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1. 发明授权

US4579866A Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents 失效
标题翻译：苯乙酰胺作为抗过敏，抗哮喘和抗炎药
公开(公告)号：US4579866A
公开(公告)日：1986-04-01
申请号：US614579
申请日：1984-05-29
申请人： David Stevenson , Robert C. Liu , Laurence L. Ho , Howard Jones , Stephen Coutts
发明人： David Stevenson , Robert C. Liu , Laurence L. Ho , Howard Jones , Stephen Coutts
IPC分类号： C07D215/14 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61P11/08 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/11 , C07C233/17 , C07C233/45 , C07C233/65 , C07C233/68 , C07C233/81 , C07C235/32 , C07C235/48 , C07D209/20 , C07D521/00 , A61K31/24 , C07C101/04
CPC分类号： C07D209/20
摘要： Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sub.1 and R.sub.2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl-lower alkyl, aryl-lower alkoxy, halogenated aryl-lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl;A is H, aryl, lower alkyl, aryl-lower alkyl or heteroaryl; andB is ##STR2## n=0-6, wherein D is H, CONR.sub.3 R.sub.4, CO.sub.2 H, CO.sub.2 R.sub.5, CH.sub.2 OH or CH.sub.2 OR.sub.6,whereinR.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H, lower alkyl, aryl, aryl-lower alkyl or heteroaryl;E is H, OH, lower alkyl, aryl or heteroaryl; andF is ##STR3## wherein G is the same as R.sub.1 and R.sub.2, useful for the treatment of allergy, asthma and inflammatory conditions.
摘要翻译：结构化合物及其药学上可接受的盐，其中：R 1和R 2独立地为H，OH，低级烷基，低级烷氧基，芳氧基，杂芳氧基，杂芳基低级烷氧基，芳基，杂芳基，芳基 - 低级烷基，芳基 - 低级烷氧基，卤代芳基 - 低级烷氧基，低级烯基，低级炔基，低级链烯氧基，低级炔氧基，卤素或三氟甲基; A是H，芳基，低级烷基，芳基 - 低级烷基或杂芳基; B为H，CONR 3 R 4，CO 2 H，CO 2 R 5，CH 2 OH或CH 2 OR 6，其中R 3，R 4，R 5和R 6独立地为H，低级烷基，芳基，芳基 - 低级烷基或杂芳基 ; E是H，OH，低级烷基，芳基或杂芳基; 且F为，其中G与R1和R2相同，可用于治疗过敏，哮喘和炎性病症。

2. 发明申请

US20090077922A1 Removable Wallboard System 审中-公开
标题翻译：可移动墙板系统
公开(公告)号：US20090077922A1
公开(公告)日：2009-03-26
申请号：US12237825
申请日：2008-09-25
申请人： Thomas Pettine , Howard Jones
发明人： Thomas Pettine , Howard Jones
IPC分类号： E04B1/38 , E04B1/00
CPC分类号： E04B2/7457 , E04B2002/725 , E04B2002/7462 , E04F13/0814 , E04F19/02 , E04F19/022 , E04F19/061 , E04F19/062 , E04F19/064 , E04F19/067
摘要： The present invention is a novel removable wallboard system. It includes a plurality of receiver strips [1] which are attached to framing members [8] of a structure to be paneled. Each receiver strip has a receiving channel [4]. Wall panels 7 are placed snugly between the receiver strips [1]. Trim units [2] are elongated strips having insertion strips [10] which are designed to fit into and be retained by receiving channels [4] of the receiver strips [1]. Since the trim units [2] are designed to have a low profile, and they cover the seams between the wall panels [7], there is no need for further finishing or caulking. Therefore, these wall panels [7] may be removed and replaced with minimal effort or cleanup. The system also includes easily installable, removable and replaceable base molding [16], crown molding [19], and chair rail molding [29]. These may be designed to create chase ways [18, 74] allowing hidden routing of electrical, utility cables, pipes and hoses. Since the system may interactively be constructed and removed, it is useful in business settings in which offices are constantly adjusted.
摘要翻译：本发明是一种新颖的可移动墙板系统。它包括多个接收器条[1]，它们连接到待镶板结构的框架件[8]上。每个接收器条具有接收通道[4]。壁板7紧密地放置在接收器条[1]之间。修剪单元[2]是具有插入条[10]的细长条，其被设计成适应接收器条[1]的接收通道[4]并被其保持。由于装饰单元[2]被设计成具有低轮廓，并且它们覆盖在墙板[7]之间的接缝，因此不需要进一步的精加工或铆接。因此，这些墙板[7]可以以最小的努力或清理被移除和更换。该系统还包括易于安装，可拆卸和可更换的基础成型模具[16]，表冠成型模具[19]和椅子轨道成型模具[29]。这些设计可以创建追逐方式[18,74]，允许电气，公用电缆，管道和软管的隐藏路由。由于系统可以交互式地构建和删除，因此在不断调整办公室的业务环境中是有用的。

