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1. 发明申请

US20060200151A1 Orthopedic screw for use in repairing small bones 审中-公开
标题翻译：用于修复小骨的矫形螺钉
公开(公告)号：US20060200151A1
公开(公告)日：2006-09-07
申请号：US11369631
申请日：2006-03-07
申请人： Dustin Ducharme , Lee Strnad , David Kay
发明人： Dustin Ducharme , Lee Strnad , David Kay
IPC分类号： A61B17/58
CPC分类号： A61B17/8605 , A61B17/863 , A61B17/8635 , A61B2017/00004
摘要： An orthopedic screw having a torque driving head with a rounded side a spherical wall for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/−0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess. In a further embodiment, the screw has an insertion tip which is forms a portion of a sphere.
摘要翻译：一种矫形螺钉，其具有具有圆形侧面的扭矩驱动头，用于多轴使用的球形壁，自启动，自攻丝插入尖端和包括松质线的螺纹部分。螺纹部分具有由螺旋螺纹和较小直径限定的大直径。头部沿着纵向轴线连接到螺纹部分约2至约6圈的螺纹区域，其中小直径锥度约4至约12度的角度和螺杆的大直径保持与螺纹部分的长度大致相同的意思，即长径大约为+/- 0.05mm。螺杆包括连接到圆柱形凹部的多叶扭矩驱动凹部。在另一实施例中，螺钉具有形成球体的一部分的插入尖端。

2. 发明申请

US20060200145A1 Orthopedic plate 有权
标题翻译：矫形板
公开(公告)号：US20060200145A1
公开(公告)日：2006-09-07
申请号：US11340027
申请日：2006-01-26
申请人： David Kay , Lee Strnad , Dustin Ducharme , G. Wynkoop
发明人： David Kay , Lee Strnad , Dustin Ducharme , G. Wynkoop
IPC分类号： A61F2/30
CPC分类号： A61B17/8061 , A61B17/8066 , A61B17/8085
摘要： The present invention relates to an orthopedic plate and screw system and instruments for surgical fixation of a small bone or bones including specifically the small bones of the spine. The plate facilitates three dimensional contouring to provide for a variety of applications and to accommodate individual variation in bone shape. The plate has a modified x shape including a central trunk portion including one or more screw holes along a longitudinal axis and a set of divergent upper and an oppositely extending set of divergent lower arms, each arm including screw holes which are placed at a radially equal distance but which diverging asymmetrically from the longitudinal axis relative to its paired upper or lower mate. The screws of the system are self-starting, self-tapping screws including the option of partial or full cannulation. In a further embodiment, the plate is intended for use through the length of the spine.
摘要翻译：本发明涉及一种整形外科和螺钉系统以及用于小骨或骨骼手术固定的器械，特别是脊柱的小骨。该板促进三维轮廓以提供各种应用并适应骨形状的个体变化。板具有改变的x形状，其包括中心主体部分，其包括沿着纵向轴线的一个或多个螺钉孔和一组发散的上部和相对延伸的一组发散的下臂，每个臂包括螺钉孔，放置在径向相等的位置但是从纵轴相对于其成对的上下配对不对称发散。系统的螺钉是自启动，自攻螺钉，包括部分或全部插管选项。在另一实施例中，该板旨在通过脊柱的长度使用。

3. 发明申请

US20080021452A1 Calcaneal plate 有权
标题翻译：跟骨板
公开(公告)号：US20080021452A1
公开(公告)日：2008-01-24
申请号：US11879118
申请日：2007-07-16
申请人： Dustin Ducharme , Bryan Den Hartog , Michael McGlamry , Bharat Desai , David Kay , Lee Strnad
发明人： Dustin Ducharme , Bryan Den Hartog , Michael McGlamry , Bharat Desai , David Kay , Lee Strnad
IPC分类号： A61B17/58
CPC分类号： A61B17/8061 , A61B17/8057
摘要： The present invention is a fully contoured calcaneal plate having substantially no planar surfaces except at the origin. The contoured plate includes radiused sections, one extending inferior to superior is curved inferior to superior in a shape which is close to cylindrical and which approximates the shape of the cuboid bone. The second radiused section is curved in the vicinity of the anterior strut, and in particular at the inferior portion of the plate, to accommodate the peroneal tubercle. The plate has a rectangular or modified ovoid body section and a dog boned shaped tail with triangular placed holes for fixation.
摘要翻译：本发明是完全成型的跟骨板，其基本上没有平面，除了原点。轮廓板包括圆形部分，一个延伸到上部的部分弯曲成较接近圆柱形并且近似长方体形状的上部的上部。第二弧形部分在前支柱附近弯曲，特别是在板的下部弯曲，以适应腓骨结节。该板具有矩形或修改的卵形体部分，并且具有三角形放置的孔用于固定的狗骨形尾部。

