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1. 发明授权

US08142721B2 Test strip with slot vent opening 有权
标题翻译：带有排气口的测试条
公开(公告)号：US08142721B2
公开(公告)日：2012-03-27
申请号：US12888990
申请日：2010-09-23
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip with a covering layer having a novel slot. The slot divides the inventive covering layer into two parts and provides a vent opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the slot doubles as a “fill line.” The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
摘要翻译：具有新颖狭缝的覆盖层的测试条。狭槽将本发明的覆盖层分成两部分，并提供通气口，当流体进入形成在测试条中的空腔或样品接收室时，允许空气逸出。在优选实施例中，覆盖层是清晰的，使得用户可以看到它，并且插槽加倍为“填充线”。因此，用户可以观察流体样品进入测试条，通过毛细管腔进行，然后停止在插槽或填充线。这为用户提供了正确的保证，即样品尺寸足够，并且测试条已被正确填充。本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准槽或通风口，而不必冲压排气口。该方法也非常适合通过辊加工技术进行批量生产。

2. 发明授权

US07892849B2 Reagent stripe for test strip 有权
标题翻译：试纸条试纸条
公开(公告)号：US07892849B2
公开(公告)日：2011-02-22
申请号：US12389954
申请日：2009-02-20
申请人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
发明人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.
摘要翻译：具有小于1微升量级的小样品接收室的测试条。本发明的测试条包括跨越测试条的宽度延伸并且还延伸到样品接收端的试剂层，使得试剂层的边缘与测试条的侧面和剂量接收边缘对准。延伸到条带的配量边缘的亲水试剂促进样品的芯吸到测试条中。试剂层的端部和侧边缘优选形成为从较大纤维网形成单独的测试条的切割过程的一部分，其导致具有均匀厚度的平滑和薄的试剂层，基本覆盖样品的整个底板接收室本发明的批量生产方法有助于提高试剂层的数量，位置，厚度和其他性质的再现性，从而提高了测试结果的准确性。

3. 发明授权

US07727467B2 Reagent stripe for test strip 有权
标题翻译：试纸条试纸条
公开(公告)号：US07727467B2
公开(公告)日：2010-06-01
申请号：US10871673
申请日：2004-06-18
申请人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
发明人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.
摘要翻译：具有小于1微升量级的小样品接收室的测试条。本发明的测试条包括跨越测试条的宽度延伸并且还延伸到样品接收端的试剂层，使得试剂层的边缘与测试条的侧面和剂量接收边缘对准。延伸到条带的配量边缘的亲水试剂促进样品的芯吸到测试条中。试剂层的端部和侧边缘优选形成为从较大纤维网形成单独的测试条的切割过程的一部分，其导致具有均匀厚度的平滑和薄的试剂层，基本覆盖样品的整个底板接收室本发明的批量生产方法有助于提高试剂层的数量，位置，厚度和其他性质的再现性，从而提高了测试结果的准确性。

4. 发明授权

US08119414B2 Test strip with slot vent opening 有权
公开(公告)号：US08119414B2
公开(公告)日：2012-02-21
申请号：US12882828
申请日：2010-09-15
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.

5. 发明申请

US20110011738A1 TEST STRIP WITH SLOT VENT OPENING 有权
标题翻译：带裂缝开口的测试条
公开(公告)号：US20110011738A1
公开(公告)日：2011-01-20
申请号：US12888990
申请日：2010-09-23
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： G01N27/26
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip with a covering layer having a novel slot. The slot divides the inventive covering layer into two parts and provides a vent opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the slot doubles as a “fill line.” The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
摘要翻译：具有新颖狭缝的覆盖层的测试条。狭槽将本发明的覆盖层分成两部分，并提供通气口，当流体进入形成在测试条中的空腔或样品接收室时，允许空气逸出。在优选实施例中，覆盖层是清晰的，使得用户可以看到它，并且插槽加倍为“填充线”。因此，用户可以观察流体样品进入测试条，通过毛细管腔进行，然后停止在插槽或填充线。这为用户提供了正确的保证，即样品尺寸足够，并且测试条已被正确填充。本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准槽或通风口，而不必冲压排气口。该方法也非常适合通过辊加工技术进行批量生产。

