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1. 发明授权

US09945763B1 Methods and systems for immunohistochemistry heat retrieval of biological samples 有权
公开(公告)号：US09945763B1
公开(公告)日：2018-04-17
申请号：US13401653
申请日：2012-02-21
申请人： David Tacha , Thomas Maxwell , Evan Barker , Hoa Nguyen , Ravishankar Melkote
发明人： David Tacha , Thomas Maxwell , Evan Barker , Hoa Nguyen , Ravishankar Melkote
IPC分类号： G01N1/28 , G01N1/30 , G01N1/34 , G01N1/44 , G01N33/53 , G01N35/00
CPC分类号： G01N1/30 , G01N1/312 , G01N1/34 , G01N1/44 , G01N33/53 , G01N35/0092 , G01N2035/0091
摘要： Heat induced antigen retrieval systems for biological specimens may include a sealable heating pressure chamber, a programmable process controller, a nonpareil operating element, and perhaps even a substantially user-disencumbering autonomous processing component of a plurality of biological samples perhaps using various user selected protocols, and the like.

2. 发明授权

US08108712B1 Method and apparatus for removing a computer from a computer cluster observing failure 有权
标题翻译：从计算机集群中清除计算机的观察故障的方法和装置
公开(公告)号：US08108712B1
公开(公告)日：2012-01-31
申请号：US12588857
申请日：2009-10-30
申请人： Charles J. Carlino , Hoa Nguyen , Jayesh Patel , Eric Soderberg , Daniel W. Hepner
发明人： Charles J. Carlino , Hoa Nguyen , Jayesh Patel , Eric Soderberg , Daniel W. Hepner
IPC分类号： G06F11/00
CPC分类号： G06F11/0757 , G06F11/0709 , G06F11/1425
摘要： A method, and a corresponding apparatus, implemented on a suitably programmed processor, selects an ideal computer to remove from a computer cluster observing a failure condition. The computer cluster includes multiple computers. The method includes the steps of recording, at each of the computers, health data for each of the computers, computing, at a health timeout, a first health score for each of the computers based on the health data, computing, at a fatal timeout, and based on the first health score, a second health score for each of the computers, and at each of the computers, selecting a computer having the highest health score for removal from the cluster.
摘要翻译：在适当编程的处理器上实现的方法和相应的装置选择理想的计算机以从观察故障状态的计算机集群中移除。计算机集群包括多台计算机。该方法包括以下步骤：在每个计算机处记录每个计算机的健康数据，在健康超时时，基于健康数据计算每个计算机的第一健康得分，在致命超时时计算，并且基于第一健康评分，对于每个计算机的第二健康得分，并且在每个计算机处，选择具有最高健康评分以从群集中移除的计算机。

3. 发明授权

US07517497B2 Passive oscillating device for cutting sample disks 有权
标题翻译：用于切割样品盘的被动振荡装置
公开(公告)号：US07517497B2
公开(公告)日：2009-04-14
申请号：US11397832
申请日：2006-04-03
申请人： Glenn Price , Hoa Nguyen
发明人： Glenn Price , Hoa Nguyen
IPC分类号： B01L3/00
CPC分类号： B26F1/16 , G01N1/286 , G01N35/0099 , G01N2001/288 , Y10T83/0453 , Y10T409/306776
摘要： Sample disks are excised from a membrane by a cutting apparatus that includes a cutting tool terminating in a hollow cylinder with an exposed cutting edge, the tool slidably retained within a sleeve or otherwise slidably mounted to a mounting body, with a spiral cam in either the tool or the mounting body. A rider is included in the construction and arranged to engage the cam such that sliding movement of the cutting tool translates into rotational movement of the cylinder and its cutting edge.
摘要翻译：样品盘通过切割装置从膜切除，该切割装置包括终止于具有暴露的切割边缘的中空圆柱体中的切割工具，该工具可滑动地保持在套筒内或以其它方式可滑动地安装到安装体上，其中螺旋凸轮工具或安装体。骑车人被包括在构造中并且被布置成与凸轮接合，使得切削工具的滑动运动转换为气缸及其切削刃的旋转运动。

