专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050129619A1 N2S2 chelate-targeting ligand conjugates 有权
标题翻译： N2S2螯合靶向配体缀合物
公开(公告)号：US20050129619A1
公开(公告)日：2005-06-16
申请号：US10732919
申请日：2003-12-10
申请人： David Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry Bryant
发明人： David Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry Bryant
IPC分类号： A61K51/04 , A61K51/08 , A61K51/10 , A61K49/00 , A61K51/00 , C07F5/00 , C07K16/46
CPC分类号： A61K51/1093 , A61K51/0497 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.
摘要翻译：本发明在一般意义上提供了使用与靶向配体缀合的N 2 S 2 N 2螯合物的化合物的新标记策略，其中靶向配体是疾病细胞周期靶向化合物，肿瘤血管生成靶向配体，肿瘤凋亡靶向配体，疾病受体靶向配体，氨磷汀，血管抑素，单克隆抗体C225，单克隆抗体CD31，单克隆抗体CD40，卡培他滨，COX-2抑制剂，脱氧胞苷，富勒烯，赫赛汀，人血清白蛋白，乳糖，促黄体激素，吡哆醛，喹唑啉，沙利度胺，转铁蛋白或三甲基赖氨酸。本发明还涉及使用目的化合物的试剂盒，以及使用本发明化合物评价感兴趣剂的药理学的方法。

2. 发明申请

US20050100506A1 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20050100506A1
公开(公告)日：2005-05-12
申请号：US10942615
申请日：2004-09-16
申请人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K31/175 , A61K31/426 , A61K31/4439 , A61K51/00 , A61K51/04
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

3. 发明授权

US07611693B2 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US07611693B2
公开(公告)日：2009-11-03
申请号：US10942615
申请日：2004-09-16
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K49/00
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

4. 发明申请

US20100278731A1 Mechanism-Based Targeted Pancreatic Beta Cell Imaging and Therapy 审中-公开
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20100278731A1
公开(公告)日：2010-11-04
申请号：US12610857
申请日：2009-11-02
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K51/04 , A61K49/10
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

5. 发明申请

US20070248537A1 Compositions and Methods for Cellular Imaging and Therapy 有权
标题翻译：细胞成像和治疗的组合和方法
公开(公告)号：US20070248537A1
公开(公告)日：2007-10-25
申请号：US11737694
申请日：2007-04-19
申请人： David Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
发明人： David Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
IPC分类号： A61K51/00 , A61K49/10 , C07F5/00 , C07K16/46
CPC分类号： C07F13/005 , A61K47/547 , A61K51/0474 , A61K51/0491
摘要： The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
摘要翻译：本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N 4+化合物及其衍生物的成像，试剂盒和成像和治疗方法。

6. 发明授权

US09050378B2 N2S2 chelate-targeting ligand conjugates 有权
标题翻译： N2S2螯合靶向配体缀合物
公开(公告)号：US09050378B2
公开(公告)日：2015-06-09
申请号：US10732919
申请日：2003-12-10
申请人： David J. Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry L. Bryant, Jr.
发明人： David J. Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry L. Bryant, Jr.
IPC分类号： A61K51/10 , A61K51/04 , A61K51/08
CPC分类号： A61K51/1093 , A61K51/0497 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing compounds that are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.
摘要翻译：本发明在一般意义上提供了使用与靶向配体缀合的N 2 S 2螯合物的化合物的新标记策略，其中靶向配体是疾病细胞周期靶向化合物，肿瘤血管生成靶向配体，肿瘤凋亡靶向配体，疾病受体靶向配体，氨磷汀，血管抑素，单克隆抗体C225，单克隆抗体CD31，单克隆抗体CD40，卡培他滨，COX-2抑制剂，脱氧胞苷，富勒烯，赫赛汀，人血清白蛋白，乳糖，促黄体激素，吡哆醛，喹唑啉，沙利度胺，转铁蛋白或三甲基赖氨酸。本发明还涉及使用目的化合物的试剂盒，以及使用本发明化合物评价感兴趣剂的药理学的方法。

7. 发明授权

US08758723B2 Compositions and methods for cellular imaging and therapy 有权
标题翻译：细胞成像和治疗的组合和方法
公开(公告)号：US08758723B2
公开(公告)日：2014-06-24
申请号：US11737694
申请日：2007-04-19
申请人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
发明人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
IPC分类号： A61K51/00 , A61B5/055
CPC分类号： C07F13/005 , A61K47/547 , A61K51/0474 , A61K51/0491
摘要： The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
摘要翻译：本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N4化合物和衍生物的成像，试剂盒和成像和治疗方法。

8. 发明授权

US08440168B2 Image-guided therapy of myocardial disease: composition, manufacturing and applications 失效
标题翻译：图像引导治疗心肌病：组成，制造和应用
公开(公告)号：US08440168B2
公开(公告)日：2013-05-14
申请号：US12340338
申请日：2008-12-19
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
IPC分类号： A61K51/04 , A61K49/00
CPC分类号： A61K51/0497 , A61K31/165 , C07C235/34 , C07F13/00 , C07F13/005
摘要： Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
摘要翻译：公开了用于成像和化疗和放射治疗的组合物和方法。更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

9. 发明申请

US20090238756A1 IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS 失效
标题翻译：心肌梗死的图像指导治疗：组合物，制造和应用
公开(公告)号：US20090238756A1
公开(公告)日：2009-09-24
申请号：US12340338
申请日：2008-12-19
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
IPC分类号： A61K51/04 , C07C233/40 , A61K49/00 , A61K49/22 , A61K31/165 , A61P9/00 , A61K49/04 , A61K49/10 , C07F13/00
CPC分类号： A61K51/0497 , A61K31/165 , C07C235/34 , C07F13/00 , C07F13/005
摘要： Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
摘要翻译：公开了用于成像和化疗和放射治疗的组合物和方法。更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

10. 发明申请

US20060198786A1 Glycopeptide compositions 有权
标题翻译：糖肽组合物
公开(公告)号：US20060198786A1
公开(公告)日：2006-09-07
申请号：US11071975
申请日：2005-03-04
申请人： I-Chien Wei , David Yang , Dong-Fang Yu
发明人： I-Chien Wei , David Yang , Dong-Fang Yu
IPC分类号： A61K51/00 , C07K9/00
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译：本发明包括具有糖苷和通过酰胺键共价结合的肽的糖肽。糖肽还可以包括与糖肽结合的诊断或治疗剂。诸如放射性核素的金属也可以与糖肽螯合。本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的壳聚糖制成的糖肽。与糖肽缀合的诊断剂可以促进成像。可以与糖肽结合的特异性治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。一些药剂如放射性核素可能具有诊断和治疗作用。糖肽可以通过在碳二亚胺和酸基活化剂的存在下组合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式