4. 发明申请

US20070005070A1 Self-centering screw and retaining screw driver for use in surgery 有权
标题翻译：自动定心螺丝和固定螺丝刀用于手术
公开(公告)号：US20070005070A1
公开(公告)日：2007-01-04
申请号：US11340372
申请日：2006-01-26
申请人： David Kay , Lee Strnad , Dustin Ducharme
发明人： David Kay , Lee Strnad , Dustin Ducharme
IPC分类号： A61B17/58
CPC分类号： A61B17/8615 , A61B17/861 , A61B17/888 , B25B15/005 , B25B23/108
摘要： The present invention relates to an orthopedic screw and a corresponding screw driver wherein the screw has a torque driving head with a rounded side a spherical wall for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4° to about 12° and the major diameter of the screw remaining substantially the same. The screw includes a multilobe torque driving recess joined to a cylindrical recess that corresponds to a cylindrical post on the torque driver so as to form a press fit which acts to self-center the screw, to help avoid stripping of the screw/driver interface and to hold the screw in place on the torque driver prior to implantation.
摘要翻译：本发明涉及一种矫形螺钉和相应的螺丝刀，其中螺钉具有扭矩驱动头，其具有圆形侧面，用于多轴使用的球形壁，自启动，自攻丝插入尖端和包括松质线的螺纹部分。螺纹部分具有由螺旋螺纹和较小直径限定的大直径。头部沿着纵向轴线连接到螺纹部分约2至约6圈的螺纹区域，其中小直径锥度约4°至约12°的角度，螺丝保持基本相同。所述螺杆包括多个转矩驱动凹部，所述多叶扭矩驱动凹部接合到对应于所述扭矩驱动器上的圆柱形柱的圆柱形凹部，以便形成用于使所述螺钉自对中心的压配合，以有助于避免螺钉/驱动器接口的剥离，在植入前将螺丝固定在扭矩驱动器上。

5. 发明申请

US20060173459A1 Orthopedic plate for use in small bone repair 有权
标题翻译：矫形板用于小骨修复
公开(公告)号：US20060173459A1
公开(公告)日：2006-08-03
申请号：US11340028
申请日：2006-01-26
申请人： David Kay , Lee Strnad , Dustin Ducharme , G. Wynkoop
发明人： David Kay , Lee Strnad , Dustin Ducharme , G. Wynkoop
IPC分类号： A61F2/30
CPC分类号： A61B17/8061 , A61B17/8066 , A61B17/8085
摘要： The present invention relates to an orthopedic plate and screw system and instruments for surgical fixation of a small bone or bones. The plate facilitates three dimensional contouring to provide for a variety of applications and to accommodate individual variation in bone shape. The plate has a modified x shape including a central trunk portion including one or more screw holes along a longitudinal axis and a set of divergent upper and an oppositely extending set of divergent lower arms, each arm including screw holes which are placed at a radially equal distance but which diverging asymmetrically from the longitudinal axis relative to its paired upper or lower mate. The screws of the system are self-starting, self-tapping screws including the option of partial or full cannulation.
摘要翻译：本发明涉及一种矫形板和螺钉系统以及用于小骨或骨骼外科固定的器械。该板促进三维轮廓以提供各种应用并适应骨形状的个体变化。板具有改变的x形状，其包括中心主体部分，其包括沿着纵向轴线的一个或多个螺钉孔和一组发散的上部和相对延伸的一组发散的下臂，每个臂包括螺钉孔，放置在径向相等的位置但是从纵轴相对于其成对的上下配对不对称地发散。系统的螺钉是自启动，自攻螺钉，包括部分或全部插管选项。

