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1. 发明授权

US6015390A System and method for stabilizing and removing tissue 失效
标题翻译：用于稳定和去除组织的系统和方法
公开(公告)号：US6015390A
公开(公告)日：2000-01-18
申请号：US96807
申请日：1998-06-12
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B17/00 , A61B18/02 , A61B19/00 , A61B5/00
CPC分类号： A61B18/02 , A61B90/17 , A61B2017/00084 , A61B2090/374 , A61B2090/3908 , A61B34/10 , Y10S128/27
摘要： A system (8) and method for stabilizing a tissue mass, using temperature sensors (10), a scanner (80), and a cryoprobe (220). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.
摘要翻译：一种使用温度传感器（10），扫描器（80）和冷冻探针（220）来稳定组织块的系统（8）和方法。传感器提供关于与其相邻的组织部分的温度信息。传感器包括识别（ID）码和ID解码器。 ID解码器将传感器ID代码与扫描器提供的询问信号中包含的ID码进行比较。如果代码匹配，传感器将温度信息传送到扫描仪，扫描仪以人类可识别的形式处理和显示温度信息。该方法包括将冷冻探针插入要稳定的组织体积中以使得一部分冷冻探针从其突出的步骤。然后，在监测组织体积的大小或温度的同时冷冻组织体积。当组织体积冷冻（或达到第一温度水平）时，冷冻终止，然后在抓住冷冻探针时移除，以便稳定组织体积。

2. 发明授权

US07098302B2 Binding peptides specific for the extracellular domain of ErbB2 and uses therefor 失效
公开(公告)号：US07098302B2
公开(公告)日：2006-08-29
申请号：US10272437
申请日：2002-10-15
申请人： David N. Krag , Stephanie C. Pero , Lyn Oligino
发明人： David N. Krag , Stephanie C. Pero , Lyn Oligino
IPC分类号： A61K38/00 , A61K38/12
CPC分类号： C07K14/475 , A61K38/00 , A61K47/64
摘要： The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).

3. 发明授权

US06401722B1 Method for stabilizing and removing tissue 有权
标题翻译：稳定和去除组织的方法
公开(公告)号：US06401722B1
公开(公告)日：2002-06-11
申请号：US09442793
申请日：1999-11-18
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B1900
CPC分类号： A61B18/02 , A61B34/10 , A61B90/17 , A61B2017/00084 , A61B2090/374 , A61B2090/3908 , Y10S128/27
摘要： A method of stabilizing a tissue mass, using a system (8) that includes temperature sensors (10), a scanner (80), and a cryoprobe (220). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.
摘要翻译：使用包括温度传感器（10），扫描器（80）和冷冻探针（220）的系统（8）来稳定组织块的方法。传感器提供关于与其相邻的组织部分的温度信息。传感器包括识别（ID）码和ID解码器。 ID解码器将传感器ID代码与扫描器提供的询问信号中包含的ID码进行比较。如果代码匹配，传感器将温度信息传送到扫描仪，扫描仪以人类可识别的形式处理和显示温度信息。该方法包括将冷冻探针插入要稳定的组织体积中以使得一部分冷冻探针从其突出的步骤。然后，在监测组织体积的大小或温度的同时冷冻组织体积。当组织体积冷冻（或达到第一温度水平）时，冷冻终止，然后在抓住冷冻探针时移除，以便稳定组织体积。

4. 发明授权

US06363940B1 System and method for bracketing and removing tissue 失效
标题翻译：包围和去除组织的系统和方法
公开(公告)号：US06363940B1
公开(公告)日：2002-04-02
申请号：US09078982
申请日：1998-05-14
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B1900
CPC分类号： A61B17/32053 , A61B17/3201 , A61B17/3211 , A61B17/3403 , A61B34/20 , A61B90/39 , A61B2017/00349 , A61B2017/320064 , A61B2017/3413 , A61B2034/2063 , A61B2090/3908 , A61B2090/392 , A61B2090/3929 , A61B2090/3937 , A61B2090/395 , A61B2090/3954 , A61B2090/3958 , A61B2090/3995
摘要： A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.
摘要翻译：一种用于包围组织体积（22）并且稍后定位被包围的组织体积的系统和方法。该系统包括多个标记（30）和探针（32）和探测器（34），用于通过提供外科医生可用的代表探针和多个标记之间的接近度变化的信息来定位标记物。标记具有各种检测特征，例如它们传输可由相关探针和检测器检测的γ射线。通过根据由检测器提供的邻近信息来操纵切割工具来去除组织体积，所述邻近信息可被外科医生用来限定组织体积的边界。提供用于去除组织体积的两部分切割工具（200），并且提供组织锚（300）以在移除期间稳定组织。本发明的系统和方法特别可用于包围并随后从无形的，柔韧的组织例如乳房组织中去除组织体积。