4. 发明申请

US20060247450A1 Exo- and diastereo- selective syntheses of himbacine analogs 有权
公开(公告)号：US20060247450A1
公开(公告)日：2006-11-02
申请号：US11331324
申请日：2006-01-12
申请人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
发明人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
IPC分类号： C07D307/02
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

5. 发明申请

US20060245839A1 Passive oscillating device for cutting sample disks 有权
公开(公告)号：US20060245839A1
公开(公告)日：2006-11-02
申请号：US11397832
申请日：2006-04-03
申请人： Glenn Price , Hoa Nguyen
发明人： Glenn Price , Hoa Nguyen
IPC分类号： B23C1/00
CPC分类号： B26F1/16 , G01N1/286 , G01N35/0099 , G01N2001/288 , Y10T83/0453 , Y10T409/306776
摘要： Sample disks are excised from a membrane by a cutting apparatus that includes a cutting tool terminating in a hollow cylinder with an exposed cutting edge, the tool slidably retained within a sleeve or otherwise slidably mounted to a mounting body, with a spiral cam in either the tool or the mounting body. A rider is included in the construction and arranged to engage the cam such that sliding movement of the cutting tool translates into rotational movement of the cylinder and its cutting edge.

6. 发明授权

US06592612B1 Method and apparatus for providing heat exchange within a catheter body 失效
标题翻译：用于在导管体内提供热交换的方法和装置
公开(公告)号：US06592612B1
公开(公告)日：2003-07-15
申请号：US09564958
申请日：2000-05-04
申请人： Wilfred Samson , Hoa Nguyen , Mike Lee , Brady Esch , Eric Olsen , Jeff Valko
发明人： Wilfred Samson , Hoa Nguyen , Mike Lee , Brady Esch , Eric Olsen , Jeff Valko
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/126
摘要： The present invention relates to catheters for selectively cooling or warming tissue within a patient's vasculature. The present invention utilizes novel heat exchanging devices, which reside inside the catheter body for selectively altering the temperature of fluid that flows through the catheter shaft. In addition, the present invention utilizes novel pumping devices, which reside within a patient's vasculature for withdrawing oxygenated blood into the catheter body where heat exchange occurs across a heat transfer interface for selective cooling or warming of the blood occurs. The present invention can be used in a multiplicity of medical disciplines where it is advantageous to selectively alter the temperature of tissue, including beating heart applications, as well as stopped heart medical interventions.
摘要翻译：本发明涉及用于选择性地冷却或加热病人脉管系统内的组织的导管。本发明利用新的热交换装置，它们位于导管主体内部，用于选择性地改变流过导管轴的流体的温度。此外，本发明利用新的泵送装置，其驻留在患者的脉管系统内，用于将含氧血液抽出到导管体中，导管主体的热交换发生在热传递界面上，用于血液的选择性冷却或升温。本发明可以用于多种医学学科，其中有选择地改变组织的温度，包括心脏跳动的应用以及停止的心脏医学干预。