6. 发明申请

US20060173462A1 Orthopedic screw for use in repairing small bones 审中-公开
标题翻译：用于修复小骨的矫形螺钉
公开(公告)号：US20060173462A1
公开(公告)日：2006-08-03
申请号：US11340365
申请日：2006-01-26
申请人： David Kay , Lee Strnad , Dustin Ducharme
发明人： David Kay , Lee Strnad , Dustin Ducharme
IPC分类号： A61B17/58
CPC分类号： A61B17/8635 , A61B17/8605 , A61B17/863 , A61B2017/00004
摘要： The present invention relates to an orthopedic screw having a torque driving head with spherical surface for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a modified cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/−0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess that corresponds to a cylindrical post on the torque driver so as to form a press fit which acts to self-center the screw, to help avoid stripping of the screw/driver interface and to hold the screw in place on the torque driver prior to implantation. In a further embodiment, the screw includes a variable pitch portion for about half of the length starting from the distil end. The screw can be used be itself, or with a plate. Further a new method of using the screw with a plate is presented in which the screw extends through a cortical section of bone into a cancellous portion but not through the adjacent cortical.
摘要翻译：本发明涉及具有用于多轴使用的具有球面的扭矩驱动头的自动螺丝，自启动，自攻丝插入尖端和包括修改的松质线的螺纹部分。螺纹部分具有由螺旋螺纹和较小直径限定的大直径。头部沿着纵向轴线连接到螺纹部分约2至约6圈的螺纹区域，其中小直径锥度约4至约12度的角度和螺杆的大直径保持与螺纹部分的长度大致相同的意思，即长径大约为+/- 0.05mm。所述螺杆包括多个转矩驱动凹部，所述多叶扭矩驱动凹部接合到对应于所述扭矩驱动器上的圆柱形柱的圆柱形凹部，以便形成用于使所述螺钉自对中心的压配合，以有助于避免螺钉/驱动器接口的剥离，在植入前将螺丝固定在扭矩驱动器上。在另一实施例中，螺杆包括从蒸馏端开始的大约一半长度的可变节距部分。螺钉可以自己使用，也可以用于板材。还提出了使用具有板的螺钉的新方法，其中螺钉通过骨的皮质部分延伸进入松质部分而不通过相邻的皮层。

7. 发明申请

US20060173461A1 Cannulated orthopedic screw 审中-公开
标题翻译：插管矫形螺钉
公开(公告)号：US20060173461A1
公开(公告)日：2006-08-03
申请号：US11340026
申请日：2006-01-26
申请人： David Kay , Lee Strnad , Dustin Ducharrme
发明人： David Kay , Lee Strnad , Dustin Ducharrme
IPC分类号： A61B17/58
CPC分类号： A61B17/8625 , A61B17/861 , A61B17/8635
摘要： The present invention relates to a cannulated orthopedic screw having a torque driving head with a spherical wall for multiaxial use, a rounded fluted insertion tip and a threaded portion including a cancellous thread contiguous with a non-threaded portion. The threaded portion has a major diameter defined by a spiraling cancellous type thread and a minor diameter. The screw includes a multilobe torque driving recess.
摘要翻译：本发明涉及一种具有扭矩驱动头的插管式矫形螺钉，该扭矩驱动头具有用于多轴使用的球形壁，圆形槽纹插入尖端和包括与无螺纹部分相邻的松质线的螺纹部分。螺纹部分具有由螺旋形松质线型和小直径限定的大直径。螺杆包括多叶扭矩驱动凹部。

