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1. 发明申请

US20100104507A1 USE OF STERICALLY STABILIZED CATIONIC LIPOSOMES TO EFFICIENTLY DELIVER CPG OLIGONUCLEOTIDES IN VIVO 审中-公开
标题翻译：使用异常稳定的阳离子脂质体在体内有效提供CPG寡核苷酸
公开(公告)号：US20100104507A1
公开(公告)日：2010-04-29
申请号：US12647320
申请日：2009-12-24
申请人： Dennis M. Klinman , Ihsan Gursel , Ken J. Ishii , Koji Kawakami , Bharat H. Joshi , Raj K. Puri
发明人： Dennis M. Klinman , Ihsan Gursel , Ken J. Ishii , Koji Kawakami , Bharat H. Joshi , Raj K. Puri
IPC分类号： A61K9/127 , A61K51/12 , A61K39/104 , A61K39/02 , A61P35/00 , A61P31/12 , A61P31/04 , A61P37/02 , A61K39/00 , C12N5/00 , A61K35/12 , A61K38/20 , A61K39/395 , A61K31/7088
CPC分类号： A61K9/1272 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , Y02A50/41 , Y02A50/412
摘要： Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.
摘要翻译：公开了封装包含CpG基序的K型寡脱氧核苷酸（ODN）的稳定的阳离子脂质体（SSCL）。封装K型ODN的这些SSCL可用于有效地将ODN传递到一个单元。还公开了一种用于生产封装K型ODN的SSCL的新方法。施用包封K型ODN的SSCL和化学治疗剂，例如包含选自IL-13和抗IL-13受体抗体的靶向分子的嵌合分子; 和选自假单胞菌外毒素，白喉毒素和放射性核素的效应分子可用于显着降低实体瘤的生长。

2. 发明申请

US20050214355A1 Washing and chilling apparatus and method 有权
标题翻译：使用空间稳定的阳离子脂质体在体内高效地输送CPG寡核苷酸
公开(公告)号：US20050214355A1
公开(公告)日：2005-09-29
申请号：US10484991
申请日：2002-07-30
申请人： Dennis Klinman , Ihsan Gursel , Ken Ishii , Koji Kawakami , Bharat Joshi , Raj Puri
发明人： Dennis Klinman , Ihsan Gursel , Ken Ishii , Koji Kawakami , Bharat Joshi , Raj Puri
IPC分类号： A61K9/127 , A61K39/00 , A61K39/39
CPC分类号： A61K9/1272 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , Y02A50/41 , Y02A50/412
摘要： Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.
摘要翻译：公开了封装包含CpG基序的K型寡脱氧核苷酸（ODN）的稳定的阳离子脂质体（SSCL）。封装K型ODN的这些SSCL可用于有效地将ODN传递到一个单元。还公开了一种用于生产封装K型ODN的SSCL的新方法。施用包封K型ODN的SSCL和化学治疗剂，例如包含选自IL-13和抗IL-13受体抗体的靶向分子的嵌合分子; 和选自假单胞菌外毒素，白喉毒素和放射性核素的效应分子可用于显着降低实体瘤的生长。

3. 发明授权

US08940863B2 Selective anticancer chimeric peptides which bind neuropilin receptor 有权
标题翻译：结合神经纤维蛋白受体的选择性抗癌嵌合肽
公开(公告)号：US08940863B2
公开(公告)日：2015-01-27
申请号：US13857754
申请日：2013-04-05
申请人： Koji Kawakami , Stella Pharma Corporation
发明人： Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , A61P35/00 , C07H21/04 , C07K7/08 , A61K47/48 , C07K14/475 , C07K14/485 , C07K14/54 , C07K7/06 , C07K14/00
CPC分类号： C07K7/08 , A61K47/6425 , C07K14/475 , C07K14/485 , C07K14/54 , C07K2319/33 , C07K2319/55
摘要： It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
摘要翻译：本发明的目的是提供一种可以作为抗癌剂或DDS的物质，其具有细胞内稳定性，其能够逃避相对于正常细胞的功能障碍的副作用或具有瞬时作用。本发明人开发了使用结合肽如结合EGFR的肽序列和裂解肽序列过表达EGFR等的靶向癌细胞的新型嵌合肽，从而解决了这样的问题。特别地，通过使用包含EGF受体结合肽等的嵌合肽和细胞毒素肽，解决了该目的。