7. 发明授权

US06199422B1 Method and system for fast probe failure determination 失效
标题翻译：快速探针故障测定的方法和系统
公开(公告)号：US06199422B1
公开(公告)日：2001-03-13
申请号：US09056157
申请日：1998-04-06
申请人： Johannes I. Boerhout , Phillip L. Maness , Hoa Nguyen , Wane D. Wier
发明人： Johannes I. Boerhout , Phillip L. Maness , Hoa Nguyen , Wane D. Wier
IPC分类号： G01H100
CPC分类号： G05B23/0256 , G05B9/03 , G05B23/0262
摘要： A method and system for monitoring the operational condition of a machine is disclosed. The system includes: a test probe configured to be coupled to the machine for measuring an operational parameter of the machine and for outputting a test signal representative of the measured operational parameter; a fault condition detection circuit, coupled to the test probe, for receiving and processing the test signal so as to detect a fault condition of the machine; a probe failure detection circuit, coupled to the test probe, for receiving the test signal and detecting a failure condition of the test probe if the test signal is not within defined limits, wherein the probe failure detection circuit provides a data path that is separate from the fault condition detection circuit; and a processor, coupled to the fault condition detection circuit and the probe failure detection circuit, for initiating a defined action in response to signals received from the fault condition detection circuit and the probe failure detection circuit. The method includes the following acts: measuring an operational parameter of the machine with a probe coupled to the machine; outputting a test signal representative of the measured operational parameter; providing the test signal to a machine fault detection circuit for processing; determining whether the test signal indicates that a machine fault condition exists; providing the test signal to a probe failure detection circuit; determining whether the test signal indicates a probe failure condition exists, wherein the probe failure detection circuit operates independently of the machine fault detection circuit; and initiating a defined action if it is determined that a machine fault condition exists and a probe failure condition is not detected.
摘要翻译：公开了一种用于监视机器操作状态的方法和系统。该系统包括：测试探针，其被配置为耦合到机器，用于测量机器的操作参数并输出表示测量的操作参数的测试信号; 耦合到测试探头的故障状态检测电路，用于接收和处理测试信号，以便检测机器的故障状况; 如果测试信号不在限定范围内，则耦合到测试探头的探针故障检测电路用于接收测试信号并检测测试探针的故障状态，其中探测器故障检测电路提供与故障状态检测电路; 以及耦合到故障状态检测电路和探针故障检测电路的处理器，用于响应于从故障状态检测电路和探针故障检测电路接收的信号而发起定义的动作。该方法包括以下动作：使用耦合到机器的探头来测量机器的操作参数; 输出表示测量的操作参数的测试信号; 向机器故障检测电路提供测试信号进行处理; 确定测试信号是否指示存在机器故障状况; 向探头故障检测电路提供测试信号; 确定测试信号是否指示探针故障条件，其中探头故障检测电路独立于机器故障检测电路工作; 并且如果确定存在机器故障条件并且未检测到探针故障条件，则启动定义的动作。

8. 发明授权

US08352473B2 Product synthesis from multiple sources 有权
标题翻译：从多个来源的产品综合
公开(公告)号：US08352473B2
公开(公告)日：2013-01-08
申请号：US12764676
申请日：2010-04-21
申请人： Ariel Fuxman , Hoa Nguyen , Juliana Freire de Lima e Silva , Stelios Paparizos , Rakesh Agrawal , Zhimin Chen , Lawrence William Colagiovanni , Prakash Sikchi
发明人： Ariel Fuxman , Hoa Nguyen , Juliana Freire de Lima e Silva , Stelios Paparizos , Rakesh Agrawal , Zhimin Chen , Lawrence William Colagiovanni , Prakash Sikchi
IPC分类号： G06Q10/00 , G06Q30/00
CPC分类号： G06F17/30386 , G06Q30/0281 , G06Q30/0603
摘要： Methods and systems for automatically synthesizing product information from multiple data sources into an on-line catalog are disclosed, and in particular, for automatically synthesizing the product information based on attribute-value pairs. Information for a product may be obtained, via entity extraction, feed ingestion, and other mechanisms, from a plurality of structured and unstructured data sources having different taxonomies and schemas. Product information may additionally or alternatively be obtained or derived based on popularity data. The product information may be cleansed, segmented and normalized. The product information may be clustered so closest products, attribute names and attribute values are associated. A representative value for an attribute name may be determined, and the on-line catalog may be updated so that entries are comprehensive, meaningful and useful to a catalog user. Updates from at least 500 million different data sources may be scheduled to occur as frequently as several times daily.
摘要翻译：公开了用于将产品信息从多个数据源自动合成到在线目录中的方法和系统，特别地，用于基于属性值对自动合成产品信息。可以通过实体提取，饲料摄取和其他机制从具有不同分类和模式的多个结构化和非结构化数据源获得信息。产品信息可以另外地或替代地基于流行度数据获得或导出。产品信息可以被清洁，分段和归一化。产品信息可能被聚集，因此最接近的产品，属性名称和属性值相关联。可以确定属性名称的代表值，并且可以更新在线目录，使得条目对目录用户是全面的，有意义的和有用的。可能会安排从至少5亿个不同数据源进行更新，频繁发生，每天多次。

