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1. 发明申请

US20090214507A1 METHOD OF TREATING PREVENTING, INHIBITING OR REDUCING DAMAGE TO CARDIAC TISSUE 审中-公开
标题翻译：治疗预防，抑制或减少对心脏组织损伤的方法
公开(公告)号：US20090214507A1
公开(公告)日：2009-08-27
申请号：US11660376
申请日：2005-08-19
申请人： Deepak Srivastava , Ildiko Bock-Marquette , Ankor Saxena , Allan L. Goldstein
发明人： Deepak Srivastava , Ildiko Bock-Marquette , Ankor Saxena , Allan L. Goldstein
IPC分类号： A61K38/45 , C12Q1/00 , A61K38/28 , A61K38/16 , A61K38/08
CPC分类号： A61K38/2292 , A61K38/00 , A61K2300/00
摘要： A method of treatment for treating, preventing, inhibiting or reducing damage to coronary tissue includes inducing at least one of a physiological function selected from: up-regulation of or increasing ILK activity in the coronary tissue, up-regulation of or increasing Akt activity in the coronary tissue, down-regulation of or reducing cardiomyocyte cell death in the coronary tissue and hibernation of cardiomyocytes in the coronary tissue. An induction agent capable of inducing such physiological function in a subject is administered to a subject in need of such treatment.
摘要翻译：用于治疗，预防，抑制或降低对冠状动脉组织损伤的治疗方法包括诱导下列生理功能中的至少一种：选自以下的生理功能：冠状组织的上调或增加ILK活性，上调Akt活性或增加Akt活性冠状组织，冠状组织中心肌细胞死亡或冠状动脉组织心肌细胞的下调或减少。将能够在受试者中诱导这种生理功能的诱导剂施用于需要这种治疗的受试者。

2. 发明授权

US07268118B2 Thymosin β4 compositions 有权
标题翻译：胸腺素β4组合物
公开(公告)号：US07268118B2
公开(公告)日：2007-09-11
申请号：US10853505
申请日：2004-05-26
申请人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
发明人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
IPC分类号： A61K38/00 , A61K38/24
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.
摘要翻译：具有包含氨基酸序列LKKTET [SEQ ID NO：1]或其保守变体的多肽的组合物，该组合物还包含用于施用于身体表面的载体。

3. 发明授权

US08716215B2 Method of treating or preventing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or restore tissue adversely affected by said disease 有权
标题翻译：治疗或预防由于神经，肌肉或神经 - 肌肉退行性疾病引起的组织退化，损伤或损伤或恢复由所述疾病不利影响的组织的方法
公开(公告)号：US08716215B2
公开(公告)日：2014-05-06
申请号：US11813264
申请日：2006-01-13
申请人： Allan L. Goldstein , Jack Finkelstein, Jr.
发明人： Allan L. Goldstein , Jack Finkelstein, Jr.
IPC分类号： A61K38/00 , A61K39/395 , A61P3/04 , A61P25/00 , C07K14/47
CPC分类号： G01N33/5058 , A61K38/08 , A61K38/1774 , A61K38/1841 , A61K38/19 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K38/2053 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/217 , A61K38/2292 , G01N33/5061
摘要： A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or for restoring tissue adversely affected by said disease, in a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, in the tissue.
摘要翻译：一种治疗用于治疗，预防，抑制或减少由于神经，肌肉或神经 - 肌肉退行性疾病或恢复受到所述疾病不利影响的组织的组织退化，损伤或损伤的治疗方法，包括施用对于需要这种治疗的受试者，有效量的包含包含氨基酸序列LKKTET或LKKTNT的肽试剂，其保守变体或刺激LKKTET或LKKTNT肽的产生的肽试剂的组合物或其保守变体，在组织。

