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1. 发明授权

US07211055B2 System and method providing directional ultrasound therapy to skeletal joints 有权
标题翻译：向骨骼关节提供定向超声治疗的系统和方法
公开(公告)号：US07211055B2
公开(公告)日：2007-05-01
申请号：US10347164
申请日：2003-01-15
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
IPC分类号： A61F7/00
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

2. 发明授权

US08414509B2 Implantable thermal treatment method and apparatus 有权
公开(公告)号：US08414509B2
公开(公告)日：2013-04-09
申请号：US12898401
申请日：2010-10-05
申请人： Chris J. Diederich , Jeffrey C. Lotz , William H. Nau, Jr. , David S. Bradford
发明人： Chris J. Diederich , Jeffrey C. Lotz , William H. Nau, Jr. , David S. Bradford
IPC分类号： A61N7/02
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

3. 发明授权

US07641691B2 Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs 失效
标题翻译：生物降解/生物活性髓核植入物和治疗退化性椎间盘的方法
公开(公告)号：US07641691B2
公开(公告)日：2010-01-05
申请号：US11505783
申请日：2006-08-16
申请人： Jeffrey C. Lotz , Olivier K. Colliou , David S. Bradford
发明人： Jeffrey C. Lotz , Olivier K. Colliou , David S. Bradford
IPC分类号： A61F2/44
CPC分类号： B29C41/14 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/30069 , A61F2002/30133 , A61F2002/30957 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2002/4635 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61F2310/0097 , A61L27/18 , A61L27/58 , A61L2430/38 , B29C41/42 , C08L75/04 , C08L71/02
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

4. 发明申请

US20090234457A1 SYSTEMS, DEVICES AND METHODS FOR TREATMENT OF INTERVERTEBRAL DISORDERS 审中-公开
标题翻译：用于治疗椎间盘突出症的系统，装置和方法
公开(公告)号：US20090234457A1
公开(公告)日：2009-09-17
申请号：US12396385
申请日：2009-03-02
申请人： Jeffrey C. Lotz , David S. Bradford
发明人： Jeffrey C. Lotz , David S. Bradford
IPC分类号： A61F2/44 , A61F2/06
CPC分类号： A61F2/441 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/30069 , A61F2002/30092 , A61F2002/30133 , A61F2002/30565 , A61F2002/30578 , A61F2002/30586 , A61F2002/30677 , A61F2002/30733 , A61F2002/30904 , A61F2002/3092 , A61F2002/30957 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2002/4635 , A61F2210/0004 , A61F2210/0014 , A61F2230/0015 , A61F2310/00365 , A61F2310/0097 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/41 , A61L2300/414 , A61L2300/604 , A61L2430/38 , B29C41/14 , B29C41/42
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

5. 发明申请

US20080243194A1 ARTICULATING INSTRUMENTATION FOR DYNAMIC SPINAL STABILIZATION 审中-公开
标题翻译：用于动态脊柱稳定的仪器仪表
公开(公告)号：US20080243194A1
公开(公告)日：2008-10-02
申请号：US12055531
申请日：2008-03-26
申请人： Jeffrey C. Lotz , David S. Bradford
发明人： Jeffrey C. Lotz , David S. Bradford
IPC分类号： A61F5/00 , A61B17/70 , A61B17/04
CPC分类号： A61B17/70 , A61B17/7023 , A61B90/03
摘要： Dynamic stabilization apparatus and methods in the context of a spinal implant configured to constrain intervertebral movement, where the constraint is meant to eliminate unwanted, non-physiologic motions. The system provides dynamic stability to motion in a compromised spinal joint by allowing motion along a centrode of the instant axis of rotation (IAR) that substantially approximates the normal centrode for the respective spinal joint. The system and method is adapted to provide stabilized motion in a spinal joint such that the IAR shifts cephalad during typical flexion ranges beyond a normal resting range of motion, and shifts posteriorly during typical extension ranges beyond the normal resting range of motion.
摘要翻译：在脊柱植入物的上下文中的动态稳定装置和方法被配置成约束椎间动作，其中约束意在消除不需要的非生理运动。该系统通过允许沿着基本上接近相应脊柱关节的正常中心的瞬时旋转轴线（IAR）的中心运动来提供在受损脊椎关节中的运动的动态稳定性。该系统和方法适于在脊柱关节中提供稳定的运动，使得IAR在典型的屈曲范围内移动头部，超过正常的静止运动范围，并且在超出正常的静止运动范围的典型延伸范围内向后移动。