4. 发明申请

US20110319336A1 SELECTIVE ANTICANCER CHIMERIC PEPTIDE 有权
标题翻译：选择性抗生素肽
公开(公告)号：US20110319336A1
公开(公告)日：2011-12-29
申请号：US13132580
申请日：2009-12-03
申请人： Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
发明人： Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
IPC分类号： A61K38/02 , C07K14/00 , C12N15/11 , C12N15/63 , C12Q1/18 , C12N5/10 , C12N1/21 , C12N1/19 , G01N33/577 , G01N21/64 , C07K2/00 , A61P35/00
CPC分类号： C07K7/08 , A61K47/6425 , C07K14/475 , C07K14/485 , C07K14/54 , C07K2319/33 , C07K2319/55
摘要： It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
摘要翻译：本发明的目的是提供一种可以作为抗癌剂或DDS的物质，其具有细胞内稳定性，其能够逃避相对于正常细胞的功能障碍的副作用或具有瞬时作用。本发明人开发了使用结合肽如结合EGFR的肽序列和裂解肽序列过表达EGFR等的靶向癌细胞的新型嵌合肽，从而解决了这样的问题。特别地，通过使用包含EGF受体结合肽等的嵌合肽和细胞毒素肽，解决了该目的。

5. 发明授权

US08940862B2 Selective anticancer chimeric peptides which bind transferrin receptor 有权
标题翻译：结合转铁蛋白受体的选择性抗癌嵌合肽
公开(公告)号：US08940862B2
公开(公告)日：2015-01-27
申请号：US13857752
申请日：2013-04-05
申请人： Koji Kawakami , Stella Pharma Corporation
发明人： Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , A61P35/00 , C07H21/04 , C07K7/08 , A61K47/48 , C07K14/475 , C07K14/485 , C07K14/54 , C07K7/06 , C07K14/00
CPC分类号： C07K7/08 , A61K47/6425 , C07K14/475 , C07K14/485 , C07K14/54 , C07K2319/33 , C07K2319/55
摘要： It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
摘要翻译：本发明的目的是提供一种可以作为抗癌剂或DDS的物质，其具有细胞内稳定性，其能够逃避相对于正常细胞的功能障碍的副作用或具有瞬时作用。本发明人开发了使用结合肽如结合EGFR的肽序列和裂解肽序列过表达EGFR等的靶向癌细胞的新型嵌合肽，从而解决了这样的问题。特别地，通过使用包含EGF受体结合肽等的嵌合肽和细胞毒素肽，解决了该目的。

6. 发明授权

US08033086B2 Lawn mower with grass collection box 有权
标题翻译：草坪割草机与草收集箱
公开(公告)号：US08033086B2
公开(公告)日：2011-10-11
申请号：US12450851
申请日：2007-12-25
申请人： Takeshi Fukumoto , Kazuma Moriguchi , Koji Kawakami
发明人： Takeshi Fukumoto , Kazuma Moriguchi , Koji Kawakami
IPC分类号： A01D43/00 , A01D43/06
CPC分类号： A01D43/0635
摘要： A lawn mower is provided with a lawn mowing mechanism, a grass collection box receiving grass mowed by the lawn mowing mechanism, a lift mechanism for lifting the grass collection box high, and a rear lid plate structured such as to openably close an opening in the rear surface of the grass collection box wherein an improvement is achieved in the stability of a support at a time of lifting up the grass collection box high in the case of discharging the mowed grass in the grass collection box in a state of lifting up the grass collection box high, and also achieves a downsizing and a weight saving. A bottom portion of the grass collection box is opened, the opened bottom portion being operably closed by a bottom lid plate, and the mowed grass is discharged from the grass collection box by an opening actuation of the bottom lid plate and the rear lid plate.
摘要翻译：割草机设置有割草机构，用草坪割草机构接收草地的草地收集箱，用于将草地收集箱提升的升降机构，以及能够可靠地闭合所述草坪收集箱的开口的后盖板草收集箱的后表面，其中，在提升草地的状态下，在将收集箱中的草地排出的情况下将提升草地收集箱时的支撑体的稳定性实现了改善收藏箱高，也实现了小型化和轻量化。打开草收集箱的底部，打开的底部由底盖板可操作地封闭，通过底盖板和后盖板的打开动作将割草从草收集箱排出。

7. 发明授权

US06871128B2 Speed change control method and speed change controller 有权
标题翻译：变速控制方式和变速控制器
公开(公告)号：US06871128B2
公开(公告)日：2005-03-22
申请号：US10121690
申请日：2002-04-15
申请人： Yukinobu Kouno , Masaaki Uenishi , Kenichi Nakashima , Tatsuhiko Goi , Koji Kawakami
发明人： Yukinobu Kouno , Masaaki Uenishi , Kenichi Nakashima , Tatsuhiko Goi , Koji Kawakami
IPC分类号： F16H15/38 , F16H37/08 , F16H61/02 , F16H61/662 , G06F19/00 , G06F7/00
CPC分类号： F16H61/6648 , F16H37/086 , F16H2037/088 , F16H2059/704 , Y10T477/606 , Y10T477/619
摘要： A speed change control method of controlling a speed change ratio of a continuously variable transmission mechanism including a traction continuously variable transmission, includes: estimating a tilt angle of a power roller included in the continuously variable transmission based on an input rotating speed and an output rotating speed of the continuously-variable transmission mechanism;estimating a position of the power roller based on an estimated tilt angle obtained by the tilt angle estimating step and a command signal given to a driving device of adjusting the tilt angle of the power roller; and executing a feedback control operation based on an estimated position of the power roller obtained by the position estimating step.
摘要翻译：一种控制包括牵引无级变速器的无级变速机构的变速比的变速控制方法，其特征在于，包括：基于输入转速来估计包括在无级变速器中的动力辊的倾斜角度，以及输出旋转所述无级变速器机构的速度;基于由所述倾斜角估计步骤获得的估计倾斜角度以及给予驱动装置的调整所述动力辊倾斜角度的指令信号来估计所述动力辊的位置; 以及基于由所述位置估计步骤获得的所述动力辊的估计位置执行反馈控制操作。