4. 发明授权

US08399412B2 Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions 有权
标题翻译：治疗或预防由牙周病或口腔粘膜疾病引起的组织退化，损伤或损伤和/或下调NF-κB或抑制NF-κB介导的作用的方法
公开(公告)号：US08399412B2
公开(公告)日：2013-03-19
申请号：US12444331
申请日：2007-10-05
申请人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
发明人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
IPC分类号： A61K38/17
CPC分类号： A61K38/08 , A61K8/64 , A61K38/2292 , A61Q11/00
摘要： A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (Tβ4), an isoform of Tβ4, an N-terminal fragment of Tβ4, a C-terminal fragment of Tβ4, Tβ4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, Tβ4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.
摘要翻译：一种治疗方法，用于治疗，至少部分地预防，抑制或减少由于牙周疾病或口腔粘膜疾病引起的组织退化，损伤或损伤，或用于恢复患者受到不良影响的组织，和/或用于在身体，器官，组织或细胞中下调NF-κB或抑制NF-κB介导的作用，包括向受试者，身体，器官，组织或细胞施用有效量的组合物，所述组合物包括包含至少一种胸腺素的肽试剂 β4（T＆bgr; 4），T＆bgr的同种型; 4，T＆bgr的N末端片段; 4，T＆bgr; 4，T＆bgr; 4亚砜的C末端片段，LKKTET肽或其保守变体，LKKTNT 肽或其保守变体，KLKKTET肽或其保守变体，LKKTETQ肽或其保守变体，T＆bgr; 4ala，T＆bgr; 9，T＆bgr; 10，T＆bgr; 11，T＆bgr; 12，T＆bgr; 13，T＆bgr; T＆Bgr; 15，凝溶胶蛋白，维生素D结合蛋白（DBP），profilin，cof 肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽或刺激剂，肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽，其刺激受试者，身体，器官，组织或细胞中有效量的肽试剂的产生。

5. 发明申请

US20110124550A1 THYMOSIN BETA 4 PROMOTES WOUND REPAIR 审中-公开
公开(公告)号：US20110124550A1
公开(公告)日：2011-05-26
申请号：US12938228
申请日：2010-11-02
申请人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
发明人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
IPC分类号： A61K38/17 , A61P9/00 , A61P9/10
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： The present invention relates to methods of treatment for treating or preventing injury to cardiovascular or heart tissue in a subject in need thereof by administering an effective amount of thymosin β4 (Tβ4) peptide.
摘要翻译：本发明涉及通过施用有效量的胸腺素和4（T＆bgr; 4）肽来治疗或预防有需要的受试者的心血管或心脏组织损伤的治疗方法。

6. 发明申请

US20090053194A1 METHOD OF TREATING OR PREVENTING BIOLOGICAL OR IMMUNOLOGICAL RESPONSES TO A REACTIVE CHEMICAL OR BIOLOGICAL OR TOXIC AGENT 审中-公开
标题翻译：治疗或预防生物或免疫反应的反应性化学或生物或毒性试剂的方法
公开(公告)号：US20090053194A1
公开(公告)日：2009-02-26
申请号：US10583852
申请日：2004-12-22
申请人： Allan L. Goldstein
发明人： Allan L. Goldstein
IPC分类号： A61K38/08 , A61K38/16 , A61K39/395 , C12Q1/02 , A61P37/00 , A61P9/00
CPC分类号： C07K14/57581 , A61K38/00
摘要： A method of treatment for treating, preventing, inhibiting or reducing a biological or immunological response to a reactive chemical agent, biological agent or toxin, by tissue of a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a response-inhibiting agent including amino acid sequence LKKTET [SEQ ID NO: 1], a conservative variant thereof, or an agent that stimulates production of an LKKTET [SEQ ID NO: 1] peptide, or a conservative variant thereof, in the tissue, so as to inhibit the response.
摘要翻译：用于治疗，预防，抑制或减少对受试者组织的反应性化学试剂，生物制剂或毒素的生物或免疫应答的治疗方法包括向需要这种治疗的受试者施用有效量的组合物包括响应抑制剂，其包括氨基酸序列LKKTET [SEQ ID NO：1]，其保守变体或刺激LKKTET [SEQ ID NO：1]肽或其保守变体的产生的试剂，其中组织，从而抑制反应。

