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1. 发明申请

US20100234790A1 OCULAR IMPLANT WITH THERAPEUTIC AGENTS AND METHODS THEREOF 有权
标题翻译：具有治疗药物的OCALAR植入物及其方法
公开(公告)号：US20100234790A1
公开(公告)日：2010-09-16
申请号：US12772889
申请日：2010-05-03
申请人： Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人： Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号： A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要： Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye such that at least a distal end of the implant is temporarily in the anterior chamber. The implant is implanted into eye tissue adjacent the anterior chamber. A therapeutic agent is eluted from the implant into at least one of the anterior chamber, a physiologic outflow pathway of the eye, and a space adjacent a choroid of the eye. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension. The therapeutic agent can be contained within the implant or coated on the implant.
摘要翻译：提供了用于治疗眼部疾病的植入物和方法。一种方法包括将植入物引入眼睛的前房，使得植入物的至少远端暂时位于前房中。将植入物植入邻近前房的眼组织。将治疗剂从植入物洗脱到前房中的至少一个，眼睛的生理流出路径和与眼睛的脉络膜相邻的空间。治疗剂可以是抗增生剂，抗炎药或治疗青光眼或高眼压症的化合物。治疗剂可以包含在植入物内或涂覆在植入物上。

2. 发明申请

US20070118147A1 Combined treatment for cataract and glaucoma treatment 有权
公开(公告)号：US20070118147A1
公开(公告)日：2007-05-24
申请号：US11653815
申请日：2007-01-16
申请人： Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
发明人： Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/00736 , A61F9/00754
摘要： A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.

3. 发明申请

US20060047263A1 Medical device and methods of use for glaucoma treatment 失效
标题翻译：用于青光眼治疗的医疗器械和方法
公开(公告)号：US20060047263A1
公开(公告)日：2006-03-02
申请号：US11255625
申请日：2005-10-21
申请人： Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
发明人： Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
IPC分类号： A61M31/00
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译：本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法，更具体地，涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法引导水流出的正常生理功能，以维持眼中正常的眼内压。

4. 发明申请

US20080015488A1 GLAUCOMA IMPLANT WITH DOUBLE ANCHOR MECHANISM 有权
标题翻译：具有双重锚固机构的GLAUCOMA植入物
公开(公告)号：US20080015488A1
公开(公告)日：2008-01-17
申请号：US11860785
申请日：2007-09-25
申请人： Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
发明人： Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
IPC分类号： A61M1/00
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译：本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法，更具体地，涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法引导水流出的正常生理功能，以维持眼中正常的眼内压。

5. 发明申请

US20070276316A1 DEVICES AND METHODS FOR GLAUCOMA TREATMENT 有权
公开(公告)号：US20070276316A1
公开(公告)日：2007-11-29
申请号：US11836112
申请日：2007-08-08
申请人： David Haffner , Gregory Smedley , Hosheng Tu
发明人： David Haffner , Gregory Smedley , Hosheng Tu
IPC分类号： A61M1/00
CPC分类号： A61F9/00781
摘要： Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.

6. 发明申请

US20070276315A1 DEVICES AND METHODS FOR GLAUCOMA TREATMENT 有权
标题翻译： GLAUCOMA治疗的装置和方法
公开(公告)号：US20070276315A1
公开(公告)日：2007-11-29
申请号：US11836106
申请日：2007-08-08
申请人： David Haffner , Gregory Smedley , Hosheng Tu
发明人： David Haffner , Gregory Smedley , Hosheng Tu
IPC分类号： A61M1/00
CPC分类号： A61F9/00781
摘要： Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.
摘要翻译：公开了用于治疗青光眼的眼内支架和敷贴器。支架构造成在眼前房和施乐姆氏管之间延伸，以增强从前房的水流出，以便降低眼内压。支架可以具有用于将支架锚定到施乐姆运河中的特征，以及阻止施莱姆运河的墙壁关闭支架的出口。施加器可以是可操纵的，以便使植入更容易。此外，施用器可以被配置成保持多个支架，使得可以通过一个切口植入多个支架，而不会从串联注入之间的切口移除施加器。

