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1. 发明授权

US4666906A Compounds for treating hypertension 失效
标题翻译：用于治疗高血压的化合物
公开(公告)号：US4666906A
公开(公告)日：1987-05-19
申请号：US756530
申请日：1985-07-19
申请人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss , John R. Regan
发明人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss , John R. Regan
IPC分类号： A61K38/00 , C07K5/02 , A61K31/54 , C07D285/22
CPC分类号： C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
摘要翻译：式IMA的化合物及其药学上可接受的盐，其中取代基如本文所定义，具有抗高血压活性。

2. 发明授权

US4596791A Compounds for treating hypertension 失效
公开(公告)号：US4596791A
公开(公告)日：1986-06-24
申请号：US690387
申请日：1985-01-10
申请人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss
发明人： John J. Piwinski , John T. Suh , Paul Menard , Howard Jones , Edward S. Neiss
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0222 , A61K38/00 , Y10S530/80
摘要： Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

3. 发明授权

US4555508A Antihypertensive spiro-cyclic compounds 失效
标题翻译：抗高血压螺环化合物
公开(公告)号：US4555508A
公开(公告)日：1985-11-26
申请号：US585697
申请日：1984-03-02
申请人： John T. Suh , John R. Regan , John J. Piwinski , Paul Menard , Howard Jones
发明人： John T. Suh , John R. Regan , John J. Piwinski , Paul Menard , Howard Jones
IPC分类号： A61K31/54 , A61K38/00 , A61K38/55 , A61P7/10 , A61P9/00 , A61P9/12 , A61P43/00 , C07D513/10 , C07K1/113 , C07K5/06 , C07K14/81 , A61K37/00 , C07D279/00
CPC分类号： C07D513/10 , Y10S530/80
摘要： Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.
摘要翻译：具有一般结构的化合物及其药学上可接受的盐，其中本文定义的取代基表现出抗高血压活性。

4. 发明授权

US4696939A Benzothiadiazole compounds for treating hypertension 失效
标题翻译：苯并噻二唑化合物治疗高血压
公开(公告)号：US4696939A
公开(公告)日：1987-09-29
申请号：US802921
申请日：1985-11-29
申请人： John T. Suh , John J. Piwinski , Howard Jones , Edward S. Neiss
发明人： John T. Suh , John J. Piwinski , Howard Jones , Edward S. Neiss
IPC分类号： C07D231/56 , C07D239/90 , C07D285/14 , C07D285/30 , A61K31/41
CPC分类号： C07D231/56 , C07D239/90 , C07D285/14 , C07D285/30
摘要： Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
摘要翻译：式IMA的化合物及其药学上可接受的盐，其中取代基如本文所定义，具有抗高血压活性。

5. 发明授权

US4576941A Compounds for treating hypertension 失效
公开(公告)号：US4576941A
公开(公告)日：1986-03-18
申请号：US584576
申请日：1984-02-29
申请人： John T. Suh , John J. Piwinski , Howard Jones , Edward S. Neiss
发明人： John T. Suh , John J. Piwinski , Howard Jones , Edward S. Neiss
IPC分类号： A61K31/165 , A61K31/17 , A61K31/18 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/265 , A61K31/415 , A61K31/433 , A61K31/505 , A61K31/517 , A61P7/10 , A61P9/00 , A61P9/12 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/60 , C07D231/56 , C07D239/90 , C07D285/06 , C07D285/14 , C07D285/24 , C07D285/30 , C07D521/00 , A61K31/54 , C07D401/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D239/90 , C07D285/14 , C07D285/30
摘要： Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

6. 发明授权

US4556652A Antihypertensive spiro-amidoamino compounds 失效
标题翻译：抗高血压螺酰氨基氨基化合物
公开(公告)号：US4556652A
公开(公告)日：1985-12-03
申请号：US585769
申请日：1984-03-02
申请人： John T. Suh , Jerry W. Skiles , John J. Piwinski , Paul Menard , Howard Jones
发明人： John T. Suh , Jerry W. Skiles , John J. Piwinski , Paul Menard , Howard Jones
IPC分类号： C07D285/20 , A61K31/54 , A61K31/5415 , A61K38/00 , A61K38/55 , A61P7/10 , A61P9/00 , A61P9/12 , A61P43/00 , C07D285/30 , C07D513/10 , C07K1/113 , C07K5/06 , C07K14/81 , A61K37/00 , C07D279/00
CPC分类号： C07D285/30 , Y10S530/80
摘要： Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substitutents are defined herein, which exhibit antihypertensive activity.
摘要翻译：具有一般结构的化合物及其药学上可接受的盐，其中本文定义的取代基表现出抗高血压活性。