6. 发明申请

US20090151864A1 REAGENT STRIPE FOR TEST STRIP 有权
标题翻译：用于测试条的试纸条
公开(公告)号：US20090151864A1
公开(公告)日：2009-06-18
申请号：US12389954
申请日：2009-02-20
申请人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
发明人： David W. Burke , Michael Marquant , Udo Zapf , Michael Fritz , Dan Mosoiu , Chris Wilsey
IPC分类号： B32B37/00
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip having a small sample-receiving chamber on the order of less than 1 microliter. The inventive test strip includes a reagent layer that extends across the width of the test strip and also extends to the sample-receiving end, such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.
摘要翻译：具有小于1微升量级的小样品接收室的测试条。本发明的测试条包括跨越测试条的宽度延伸并且还延伸到样品接收端的试剂层，使得试剂层的边缘与测试条的侧面和剂量接收边缘对准。延伸到条带的配量边缘的亲水试剂促进样品的芯吸到测试条中。试剂层的端部和侧边缘优选形成为从较大纤维网形成单独的测试条的切割过程的一部分，其导致具有均匀厚度的平滑和薄的试剂层，基本覆盖样品的整个底板接收室本发明的批量生产方法有助于提高试剂层的数量，位置，厚度和其他性质的再现性，从而提高了测试结果的准确性。

7. 发明申请

US20130277234A1 SYSTEMS AND METHODS TO COMPENSATE FOR SOURCES OF ERROR DURING ELECTROCHEMICAL TESTING 审中-公开
标题翻译：在电化学测试期间补偿误差源的系统和方法
公开(公告)号：US20130277234A1
公开(公告)日：2013-10-24
申请号：US13920183
申请日：2013-06-18
申请人： David W. Burke , Michael Marquant , Nigel A. Surridge
发明人： David W. Burke , Michael Marquant , Nigel A. Surridge
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： A method is disclosed for determining analyte concentration that includes applying a first electrical potential excitation pulse to a body fluid sample in an analyte sensor, and a first current response of the body fluid sample to the first pulse is measured. A second excitation pulse is applied to the body fluid sample in the analyte sensor, and a second current response of the body fluid sample to the second pulse is measured. An analyte level in the body fluid sample is determined by compensating for sources of error based on the first current response to the first pulse.
摘要翻译：公开了一种用于确定分析物浓度的方法，其包括将第一电势激发脉冲施加到分析物传感器中的体液样品，并且测量体液样品与第一脉冲的第一电流响应。第二激励脉冲被施加到分析物传感器中的体液样品，并且测量体液样品与第二脉冲的第二电流响应。通过基于对第一脉冲的第一电流响应来补偿误差源来确定体液样品中的分析物水平。

8. 发明授权

US08211379B2 Test strip with slot vent opening 有权
标题翻译：带有排气口的测试条
公开(公告)号：US08211379B2
公开(公告)日：2012-07-03
申请号：US13236753
申请日：2011-09-20
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
摘要翻译：公开了测试条的制造方法。实施例包括将两片覆盖层层叠在基片上并具有一系列空腔，其中两片由间隙隔开，间隙形成空腔的通气口。其他实施例包括用比覆盖测试条的主体的盖更薄的盖覆盖样品接收室，较厚的主体盖吸收比腔盖更大的力，以减少粘合剂从室盖下方挤出的可能性。本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准槽或通风口，而不必冲压排气口。该方法也非常适合通过辊加工技术进行批量生产。

9. 发明授权

US07829023B2 Test strip with vent opening 有权
标题翻译：试纸带通风孔
公开(公告)号：US07829023B2
公开(公告)日：2010-11-09
申请号：US10871468
申请日：2004-06-18
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： A test strip with a covering layer having a novel vent. The vent divides the inventive covering layer into two parts and provides an opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the vent doubles as a “fill line.” The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
摘要翻译：具有新颖通风口的覆盖层的测试条。通气口将本发明的覆盖层分成两部分，并提供一个开口，当流体进入形成在测试条中的空腔或样品接收室时，允许空气逸出。在优选实施例中，覆盖层是透明的，使得用户可以透过它观察并且通气孔加倍为“填充线”。因此，用户可以观察流体样品进入测试条，通过毛细管腔进行，然后停止在插槽或填充线。这为用户提供了正确的保证，即样品尺寸足够，并且测试条已被正确填充。本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准排气口，而不必冲压通气口。该方法也非常适合通过辊加工技术进行批量生产。

10. 发明申请

US20120009095A1 TEST STRIP WITH SLOT VENT OPENING 有权
标题翻译：带裂缝开口的测试条
公开(公告)号：US20120009095A1
公开(公告)日：2012-01-12
申请号：US13236753
申请日：2011-09-20
申请人： David W. Burke , Michael Marquant
发明人： David W. Burke , Michael Marquant
IPC分类号： B01L3/00
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
摘要翻译：公开了测试条的制造方法。实施例包括将两片覆盖层层叠在基片上并具有一系列空腔，其中两片由间隙隔开，间隙形成空腔的通气口。其他实施例包括用比覆盖测试条的主体的盖更薄的盖覆盖样品接收室，较厚的主体盖吸收比腔盖更大的力，以减少粘合剂从室盖下方挤出的可能性。本发明还提供了批量生产本发明测试条的有利方法，而不必相对于测试条横向对准槽或通风口，而不必冲压排气口。该方法也非常适合通过辊加工技术进行批量生产。

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