7. 发明申请

US20060200113A1 Liquid jet for glaucoma treatment 审中-公开
标题翻译：液体射流青光眼治疗
公开(公告)号：US20060200113A1
公开(公告)日：2006-09-07
申请号：US11353854
申请日：2006-02-13
申请人： David Haffner , Hosheng Tu , Gregory Smedley
发明人： David Haffner , Hosheng Tu , Gregory Smedley
IPC分类号： A61B18/18
CPC分类号： A61F9/00781 , A61M5/14
摘要： Methods of treating glaucoma are described including treatment of an eye with a liquid jet. The liquid jet can be generated by a laser-induced liquid jet instrument which is inserted through an incision in an eye. A stent can also be used, the stent having an inflow portion that is in fluid communication with an outflow portion. The stent can be inserted into the eye and transported from the incision through the anterior chamber of the eye toward the trabecular meshwork of the eye. In some embodiments, the stent can be advanced through the anterior chamber of the eye and provide fluid communication between the anterior chamber and Schlemm's canal. The method includes infusing fluid into an aqueous cavity and increasing the pressure of the fluid within the aqueous cavity.
摘要翻译：描述治疗青光眼的方法，包括用液体射流治疗眼睛。液体射流可以通过激光诱导的液体喷射器产生，其通过眼睛中的切口插入。还可以使用支架，所述支架具有与流出部分流体连通的流入部分。支架可以插入眼睛，并从切口通过眼睛的前房转移到眼睛的小梁网。在一些实施例中，支架可以推进穿过眼睛的前房并且在前房和施莱姆氏管之间提供流体连通。该方法包括将流体输入水腔并增加水腔内的流体的压力。

8. 发明授权

US08617094B2 Fluid infusion methods for glaucoma treatment 有权
标题翻译：用于眼部疾病治疗的流体输注方法
公开(公告)号：US08617094B2
公开(公告)日：2013-12-31
申请号：US11332746
申请日：2006-01-12
申请人： Gregory Smedley , David Haffner , Hosheng Tu
发明人： Gregory Smedley , David Haffner , Hosheng Tu
IPC分类号： A61M5/00 , A61M5/14 , A61F2/02 , A61F2/04 , A61F2/82
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要： Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.
摘要翻译：公开了治疗眼部疾病的方法，例如包括使用输送器械将植入物插入眼睛组织中的方法，使得植入物的入口部分在眼睛的前房中并且植入物的出口部分是在生理流出途径; 在不移除植入物的情况下从眼睛移除输送器械; 以及通过植入物导入包含治疗物质的流体并进入生理流出道。另一种方法包括将器械插入生理流出通道，通过该生理流出通道从眼睛的前房排出房水; 通过在所述仪器保持在所述生理流出路径中时从所述仪器注入包含药物的流体来分离包括所述生理流出路径的组织的第一和第二壁; 并且在所述注射之后，将所述液体留在眼睛内，使得药物对眼睛具有治疗作用。

9. 发明申请

US20100056979A1 IMPLANTABLE OCULAR PUMP TO REDUCE INTRAOCULAR PRESSURE 审中-公开
标题翻译：可压缩的泵式泵减少内压
公开(公告)号：US20100056979A1
公开(公告)日：2010-03-04
申请号：US12618437
申请日：2009-11-13
申请人： Gregory Smedley , David Haffner , Hosheng Tu , Morteza Gharib
发明人： Gregory Smedley , David Haffner , Hosheng Tu , Morteza Gharib
IPC分类号： A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017
摘要： A trabecular pump is implantable in the eye to reduce intraocular pressure. The pump drains aqueous humor from the anterior chamber into outflow pathways, such as Schlemm's canal. A feedback system includes an intraocular pump and a pressure sensor in communication with the pump, for regulating intraocular pressure.
摘要翻译：小梁泵可植入眼睛以降低眼内压。泵将房水从前房排出到流出路径，如施勒姆运河。反馈系统包括与泵连通的眼内泵和压力传感器，用于调节眼内压。

10. 发明申请

US20080183121A2 FLUID INFUSION METHODS FOR OCULAR DISORDER TREATMENT 有权
标题翻译：流体输血治疗眼部疾病治疗方法
公开(公告)号：US20080183121A2
公开(公告)日：2008-07-31
申请号：US11332746
申请日：2006-01-12
申请人： Gregory Smedley , David Haffner , Hosheng Tu
发明人： Gregory Smedley , David Haffner , Hosheng Tu
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要： Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.
摘要翻译：公开了治疗眼部疾病的方法，例如包括使用输送器械将植入物插入眼睛组织中的方法，使得植入物的入口部分在眼睛的前房中并且植入物的出口部分是在生理流出途径; 在不移除植入物的情况下从眼睛移除输送器械; 以及通过植入物导入包含治疗物质的流体并进入生理流出道。另一种方法包括将器械插入生理流出通道，通过该生理流出通道从眼睛的前房排出房水; 通过在所述仪器保持在所述生理流出路径中时从所述仪器注入包含药物的流体来分离包括所述生理流出路径的组织的第一和第二壁; 并且在所述注射之后，将所述液体留在眼睛内，使得药物对眼睛具有治疗作用。

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