3. 发明申请

US20060259392A1 SYSTEM FOR GENERATING INSPECTION REPORTS FOR INSPECTED ITEMS 有权
标题翻译：检查检验报告系统
公开(公告)号：US20060259392A1
公开(公告)日：2006-11-16
申请号：US10908535
申请日：2005-05-16
申请人： Nancy Rabenold , James Simmons , Peter Ogden , Howard Jones , Lewis Glow
发明人： Nancy Rabenold , James Simmons , Peter Ogden , Howard Jones , Lewis Glow
IPC分类号： G06Q40/00
CPC分类号： G06Q30/0609 , G06F17/30371 , G06Q10/10 , G06Q40/04
摘要： An electronic inspection report system includes a central report generator and a data collection device. The central report generator is adapted to produce multiple types of inspection report template. The central report generator is adapted to select a type of inspection report template to provide to a data collection device based upon various criteria. The central report generator is adapted to receive electronic information from various databases and format the information such that the information can be used in inspection reports. While inspecting an item, an inspector uses a data collection device to access an inspection report template and fill in fields of the inspection report template. The data collection device can be configured to check the consistency of information carried in fields of the inspection report and signal the inspector when some of the information is inconsistent. The central report generator can include a repository of completed inspection reports. The central report generator can be configured to mine the repository of completed inspection reports and determine correlations between fields of the completed inspection reports. Software in the data collection device can updated such that the data collection device can perform consistency checks between fields that the central report generator has determined have a correlation.
摘要翻译：电子检查报告系统包括中央报告发生器和数据收集装置。中央报告生成器适用于生成多种类型的检查报告模板。中央报告生成器适于根据各种标准选择一种检查报告模板以提供给数据收集装置。中央报告生成器适用于从各种数据库接收电子信息，并格式化信息，以便信息可以在检验报告中使用。在检查项目时，检查员使用数据收集设备访问检查报告模板并填写检查报告模板的字段。数据采集装置可以被配置为检查在检查报告的领域中携带的信息的一致性，并且当某些信息不一致时发出信号。中央报告生成器可以包括已完成的检查报告的存储库。中央报告生成器可以配置为挖掘完成的检查报告的存储库，并确定完成的检查报告的字段之间的相关性。可以更新数据收集装置中的软件，使得数据收集装置可以执行中央报告生成器确定的相关的字段之间的一致性检查。

4. 发明授权

US5503989A Production of peptide amides 失效
标题翻译：生产肽酰胺
公开(公告)号：US5503989A
公开(公告)日：1996-04-02
申请号：US927755
申请日：1992-08-10
申请人： Jeffrey A. Bibbs , Laura S. Lehman De Gaeta , Howard Jones
发明人： Jeffrey A. Bibbs , Laura S. Lehman De Gaeta , Howard Jones
IPC分类号： A61K38/00 , A61K38/04 , A61K38/11 , A61K38/22 , A61K38/23 , C07C1/08 , C07K1/00 , C07K1/06 , C07K1/113 , C07K7/16 , C07K7/23 , C07K14/575 , C07K14/585 , C12P21/06 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K1/003 , C07K14/575
摘要： Methods of preparing a peptide having a C-terminal amide group from peptides having a C-terminal carboxyl group are provided.
摘要翻译：提供从具有C末端羧基的肽制备具有C末端酰胺基的肽的方法。

