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1. 发明申请

US20100170481A1 Fog carburetor 审中-公开
标题翻译：雾化油器
公开(公告)号：US20100170481A1
公开(公告)日：2010-07-08
申请号：US12653337
申请日：2009-12-08
申请人： David H. Walker , Andrew C. Harvey , Nathan B. Longo
发明人： David H. Walker , Andrew C. Harvey , Nathan B. Longo
IPC分类号： F02M15/04 , F02M15/00 , F02M31/093 , F02M17/00
CPC分类号： F02M31/18 , F02M29/06 , Y02T10/126
摘要： A conversion system for a gasoline engine based generator enables the use of heavier fuels. A vertically disposed vortex separation chamber includes an inlet proximate the bottom of the chamber and tangential to the longitudinal axis of the chamber for delivering to the chamber partially vaporized fuel in an air-fuel mixture from a carburetor associated with the engine. An outlet proximate the top of the chamber also tangential to the longitudinal axis of the chamber for delivering vaporized fuel from the chamber to the engine. An electric heater is in communication with the bottom of the chamber for heating the chamber wall to vaporize any fuel thereon so vaporized fuel is reintroduced in swirling air-fuel mixture in the chamber. A battery source charged by the generator provides power to the electric heater. A jacket is disposed about and spaced from the chamber wall creating an annulus between the jacket and the chamber wall. An inlet through the jacket is connected to receive exhaust gas from the engine and to deliver the exhaust gas into the annulus for heating the chamber.
摘要翻译：用于基于汽油发动机的发电机的转换系统能够使用较重的燃料。垂直设置的涡流分离室包括靠近室底部的入口，并且与室的纵向轴线相切，用于在与发动机相关的化油器的空气 - 燃料混合物中将部分蒸发的燃料输送到室中。靠近腔室顶部的出口也与腔室的纵向轴线相切，用于将蒸发的燃料从腔室输送到发动机。电加热器与腔室的底部连通，用于加热室壁以使其上的任何燃料蒸发，从而将汽化的燃料重新引入室内旋转的空气 - 燃料混合物。由发电机充电的电池源为电加热器供电。护套被设置在室壁周围并与室壁间隔开，从而在护套和腔室壁之间产生环形空间。通过护套的入口被连接以接收来自发动机的废气并将废气输送到环形空间中以加热室。

2. 发明授权

US09151755B2 Methods for detecting Ehrlichia infection 有权
标题翻译：检测埃里克病毒感染的方法
公开(公告)号：US09151755B2
公开(公告)日：2015-10-06
申请号：US14174815
申请日：2014-02-06
申请人： David H. Walker , Sunil Thomas
发明人： David H. Walker , Sunil Thomas
IPC分类号： G01N33/53 , G01N33/569 , A61K39/02 , C07K14/29 , C07K16/12 , A61K38/00 , A61K39/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/0233 , A61K2039/6081 , C07K14/29 , C07K16/1246 , C07K2317/34 , Y02A50/403
摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.
摘要翻译：本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

3. 发明授权

US07309583B2 Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof 失效
标题翻译： Ehrlichia canis的同源28千道尔顿免疫显性蛋白基因及其用途
公开(公告)号：US07309583B2
公开(公告)日：2007-12-18
申请号：US10062920
申请日：2002-01-31
申请人： David H. Walker , Xue-Jie Yu , Jere W. McBride
发明人： David H. Walker , Xue-Jie Yu , Jere W. McBride
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C07K14/29 , A61K39/00 , A61K2039/52 , Y02A50/403
摘要： The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
摘要翻译：本发明涉及来自多态性多基因家族的同源免疫反应性28-kDa蛋白基因p28-1，-2，-3，-5，-6，-7，-9的克隆，测序和表达艾氏杆菌进一步披露的是编码所有9个同源的28-kDa蛋白质基因的多基因位点。重组埃氏杆菌28-kDa蛋白质与来自犬属感染狗的恢复期抗血清反应，并且可用于开发对疾病预防和血清诊断特别有效的疫苗和血清学诊断。

4. 发明授权

US07204992B2 P153 and P156 antigens for the immunodiagnosis of canine and human ehrlichioses and uses thereof 有权
标题翻译： P153和P156抗原用于犬和人类ehrlichioses的免疫诊断及其用途
公开(公告)号：US07204992B2
公开(公告)日：2007-04-17
申请号：US10701038
申请日：2003-11-04
申请人： Jere W. McBride , David H. Walker
发明人： Jere W. McBride , David H. Walker
IPC分类号： A61K39/02
CPC分类号： C07H21/04 , A61K39/00 , C07H21/02 , C07K14/29 , Y02A50/403 , Y10S530/81 , Y10S530/82 , Y10S530/825
摘要： Sequences encoding two immunoreactive glycoproteins were cloned from Ehrlichia canis (p153 gene) and Ehrlichia chaffeensis (p156 gene). These two glycoproteins are species-specific immunoreactive orthologs that are useful as subunit vaccines and for serologic and molecular diagnostics for E. canis and E. chaffeensis.
摘要翻译：从埃氏杆菌（p153基因）和埃里希氏梭菌（p156基因）克隆编码两种免疫反应性糖蛋白的序列。这两种糖蛋白是物种特异性的免疫反应性直向同源物，其可用作亚单位疫苗和用于E. canis和E.Chaffeensis的血清学和分子诊断。

5. 发明授权

US10335476B2 Vaccine to protect against Ehrlichia infection 有权
公开(公告)号：US10335476B2
公开(公告)日：2019-07-02
申请号：US14919494
申请日：2015-10-21
申请人： Sunil Thomas , David H. Walker
发明人： Sunil Thomas , David H. Walker
IPC分类号： A61K39/02 , A61K39/00
摘要： Certain embodiments are direct to a vaccine composition comprising an immunizing amount of an Ehrlichia sonicate, wherein the Ehrlichia sonicate elicits a protective physiologic response. In certain aspects the Ehrlichia is one or more of E. canis, E. chaffeensis, E. muris, E. ruminantium, E. ewingii, and E. ovis.

