CPC分类号： C12N15/62 , C07K14/47 , C07K16/1063 , C07K2317/21 , C07K2317/565 , C07K2318/10 , C07K2319/00 , G01N33/6896
摘要： Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious form of a prion (PrPSc) is provided.

3. 发明授权

US06376170B1 Ligand capture-directed selection of antibody 失效
公开(公告)号：US06376170B1
公开(公告)日：2002-04-23
申请号：US08972564
申请日：1997-11-18
申请人： Dennis R. Burton , Roberto Burioni , R. Anthony Williamson , Pietro P. Sanna
发明人： Dennis R. Burton , Roberto Burioni , R. Anthony Williamson , Pietro P. Sanna
IPC分类号： C12Q170
CPC分类号： C07K16/00 , C07K16/087 , C07K2317/21 , C07K2317/55
摘要： The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.

4. 发明申请

US20110135645A1 HUMAN ANTIBODIES NEUTRALIZING HUMAN METAPNEUMOVIRUS 审中-公开
标题翻译：人类抗体中和人类METAPNEUMOVIRUS
公开(公告)号：US20110135645A1
公开(公告)日：2011-06-09
申请号：US12311587
申请日：2007-10-04
申请人： R. Anthony Williamson , Zhifeng Chen , Pietro Paolo Sanna , Dennis R. Burton , James Crowe , John V. Williams
发明人： R. Anthony Williamson , Zhifeng Chen , Pietro Paolo Sanna , Dennis R. Burton , James Crowe , John V. Williams
IPC分类号： A61K39/395 , C07K16/10 , G01N33/68 , C12Q1/70 , A61P31/14 , A61P37/04
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses methods for generating antibodies to human metapneumovirus (HMPV) polypeptides, including antibodies that immunospecifically bind to a HMPV F-protein. The invention also discloses methods for preventing, treating, or ameliorating symptoms associated with HMPV infection.
摘要翻译：本发明公开了产生针对人类偏肺病毒（HMPV）多肽的抗体的方法，包括免疫特异性结合HMPV F蛋白的抗体。本发明还公开了用于预防，治疗或改善与HMPV感染相关的症状的方法。

5. 发明授权

US07060799B2 Antibody for ligand capture assay 失效
标题翻译：抗体用于配体捕获测定
公开(公告)号：US07060799B2
公开(公告)日：2006-06-13
申请号：US10079802
申请日：2002-02-19
申请人： Dennis R. Burton , Roberto Burioni , R. Anthony Williamson , Pietro P. Sanna
发明人： Dennis R. Burton , Roberto Burioni , R. Anthony Williamson , Pietro P. Sanna
IPC分类号： C12P21/08 , C12Q1/70
CPC分类号： C07K16/00 , C07K16/087 , C07K2317/21 , C07K2317/55
摘要： The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.
摘要翻译：本发明提供了用于鉴定和克隆结合独特表位的抗体的克隆分离的新方法。该方法基于使用抗体作为固相捕获试剂来结合已知的捕获抗体表位，从而排除了捕获抗体表位被呈递给要筛选的抗体群体。该方法特别适用于筛选克隆抗体的文库，例如噬菌体展示组合抗体。采用特异于单纯疱疹病毒（HSV）的抗体作为测定的模型。

