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1. 发明授权

US08613903B2 Humanized L243 antibodies 有权
公开(公告)号：US08613903B2
公开(公告)日：2013-12-24
申请号：US12556718
申请日：2009-09-10
申请人： David M. Goldenberg , Hans J. Hansen , Zhengxing Qu , Chien-Hsing Chang
发明人： David M. Goldenberg , Hans J. Hansen , Zhengxing Qu , Chien-Hsing Chang
IPC分类号： A61K38/43 , A61K45/00 , A61K51/00 , A61K39/00 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2833 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2887 , C07K16/4241 , C07K19/00 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： Humanized antibodies are provided that specifically bind HLA-DR. The antibodies recognize the epitope recognized by the murine monoclonal antibody L243. Processes for preparing such antibodies, pharmaceutical compositions containing such antibodies, and clinical therapeutic and diagnostic, as well as research-related uses for such antibodies, are provided.

2. 发明申请

US20120196326A1 Mammalian Cell Lines for Increasing Longevity and Protein Yield from a Cell Culture 有权
标题翻译：哺乳动物细胞系从细胞培养增加寿命和蛋白质产量
公开(公告)号：US20120196326A1
公开(公告)日：2012-08-02
申请号：US13413871
申请日：2012-03-07
申请人： David M. Goldenberg , Zhengxing Qu , Chien Hsing Chang , Edmund A. Rossi , Jeng-Dar Yang , Diane Nordstrom
发明人： David M. Goldenberg , Zhengxing Qu , Chien Hsing Chang , Edmund A. Rossi , Jeng-Dar Yang , Diane Nordstrom
IPC分类号： C12P21/00 , C12N9/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/005 , C07K14/4747 , C07K16/00 , C07K16/18 , C07K16/2803 , C07K16/3007 , C07K2317/24 , C07K2317/31 , C12N5/0694 , C12N15/85 , C12N15/86 , C12N2500/90 , C12N2501/48 , C12N2510/02 , C12N2710/20022 , C12N2740/10043 , C12P21/02
摘要： Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transformation under serum-free conditions. The method preferably involves eukaryotic cells, more preferably mammalian cells.
摘要翻译：公开了用于增加细胞培养物的寿命并允许增加蛋白质生产的组合物和方法，优选重组蛋白，例如抗体，肽，酶，生长因子，白细胞介素，干扰素，激素和疫苗。用凋亡抑制基因或载体如三重突变体Bcl-2基因转染的细胞可以在培养物中更长时间地存活，导致蛋白质生物合成的状态和产量的延长。这样的转染细胞表现出最大的细胞密度，其等于或超过由亲本细胞系实现的最大密度。转染的细胞也可以预先适应于无血清培养基中生长，大大减少了在无血清培养基中获得蛋白质产生所需的时间。在某些方法中，预先调节的细胞可以在无血清条件下转化后用于蛋白质生产。该方法优选涉及真核细胞，更优选哺乳动物细胞。

3. 发明授权

US08084583B2 RS7 antibodies 有权
标题翻译： RS7抗体
公开(公告)号：US08084583B2
公开(公告)日：2011-12-27
申请号：US12389503
申请日：2009-02-20
申请人： Serengulam V. Govindan , Zhengxing Qu , Hans J. Hansen , David M. Goldenberg
发明人： Serengulam V. Govindan , Zhengxing Qu , Hans J. Hansen , David M. Goldenberg
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译：本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。

4. 发明授权

US08084029B2 Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof 有权
公开(公告)号：US08084029B2
公开(公告)日：2011-12-27
申请号：US13090391
申请日：2011-04-20
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K41/0095 , A61K47/6843 , A61K49/0002 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , G01N33/57484 , G01N33/689
摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.

5. 发明授权

US08017736B2 Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof 有权
标题翻译：甲胎蛋白Immu31抗体和融合蛋白及其使用方法
公开(公告)号：US08017736B2
公开(公告)日：2011-09-13
申请号：US12359745
申请日：2009-01-26
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K41/0095 , A61K47/6843 , A61K49/0002 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , G01N33/57484 , G01N33/689
摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.
摘要翻译：本发明提供人源化，嵌合和人抗甲胎蛋白抗体，融合蛋白及其片段。抗体，融合蛋白及其片段以及与其它合适抗体的组合可用于治疗和诊断肝细胞癌，肝母细胞瘤，生殖细胞肿瘤癌和其他产生AFP的肿瘤。