8. 发明申请

US20070239163A1 Orthopedic Plate 有权
标题翻译：矫形板
公开(公告)号：US20070239163A1
公开(公告)日：2007-10-11
申请号：US11714023
申请日：2007-03-05
申请人： Lee Strnad , David Kay , Amanda Martin , G. Wynkoop
发明人： Lee Strnad , David Kay , Amanda Martin , G. Wynkoop
IPC分类号： A61B17/58
CPC分类号： A61B17/8061 , A61B17/1728 , A61B17/1782 , A61B17/80 , A61B17/8047 , A61B17/8052 , A61B17/8057 , A61B17/8605
摘要： An orthopedic plate has a portion with a curved bottom surface that is designed to extend longitudinally along the bone and change the inferior curve as it advances proximally along the bone from a shallower to a sharper radius and further spirals downward as the plate advances. The plate includes a set of tabs, offset from the longitudinal axis of the plate to provide for better pullout values. The ears may be located at the terminal portion of the plate or somewhat more intermediate to the terminus of the plate, depending on the intended application. A point in the center of the central screw hole can be used to define the origin of the plate, and the angles of the screw and/or pegs holes can be referenced with Z, Y, and Z coordinates relative to this central hole.
摘要翻译：矫形板具有弯曲的底部表面的部分，其被设计成沿着骨骼纵向延伸，并且随着其沿着骨骼从近处向远侧前进到更锐利的半径而改变下部曲线，并且随着板前进而进一步向下螺旋。该板包括从板的纵向轴线偏移的一组突片，以提供更好的拉出值。取决于预期的应用，耳朵可以位于板的端部部分或稍微更中间到板的终点。中心螺丝孔的中心点可用于限定板的原点，螺钉和/或钉孔的角度可以相对于该中心孔以Z，Y和Z坐标为参考。

9. 发明申请

US20070265629A1 Distal radius plate 有权
标题翻译：远半径板
公开(公告)号：US20070265629A1
公开(公告)日：2007-11-15
申请号：US11713856
申请日：2007-03-05
申请人： Amanda Martin , David Kay , Lee Strnad , G. Wynkoop
发明人： Amanda Martin , David Kay , Lee Strnad , G. Wynkoop
IPC分类号： A61B17/58
CPC分类号： A61B17/8061 , A61B17/1728 , A61B17/1782 , A61B17/8047 , A61B17/8052 , A61B17/8057 , A61B17/8605
摘要： A distal radius plate having a head with a complex palm shaped profile which flares from the sides of the plate to a leading edge that includes a central oblique linking area that helps to mark the placement of the plate relative to the radius. Further, the plate includes an oblique depression that extends from the rounded pinky side of the head and gradually morphs into the elevated styloid prominence in one diagonal direction, and rises less gradually upward into the lunate prominence on the other side of the head. A proximal plate portion mimics the spiral of the radial bone as it spirals along the longitudinal axis, and includes a tighter radial bend. The head includes holes or bores for pegs which extend into the distal portion of the radius to lock fragments into position. In the first embodiment, the angles of the pegs are fixed. In a second embodiment, one or more of the peg holes are provided with a variable axis locking mechanism assembly and the remaining holes are fixed.
摘要翻译：一种远端半径板，其具有头部，该头部具有复杂的手掌形状，其从板的侧面向前缘突出，其包括有助于标记板相对于半径的位置的中心倾斜连接区域。此外，板包括从头部的圆形小脸侧延伸的倾斜凹部，并且在一个对角线方向上逐渐变形成升高的茎突突出部，并且逐渐向上升高到头部另一侧的月球突出部。近端板部分沿着纵向轴线螺旋地模拟径向骨的螺旋，并且包括较紧的径向弯曲部。头部包括用于钉的孔或孔，其延伸到半径的远侧部分以将碎片锁定到位。在第一实施例中，钉的角度是固定的。在第二实施例中，一个或多个钉孔设置有可变轴锁定机构组件，并且剩余的孔是固定的。

10. 发明授权

US09630956B2 Compounds useful as inhibitors of ATR kinase 有权
公开(公告)号：US09630956B2
公开(公告)日：2017-04-25
申请号：US13106476
申请日：2011-05-12
申请人： Jean-Damien Charrier , Hayley Marie Binch , Dennis James Hurley , Thomas Cleveland , Pramod Joshi , Lev Tyler Dewey Fanning , Joanne Pinder , Michael O'Donnell , Anisa Nizarali Virani , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , David Kay , Philip Michael Reaper , Matthew Paul Grote
发明人： Jean-Damien Charrier , Hayley Marie Binch , Dennis James Hurley , Thomas Cleveland , Pramod Joshi , Lev Tyler Dewey Fanning , Joanne Pinder , Michael O'Donnell , Anisa Nizarali Virani , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , David Kay , Philip Michael Reaper , Matthew Paul Grote
IPC分类号： A61K31/497 , A61K33/24 , C07D413/14 , C07D401/14 , C07D241/10
CPC分类号： C07D413/14
摘要： The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

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