5. 发明授权

US07229960B2 Methods and compositions for inhibiting GRB7 有权
标题翻译：抑制GRB7的方法和组合物
公开(公告)号：US07229960B2
公开(公告)日：2007-06-12
申请号：US10013815
申请日：2001-11-05
申请人： Stephanie C. Pero , David N. Krag , Lyn Oligino
发明人： Stephanie C. Pero , David N. Krag , Lyn Oligino
IPC分类号： A01N37/18 , A61K38/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/47 , A61K38/06 , C07K1/047
摘要： The invention provides methods and compositions for treating subjects using Grb7 antagonists. Specifically disclosed are Grb7 antagonists that bind selectively to Grb7 and interfere with the ability of Grb7 to bind to its native ligands. These compositions are useful in the prevention and treatment of disorders characterized by abnormal interaction of Grb7 with its native ligands (e.g., ErbB2).
摘要翻译：本发明提供了使用Grb7拮抗剂治疗受试者的方法和组合物。具体公开了Grb7拮抗剂，其选择性结合Grb7并干扰Grb7结合其天然配体的能力。这些组合物可用于预防和治疗以Grb7与其天然配体（例如ErbB2）的异常相互作用为特征的疾病。

6. 发明申请

US20110130655A1 IMPLANTABLE DEVICES AND METHODS FOR EXTERNAL BEAM RADIATION TREATMENTS 审中-公开
标题翻译：外部射束辐射治疗的可植入装置和方法
公开(公告)号：US20110130655A1
公开(公告)日：2011-06-02
申请号：US12956820
申请日：2010-11-30
申请人： Eric D. Nielson , Steven C. Dimmer , David N. Krag , Timothy P. Mate , Roland Perez , Fergus Quigley
发明人： Eric D. Nielson , Steven C. Dimmer , David N. Krag , Timothy P. Mate , Roland Perez , Fergus Quigley
IPC分类号： A61B5/05
CPC分类号： A61N5/1049 , A61N2005/1051
摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.
摘要翻译：公开了用于外部束辐射处理的可植入装置和方法。用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线发射的源能发射非电离无线信号的活动标记。该装置还包括紧固单元，其联接到主动标记并且被配置为（a）将标记保持在组织中的目标的期望距离内，并且（b）抑制组织相对于目标移动主动标记物的变形。

7. 发明授权

US06675810B2 System and method for bracketing and removing tissue 有权
公开(公告)号：US06675810B2
公开(公告)日：2004-01-13
申请号：US09954588
申请日：2001-09-14
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B1900
CPC分类号： A61B17/32053 , A61B17/3201 , A61B17/3211 , A61B17/3403 , A61B34/20 , A61B90/39 , A61B2017/00349 , A61B2017/320064 , A61B2017/3413 , A61B2034/2063 , A61B2090/3908 , A61B2090/392 , A61B2090/3929 , A61B2090/3937 , A61B2090/395 , A61B2090/3954 , A61B2090/3958 , A61B2090/3995
摘要： A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.

8. 发明授权

US06918919B2 System and method for bracketing and removing tissue 有权
标题翻译：包围和去除组织的系统和方法
公开(公告)号：US06918919B2
公开(公告)日：2005-07-19
申请号：US09815393
申请日：2001-03-22
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B10/02 , A61B8/08 , A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00
CPC分类号： A61B17/32053 , A61B17/3201 , A61B17/3211 , A61B17/3403 , A61B34/20 , A61B90/39 , A61B2017/00349 , A61B2017/320064 , A61B2017/3413 , A61B2034/2063 , A61B2090/3908 , A61B2090/392 , A61B2090/3929 , A61B2090/3937 , A61B2090/395 , A61B2090/3954 , A61B2090/3958 , A61B2090/3995
摘要： A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.
摘要翻译：一种用于包围组织体积（22）并且稍后定位被包围的组织体积的系统和方法。该系统包括多个标记（30）和探针（32）和探测器（34），用于通过提供外科医生可用的代表探针和多个标记之间的接近度变化的信息来定位标记物。标记具有各种检测特征，例如它们传输可由相关探针和检测器检测的γ射线。通过根据由检测器提供的邻近信息来操纵切割工具来去除组织体积，所述邻近信息可被外科医生用来限定组织体积的边界。提供用于去除组织体积的两部分切割工具（200），并且提供组织锚（300）以在移除期间稳定组织。本发明的系统和方法特别可用于包围并随后从无形的，柔韧的组织例如乳房组织中去除组织体积。

9. 发明授权

US06698433B2 System and method for bracketing and removing tissue 有权
标题翻译：包围和去除组织的系统和方法
公开(公告)号：US06698433B2
公开(公告)日：2004-03-02
申请号：US10047735
申请日：2002-01-14
申请人： David N. Krag
发明人： David N. Krag
IPC分类号： A61B1900
CPC分类号： A61B17/32053 , A61B17/3201 , A61B17/3211 , A61B17/3403 , A61B34/20 , A61B90/39 , A61B2017/00349 , A61B2017/320064 , A61B2017/3413 , A61B2034/2063 , A61B2090/3908 , A61B2090/392 , A61B2090/3929 , A61B2090/3937 , A61B2090/395 , A61B2090/3954 , A61B2090/3958 , A61B2090/3995
摘要： A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.
摘要翻译：一种用于包围组织体积（22）并且稍后定位被包围的组织体积的系统和方法。该系统包括多个标记（30）和探针（32）和探测器（34），用于通过提供外科医生可用的代表探针和多个标记之间的接近度变化的信息来定位标记物。标记具有各种检测特征，例如它们传输可由相关探针和检测器检测的γ射线。通过根据由检测器提供的邻近信息来操纵切割工具来去除组织体积，所述邻近信息可被外科医生用来限定组织体积的边界。提供用于去除组织体积的两部分切割工具（200），并且提供组织锚（300）以在移除期间稳定组织。本发明的系统和方法特别可用于包围并随后从无形的，柔韧的组织例如乳房组织中去除组织体积。

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