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    • 2. 发明授权
    • B1-robust and T1-robust species suppression in MRI
    • 在MRI中B1强壮和T1强壮的物种抑制
    • US08723516B2
    • 2014-05-13
    • US12713548
    • 2010-02-26
    • Andrew J. WheatonJames B. Murdoch
    • Andrew J. WheatonJames B. Murdoch
    • G01V3/00
    • G01R33/5607G01R33/5659
    • An MRI multi-echo data acquisition sequence (REFUSAL=REFocusing Used to Selectively Attenuate Lipids) includes a spectrally-selective re-focusing RF pulse. The REFUSAL pulse can be non-spatially selective or spatially-selective. The REFUSAL pulse selectively refocuses water spins and avoids refocusing lipid spins. The REFUSAL pulse ideally maximizes refocusing for water and minimizes any lipid refocusing, with built-in robustness to B0-inhomogeneity and B1-inhomogeneity. Following the REFUSAL pulse, the remainder of the echo train continues in a conventional fashion. Only those spins that were refocused with the spectrally selective REFUSAL pulse continue to evolve coherently and generate a train of echoes. Those spins that were minimally refocused are spoiled and thus do not contribute signal to the final image. To incorporate a longer duration REFUSAL pulse, the echo spacing can be made non-uniform such that the first echo spacing is longer than the remainder of the echo spacings in the echo train.
    • MRI多回波数据采集序列(REFUSAL =用于选择性衰减脂质的重新聚焦)包括光谱选择性重聚焦RF脉冲。 REFUSAL脉冲可以是非空间选择性或空间选择性的。 REFUSAL脉冲选择性地重新聚焦水分,避免重新聚焦脂质旋转。 REFUSAL脉冲理想地最大限度地重新聚焦水,并最大限度地减少任何脂质重聚焦,具有内在的B0不均匀性和B1不均匀性的鲁棒性。 在REFUSAL脉冲之后,回波串的其余部分以常规方式继续。 只有那些重新聚焦于光谱选择性反射脉冲脉冲的旋转才能持续演变,产生一系列的回声。 那些最少重新聚焦的旋转被宠坏,因此不会对最终形象产生信号。 为了结合较长持续时间的REFUSAL脉冲,可以使回波间隔不均匀,使得第一回波间隔长于回波串中回波间隔的其余部分。
    • 3. 发明授权
    • High temporal resolution black blood cine imaging
    • 高时间分辨率黑血丝成像
    • US5447155A
    • 1995-09-05
    • US859153
    • 1992-03-27
    • Moriel S. NessAiverJames B. Murdoch
    • Moriel S. NessAiverJames B. Murdoch
    • A61B5/026A61B5/055A61B5/107G01R33/56G01R33/561G01R33/563G06T7/00G06T7/60
    • A61B5/1076A61B5/0263A61B5/055G01R33/563G06T7/602G06T7/606G01R33/56G01R33/5608G01R33/5617G01R33/5619G06T2207/20224
    • During a cardiac cine examination, a multiplicity of imaging sequences, each about 20 msec long, are applied following the R-wave. Each imaging sequence includes a saturation portion in which a bi-modal pre-saturation pulse (38) and a spoiler gradient (56) are applied. The bi-modal RF pulse has a relatively low tip angle, about 50.degree., but is repeated sufficiently often that blood in regions (30a, 30b) parallel to a selected slice (32) are driven toward saturation. Each imaging sequence further includes a gradient echo or other conventional imaging sequence during an imaging portion to generate magnetic resonance data (60). Each imaging sequence is repeated twice for each temporal interval with the same phase encoding, but once with the relative phase of the signal in the slice and the relative phase of the signals from within the pair of regions (30a, 30b) reversed. These two signals are combined such that the signals from within the slice add and the signals from with the pair of regions subtract. Signals corresponding to the same temporal interval after the R-wave with each of a multiplicity of phase encodings are reconstructed (82) into an image representations (84) for display on a video monitor (96).