7. 发明授权

US4661515A Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity 失效
公开(公告)号：US4661515A
公开(公告)日：1987-04-28
申请号：US821201
申请日：1986-01-17
申请人： Edward S. Neiss , John T. Suh , John J. Piwinski
发明人： Edward S. Neiss , John T. Suh , John J. Piwinski
IPC分类号： C07D307/52 , A61K31/265 , A61K31/34 , C07C153/017 , C07D307/54
CPC分类号： C07D307/52
摘要： Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, and cycloalkyl, and may be the same or different; n is an integer from 0 to 4 inclusive; M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cyloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl, or M and R.sub.6 taken together with the nitrogen to which M is bonded and the carbon to which R.sub.6 is bonded form a saturated unsubstituted heterocyclic group containing 3 or 4 ring carbon atoms; Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy; Z.sub.1 and Z.sub.2 each is a chemical bond, the group X.sub.3 --(CH.sub.2).sub.m, an amino acid group or the group X.sub.3 --(CH.sub.2).sub.m --X.sub.3 wherein X.sub.3 is oxygen, sulfur or NH and m is an integer from 0 to 4 inclusive; A and B each is the same as R.sub.1 or halogen, trifluoromethyl, OR.sub.1, NO.sub.2, NR.sub.1 R.sub.2, SO.sub.2 NH.sub.2, CN, SR.sub.1, SOR.sub.1, SO.sub.2 R.sub.1, CONR.sub.1 R.sub.2, COOR.sub.1 ; C is hydrogen alkyl, heteroallyl, amino, --CR.sub.1 .dbd.CR.sub.2 --, ##STR3## aminoalkyl, furfurylmethylamino, aminoaryl or aminobenzyl; X.sub.1 and X.sub.2 are each S, SO, SO.sub.2, NR.sub.1, O, chemical bond, (CR.sub.9 R.sub.10).sub.m, --CR.sub.9 .dbd.CR.sub.10 --, and CHOH, with the proviso that at least one of X.sub.1 and X.sub.2 be (CR.sub.9 R.sub.10).sub.m, wherein R.sub.9 and R.sub.10 are each hydrogen or lower alkyl, and m is an integer from 1 to 5; Ar is a divalent arylene or heteroarylene; and R.sub.7 and R.sub.8 are each hydrogen, alkyl, halo, cyano, hydroxy, alkoxy, amino, alkylamino, dialkylamino, mercapto, alkylmercapto, nitro, trifluoromethyl, carboxy, carbalkoxy, COY and NHCONHR.sub.1 wherein R.sub.1 and Y are as hereindefined; and pharmaceutically-acceptable salts thereof.

8. 发明授权

US08697694B2 Substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权
标题翻译：取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
公开(公告)号：US08697694B2
公开(公告)日：2014-04-15
申请号：US13059193
申请日：2009-08-19
申请人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
发明人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
IPC分类号： C07D239/48 , C07D491/04 , A61K31/506
CPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2， R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

9. 发明授权

US07300941B2 Non-imidazole compounds 失效
标题翻译：非咪唑化合物
公开(公告)号：US07300941B2
公开(公告)日：2007-11-27
申请号：US10699189
申请日：2003-10-31
申请人： Robert G. Aslanian , Neng-Yang Shih , Pauline C. Ting , Michael Y. Berlin , Stuart B. Rosenblum , Kevin D. McCormick , Wing C. Tom , Christopher W. Boyce , Pietro Mangiaracina , Mwangi W. Mutahi , John J. Piwinski
发明人： Robert G. Aslanian , Neng-Yang Shih , Pauline C. Ting , Michael Y. Berlin , Stuart B. Rosenblum , Kevin D. McCormick , Wing C. Tom , Christopher W. Boyce , Pietro Mangiaracina , Mwangi W. Mutahi , John J. Piwinski
IPC分类号： A61K31/44
CPC分类号： C07D213/73 , A61K31/435 , A61K31/445 , A61K31/495 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.
摘要翻译：公开的是式的新化合物还公开了包含式I化合物的药物组合物。还公开了治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻拥塞）。还公开了使用组合式I化合物来治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻塞）具有H 1受体拮抗剂。

10. 发明授权

US06720328B2 Non-imidazole compounds 失效
标题翻译：非咪唑化合物
公开(公告)号：US06720328B2
公开(公告)日：2004-04-13
申请号：US09978267
申请日：2001-10-15
申请人： Robert G. Aslanian , Neng-Yang Shih , Pauline C. Ting , Michael Y. Berlin , Stuart B. Rosenblum , Kevin D. McCormick , Wing C. Tom , Christopher W. Boyce , Pietro Mangiaracina , Mwangi W. Mutahi , John J. Piwinski
发明人： Robert G. Aslanian , Neng-Yang Shih , Pauline C. Ting , Michael Y. Berlin , Stuart B. Rosenblum , Kevin D. McCormick , Wing C. Tom , Christopher W. Boyce , Pietro Mangiaracina , Mwangi W. Mutahi , John J. Piwinski
IPC分类号： C07D40114
CPC分类号： C07D213/73 , A61K31/435 , A61K31/445 , A61K31/495 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Disclosed are novel compounds of the formula In Formula I, M1 is carbon, M2, M3 and M4 are carbon or nitrogen and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.
摘要翻译：公开了式I的新化合物，式I中M 1是碳，M 2，M 3和M 4是碳或氮，其余的变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了使用式（I）的化合物治疗各种疾病或病症例如过敏，过敏诱发的气道反应和充血（例如，鼻塞）的方法还公开了使用式I化合物与H1受体拮抗剂组合来治疗各种疾病或病症的方法，例如过敏，过敏诱导的气道反应和充血（例如，鼻塞）。

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