专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07470786B2 Method for manufacture of ceftriaxone sodium 失效
标题翻译：头孢曲松钠制造方法
公开(公告)号：US07470786B2
公开(公告)日：2008-12-30
申请号：US11532469
申请日：2006-09-15
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Narayana Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Narayana Sharma , Brijkishore Mishra
IPC分类号： C07D501/04 , C07D501/36
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

2. 发明申请

US20080200670A1 METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM 审中-公开
标题翻译：碳酸钠制造方法
公开(公告)号：US20080200670A1
公开(公告)日：2008-08-21
申请号：US12013187
申请日：2008-01-11
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Narayana Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Narayana Sharma , Brijkishore Mishra
IPC分类号： C07D501/16
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

3. 发明授权

US07452990B2 Intermediates for synthesis of cephalosporins and process for preparation of such intermediates 失效
标题翻译：用于合成头孢菌素的中间体及其制备方法
公开(公告)号：US07452990B2
公开(公告)日：2008-11-18
申请号：US10540770
申请日：2002-12-26
申请人： Debashish Datta , Muralikrishna Dantu , Brijkishore Mishra , Pollepeddi Lakshmi Narayana Sharma
发明人： Debashish Datta , Muralikrishna Dantu , Brijkishore Mishra , Pollepeddi Lakshmi Narayana Sharma
IPC分类号： C07D501/22 , C07D501/24 , C07D501/36 , C07D501/46 , C07D501/34 , C07C305/14
CPC分类号： C07D501/00 , C07C303/24 , C07C305/00 , Y02P20/55
摘要： A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, —CH2COOR5, or —C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII) in an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.
摘要翻译：用于制备头孢菌素抗生素的式（I）的新的4-卤代-2-氧亚氨基-3-氧代丁酸-N-，N-二甲基氯化亚硫酸盐，其中X是氯或溴; R为氢，C 1-4烷基，易脱除的羟基保护基，-CH 2 COOR 5或-C（CH 3）其中R 5是氢或易水解的酯基。其中R 5是氢或易水解的酯基。式（I）化合物通过使式（IV ^{）的4-卤代-2-氧亚氨基-3-氧代丁酸（其中X，R和R 5）与式（VII）的N，N-二甲基甲酰亚胺氯化硫酸盐在有机溶剂中在-30℃至-15℃的温度范围内。可从中间体制备的头孢菌素包括头孢地尼头孢匹罗，头孢匹肟，头孢他啶，头孢克肟，头孢匹肟，头孢匹肟，头孢噻肟，头孢噻肟，头孢匹罗，头孢泊肟酯，头孢喹肟，头孢他啶，头孢曲松，头孢噻呋，头孢唑肟，头孢曲松和头孢唑胺。}

4. 发明申请

US20070049749A1 Method for Manufacture of Ceftriaxone Sodium 失效
标题翻译：头孢曲松钠制造方法
公开(公告)号：US20070049749A1
公开(公告)日：2007-03-01
申请号：US11532469
申请日：2006-09-15
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
IPC分类号： C07D501/14
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

5. 发明申请

US20060135761A1 Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates 失效
标题翻译：用于合成头孢菌素的新型中间体及其制备方法
公开(公告)号：US20060135761A1
公开(公告)日：2006-06-22
申请号：US10540770
申请日：2002-12-26
申请人： Debashish Datta , Muralikrishna Dantu , Brijkishore Mishra , Pollepeddi Sharma
发明人： Debashish Datta , Muralikrishna Dantu , Brijkishore Mishra , Pollepeddi Sharma
IPC分类号： C07D501/14
CPC分类号： C07D501/00 , C07C303/24 , C07C305/00 , Y02P20/55
摘要： A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, —CH2COOR5, or —C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII) in an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.
摘要翻译：用于制备头孢菌素抗生素的式（I）的新的4-卤代-2-氧亚氨基-3-氧代丁酸-N-，N-二甲基氯化亚硫酸盐，其中X是氯或溴; R为氢，C 1-4烷基，易脱除的羟基保护基，-CH 2 COOR 5或-C（CH 3）其中R 5是氢或易水解的酯基。其中R 5是氢或易水解的酯基。式（I）化合物通过使式（IV ^{）的4-卤代-2-氧亚氨基-3-氧代丁酸（其中X，R和R 5）与式（VII）的N，N-二甲基甲酰亚胺氯化硫酸盐在有机溶剂中在-30℃至-15℃的温度范围内。可从中间体制备的头孢菌素包括头孢地尼头孢匹罗，头孢匹肟，头孢他啶，头孢克肟，头孢匹肟，头孢匹肟，头孢噻肟，头孢噻肟，头孢匹罗，头孢泊肟酯，头孢喹肟，头孢他啶，头孢曲松，头孢噻呋，头孢唑肟，头孢曲松和头孢唑胺。}

6. 发明申请

US20070015917A1 Method For Manufacture of Ceftriaxone Sodium 审中-公开
标题翻译：头孢曲松钠制造方法
公开(公告)号：US20070015917A1
公开(公告)日：2007-01-18
申请号：US11532485
申请日：2006-09-15
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Lakshmi Sharma , Brijkishore Mishra
IPC分类号： C07D501/14
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

7. 发明申请

US20050059821A1 Method for manufacture of ceftriaxone sodium 审中-公开
公开(公告)号：US20050059821A1
公开(公告)日：2005-03-17
申请号：US10830806
申请日：2004-04-21
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Narayana Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Narayana Sharma , Brijkishore Mishra
IPC分类号： C07D501/00 , C07D501/14
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.

8. 发明申请

US20050059820A1 Method for manufacture of ceftriaxone sodium 审中-公开
标题翻译：头孢曲松钠制造方法
公开(公告)号：US20050059820A1
公开(公告)日：2005-03-17
申请号：US10671298
申请日：2003-09-25
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
IPC分类号： C07D501/00 , C07D501/14
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式