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1. 发明授权

US07147644B2 Apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的装置
公开(公告)号：US07147644B2
公开(公告)日：2006-12-12
申请号：US10853584
申请日：2004-05-24
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61B17/3468
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

2. 发明授权

US06899717B2 Methods and apparatus for delivery of ocular implants 有权
公开(公告)号：US06899717B2
公开(公告)日：2005-05-31
申请号：US10246884
申请日：2002-09-18
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert L. Lathrop, III , Kenny Aptekarev
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61B17/3468
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

3. 发明申请

US20060241650A1 Methods and apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的方法和装置
公开(公告)号：US20060241650A1
公开(公告)日：2006-10-26
申请号：US11475268
申请日：2006-06-26
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
IPC分类号： A61F9/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

4. 发明申请

US20050203542A1 Apparatus for delivery of ocular implants with reduced incidence of ocular adverse events 审中-公开
标题翻译：用于递送眼部植入物的装置，其具有减少眼部不良事件的发生率
公开(公告)号：US20050203542A1
公开(公告)日：2005-09-15
申请号：US10917909
申请日：2004-08-13
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Whitcup
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Whitcup
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F9/0017 , A61F2/167 , A61M37/0069
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

5. 发明申请

US20050154399A1 Apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的装置
公开(公告)号：US20050154399A1
公开(公告)日：2005-07-14
申请号：US11021947
申请日：2004-12-23
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter , Scott Gerondale , Rahul Bhagat , Shawn Davis
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/167 , A61F9/0017 , A61F9/007
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

6. 发明申请

US20050101967A1 Methods and apparatus for delivery of ocular implants 有权
标题翻译：用于输送眼部植入物的方法和装置
公开(公告)号：US20050101967A1
公开(公告)日：2005-05-12
申请号：US10666872
申请日：2003-09-18
申请人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
发明人： David Weber , Ingrid Kane , Mike Rehal , Robert Lathrop , Kenny Aptekarev , Jeffrey Etter
IPC分类号： A61B17/00 , A61F2/14 , A61F2/16 , A61F9/00 , A61F9/007 , A61M37/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

7. 植物专利

USPP27642P3 Vaccinium plant named ‘Winter Bell’ 有权
标题翻译：牛痘植物名为“冬眠”
公开(公告)号：USPP27642P3
公开(公告)日：2017-02-07
申请号：US14121437
申请日：2014-09-08
申请人： David Weber
发明人： David Weber
IPC分类号： A01H5/08
摘要： A new and distinct Vaccinium spp. cultivar named ‘WINTER BELL’ is disclosed, characterized by a semi-upright plant habit, vigorous growth and semi-deciduous habit in Florida. The new variety shows tolerance for wetter soil conditions. Fruit yield is exceptionally high, with fruit ripening early, with first harvest in mid to late March. Fruit is somewhat bell-shaped with good size and an attractive waxy coating. The new variety is a Vaccinium, and is normally used as an ornamental garden or landscape plant.
摘要翻译：一种新的和不同的牛痘属披露了名为“冬季贝尔”的品种，其特征在于佛罗里达州的半直立植物习性，旺盛的生长和半脱落习惯。新品种显示了对湿润土壤条件的耐受性。果实产量异常高，果实成熟早熟，3月中下旬首次收获。水果有点钟形，尺寸好，有吸引力的蜡质涂层。新品种是牛痘，通常用作观赏花园或景观植物。

8. 发明授权

US08722624B2 Alpha-1-antitrypsin compositions and methods of use 有权
标题翻译： α-1-抗胰蛋白酶组合物和使用方法
公开(公告)号：US08722624B2
公开(公告)日：2014-05-13
申请号：US13385642
申请日：2012-02-28
申请人： Scott M Kee , Paul I Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
发明人： Scott M Kee , Paul I Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
IPC分类号： A61K38/17
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
摘要翻译：提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。还描述了一种以商业规模提供高产量的药物级AAT的方法。

9. 发明申请

US20140046325A1 DISPOSABLE ELECTROTHERMAL CAUTERIZATION AND LIGATION TOOL 审中-公开
标题翻译：不可替代的电热焦化和配位工具
公开(公告)号：US20140046325A1
公开(公告)日：2014-02-13
申请号：US13569667
申请日：2012-08-08
申请人： David Weber , Thomas P. Clement
发明人： David Weber , Thomas P. Clement
IPC分类号： A61B18/14
CPC分类号： A61B18/1447 , A61B2018/00077 , A61B2018/00202 , A61B2018/00595 , A61B2018/1475
摘要： A disposable device for tissue cauterization, including a generally electrically insulating housing assembly and a generally electrically conducting elongated assembly. The housing assembly includes a barrel having a cylindrical aperture formed therethrough, a grip extending from the barrel, a trigger slidingly connected to the barrel, a spring connected to the trigger, and an end plug positioned adjacent the proximal end of the barrel. The elongated assembly includes a hollow elongated outer cylinder disposed within the barrel and extending from the distal end, a generally hollow elongated inner cylinder slidably disposed within the elongated outer cylinder and extending to snugly engage the end plug, and bipolar forceps operationally connected to the distal end of the elongated inner cylinder and defining a leaf spring. Actuation of the trigger urges the inner cylinder to slide in a proximal direction relative to the outer cylinder, urging the bipolar forceps partially into the outer cylinder and closer together.
摘要翻译：一种用于组织烧灼的一次性装置，包括通常电绝缘的壳体组件和通常导电的细长组件。壳体组件包括具有穿过其形成的圆柱形孔的筒，从筒延伸的手柄，滑动地连接到筒的触发器，连接到触发器的弹簧以及邻近筒的近端定位的端塞。细长组件包括设置在筒内并且从远端延伸的中空细长外筒，大致中空的细长内筒，其可滑动地设置在细长外筒内并延伸以紧密地接合端塞，并且双极镊操作地连接到远端伸长的内筒的端部并限定一个板簧。触发器的致动促使内筒相对于外筒沿近端方向滑动，将双极钳部分地推入外筒并更靠近在一起。

10. 发明授权

US08647055B2 Ceramic matrix composite shroud attachment system 有权
标题翻译：陶瓷基复合护罩附件系统
公开(公告)号：US08647055B2
公开(公告)日：2014-02-11
申请号：US13064815
申请日：2011-04-18
申请人： Gregory Thomas Foster , Robert Coign , Kevin McGovern , David Weber
发明人： Gregory Thomas Foster , Robert Coign , Kevin McGovern , David Weber
IPC分类号： F01D25/28
CPC分类号： F01D25/246 , F01D11/24 , F05D2230/64 , F05D2240/11 , F05D2300/20 , F05D2300/21 , F05D2300/6033 , Y02T50/672
摘要： Shroud assembly for use in a turbine, having an outer shroud having a side proximate to flow of operative fluid of the turbine, the side having a boss and an outer shroud aperture extending through the boss. An inner shroud is located between the side of the outer shroud proximate to the flow of operative fluid and the operative fluid flow of the turbine, the inner shroud having an inner shroud aperture which is dimensioned to fit over the boss.
摘要翻译：用于涡轮机的护罩组件，其具有外侧护罩，所述外护罩具有靠近所述涡轮机的操作流体流动的一侧，所述侧部具有延伸穿过所述凸台的凸台和外护罩孔。内护罩位于外护罩的靠近操作流体流动和涡轮机的操作流体流动的侧面之间，内护罩具有内护罩孔口，其尺寸适于安装在凸台上。

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