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1. 发明申请

US20120103112A1 DUAL FEEDBACK VACUUM FLUIDICS FOR A FLOW-TYPE PARTICLE ANALYZER 有权
标题翻译：双反馈真空流体流动型颗粒分析仪
公开(公告)号：US20120103112A1
公开(公告)日：2012-05-03
申请号：US13239256
申请日：2011-09-21
申请人： David Vrane , Pierce O. Norton
发明人： David Vrane , Pierce O. Norton
IPC分类号： G01N1/24
CPC分类号： G05D16/00 , G01N15/1404 , G01N2015/1409 , Y10T137/0379
摘要： The present invention relates to a vacuum-driven fluidic system for a flow-type particle analyzer. The system includes a vacuum pump which creates a pressure drop downstream of the flow cell, which pulls sheath fluid and sample fluid through the flow cell. A variable-resistance fluidic resistor is configured to control the ratio of sample fluid flow to sheath fluid flow. Dual feedback circuits, one configured to modulate the vacuum pump power in response to the pressure drop across the flow cell, referred to as the dynamic pressure drop, and a second configured to modulate the vacuum pump power in response to the pressure drop created by the vacuum pump relative to ambient pressure, referred to as the static pressure drop, are used to automatically control the system. The present invention enables adjustment of the sample fluid flow rate while maintaining a constant total fluid flow through the flow cell, and further, enables pausing the system without significant fluctuations in the vacuum.
摘要翻译：本发明涉及一种用于流式粒子分析仪的真空驱动流体系统。该系统包括真空泵，该真空泵在流动池下游产生压力降，其将护套流体和样品流体拉过流动池。可变阻力流体电阻器被配置为控制样品流体流与鞘液流量的比率。双反馈电路，一个被配置为响应于流动池上的压降而调节真空泵功率，被称为动态压降，以及第二配置成响应于由所述动压降引起的压降来调节真空泵功率真空泵相对于环境压力，被称为静压力，用于自动控制系统。本发明能够在保持流过流动池的恒定的总流体流量的同时调节样品流体流速，并且还能够在没有真空的显着波动的情况下暂停该系统。

2. 发明授权

US08528427B2 Dual feedback vacuum fluidics for a flow-type particle analyzer 有权
公开(公告)号：US08528427B2
公开(公告)日：2013-09-10
申请号：US13239256
申请日：2011-09-21
申请人： David Vrane , Pierce O. Norton
发明人： David Vrane , Pierce O. Norton
IPC分类号： G01N15/10 , G01N35/08
CPC分类号： G05D16/00 , G01N15/1404 , G01N2015/1409 , Y10T137/0379
摘要： The present invention relates to a vacuum-driven fluidic system for a flow-type particle analyzer. The system includes a vacuum pump which creates a pressure drop downstream of the flow cell, which pulls sheath fluid and sample fluid through the flow cell. A variable-resistance fluidic resistor is configured to control the ratio of sample fluid flow to sheath fluid flow. Dual feedback circuits, one configured to modulate the vacuum pump power in response to the pressure drop across the flow cell, referred to as the dynamic pressure drop, and a second configured to modulate the vacuum pump power in response to the pressure drop created by the vacuum pump relative to ambient pressure, referred to as the static pressure drop, are used to automatically control the system. The present invention enables adjustment of the sample fluid flow rate while maintaining a constant total fluid flow through the flow cell, and further, enables pausing the system without significant fluctuations in the vacuum.

3. 发明授权

US09423348B2 Absorbance spectrum scanning flow cytometry 有权
标题翻译：吸光度谱扫描流式细胞术
公开(公告)号：US09423348B2
公开(公告)日：2016-08-23
申请号：US14123630
申请日：2012-05-31
申请人： Pierce O. Norton , Yong Qin Chen
发明人： Pierce O. Norton , Yong Qin Chen
IPC分类号： G01N21/64 , G01N15/14 , G01N15/10
CPC分类号： G01N21/6428 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N21/64 , G01N2015/0065 , G01N2015/1006 , G01N2015/1438 , G01N2015/144 , G01N2015/1477 , G01N2021/6417 , G01N2021/6439 , G01N2201/06113 , G01N2201/0633 , G01N2201/068
摘要： The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle.
摘要翻译：本发明提供了用于分析流动流中的荧光颗粒的激发光谱的系统和方法。该系统使用白光激光器和分色光学器件来提供用于照亮流动区域的空间分布的连续色谱激发光系统。通过检测区域的粒子穿过激发光的全部分散光谱，并且当粒子通过检测区域时，粒子的荧光发射被连续地测量。在颗粒通过检测区域时，通过激发光的全谱变化的激发光的每个波长处的测量的荧光发射提供了颗粒的激发光谱。

