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    • 3. 发明授权
    • RS7 antibodies
    • RS7抗体
    • US08084583B2
    • 2011-12-27
    • US12389503
    • 2009-02-20
    • Serengulam V. GovindanZhengxing QuHans J. HansenDavid M. Goldenberg
    • Serengulam V. GovindanZhengxing QuHans J. HansenDavid M. Goldenberg
    • C07K16/00
    • A61K45/06A61K39/39558A61K51/1045A61K51/1051A61K2039/505C07K16/30C07K16/3015C07K2317/21C07K2317/24
    • This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
    • 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点,其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或更多个结合位点,其中每个结合位点对靶抗原上的不同表位具有亲和力,或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地,本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化,人和嵌合RS7抗原结合蛋白,以及这种结合蛋白在诊断和治疗中的用途。