6. 发明授权

US07052675B2 Antibodies specific for native PrPSc 失效
标题翻译：针对天然PrPSc特异的抗体
公开(公告)号：US07052675B2
公开(公告)日：2006-05-30
申请号：US11027139
申请日：2004-12-29
申请人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
发明人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
IPC分类号： A61K39/395 , G01N33/53 , G01N33/567 , C07K16/00
CPC分类号： C07K16/18 , C07K2317/55 , G01N33/56983 , G01N33/6896 , G01N2800/2828
摘要： Antibodies are disclosed which specifically bind to native PrPSc in situ. Preferred antibodies bind only to the native PrPSc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrPSc. Preferred antibodies of the invention are (1) produced by phage display methodology, (2) bind specifically to native PrPSc, (3) neutralizes the infectivity of prions, (4) bind to PrPSc in situ and (5) bind 50% or more of PrPSc in a liquid flowable sample. Antibodies of the invention can be bound to a substrate and used to assay a sample (which has any PrPc denatured via proteinase K) for the presence of PrPSc of a specific species which PrPSc is associated with disease. Antibodies which specifically bind to human PrPSc can be labeled and injected carrying out an in vivo diagnostic test to determine if the human is infected with prions associated with disease. The antibodies are preferably produced using phage display technology wherein the genetic material in the phage expressing the antibody is obtained from a mammal with an ablated endogenous PrP protein gene and an endogenous chimeric PrP gene which mammal had been inoculated with PrPSc to induce antibody production.
摘要翻译：公开了原位特异性结合天然PrP Sc的抗体。优选的抗体仅结合特定种类例如人，牛，绵羊，猪等的天然PrP Sc。特别优选的抗体特异性结合人PrP < SUP>。本发明优选的抗体是（1）通过噬菌体展示法产生，（2）特异性结合天然PrP ，（3）中和朊病毒感染性，（4）结合PrP < Sc（5）在液体可流动的样品中结合50％以上的PrP Sc 。本发明的抗体可以与底物结合并用于测定样品（其通过蛋白酶K变性的任何PrP c），以获得特异性的PrP PrP Sc 与疾病相关的物种。可以标记并注射与人PrP标准物质特异性结合的抗体进行体内诊断测试，以确定人是否感染与疾病相关的朊病毒。优选使用噬菌体展示技术产生抗体，其中表达抗体的噬菌体中的遗传物质是从具有消融的内源性PrP蛋白基因的哺乳动物和内源性嵌合PrP基因获得的，哺乳动物已用PrP < SUP>以诱导抗体产生。

7. 发明授权

US06858397B2 Antibodies specific for native PrPsc 失效
标题翻译：特异于天然PrPsc的抗体
公开(公告)号：US06858397B2
公开(公告)日：2005-02-22
申请号：US10435602
申请日：2003-05-09
申请人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
发明人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
IPC分类号： G01N33/53 , C07K16/18 , C07K16/44 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/569 , G01N33/68 , A61K39/395 , C07K16/00 , G01N33/567
CPC分类号： C07K16/18 , C07K2317/55 , G01N33/56983 , G01N33/6896 , G01N2800/2828
摘要： Antibodies are disclosed which specifically bind to native PrPSc in situ. Preferred antibodies bind only to the native PrPSc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrPSc. Preferred antibodies of the invention are (1) produced by phage display methodology, (2) bind specifically to native PrPSc, (3) neutralizes the infectivity of prions, (4) bind to PrPSc in situ and (5) bind 50% or more of PrPSc in a liquid flowable sample. Antibodies of the invention can be bound to a substrate and used to assay a sample (which has any PrPc denatured via proteinase K) for the presence of PrPSc of a specific species which PrPSc is associated with disease. Antibodies which specifically bind to human PrPSc can be labeled and injected carrying out an in vivo diagnostic test to determine if the human is infected with prions associated with disease. The antibodies are preferably produced using phage display technology wherein the genetic material in the phage expressing the antibody is obtained from a mammal with an ablated endogenous PrP protein gene and an endogenous chimeric PrP gene which mammal had been inoculated with PrPSc to induce antibody production.
摘要翻译：公开了与原位PrP 特异性结合的抗体。优选的抗体仅与特定物种例如人，牛，绵羊，猪等的天然PrP 。本发明的抗体可以与底物结合并用于测定样品（其通过蛋白酶K变性的任何PrPc）存在PrP Sc与PrP Sc相关的特定物种的PrP 。可以对与人PrP 特异性结合的抗体进行标记和注射进行体内诊断测试，以确定人是否感染与疾病相关的朊病毒。优选使用噬菌体展示技术产生抗体，其中表达抗体的噬菌体中的遗传物质是从具有消融的内源性PrP蛋白基因的哺乳动物和内源性嵌合PrP基因获得的，哺乳动物用PrP 接种以诱导抗体生产。