4. 发明授权

US07544326B2 Fixed mounted sorting cuvette with user replaceable nozzle 有权
标题翻译：固定式分选比色杯，带有用户可更换的喷嘴
公开(公告)号：US07544326B2
公开(公告)日：2009-06-09
申请号：US11711320
申请日：2007-02-26
申请人： Pierce O. Norton , David R. Vrane , Shervin Javadi
发明人： Pierce O. Norton , David R. Vrane , Shervin Javadi
IPC分类号： G01N33/00
CPC分类号： G01N15/14 , G01N15/1404 , Y10T436/101666 , Y10T436/117497 , Y10T436/119163
摘要： A flow cell and flow cytometer in which a nozzle at the end of a flow channel is disposed on a removable substrate held at a registered location on a flow cell. Other elements including illumination optics, light collection optics, and the flow cell may then be positioned at fixed locations and would not require subsequent periodic adjustment. The registered location for positioning the nozzle allows removal and replacement of the nozzle key with the nozzle subsequently positioned in the identical location.
摘要翻译：流动池和流式细胞仪，其中在流动通道的端部处的喷嘴设置在保持在流动池上的注册位置的可移除基板上。然后可以将包括照明光学器件，光收集光学器件和流动池的其它元件定位在固定位置，并且不需要随后的周期性调整。用于定位喷嘴的注册位置允许喷嘴钥匙的移除和更换，喷嘴随后位于同一位置。

5. 发明申请

US20080291425A1 Removable sorting cuvette and nozzle 审中-公开
标题翻译：可拆卸比色杯和喷嘴
公开(公告)号：US20080291425A1
公开(公告)日：2008-11-27
申请号：US12152733
申请日：2008-05-15
申请人： Pierce O. Norton , David R. Vrane , Shervin Javadi
发明人： Pierce O. Norton , David R. Vrane , Shervin Javadi
IPC分类号： G01N33/48
CPC分类号： G01N15/14 , G01N15/1404 , Y10T436/101666 , Y10T436/117497 , Y10T436/119163
摘要： A flow cell and flow cytometer in which a nozzle at the end of a flow channel is disposed on a removable substrate held at a registered location on a flow cell. Other elements including illumination optics, light collection optics, and the flow cell may then be positioned at fixed locations and would not require subsequent periodic adjustment. The registered location for positioning the nozzle allows removal and replacement of the nozzle key with the nozzle subsequently positioned in the identical location.
摘要翻译：流动池和流式细胞仪，其中在流动通道的端部处的喷嘴设置在保持在流动池上的注册位置的可移除基板上。然后可以将包括照明光学器件，光收集光学器件和流动池的其它元件定位在固定位置，并且不需要随后的周期性调整。用于定位喷嘴的注册位置允许喷嘴钥匙的移除和更换，喷嘴随后位于同一位置。

6. 发明授权

US07201875B2 Fixed mounted sorting cuvette with user replaceable nozzle 有权
公开(公告)号：US07201875B2
公开(公告)日：2007-04-10
申请号：US10259332
申请日：2002-09-27
申请人： Pierce O. Norton , David R. Vrane , Shervin Javadi
发明人： Pierce O. Norton , David R. Vrane , Shervin Javadi
IPC分类号： G01N33/00
CPC分类号： G01N15/14 , G01N15/1404 , Y10T436/101666 , Y10T436/117497 , Y10T436/119163
摘要： A flow cell and flow cytometer in which a nozzle at the end of a flow channel is disposed on a removable substrate held at a registered location on a flow cell. Other elements including illumination optics, light collection optics, and the flow cell may then be positioned at fixed locations and would not require subsequent periodic adjustment. The registered location for positioning the nozzle allows removal and replacement of the nozzle key with the nozzle subsequently positioned in the identical location.

7. 发明申请

US20140093949A1 ABSORBANCE SPECTRUM SCANNING FLOW CYTOMETRY 有权
标题翻译：吸收光谱扫描流式细胞仪
公开(公告)号：US20140093949A1
公开(公告)日：2014-04-03
申请号：US14123630
申请日：2012-05-31
申请人： Pierce O. Norton , Yong Qin Chen
发明人： Pierce O. Norton , Yong Qin Chen
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N21/64 , G01N2015/0065 , G01N2015/1006 , G01N2015/1438 , G01N2015/144 , G01N2015/1477 , G01N2021/6417 , G01N2021/6439 , G01N2201/06113 , G01N2201/0633 , G01N2201/068
摘要： The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle.
摘要翻译：本发明提供了用于分析流动流中的荧光颗粒的激发光谱的系统和方法。该系统使用白光激光器和分色光学器件来提供用于照亮流动区域的空间分布的连续色谱激发光系统。通过检测区域的粒子穿过激发光的全部分散光谱，并且当粒子通过检测区域时，粒子的荧光发射被连续地测量。在颗粒通过检测区域时，通过激发光的全谱变化的激发光的每个波长处的测量的荧光发射提供了颗粒的激发光谱。

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