    • 在心脏电影检查期间,在R波之后施加大约20毫秒长的多个成像序列。 每个成像序列包括其中施加双模式预饱和脉冲(38)和扰流器梯度(56)的饱和部分。 双模式RF脉冲具有约50°的相对低的尖端角度,但是经常重复地反复使得平行于选定切片(32)的区域(30a,30b)中的血液被驱动朝向饱和。 每个成像序列还包括在成像部分期间产生磁共振数据的梯度回波或其他常规成像序列(60)。 每个成像序列对于具有相同相位编码的每个时间间隔重复两次,但是一旦与切片中的信号的相对相位和来自一对区域(30a,30b)内的信号的相对相位相反。 这两个信号被组合,使得来自片内的信号加上来自与该对区域的信号相减。 在具有多个相位编码中的每一个的R波之后对应于相同时间间隔的信号被重建(82)成为用于在视频监视器(96)上显示的图像表示(84)。
    • 5. 发明授权
    • Phase rotated spoiling for spatial and spectral saturation techniques
    • 相位旋转破坏用于空间和频谱饱和技术
    • US5500593A
    • 1996-03-19
    • US344372
    • 1994-11-23
    • Mark J. LoncarJames B. MurdochRao P. Gullapalli
    • Mark J. LoncarJames B. MurdochRao P. Gullapalli
    • G01R33/48A61B5/055G01R33/483G01V3/00G01V3/14
    • G01R33/4838
    • Magnets (12) create a temporally constant magnetic field through an examination region (14). Radio frequency coils (26, 34) and a transmitter (24) transmit radio frequency saturation pulses (52) and the resonance excitation and manipulation pulses of a magnetic resonance imaging sequence (72) into the examination region. Gradient amplifiers (20) and gradient coils (22, 32) create magnetic field gradients across the examination region for spatially focusing the saturation, for spoiling (62, 66, 70) residual transverse magnetization and for frequency and phase encoding in the magnetic resonance imaging sequence. A sequence controller (40) includes a saturation pulse controller (44) for generating the saturation pulse (52) and slice select gradients (58) and a steady state sequence controller (48) for generating the imaging sequence (72). The saturation is spectrally focused by limiting the frequency of the saturation pulse to selected frequencies. The saturation is spatially focused by applying the slice or other spatially limiting gradient pulses concurrently with the radio frequency saturation pulse. A phase shift controller (76) increments the phase of the RF saturation pulse by a preselected phase increment, e.g., 105.degree.. Preferably, the phase shift increment increases linearly in each cyclic repetition, i.e., increases 105.degree. in the first repetition, 210.degree. in the next repetition, 315.degree. in the next repetition, etc. A reconstruction processor (80) reconstructs resonance signals generated during the imaging sequences into an image representation for storage in a memory (82) and display on a video monitor (86).
    • 磁体(12)通过检查区域(14)产生时间上恒定的磁场。 射频线圈(26,34)和发射器(24)将射频饱和脉冲(52)和磁共振成像序列(72)的共振激励和操作脉冲发送到检查区域。 梯度放大器(20)和梯度线圈(22,32)在整个检查区域产生磁场梯度,用于空间聚焦饱和度,用于破坏(62,66,70)残余横向磁化和用于磁共振成像中的频率和相位编码 序列。 序列控制器(40)包括用于产生饱和脉冲(52)和切片选择梯度(58)的饱和脉冲控制器(44)和用于产生成像序列(72)的稳态序列控制器(48)。 通过将饱和脉冲的频率限制到选定的频率,饱和度被光谱聚焦。 饱和度通过与射频饱和脉冲同时施加切片或其它空间限制的梯度脉冲来进行空间聚焦。 相移控制器(76)将RF饱和脉冲的相位增加预选相位增量,例如105度。 优选地,相移增量在每个循环重复中线性增加,即,在第一次重复中增加105度,在下一次重复中增加210度,在下一次重复中增加315度。重构处理器(80)重构在 所述成像序列变成用于存储在存储器(82)中并在视频监视器(86)上显示的图像表示。
    • 6. 发明授权
    • Multi-axis pre-saturated spin echo phase encoded spectroscopy
    • 多轴预饱和自旋回波相位编码光谱
    • US5010300A
    • 1991-04-23
    • US440894
    • 1989-11-22
    • Martyn N. J. PaleyJames B. MurdochDavid A. LampmanJames M. McNally
    • Martyn N. J. PaleyJames B. MurdochDavid A. LampmanJames M. McNally
    • G01R33/483G01R33/485
    • G01R33/4838G01R33/485
    • RF and gradient pulse combinations (30, 32, 36, 38) are applied to limit or define a region of interest in two dimensions (42) by pre-saturating surrounding regions (34a, 34b, 40a, 40b). A 90.degree. RF pulse (50) is applied in the presence of a slice select gradient (60) to excite selected dipoles in a slice or slab, defining the region of interest or voxel in the third dimension. Phase encoding gradients (62) and (64) are applied to encode spatial position in two dimensions of the slice. A binomial refocusing pulse (52) suppresses the water and refocuses the metabolite resonance into an echo which is acquired (68) by a receiver (26). A Fourier transform means (72, 74) transforms the received magnetic resonance signals to create a two dimensional array (76) or matrix of spectra (78) corresponding to a two dimensional array of spatial positions within the slice. A third phase encode gradient (66) may be applied to encode the regionof interest in three dimensions for generating a three dimensional array of the spectra.
    • 施加RF和梯度脉冲组合(30,32,36,38)以通过预饱和周围区域(34a,34b,40a,40b)限制或限定二维(42)中的感兴趣区域。 在切片选择梯度(60)的存在下施加90°RF脉冲(50)以在切片或平板中激发所选择的偶极子,以限定第三维度中的感兴趣区域或体素。 相位编码梯度(62)和(64)被应用于编码切片的二维空间位置。 二项式重聚焦脉冲(52)抑制水并将代谢物共振重新聚焦成由接收器(26)获取的回波(68)。 傅立叶变换装置(72,74)转换所接收的磁共振信号以产生对应于片内空间位置的二维阵列的二维阵列(76)或光谱矩阵(78)。 可以应用第三相位编码梯度(66)以在三维中对感兴趣的区域进行编码以产生光谱的三维阵列。