7. 发明申请

US20080248993A1 Modified Beta Thymosin Peptides 审中-公开
标题翻译：改性β-胸腺素肽
公开(公告)号：US20080248993A1
公开(公告)日：2008-10-09
申请号：US11722979
申请日：2006-01-17
申请人： Ewald Hannappel , Thomas Huff , Allan L. Goldstein , David Crockford
发明人： Ewald Hannappel , Thomas Huff , Allan L. Goldstein , David Crockford
IPC分类号： A61K38/02
CPC分类号： C07K14/57581 , A61K38/00
摘要： A composition including an oxidized or superoxidized methionine-containing beta thymosin peptide, isoform thereof, fragment thereof, isolated R-enantiomer thereof or isolated S-enantiomer thereof, other than racemic thymosin beta 4 sulfoxide, or a modified beta thymosin peptide, isoform or fragment thereof with an amino acid substituent substituted for at least one methionine of an amino acid sequence of a normally methionine-containing beta thymosin peptide, isoform or fragment thereof, and method for forming same.
摘要翻译：包含氧化或超氧化的含甲硫氨酸的β胸腺素肽，其同种型，其片段，其分离的R-对映异构体或其分离的S-对映异构体，除外消旋胸腺素β4亚砜，或经修饰的β胸腺素肽，同种型或片段的氨基酸取代基取代至少一种含有正常甲硫氨酸的β-胸腺素肽，同种型或其片段的氨基酸序列的甲硫氨酸及其形成方法。

8. 发明授权

US4264571A Radioimmunoassay of thymosin .alpha..sub.1 失效
标题翻译：胸腺素α1的放射免疫测定
公开(公告)号：US4264571A
公开(公告)日：1981-04-28
申请号：US4971
申请日：1979-01-22
申请人： Allan L. Goldstein , John E. McClure
发明人： Allan L. Goldstein , John E. McClure
IPC分类号： G01N33/53 , A61K39/00 , C07K16/26 , G01N33/74 , G01N33/48 , A61K43/00 , C07G7/00 , G01T1/00
CPC分类号： C07K16/26 , G01N33/74 , A61K39/00 , Y10S436/813 , Y10S436/817 , Y10S436/823
摘要： An immunoassay for the polypeptidic thymic hormone thymosin .alpha..sub.1 is described. Determination of thymosin .alpha..sub.1 levels in biological fluids, particularly serum, provides a useful diagnostic test for immune deficiency diseases, autoimmune diseases, immunologically mediated diseases, neoplastic diseases and also allows one to monitor therapy with thymosin .alpha..sub.1 by following blood levels of the hormone.
摘要翻译：描述了多肽胸腺激素胸腺素α1的免疫测定。测定生物液体，特别是血清中的胸腺素α1水平，为免疫缺陷疾病，自身免疫性疾病，免疫介导的疾病，肿瘤疾病提供了有用的诊断试验，并且还允许人们通过遵循激素的血液水平监测胸腺素α1的治疗。

9. 发明授权

US09821030B2 LKKTET and/or LKKTNT peptide compositions which are lyophilized or in a form capable of being lyophilized 有权
公开(公告)号：US09821030B2
公开(公告)日：2017-11-21
申请号：US13219394
申请日：2011-08-26
申请人： David Crockford , Allan L. Goldstein
发明人： David Crockford , Allan L. Goldstein
IPC分类号： A61K38/00 , A61K9/08 , A61K38/22 , A61K9/00 , A61K38/08 , A61K47/18 , A61K9/10 , A61K9/14
CPC分类号： A61K38/2292 , A61K9/0048 , A61K9/08 , A61K9/10 , A61K9/14 , A61K38/08 , A61K47/186
摘要： A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2] peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized.

10. 发明授权

US08383576B2 LKKTET and/or LKKTNT peptide compositions which are lyophilized or in a form capable of being lyophilized 有权
标题翻译： LKKTET和/或LKKTNT肽组合物，其冻干或以能够冻干的形式
公开(公告)号：US08383576B2
公开(公告)日：2013-02-26
申请号：US11917848
申请日：2006-06-19
申请人： David Crockford , Allan L. Goldstein , Gabriel Sosne
发明人： David Crockford , Allan L. Goldstein , Gabriel Sosne
IPC分类号： A61K38/08
CPC分类号： A61K38/2292 , A61K9/0048 , A61K9/08 , A61K9/10 , A61K9/14 , A61K38/08 , A61K47/186
摘要： A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2] peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized.
摘要翻译：包含包含氨基酸序列LKKTET [SEQ ID NO：1]或LKKTNT [SEQ ID NO：2]的肽试剂，其保守变体或刺激LKKTET [SEQ ID NO：1]的产生的刺激剂的组合物，或LKKTNT [SEQ ID NO：2]肽或其保守变体，所述组合物包含至少一种氨基酸稳定剂或冻干填充剂，所述组合物为冻干形式或能够冻干的形式。

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