6. 发明授权

US08915949B2 Method for providing directional therapy to skeletal joints 有权
标题翻译：为骨骼关节提供定向治疗的方法
公开(公告)号：US08915949B2
公开(公告)日：2014-12-23
申请号：US12781689
申请日：2010-05-17
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
IPC分类号： A61N7/00 , A61N7/02 , A61B18/04 , A61B17/00 , A61B19/00
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

7. 发明申请

US20090030308A1 SYSTEMS, COMPOSITIONS, AND METHODS FOR LOCAL IMAGING AND TREATMENT OF PAIN 有权
标题翻译：用于局部成像和治疗疼痛的系统，组合物和方法
公开(公告)号：US20090030308A1
公开(公告)日：2009-01-29
申请号：US12053379
申请日：2008-03-21
申请人： David S. Bradford , Jeffrey C. Lotz
发明人： David S. Bradford , Jeffrey C. Lotz
IPC分类号： A61B18/18 , A61K101/02 , A61K51/10 , A61K49/00 , A61N7/00 , A61B6/00 , A61K49/22 , A61K49/06 , A61B18/08
CPC分类号： A61B6/506 , A61B5/4041 , A61B5/4824 , A61B18/14 , A61B2018/00339 , A61B2018/00577 , A61B2018/00642 , A61K49/0002 , A61K51/1096 , A61M5/007 , A61M5/1723 , A61M2230/005 , A61N7/02
摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.
摘要翻译：疼痛因素用传递到体内的靶向药物或标记进行标记。标记的疼痛因子以适当的成像工具以允许选择性识别和定位疼痛源或传播区域的方式成像。标记的疼痛因子允许成像中的空间分化足以指定疼痛的位置，以便驱动治疗决定和技术以治疗疼痛。以这种方式标记和成像的疼痛因子可包括神经因子，血管因子，细胞因子和炎症因子中的一种或多种。标记的标记可以包括例如放射性材料（例如氚化或碘化分子）或其它材料，例如金属（例如金）纳米颗粒。可以使用中间结合材料，例如双特异性抗体。系统和方法的治疗组件包括例如局部能量递送或消融治疗，或局部药物或其它化学物质递送。选择性地由靶向药物结合的含有疼痛因子的位置被选择性地用定向能量处理到含有与疼痛因子结合的靶向药剂的区域中。

8. 发明授权

US08344728B2 Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue 有权
标题翻译：使用核磁共振（NMR）光谱法评估组织的疼痛和退化性质的系统和方法
公开(公告)号：US08344728B2
公开(公告)日：2013-01-01
申请号：US11829847
申请日：2007-07-27
申请人： Sharmila Majumdar , John Kurhanewicz , Jeffrey C. Lotz , David S. Bradford , Kayvan Keshari
发明人： Sharmila Majumdar , John Kurhanewicz , Jeffrey C. Lotz , David S. Bradford , Kayvan Keshari
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/4824 , G01N24/08 , G01R33/465 , G01R33/483 , G01R33/485
摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3 T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3 T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.
摘要翻译：对椎间盘组织进行NMR光谱。基于NMR光谱测定退化程度。 NMR光谱区域与组织变性和疼痛中的至少一种之间的相关性。因此，使用NMR光谱来确定与组织区域相关的变性或疼痛中的至少一种的位置和/或程度，例如特别是椎间盘变性或椎间盘性疼痛。核磁共振光谱峰比例，如N-乙酰基/ cho和cho / carb之间，容易获得和分析，以预测组织变性和/或疼痛程度：组织样本使用HR-MAS光谱; 和较大部分的解剖结构，如关节节段如脊柱，使用具有表面头部或膝部线圈的临床3 T MRI系统; 和组织区域，例如使用具有表面脊髓线圈的3T MRI系统的活体患者脊柱内的椎间盘，从而提供完全无创的诊断工具和方法来成像和定位变性和/或疼痛。

9. 发明申请

US20110022133A1 METHOD FOR PROVIDING DIRECTIONAL THERAPY TO SKELETAL JOINTS 有权
标题翻译：用于向骨骼接合提供方向治疗的方法
公开(公告)号：US20110022133A1
公开(公告)日：2011-01-27
申请号：US12781689
申请日：2010-05-17
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
IPC分类号： A61F7/00
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

10. 发明授权

US07819826B2 Implantable thermal treatment method and apparatus 有权
标题翻译：可植入热处理方法和装置
公开(公告)号：US07819826B2
公开(公告)日：2010-10-26
申请号：US10351450
申请日：2003-01-23
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford , John P. O'Banion , James C. Peacock, III
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford , John P. O'Banion , James C. Peacock, III
IPC分类号： A61B8/00
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

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