6. 发明授权

US07785880B2 Mammalian cell lines for increasing longevity and protein yield from cell culture 有权
标题翻译：哺乳动物细胞系增加细胞培养的寿命和蛋白质产量
公开(公告)号：US07785880B2
公开(公告)日：2010-08-31
申请号：US12405733
申请日：2009-03-17
申请人： David M. Goldenberg , Zhengxing Qu , Chien-Hsing Chang , Edmund A. Rossi , Jeng-Dar Yang , Diane Nordstrom
发明人： David M. Goldenberg , Zhengxing Qu , Chien-Hsing Chang , Edmund A. Rossi , Jeng-Dar Yang , Diane Nordstrom
IPC分类号： C12N5/00 , C12N15/00 , C12P21/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/005 , C07K14/4747 , C07K16/00 , C07K16/18 , C07K16/2803 , C07K16/3007 , C07K2317/24 , C07K2317/31 , C12N5/0694 , C12N15/85 , C12N15/86 , C12N2500/90 , C12N2501/48 , C12N2510/02 , C12N2710/20022 , C12N2740/10043 , C12P21/02
摘要： Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transformation under serum-free conditions. The method preferably involves eukaryotic cells, more preferably mammalian cells.
摘要翻译：公开了用于增加细胞培养物的寿命并允许增加蛋白质生产的组合物和方法，优选重组蛋白，例如抗体，肽，酶，生长因子，白细胞介素，干扰素，激素和疫苗。用凋亡抑制基因或载体如三重突变体Bcl-2基因转染的细胞可以在培养物中更长时间地存活，导致蛋白质生物合成的状态和产量的延长。这样的转染细胞表现出最大的细胞密度，其等于或超过由亲本细胞系实现的最大密度。转染的细胞也可以预先适应于无血清培养基中生长，大大减少了在无血清培养基中获得蛋白质产生所需的时间。在某些方法中，预先调节的细胞可以在无血清条件下转化后用于蛋白质生产。该方法优选涉及真核细胞，更优选哺乳动物细胞。

7. 发明授权

US07772373B2 Internalizing anti-CD74 antibodies and methods of use 有权
标题翻译：内化抗CD74抗体及其使用方法
公开(公告)号：US07772373B2
公开(公告)日：2010-08-10
申请号：US11867775
申请日：2007-10-05
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K38/00 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2833 , C07K16/2896 , C07K2317/24 , C07K2317/77
摘要： The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.
摘要翻译：本发明提供人源化，嵌合和人抗CD74抗体，CD74抗体融合蛋白，免疫缀合物，疫苗和结合CD74的双特异性，主要组织相容性复合体（MHC）II类不变链I 1可用于治疗 B细胞病变，B细胞恶性肿瘤，其他细胞与CD74反应的其他恶性肿瘤，以及自身免疫性疾病以及治疗和诊断方法的诊断。

8. 发明申请

US20100136626A1 Production and Use of Novel Peptide-Based Agents for Use with Bi-Specific Antibodies 有权
公开(公告)号：US20100136626A1
公开(公告)日：2010-06-03
申请号：US12582009
申请日：2009-10-20
申请人： Hans J. Hansen , Gary L. Griffiths , Shui-on Leung , William J. McBride , Zhengxing Qu
发明人： Hans J. Hansen , Gary L. Griffiths , Shui-on Leung , William J. McBride , Zhengxing Qu
IPC分类号： C12P21/08 , C12N15/13 , C12N15/85 , C12N5/10
CPC分类号： C07K16/468 , A61K47/6863 , A61K47/6899 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The targetable conjugate is attached to one or more therapeutic and/or diagnostic agents. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them and kits comprising them.

9. 发明授权

US07563439B2 Production and use of novel peptide-based agents for use with bi-specific antibodies 有权
标题翻译：用于双特异性抗体的新型基于肽的试剂的生产和使用
公开(公告)号：US07563439B2
公开(公告)日：2009-07-21
申请号：US11923279
申请日：2007-10-24
申请人： Hans J. Hansen , Gary L. Griffiths , Shui-on Leung , William J. McBride , Zhengxing Qu
发明人： Hans J. Hansen , Gary L. Griffiths , Shui-on Leung , William J. McBride , Zhengxing Qu
IPC分类号： A61K39/395 , C07K16/30 , C07K16/44
CPC分类号： C07K16/468 , A61K47/6863 , A61K47/6899 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. In one embodiment, the invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.
摘要翻译：本发明涉及一种双特异性抗体或抗体片段，其具有至少一个对靶组织有反应性的臂，以及至少一个对接头部分具有反应性的其它臂。接头部分包括已经制备抗体的半抗原。在优选的实施方案中，半抗原是组胺 - 琥珀酰甘氨酸（HSG）。在更优选的实施方案中，所述至少一个臂包含HSG结合679抗体的CDR序列。抗原性接头与一种或多种治疗剂或诊断剂或酶缀合。在一个实施方案中，本发明提供了用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

10. 发明授权

US07501498B2 Alpha-fetoprotein Immu31 antibodies and fusion proteins 有权
标题翻译：甲胎蛋白Immu31抗体和融合蛋白
公开(公告)号：US07501498B2
公开(公告)日：2009-03-10
申请号：US11870627
申请日：2007-10-11
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： C07K16/00 , C12P21/08 , C12P21/04 , A61K39/395 , C07H21/04
CPC分类号： C07K16/30 , A61K41/0095 , A61K47/6843 , A61K49/0002 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , G01N33/57484 , G01N33/689
摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.
摘要翻译：本发明提供人源化，嵌合和人抗甲胎蛋白抗体，融合蛋白及其片段。抗体，融合蛋白及其片段以及与其它合适抗体的组合可用于治疗和诊断肝细胞癌，肝母细胞瘤，生殖细胞肿瘤癌和其他产生AFP的肿瘤。

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