8. 发明授权

US06562341B2 Antibodies specific for native PrPSc 失效
公开(公告)号：US06562341B2
公开(公告)日：2003-05-13
申请号：US09943906
申请日：2001-08-30
申请人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
发明人： Stanley B. Prusiner , R. Anthony Williamson , Dennis R. Burton
IPC分类号： A61K39395
CPC分类号： C07K16/18 , C07K2317/55 , G01N33/56983 , G01N33/6896 , G01N2800/2828
摘要： Antibodies are disclosed which specifically bind to native PrPSc in situ. Preferred antibodies bind only to the native PrPSc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrPSc. Preferred antibodies of the invention are (1) produced by phage display methodology, (2) bind specifically to native PrPSc, (3) neutralizes the infectivity of prions, (4) bind to PrPSc in situ and (5) bind 50% or more of PrPSc in a liquid flowable sample. Antibodies of the invention can be bound to a substrate and used to assay a sample (which has any PrPc denatured via proteinase K) for the presence of PrPSc of a specific species which PrPSc is associated with disease. Antibodies which specifically bind to human PrPSc can be labeled and injected carrying out an in vivo diagnostic test to determine if the human is infected with prions associated with disease. The antibodies are preferably produced using phage display technology wherein the genetic material in the phage expressing the antibody is obtained from a mammal with an ablated endogenous PrP protein gene and an endogenous chimeric PrP gene which mammal had been inoculated with PrPSc to induce antibody production.

9. 发明授权

US07094553B2 Antibodies specific for ungulate PrP 失效
标题翻译：针对有蹄类PrP的特异性抗体
公开(公告)号：US07094553B2
公开(公告)日：2006-08-22
申请号：US10355780
申请日：2003-01-30
申请人： Stanley B. Prusiner , Jiri G. Safar , R. Anthony Williamson , Dennis R. Burton
发明人： Stanley B. Prusiner , Jiri G. Safar , R. Anthony Williamson , Dennis R. Burton
IPC分类号： G01N33/53
CPC分类号： C07K16/2872 , C07K16/18 , C07K2317/34 , C07K2317/55 , G01N33/6896 , G01N2800/2828
摘要： The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC and/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPC and treated PrPSc but not native bovine PrPSc and can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
摘要翻译：本发明提供了与天然有蹄类动物PrP和/或变性有蹄类动物PrP 特异性结合的抗体，而不是天然有蹄类动物 PrP ^{Sc 。优选的抗体发现天然牛PrP和治疗的PrP 而不是天然牛PrP Sc Sc，并且可用于测定中以确定样品感染了朊病毒，即PrP ^{Sc 。}}

10. 发明授权

US06537548B1 Antibodies specific for ungulate PrP 失效
标题翻译：针对有蹄类PrP的特异性抗体
公开(公告)号：US06537548B1
公开(公告)日：2003-03-25
申请号：US09627218
申请日：2000-07-27
申请人： Stanley B. Prusiner , Jiri Safar , R. Anthony Williamson , Dennis R. Burton
发明人： Stanley B. Prusiner , Jiri Safar , R. Anthony Williamson , Dennis R. Burton
IPC分类号： A61K39395
CPC分类号： C07K16/2872 , C07K16/18 , C07K2317/34 , C07K2317/55 , G01N33/6896 , G01N2800/2828
摘要： The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC and/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPC and treated PrPSc but not native bovine PrPSc and can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
摘要翻译：本发明提供了与天然有蹄类动物PrPC和/或变性的有蹄类动物PrPSc具有高度结合亲和力的特异性结合的抗体，而不是天然的有蹄类PrPSc结合的抗体。优选的抗体发现天然牛PrPC和处理的PrPSc而不是天然牛PrPSc，并且可用于测定以确定样品是否感染有感染性朊病毒，即PrPSc。

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