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1. 发明申请

US20110209658A1 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 有权
标题翻译：具有受控温度响应的冷冻指示器
公开(公告)号：US20110209658A1
公开(公告)日：2011-09-01
申请号：US12871034
申请日：2010-08-30
申请人： Dawn E. SMITH , Carl M. LENTZ , Dene H. TAYLOR , Yvonne OSUNGA , Brian HUFFMAN
发明人： Dawn E. SMITH , Carl M. LENTZ , Dene H. TAYLOR , Yvonne OSUNGA , Brian HUFFMAN
IPC分类号： G01K1/02
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about −1.9° C. or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰 - 成核剂的比例。

2. 发明申请

US20120079980A1 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 有权
标题翻译：冷冻指示剂的颜色变化乳液
公开(公告)号：US20120079980A1
公开(公告)日：2012-04-05
申请号：US13246392
申请日：2011-09-27
申请人： Dene H. TAYLOR , Carl M. Lentz , Dawn E. Smith
发明人： Dene H. TAYLOR , Carl M. Lentz , Dawn E. Smith
IPC分类号： G01D21/00 , G01N21/75
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。响应于冷冻温度，变色乳液可以不可逆地凝结和变色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

3. 发明申请

US20100024714A1 FREEZE INDICATORS, FLEXIBLE FREEZE INDICATORS, COMBINATION INDICATORS AND MANUFACTURING METHODS 有权
标题翻译：冷冻指示器，灵活冻结指示器，组合指示器和制造方法
公开(公告)号：US20100024714A1
公开(公告)日：2010-02-04
申请号：US12500799
申请日：2009-07-10
申请人： Dene H. TAYLOR , Thaddeus Prusik , Dawn E. Smith , Ray H. Baughman
发明人： Dene H. TAYLOR , Thaddeus Prusik , Dawn E. Smith , Ray H. Baughman
IPC分类号： G01K1/02 , G01D21/00
CPC分类号： G01K3/005 , G01K3/04 , G01K11/06 , Y10S252/962
摘要： Freeze indicators providing a visual indication of exposure of the freeze indicator to a freezing or near-freezing temperature and their manufacture are disclosed. The freeze indicators employ colloidal dispersions as active elements and include flexible freeze indicators, freeze indicators protected against drying out and freeze indicators employing core shell composites, for example gold coated pigments as active indicator elements. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.
摘要翻译：公开了冻结指示器，其提供了将冷冻指示剂暴露于冷冻或接近冻结温度的视觉指示及其制造。冻结指示剂使用胶体分散体作为活性元素，并且包括灵活的冷冻指示剂，防止干燥的冷冻指示剂和使用核心壳复合材料的冷冻指示剂，例如镀金颜料作为活性指示剂元素。还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

4. 发明申请

US20080110391A1 FREEZE INDICATORS, FLEXIBLE FREEZE INDICATORS AND MANUFACTURING METHODS 有权
标题翻译：冷冻指示器，灵活冻结指示器和制造方法
公开(公告)号：US20080110391A1
公开(公告)日：2008-05-15
申请号：US11750054
申请日：2007-05-17
申请人： Dene H. TAYLOR , Thaddeus PRUSIK , Dawn E. SMITH , Ray H. BAUGHMAN
发明人： Dene H. TAYLOR , Thaddeus PRUSIK , Dawn E. SMITH , Ray H. BAUGHMAN
IPC分类号： G01K11/12
CPC分类号： G01K3/005 , G01K3/04 , G01K11/06 , Y10S252/962
摘要： Freeze indicators providing a visual indication of exposure of the freeze indicator to a freezing or near-freezing temperature and their manufacture are disclosed. The freeze indicators employ colloidal dispersions as active elements and include flexible freeze indicators, freeze indicators protected against drying out and freeze indicators employing core shell composites, for example gold coated pigments as active indicator elements. Also disclosed are: a combination freeze indicator and threshold temperature indicator; a combination threshold indicator and cumulative temperature indicator; and three-way combination indicators that can provide indications of cumulative past temperature exposure, exposure to freezing temperatures and exposure to a temperature above a threshold.
摘要翻译：公开了冻结指示器，其提供了将冷冻指示剂暴露于冷冻或接近冻结温度的视觉指示及其制造。冻结指示剂使用胶体分散体作为活性元素，并且包括灵活的冷冻指示剂，防止干燥的冷冻指示剂和使用核心壳复合材料的冷冻指示剂，例如镀金颜料作为活性指示剂元素。还公开了：组合冻结指示器和阈值温度指示器; 组合阈值指标和累积温度指标; 和三路组合指示器，可以提供累积过去的温度暴露，暴露于冷冻温度和暴露于高于阈值的温度的指示。

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