6. 发明授权

US07754224B2 P153 and p156 antigens for the immunodiagnosis of canine and human ehrlichioses and uses thereof 有权
标题翻译： P153和p156抗原用于犬和人类ehrlichioses的免疫诊断及其用途
公开(公告)号：US07754224B2
公开(公告)日：2010-07-13
申请号：US11684832
申请日：2007-03-12
申请人： Jere W. McBride , David H. Walker
发明人： Jere W. McBride , David H. Walker
IPC分类号： A61K39/02 , G01N33/53 , C07H21/04 , C07K14/00 , C07K16/00
CPC分类号： C07H21/04 , A61K39/00 , C07H21/02 , C07K14/29 , Y02A50/403 , Y10S530/81 , Y10S530/82 , Y10S530/825
摘要： Sequences encoding two immunoreactive glycoproteins were cloned from Ehrlichia canis (p153 gene) and Ehrlichia chaffeensis (p156 gene). These two glycoproteins are species-specific immunoreactive orthologs that are useful as subunit vaccines and for serologic and molecular diagnostics for E. canis and E. chaffeensis.
摘要翻译：从埃氏杆菌（p153基因）和埃里希氏梭菌（p156基因）克隆编码两种免疫反应性糖蛋白的序列。这两种糖蛋白是物种特异性的免疫反应性直向同源物，其可用作亚单位疫苗和用于E. canis和E.Chaffeensis的血清学和分子诊断。

7. 发明授权

US07722880B2 Immunoreactive 38-KDA ferric binding protein of ehrlichia canis and uses thereof 有权
标题翻译：埃里希氏菌的免疫反应性38-KDA三价铁结合蛋白及其用途
公开(公告)号：US07722880B2
公开(公告)日：2010-05-25
申请号：US11066648
申请日：2005-02-25
申请人： Jere W. McBride , David H. Walker , Christopher Kuyler Doyle
发明人： Jere W. McBride , David H. Walker , Christopher Kuyler Doyle
IPC分类号： A61K39/00 , A61K39/02 , A61K39/38 , A61K45/00 , C12P21/08
CPC分类号： C07K14/29 , A61K38/00 , A61K39/00 , A61K2039/505 , Y02A50/403
摘要： The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein is employed in an immunogenic composition, such as a vaccine. Methods to induce an immune reaction in an individual with compositions of the invention are provided.
摘要翻译：本发明涉及由其多核苷酸编码的埃立克氏杆菌的免疫反应性铁结合蛋白（Fbp）（38-kDa）蛋白的克隆，测序，表达和表征。在具体实施方案中，蛋白质用于免疫原性组合物，例如疫苗。提供了使用本发明的组合物在个体中诱导免疫反应的方法。

8. 发明申请

US20090297526A1 Membranolytic Polypeptides and Methods of Use 审中-公开
标题翻译：膜溶性多肽和使用方法
公开(公告)号：US20090297526A1
公开(公告)日：2009-12-03
申请号：US11921695
申请日：2006-06-08
申请人： Ted J. Whitworth , Donald H. Bouyer , David H. Walker
发明人： Ted J. Whitworth , Donald H. Bouyer , David H. Walker
IPC分类号： A61K39/395 , G01N33/569 , C07K16/12 , C12P21/02 , A61P31/04
CPC分类号： C12N9/16 , A61K2039/505 , C07K16/1246 , G01N33/56911 , Y02A50/403 , Y02A50/59
摘要： The present invention includes polypeptides, polynucleotides encoding the polypeptides, antibodies to the polypeptides, and methods for using the polypeptides and antibodies. The polypeptides include those with at least 80% identity to Rickettsia prowazekii TIyC or PId.
摘要翻译：本发明包括多肽，编码多肽的多核苷酸，针对多肽的抗体，以及使用多肽和抗体的方法。所述多肽包括与立克次体立克次体（TIYC）或PId具有至少80％同一性的多肽。

9. 发明授权

US08685406B2 Compositions of and method of using heat shock protein peptides 有权
标题翻译：使用热休克蛋白肽的组成和方法
公开(公告)号：US08685406B2
公开(公告)日：2014-04-01
申请号：US12927220
申请日：2010-11-10
申请人： David H. Walker , Sunil Thomas
发明人： David H. Walker , Sunil Thomas
IPC分类号： A61K39/02 , C07K16/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/0233 , A61K2039/6081 , C07K14/29 , C07K16/1246 , C07K2317/34 , Y02A50/403
摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.
摘要翻译：本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

10. 发明申请

US20120219972A1 DIAGNOSIS AND TREATMENT OF EHRLICHIOSIS 有权
标题翻译：诊断和治疗老年病
公开(公告)号：US20120219972A1
公开(公告)日：2012-08-30
申请号：US13362765
申请日：2012-01-31
申请人： Sunil Thomas , David H. Walker
发明人： Sunil Thomas , David H. Walker
IPC分类号： G01N33/53 , C07K16/12 , C07K17/00 , C07K17/02 , C07K7/08 , C07K14/195
CPC分类号： C07K16/1246 , C07K14/29 , G01N33/56911 , G01N2333/29
摘要： The present invention provides an isolated Ehrlichia peptide and therapeutic and diagnostic uses therefor.
摘要翻译：本发明提供了一种分离的埃里希肽及其治疗和诊断用途。

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