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1. 发明申请

US20080275062A1 Chemical Compounds 审中-公开
标题翻译：化学化合物
公开(公告)号：US20080275062A1
公开(公告)日：2008-11-06
申请号：US10597473
申请日：2005-01-28
申请人： David Harold Drewry , David Kendall Jung , James Andrew Linn , Robert Neil Hunter , Dennis Lee , Robert A. Stavenger , Clark Sehon
发明人： David Harold Drewry , David Kendall Jung , James Andrew Linn , Robert Neil Hunter , Dennis Lee , Robert A. Stavenger , Clark Sehon
IPC分类号： A61K31/4409 , C07D213/04 , A61K31/415 , C07D231/10 , C07D239/42 , A61K31/505 , C07D239/24 , C07D231/56 , C07D401/10
CPC分类号： C07D213/56 , C07D231/12 , C07D231/56 , C07D239/26 , C07D239/42 , C07D403/04
摘要： There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-4alkyl, C1-4alkanoyl, C1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy and C1-4alkoxycarbonyl; and X is indazolyl, pyrazolyl or a group: wherein G is CH or N; and Y1 and Y2 are independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, C1-6alkyl or C2-6alkenyl).
摘要翻译：提供式（I）化合物及其盐，溶剂化物和生理功能衍生物：其中R1是氢或C 1-6烷基; n为1,2,3或4; R2是芳基，任选地被一个或两个选自卤素，羟基，氰基，C 1-4烷基，C 1-4烷氧基，C 1-4烷基，烷基，卤代C 1-4烷基，卤代C 1-4烷氧基，芳基，芳氧基，C 1-4烷基，烷氧基羰基，C 1-4烷基磺酰基和基团R 3 R 4 NSO 2（其中R 3和R 4独立地是氢或C 1-4烷基）和5-或6-元杂芳基; 或n为0，并且R 1和R 2与它们连接的氮原子一起形成5-或6-元单环杂环或9-或10-元双环杂环，其中至少含有 R 1和R 2连接的氮原子是非芳族的，其中5或6元单环杂环或9或10元双环杂环任选被一个或两个选自以下的基团取代：卤素，羟基，氰基，氧代，C 1-4烷基，C 1-4烷酰基，C 1-4烷氧基，卤代C 1-4烷基，烷基，卤代C 1-4烷氧基，芳基，芳氧基和C 1-4烷氧基羰基; 并且X是吲唑基，吡唑基或基团：其中G是CH或N; 和Y 1和Y 2独立地是氢，卤素和基团NR 5 R 6（其中R 5和R 6独立地是氢，C 1-6烷基或C 2-6烯基）。

2. 发明申请

US20080293716A1 Chemical Compounds 审中-公开
标题翻译：化学化合物
公开(公告)号：US20080293716A1
公开(公告)日：2008-11-27
申请号：US10597475
申请日：2005-01-28
申请人： David Harold Drewry , Robert Neil Hunter, III , David Kendall Jung , James Andrew Linn , Clark Sehon , Robert A. Stavenger
发明人： David Harold Drewry , Robert Neil Hunter, III , David Kendall Jung , James Andrew Linn , Clark Sehon , Robert A. Stavenger
IPC分类号： A61K31/5377 , C07D409/04 , A61K31/4436 , C07D413/14
CPC分类号： C07D409/04 , C07D409/14 , C07D417/14 , C07D471/10
摘要： There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:
摘要翻译：提供式（I）化合物或其盐，溶剂合物或生理功能衍生物：

3. 发明申请

US20050245576A1 Substituted pyrazoles 审中-公开
公开(公告)号：US20050245576A1
公开(公告)日：2005-11-03
申请号：US11174077
申请日：2005-06-30
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Kevin Tays , Jianmei Wei
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Kevin Tays , Jianmei Wei
IPC分类号： C07D401/14 , A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/549 , A61K31/55 , A61P11/06 , A61P29/00 , A61P37/06 , A61P43/00 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D43/02
CPC分类号： C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/454 , A61K31/495 , A61K31/55 , C07D471/04 , C07D471/14
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.

4. 发明申请

US20050197377A1 CCK-1 receptor modulators 有权
标题翻译： CCK-1受体调节剂
公开(公告)号：US20050197377A1
公开(公告)日：2005-09-08
申请号：US11018049
申请日：2004-12-21
申请人： J. Breitenbucher , Michael Hack , Clark Sehon
发明人： J. Breitenbucher , Michael Hack , Clark Sehon
IPC分类号： A61K31/4178 , C07D233/26 , C07D401/04 , C07D405/04 , C07D43/02 , C07D45/14
CPC分类号： C07D401/04 , C07D233/26 , C07D405/04
摘要： Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
摘要翻译：某些咪唑化合物是可用于治疗CCK1介导的疾病的CCK1调节剂。

5. 发明申请

US20060014817A1 CCK-1 receptor modulators 有权
标题翻译： CCK-1受体调节剂
公开(公告)号：US20060014817A1
公开(公告)日：2006-01-19
申请号：US11230200
申请日：2005-09-19
申请人： Terrance Barrett , J. Breitenbucher , Laurent Gomez , Michael Hack , Liming Huang , Kelly McClure , Magda Morton , Clark Sehon , Nigel Shankley
发明人： Terrance Barrett , J. Breitenbucher , Laurent Gomez , Michael Hack , Liming Huang , Kelly McClure , Magda Morton , Clark Sehon , Nigel Shankley
IPC分类号： A61K31/416 , A61K31/415 , C07D403/02 , C07D405/02
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/06
摘要： There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
摘要翻译：本发明提供了一些基于吡唑的CCK-1受体调节剂。

6. 发明申请

US20050101587A9 Method for treating allergies using substituted pyrazoles 审中-公开
标题翻译：使用取代的吡唑治疗过敏症的方法
公开(公告)号：US20050101587A9
公开(公告)日：2005-05-12
申请号：US09947117
申请日：2001-09-05
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
IPC分类号： A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
CPC分类号： A61K31/541 , A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/55
摘要： A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译：一种使用取代的吡唑治疗过敏性疾病（包括特应性过敏症状）的方法。

7. 发明申请

US20070249698A1 CCK-1 Receptor Modulators 有权
标题翻译： CCK-1受体调节剂
公开(公告)号：US20070249698A1
公开(公告)日：2007-10-25
申请号：US11773049
申请日：2007-07-03
申请人： J. Breitenbucher , Michael Hack , Clark Sehon
发明人： J. Breitenbucher , Michael Hack , Clark Sehon
IPC分类号： A61K31/4174 , A61P5/48
CPC分类号： C07D401/04 , C07D233/26 , C07D405/04
摘要： Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
摘要翻译：某些咪唑化合物是可用于治疗CCK1介导的疾病的CCK1调节剂。

8. 发明申请

US20070117785A1 Substituted pyrazoles and methods of treatment with substituted pyrazoles 审中-公开
标题翻译：取代的吡唑和用取代的吡唑处理的方法
公开(公告)号：US20070117785A1
公开(公告)日：2007-05-24
申请号：US11542838
申请日：2006-10-04
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/416
CPC分类号： A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
摘要翻译：描述了取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如自身免疫性疾病或过敏性疾病（包括由组织蛋白酶S介导的特应性过敏性病症）的方法。

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