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1. 发明申请

US20070208166A1 Tao Kinase Modulators And Method Of Use 审中-公开
标题翻译：陶激酶调节剂及其使用方法
公开(公告)号：US20070208166A1
公开(公告)日：2007-09-06
申请号：US10576932
申请日：2004-10-22
申请人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
发明人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
IPC分类号： C07D471/02
CPC分类号： C07C237/22 , C07C275/16 , C07C275/34 , C07C2602/10 , C07D207/16 , C07D209/20 , C07D209/42 , C07D209/44 , C07D213/56 , C07D213/75 , C07D215/48 , C07D215/54 , C07D217/06 , C07D217/22 , C07D233/56 , C07D233/58 , C07D263/32 , C07D277/46 , C07D277/66 , C07D277/82 , C07D295/155 , C07D295/185 , C07D319/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译：本发明提供了用于抑制激酶的化合物和方法，例如TAO族的那些，更具体地是KIAA1361，TAO和JIK激酶。本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明的化合物抑制，调节和/或调节与上述细胞活性变化相关的激酶受体信号转导途径，本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。

2. 发明申请

US20070275952A1 Tie-2 Modulators and Methods of Use 失效
标题翻译： Tie-2调制器和使用方法
公开(公告)号：US20070275952A1
公开(公告)日：2007-11-29
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
发明人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
IPC分类号： A61K31/41 , A61K31/44 , A61K31/445 , A61K31/497 , A61K31/535 , A61K31/551 , A61P35/00 , C07D243/08 , C07D285/10 , C07D401/14 , C07D413/00 , C07D417/02 , C12N5/00 , C12Q1/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译：本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

3. 发明申请

US20110263544A1 1-Phenylpyrrole Derivatives 有权
标题翻译： 1-苯基吡咯衍生物
公开(公告)号：US20110263544A1
公开(公告)日：2011-10-27
申请号：US13122239
申请日：2009-10-07
申请人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
发明人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
IPC分类号： A61K31/635 , A61K31/402 , A61P9/10 , C12N5/071 , A61P13/12 , A61P5/42 , A61P7/10 , C07D207/34 , A61P9/12
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
摘要翻译：本发明包括用于预防和/或治疗心血管疾病，肾病，纤维化，原发性醛固酮增多症或水肿的化合物。该化合物具有以下通式（I）：其中R 1表示C 1 -C 3烷基; R2表示羟基-C1-C4烷基等; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4表示氢原子，卤代基等，-R5表示氨磺酰基或C1-C3烷基磺酰基; R6表示氢原子，卤代基等]或上述的N-氧化物，阻转异构体或上述的药学上可接受的盐。

4. 发明授权

US08642640B2 1-phenylpyrrole derivatives 有权
标题翻译： 1-苯基吡咯衍生物
公开(公告)号：US08642640B2
公开(公告)日：2014-02-04
申请号：US13122239
申请日：2009-10-07
申请人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
发明人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
IPC分类号： A61K31/40 , C07D207/08
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
摘要翻译：本发明包括用于预防和/或治疗心血管疾病，肾病，纤维化，原发性醛固酮增多症或水肿的化合物。该化合物具有以下通式（I）：其中R 1表示C 1 -C 3烷基; R2表示羟基-C1-C4烷基等; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4表示氢原子，卤代基等，-R5表示氨磺酰基或C1-C3烷基磺酰基; R6表示氢原子，卤代基等]或上述的N-氧化物，阻转异构体或上述的药学上可接受的盐。

5. 发明授权

US08487117B2 Atropisomers of (hydroxyalkyl) pyrrole derivatives 有权
标题翻译：（羟烷基）吡咯衍生物的阻转异构体
公开(公告)号：US08487117B2
公开(公告)日：2013-07-16
申请号：US13122147
申请日：2009-10-07
申请人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Kazumasa Aoki , Hiroyuki Tsuruoka , Noriyuki Hayashi , Tsuyoshi Homma
发明人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Kazumasa Aoki , Hiroyuki Tsuruoka , Noriyuki Hayashi , Tsuyoshi Homma
IPC分类号： C07D207/30 , A61K31/40
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy-C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.
摘要翻译：本发明包括用于预防和/或治疗心血管疾病的化合物。该化合物是由以下通式（I）表示的化合物的阻转异构体：其中R1表示C1-C3烷基; R2表示2-羟基-C4-C6烷基; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4代表氢原子，卤代基等; R5代表C1-C3烷基; R6表示氢原子，卤代基等]或它们的阻转异构体。

6. 发明申请

US20110263673A1 Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives 有权
标题翻译：（羟烷基）吡咯衍生物的阻转异构体
公开(公告)号：US20110263673A1
公开(公告)日：2011-10-27
申请号：US13122147
申请日：2009-10-07
申请人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Kazumasa Aoki , Hiroyuki Tsuruoka , Noriyuki Hayashi , Tsuyoshi Homma
发明人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Kazumasa Aoki , Hiroyuki Tsuruoka , Noriyuki Hayashi , Tsuyoshi Homma
IPC分类号： A61K31/40 , C12N5/071 , A61P3/10 , A61P9/10 , C07D207/34 , A61P9/00
CPC分类号： C07D207/34
摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy-C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.
摘要翻译：本发明包括用于预防和/或治疗心血管疾病的化合物。该化合物是由以下通式（I）表示的化合物的阻转异构体：其中R1表示C1-C3烷基; R2表示2-羟基-C4-C6烷基; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4代表氢原子，卤代基等; R5代表C1-C3烷基; R6表示氢原子，卤代基等]或它们的阻转异构体。