5. 发明授权

US4839367A Antihypertensive amide compounds 失效
标题翻译：抗高血压酰胺化合物
公开(公告)号：US4839367A
公开(公告)日：1989-06-13
申请号：US895107
申请日：1986-08-11
申请人： Raymond D. Youssefyeh , Howard Jones
发明人： Raymond D. Youssefyeh , Howard Jones
IPC分类号： A61K31/47 , C07D209/02 , C07D209/36 , C07D211/72
CPC分类号： A61K31/47 , C07D209/02 , C07D209/36 , C07D211/72
摘要： Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,m is an integer from 0 to 2 inclusive,n is an integer from 0 to 4 inclusive,M is alkyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl,Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclic, --CO--SR, --CS--SR, ##STR2## CH.sub.2 CO.sub.R, --CHM--CO.sub.2 R, --CH.sub.2 --CO--SR, --CN, ##STR3## --CO--NH--CH.sub.2 CO.sub.2 R, ##STR4## or --CO--CO.sub.2 CO.sub.2 R, wherein R is hydrogen, alkyl, or aryl, and where Y is hydroxy, their pharmaceutically acceptable, nontoxic alkali metal, alkaline earth metal, and amine salts.
摘要翻译：本发明提供了下式的抗高血压化合物：其中R1，R2，R3，R4，R5和R6是氢，烷基，烯基，炔基，苯基 - 烷基或环烷基，并且可以相同或不同，m是 0〜2的整数，n为0〜4的整数，M为烷基，炔基，环烷基，环烷基 - 烷基，多环烷基，多环烷基 - 烷基，芳基，芳烷基，杂芳基，杂芳基 - 烷基，杂环烷基，稠合芳基 - 环烷基，稠合芳基 - 环烷基 - 烷基，稠合的杂芳基 - 环烷基，稠合的杂芳基 - 环烷基 - 烷基，烷氧基烷基，烷硫基烷基，烷基氨基 - 烷基或二烷基氨基烷基，Y是羟基，烷氧基，氨基或取代氨基，氨基烷酰基，芳氧基，氨基烷氧基或羟基烷氧基，R7是烷基，芳基，芳烷基，环烷基，环烷基 - 烷基，杂环基，-CO-SR，-CS-SR，CH2COR，-CHM-CO2R，-CH2 -CO-SR，-CN， -CO-NH-CH 2 CO 2 R，IMA或-CO-CO 2 CO 2 R，其中R是氢，烷基或芳基，并且其中Y是羟基，药学上可接受的，无毒的碱金属，碱土金属和胺盐。

6. 发明授权

US4722939A Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis 失效
标题翻译：可用于治疗牛皮癣的α-烷基聚烯烃羧酸的衍生物
公开(公告)号：US4722939A
公开(公告)日：1988-02-02
申请号：US678128
申请日：1984-12-04
申请人： Bernard Loev , Howard Jones , Wan-kit Chan
发明人： Bernard Loev , Howard Jones , Wan-kit Chan
IPC分类号： A61K31/23 , C07C43/23 , A61K31/215 , A61K31/235
CPC分类号： C07C403/16 , C07C403/02 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/18 , C07C403/22 , C07C403/24 , C07C43/23 , C07C69/145 , C07C69/24 , C07C69/608 , C07C2101/16
摘要： This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.
摘要翻译：本发明涉及具有药物活性且具有通式结构的新化合物，其中Z，R 1，R 2，R 3，R 4，n和m定义在其中。

7. 发明授权

US4666906A Compounds for treating hypertension 失效
标题翻译：用于治疗高血压的化合物
公开(公告)号：US4666906A
公开(公告)日：1987-05-19
申请号：US756530
申请日：1985-07-19
申请人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss , John R. Regan
发明人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss , John R. Regan
IPC分类号： A61K38/00 , C07K5/02 , A61K31/54 , C07D285/22
CPC分类号： C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
摘要翻译：式IMA的化合物及其药学上可接受的盐，其中取代基如本文所定义，具有抗高血压活性。

8. 发明授权

US4505920A Certain N-substituted-4-aryl-3,5-pyridine dicarboxylates and their antihypertensive use 失效
标题翻译：某些N-取代-4-芳基-3,5-吡啶二羧酸盐及其抗高血压用途
公开(公告)号：US4505920A
公开(公告)日：1985-03-19
申请号：US471916
申请日：1983-03-03
申请人： Bernard Loev , Howard Jones , John T. Suh
发明人： Bernard Loev , Howard Jones , John T. Suh
IPC分类号： C07D211/90 , C07D401/06 , C07D521/00 , C07D403/06 , A61K31/455
CPC分类号： C07D231/12 , C07D211/90 , C07D233/56 , C07D249/08 , C07D401/06
摘要： Unsaturated heterocyclic dihydropyridine of the formula ##STR1## wherein R.sub.3 and R.sub.4 together with the N to which they are attached form an unsaturated heterocyclic group, have been found to possess useful anti-hypertensive activity.
摘要翻译：已发现具有式“IMAGE”的不饱和杂环二氢吡啶，其中R3和R4与它们所连接的N一起形成不饱和杂环基，已被发现具有有用的抗高血压活性。