8. 发明授权

US06561940B2 Method of and apparatus for driving aircraft generator at a constant-speed 有权
标题翻译：以恒速驱动飞机发电机的方法和装置
公开(公告)号：US06561940B2
公开(公告)日：2003-05-13
申请号：US09725284
申请日：2000-11-29
申请人： Tatsuhiko Goi , Koji Kawakami , Kenichiro Tanaka , Takayuki Isano , Hisashi Machida , Hiroyuki Ito , Shinji Miyata
发明人： Tatsuhiko Goi , Koji Kawakami , Kenichiro Tanaka , Takayuki Isano , Hisashi Machida , Hiroyuki Ito , Shinji Miyata
IPC分类号： F16H3702
CPC分类号： F16H37/086 , F16H61/6648 , F16H2037/088 , Y10T477/619 , Y10T477/6223
摘要： An output rotational driving power of the engine is split into a first split power and a second split power. The first split power is transmitted to a continuously variable speed transmission that transmits the first split power by a shearing resistance of a fluid. The second split power is transmitted to a differential planetary gear system. An output power of the continuously variable speed transmission is transmitted to the differential planetary gear system to combine the first split power and the second split power in the differential planetary gear system. A variation of a rotating speed of the output rotational driving power is absorbed by the continuously variable speed transmission to adjust an output rotating speed of the differential planetary gear system to a constant speed.
摘要翻译：发动机的输出旋转驱动力分为第一分离动力和第二分力。第一分离动力传递到通过流体的剪切阻力传递第一分裂功率的无级变速传动。第二分离动力传递到差速行星齿轮系统。无级变速传动装置的输出功率被传递到差速行星齿轮系统，以将差分行星齿轮系统中的第一分离动力和第二分动力组合。输出旋转驱动力的转速的变化被无级变速传动吸收，以将差速行星齿轮系的输出转速调整到一定的速度。

9. 发明授权

US09072716B2 Methods of treating and preventing inflammatory bowel disease involving IL-13 and NKT cells 有权
标题翻译：治疗和预防涉及IL-13和NKT细胞的炎症性肠病的方法
公开(公告)号：US09072716B2
公开(公告)日：2015-07-07
申请号：US11918711
申请日：2006-04-14
申请人： Warren Strober , Ivan Fuss , Peter Mannon , Jan Preiss , Raj Puri , Koji Kawakami , Stefan Fichtner-Feigl , Atsushi Kitani
发明人： Warren Strober , Ivan Fuss , Peter Mannon , Jan Preiss , Raj Puri , Koji Kawakami , Stefan Fichtner-Feigl , Atsushi Kitani
IPC分类号： A61K51/08 , A61K38/20 , A61K31/00 , A61K38/16 , C07K14/54
CPC分类号： A61K38/2086 , A61K31/00 , A61K38/164 , C07K14/5437
摘要： The present invention provides a method of treating or preventing the inflammatory response of ulcerative colitis or Crohn's disease in a subject comprising administering to the subject an effective amount of a substance that inhibits the binding of IL-13 to IL-13 receptors on NKT cells or delivers an effector molecule to the NKT cells.
摘要翻译：本发明提供了治疗或预防受试者溃疡性结肠炎或克罗恩病的炎性反应的方法，其包括向受试者施用有效量的抑制NKT细胞上IL-13与IL-13受体结合的物质或向NKT细胞递送效应分子。

10. 发明申请

US20130274201A1 SELECTIVE ANTICANCER CHIMERIC PEPTIDE 有权
标题翻译：选择性抗生素肽
公开(公告)号：US20130274201A1
公开(公告)日：2013-10-17
申请号：US13857754
申请日：2013-04-05
申请人： Stella Pharma Corporation , Koji Kawakami
发明人： Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , A61K47/6425 , C07K14/475 , C07K14/485 , C07K14/54 , C07K2319/33 , C07K2319/55
摘要： It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
摘要翻译：本发明的目的是提供一种可以作为抗癌剂或DDS的物质，其具有细胞内稳定性，其能够逃避相对于正常细胞的功能障碍的副作用或具有瞬时作用。本发明人开发了使用结合肽如结合EGFR的肽序列和裂解肽序列过表达EGFR等的靶向癌细胞的新型嵌合肽，从而解决了这样的问题。特别地，通过使用包含EGF受体结合肽等的嵌合肽和细胞毒素肽，解决了该目的。

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