7. 发明申请

US20160363695A9 METHODS FOR LOCATION IDENTIFICATION OF RENEWABLE ENERGY SYSTEMS 审中-公开
公开(公告)号：US20160363695A9
公开(公告)日：2016-12-15
申请号：US13623232
申请日：2012-09-20
申请人： Shawn Kerrigan , Michael Herzig , Matthew Williams
发明人： Shawn Kerrigan , Michael Herzig , Matthew Williams
IPC分类号： G01V99/00
CPC分类号： G01V99/00 , G06Q50/06
摘要： A computer processor implemented method of identifying the location of a renewable energy system; providing a set of renewable energy systems having at least two location-known renewable energy systems each having a longitude and latitude pair and production data; providing at least one location-unknown renewable energy system in a computer processor; correlating by a computer processor each location-unknown renewable energy system to at least one location-known renewable energy system according to location-known renewable energy systems longitude and latitude pair and production data; providing a best-fit location for each location-unknown renewable energy system by triangulating the location-unknown renewable energy system to provide a triangulated latitude and longitude; setting the triangulated latitude and longitude for the location-unknown renewable energy system to become a location-known renewable energy system that is part of the set of renewable energy systems.

8. 发明申请

US20120187930A1 VOLTAGE REGULATOR HAVING CURRENT AND VOLTAGE FOLDBACK BASED UPON LOAD IMPEDANCE 有权
标题翻译：具有基于负载阻抗的电流和电压回归的电压调节器
公开(公告)号：US20120187930A1
公开(公告)日：2012-07-26
申请号：US13353995
申请日：2012-01-19
申请人： Matthew Williams , Daniel Leonescu , Scott Dearborn , Christian Albrecht
发明人： Matthew Williams , Daniel Leonescu , Scott Dearborn , Christian Albrecht
IPC分类号： G05F1/10
CPC分类号： G05F1/5735
摘要： The regulated output voltage of a voltage regulator is maintained up to a current limit, Ilimit, then as the load impedance continues to decrease the output current does not increase past the current limit, Ilimit, but rather the output voltage decreases forcing the output current to also decrease to satisfy Ohm's Law: IOUT=VOUT/ZLoad. When the output voltage drops below the regulated voltage value because of current limiting the voltage regulator shifts from a current limit mode to a current foldback mode wherein the output current decreases with the decrease in output voltage until the output current reaches a current foldback minimum, Ifoldback, at an output voltage of substantially zero volts. As the load impedance increases so will the output voltage and current until the output voltage is back at substantially the regulation voltage value, and the output current is less than or equal to the current limit, Ilimit.
摘要翻译：电压调节器的稳压输出电压保持在电流限制Ilimit，因此当负载阻抗持续降低时，输出电流不会超过电流限制Ilimit，而是输出电压降低迫使输出电流也降低到符合欧姆定律：IOUT = VOUT / ZLoad。当输出电压由于电流限制而降低到调节电压值以下时，电压调节器从电流限制模式转换到电流折返模式，其中输出电流随着输出电压的降低而减小，直到输出电流达到当前折返最小值Ifoldback ，输出电压基本为零伏特。当负载阻抗增加时，输出电压和电流将直到输出电压恢复到基本上的调节电压值，并且输出电流小于或等于电流限制Ilimit。

9. 发明授权

US07810998B2 Multi-handle utility bag 有权
标题翻译：多功能实用包
公开(公告)号：US07810998B2
公开(公告)日：2010-10-12
申请号：US11714713
申请日：2007-03-05
申请人： Matthew Williams
发明人： Matthew Williams
IPC分类号： B65D33/06 , B65D30/00 , B65D85/28
CPC分类号： B65D33/06 , A45C13/26
摘要： A multi-handle utility bag comprising a durable outer body and underframe, multiple handles, and a series of externally-disposed pockets. Extending from the peripheral lip or mouth of the bag are two pairs of diametrically-opposed handles, wherein the first pair of handles enables single-person carriage of the bag, whereas the second pair of handles enables, at a minimum, two-person in-line or side-by-side carriage of the bag.
摘要翻译：一种多把手实用袋，包括耐用的外部本体和底架，多个把手和一系列外部设置的口袋。从袋的外围唇缘或嘴部延伸的是两对直径相对的手柄，其中第一对手柄能够单人携带袋子，而第二对手柄能够至少两个人行或者并排的行李。

10. 发明申请

US20090101253A1 Shopping cart engageable tote bag 审中-公开
标题翻译：购物车可携带手提包
公开(公告)号：US20090101253A1
公开(公告)日：2009-04-23
申请号：US11975557
申请日：2007-10-19
申请人： Terry Kinskey , Matthew Williams
发明人： Terry Kinskey , Matthew Williams
IPC分类号： A45C3/00
CPC分类号： A45C3/04 , A45C13/02 , A45C13/1046 , A45C13/126
摘要： A reusable shopping bag, wherein environmentally beneficial avoidance of disposable shopping receptacles is enabled, wherein temporary securing to essentially any type of shopping cart is facilitated by the specially configured hangers defined coincident with a pair of engageable jaws, in order to effectively line the cargo compartment of a cart in order to prevent the passage of small articles therethrough, and wherein the jaws provide structural reinforcement and a general locking of the bag opening edge, requiring a multi-directional application of force in order for unlock and full access to bag contents.
摘要翻译：一种可重复使用的购物袋，其中环保有利地避免了一次性购物容器，其中通过与一对可接合的钳口重合而定义的特殊配置的衣架便于基本上任何类型的购物车的临时固定，以便有效地将货舱的小车以防止小物品通过其中，并且其中所述夹爪提供结构加强和袋开口边缘的一般锁定，需要多方向施加力以便解锁和完全访问袋内容物。

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