9. 发明授权

US4479950A Aroylaminoacid disulfides 失效
标题翻译：芳酰胺酸二硫化物
公开(公告)号：US4479950A
公开(公告)日：1984-10-30
申请号：US439525
申请日：1982-11-05
申请人： Paul R. Menard , Howard Jones , John T. Suh
发明人： Paul R. Menard , Howard Jones , John T. Suh
IPC分类号： A61K31/195 , A61K31/215 , C07D307/58 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07C149/40 , C07C149/41
CPC分类号： C07C323/00 , C07C327/00
摘要： Compounds of the structure ##STR1## wherein: P and Q are independently hydrogen, halo, CF.sub.3, OR.sub.1, SR.sub.1, sulfamoyl, alkyl and NR.sub.1 R.sub.2 ;R.sub.1, and R.sub.2 are independently hydrogen, alkyl, aminoalky, aryl, aralkyl, heteroaryl or cycloalkyl;Y is OH, OR.sub.1, NH.sub.2, or, N(R.sub.1 R.sub.2); andM is alkyl, cycloalkyl, aryl, aminoalkyl, aralkyl, heteroaryl or heterocyclicwherein:the alkyl groups and the alkyl moieties of aminoalkyl, alkoxy and thioalkyl contain from 1 to 6 carbon atoms; the cycloalkyl group contains from 3 to 8 carbon atoms; the aryl group contains from 6 to 10 carbon atoms; the aralkyl group contains from 7 to 16 carbon atoms; and the hetero group is selected from pyrrolidyl, piperidinyl, morpholinyl, pyridyl, quinolinyl, furyl, furfuryl and thienyl; and where Y is a hydroxy, their pharmaceutically acceptable, non-toxic alkali, alkaline earth and amine salts, have angiotensin converting enzyme inhibitory activity.
摘要翻译：其中：P和Q独立地是氢，卤素，CF 3，OR 1，SR 1，氨磺酰基，烷基和NR 1 R 2; R1和R2独立地是氢，烷基，氨基烷基，芳基，芳烷基，杂芳基或环烷基; Y是OH，OR1，NH2或N（R1R2）; 并且M是烷基，环烷基，芳基，氨基烷基，芳烷基，杂芳基或杂环，其中：烷基和氨基烷基，烷氧基和硫代烷基的烷基部分含有1至6个碳原子; 环烷基含有3至8个碳原子; 芳基含有6至10个碳原子; 芳烷基含有7至16个碳原子; 杂基选自吡咯烷基，哌啶基，吗啉基，吡啶基，喹啉基，呋喃基，糠基和噻吩基; 并且其中Y是羟基，其药学上可接受的，无毒的碱金属，碱土金属和胺盐具有血管紧张素转化酶抑制活性。

10. 发明授权

US4329363A Substituted mercapto acid amides and their use 失效
标题翻译：取代巯基酰胺及其用途
公开(公告)号：US4329363A
公开(公告)日：1982-05-11
申请号：US112581
申请日：1980-01-16
申请人： Conrad P. Dorn , Howard Jones
发明人： Conrad P. Dorn , Howard Jones
IPC分类号： C07D207/34 , C07D215/48 , C07D215/50 , C07D241/44 , C07D277/56 , C07D279/30 , C07D307/68 , C07D309/38 , C07D311/12 , C07D333/38 , C07C153/057 , A61K31/16 , A61K31/165 , C07C103/127
CPC分类号： C07D215/48 , C07D207/34 , C07D215/50 , C07D241/44 , C07D277/56 , C07D279/30 , C07D307/68 , C07D309/38 , C07D311/12 , C07D333/38
摘要： The present application discloses a method of correcting an imbalance of immune homeostasis caused by cytostatic treatment or radiotherapy by administering to a patient in need of such treatment an effective amount of a novel substituted mercapto acid amide and pharmaceutical compositions containing such novel substituted mercapto acid amides.
摘要翻译：本申请公开了一种通过向需要这种治疗的患者施用有效量的新型取代的巯基酰胺和含有这种新型取代的巯基酰胺的药物组合物来校正由细胞抑制治疗或放射治疗引起的免疫稳态失衡的方法。

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