9. 发明申请

US20100041164A1 Mechanical device for mixing a fluid sample with a treatment solution 有权
公开(公告)号：US20100041164A1
公开(公告)日：2010-02-18
申请号：US12462810
申请日：2009-08-10
申请人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
发明人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
IPC分类号： G01N1/00
CPC分类号： G01N1/38 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150343 , A61B5/150755 , A61B5/157 , B01F5/0646 , B01F5/0655 , B01F11/0005 , B01F15/00512 , B01F15/0205 , B01F15/0206 , B01F15/0212 , Y10T436/25 , Y10T436/25625
摘要： A method of preparing a fluid sample for use in a fluid analyte monitor, the method including drawing a fluid sample into a capillary channel in a body having a septum piercing projection; piercing a first septum covering a treatment solution chamber with the septum piercing projection, thereby exposing the fluid sample in the capillary channel to the contents of the treatment solution chamber; mixing the fluid sample with the contents of the treatment solution chamber; and piercing a second septum covering the treatment solution channel such that the mixed fluid and treatment solution chamber contents are received into a fluid analyte meter. The method may also include shaking the treatment solution chamber with the capillary channel therein, thereby mixing the fluid sample with the contents of the treatment solution chamber.

10. 发明授权

US07588724B2 Mechanical device for mixing a fluid sample with a treatment solution 有权
标题翻译：用于将流体样品与处理溶液混合的机械装置
公开(公告)号：US07588724B2
公开(公告)日：2009-09-15
申请号：US11043510
申请日：2005-01-25
申请人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
发明人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
IPC分类号： C12Q1/68 , G01N21/00 , G01N31/22 , G01N15/06 , B01L3/02 , B01L3/00
CPC分类号： G01N1/38 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150343 , A61B5/150755 , A61B5/157 , B01F5/0646 , B01F5/0655 , B01F11/0005 , B01F15/00512 , B01F15/0205 , B01F15/0206 , B01F15/0212 , Y10T436/25 , Y10T436/25625
摘要： A device for preparing a fluid sample for use in a fluid analyte meter, including: (a) a first portion, comprising: a capillary channel dimensioned to receive a fluid sample therein, an internal nozzle in communication with the capillary channel, a mixing chamber in communication with both the capillary channel and the internal nozzle, and a dispensing nozzle in communication with the mixing chamber; (b) a treatment solution chamber covered by a septum; and (c) a second portion that is moveable with respect to the first portion to pierce the septum such that contents of the treatment solution chamber mix with contents of the capillary channel in the mixing chamber and are ejected through the dispensing nozzle when the second portion is moved with respect to the first portion.
摘要翻译：一种用于制备用于流体分析物仪表的流体样品的装置，包括：（a）第一部分，包括：毛细通道，其尺寸设置成在其中接收流体样品，与毛细通道连通的内部喷嘴，混合室与毛细通道和内部喷嘴连通，以及与混合室连通的分配喷嘴; （b）由隔膜覆盖的处理溶液室; 和（c）第二部分，其相对于第一部分可移动以刺穿隔膜，使得处理溶液室的内容物与混合室中的毛细通道的内容物混合，并且当第二部分相对于第一部分移动。

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