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1. 发明申请

US20100023004A1 SYSTEMS AND METHODS FOR CARDIAC TISSUE ELECTROPORATION ABLATION 有权
标题翻译：用于心脏组织电泳消融的系统和方法
公开(公告)号：US20100023004A1
公开(公告)日：2010-01-28
申请号：US12331004
申请日：2008-12-09
申请人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
发明人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2018/00291 , A61B2018/00351 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00738 , A61B2018/00839 , A61B2018/00875 , A61B2018/122 , A61B2218/002 , A61B2218/007
摘要： Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.
摘要翻译：心脏电穿孔消融系统和方法，其中递送脉冲的高电压能量以诱导心脏组织细胞的电穿孔，随后细胞破裂。在一些实施方案中，所递送的能量是双相的，循环时间不超过500微秒。

2. 发明授权

US08221411B2 Systems and methods for cardiac tissue electroporation ablation 有权
标题翻译：心脏组织电穿孔消融的系统和方法
公开(公告)号：US08221411B2
公开(公告)日：2012-07-17
申请号：US12331004
申请日：2008-12-09
申请人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
发明人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
IPC分类号： A61B18/18
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2018/00291 , A61B2018/00351 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00738 , A61B2018/00839 , A61B2018/00875 , A61B2018/122 , A61B2218/002 , A61B2218/007
摘要： Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.
摘要翻译：心脏电穿孔消融系统和方法，其中递送脉冲的高电压能量以诱导心脏组织细胞的电穿孔，随后细胞破裂。在一些实施方案中，所递送的能量是双相的，循环时间不超过500微秒。

3. 发明申请

US20090299365A1 Tissue Lesion Evaluation 有权
标题翻译：组织病变评估
公开(公告)号：US20090299365A1
公开(公告)日：2009-12-03
申请号：US12465435
申请日：2009-05-13
申请人： Mark Stewart , David Francischelli , Jinback Hong , Sarah Ahlberg
发明人： Mark Stewart , David Francischelli , Jinback Hong , Sarah Ahlberg
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B2018/00029 , A61B2018/00065 , A61B2018/00113 , A61B2018/0016 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00839 , A61B2018/1472 , A61B2090/064 , A61B2218/002
摘要： Device, system and method for ablating tissue of a heart of a patient. The tissue is clamped between a pair of opposing jaws. A portion of the tissue is ablated at a first generally linear position on the tissue by applying ablative energy to two of a plurality of elongate electrodes, each of the two of the plurality of elongate electrodes being coupled in opposing relationship to each other and the pair of opposing jaws, respectively. An effectiveness of the ablation is sensed at a second generally linear position on the tissue with at least one of the plurality of elongate electrodes positioned on one of the pair of opposing jaws. The second linear position on the tissue is laterally distal to the first linear position on the tissue with respect to the atrium of the heart.
摘要翻译：用于消除患者心脏的组织的装置，系统和方法。将组织夹在一对相对的夹爪之间。通过向多个细长电极中的两个施加烧蚀能量，组织的一部分在组织上的第一大致线性位置被消融，多个细长电极中的每一个彼此相对地相互耦合，并且该对的对颚分别。在组织上的第二大致直线位置处感测消融的有效性，其中多个细长电极中的至少一个位于一对相对的夹爪中的一个上。组织上的第二线性位置相对于心脏的心房横向远离组织上的第一线性位置。

4. 发明申请

US20080015562A1 TRANSMURAL ABLATION SYSTEMS AND METHODS 有权
标题翻译：传递系统和方法
公开(公告)号：US20080015562A1
公开(公告)日：2008-01-17
申请号：US11780911
申请日：2007-07-20
申请人： Jinback Hong , David Francischelli , Mark Stewart
发明人： Jinback Hong , David Francischelli , Mark Stewart
IPC分类号： A61B18/12
CPC分类号： A61B18/1206 , A61B5/053 , A61B5/7203 , A61B18/14 , A61B18/1442 , A61B2017/00092 , A61B2018/0016 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00761 , A61B2018/00791 , A61B2018/00875 , A61B2018/00886 , A61B2018/1467 , A61B2218/002
摘要： A method of applying ablation energy to achieve transmurality including applying ablation energy at a starting power to a tissue site and monitoring the impedance of the tissue site. The power applied to the tissue site can be increased in response to detection of a power plateau or application of a first power for a minimum time according to some embodiments. A power applied to the tissue site can be reduced in response to an increase in impedance according to some embodiments. Transmurality can be indicated in response to a transmurality plateau following a rise in impedance according to some embodiments.
摘要翻译：一种施加消融能量以实现透视性的方法，包括以起始功率对组织部位施加消融能量并监测组织部位的阻抗。根据一些实施例，施加到组织部位的功率可以响应于功率平台的检测或最小时间的应用而增加。根据一些实施例，响应于阻抗的增加，施加到组织部位的功率可以减小。根据一些实施例，可以响应于阻抗上升之后的透壁平台来指示透明度。

5. 发明授权

US08821488B2 Tissue lesion evaluation 有权
标题翻译：组织病变评估
公开(公告)号：US08821488B2
公开(公告)日：2014-09-02
申请号：US12465435
申请日：2009-05-13
申请人： Mark Stewart , David Francischelli , Jinback Hong , Sarah Ahlberg
发明人： Mark Stewart , David Francischelli , Jinback Hong , Sarah Ahlberg
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B2018/00029 , A61B2018/00065 , A61B2018/00113 , A61B2018/0016 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00839 , A61B2018/1472 , A61B2090/064 , A61B2218/002
摘要： Device, system and method for ablating tissue of a heart of a patient. The tissue is clamped between a pair of opposing jaws. A portion of the tissue is ablated at a first generally linear position on the tissue by applying ablative energy to two of a plurality of elongate electrodes, each of the two of the plurality of elongate electrodes being coupled in opposing relationship to each other and the pair of opposing jaws, respectively. An effectiveness of the ablation is sensed at a second generally linear position on the tissue with at least one of the plurality of elongate electrodes positioned on one of the pair of opposing jaws. The second linear position on the tissue is laterally distal to the first linear position on the tissue with respect to the atrium of the heart.
摘要翻译：用于消除患者心脏的组织的装置，系统和方法。将组织夹在一对相对的夹爪之间。通过向多个细长电极中的两个施加烧蚀能量，组织的一部分在组织上的第一大致线性位置被消融，多个细长电极中的每一个彼此相对地相互耦合，并且该对的对颚分别。在组织上的第二大致直线位置处感测消融的有效性，其中多个细长电极中的至少一个位于一对相对的夹爪中的一个上。组织上的第二线性位置相对于心脏的心房横向远离组织上的第一线性位置。

6. 发明申请

US20080275439A1 CARDIAC ABLATION AND ELECTRICAL INTERFACE SYSTEM AND INSTRUMENT 审中-公开
标题翻译：心脏吸收和电接口系统和仪器
公开(公告)号：US20080275439A1
公开(公告)日：2008-11-06
申请号：US12055991
申请日：2008-03-26
申请人： David Francischelli , Mark Stewart , Daniel Cheek , Brian Ross , Paul Rothstein , Scott Klein , Asif Hameed , Doug Crowe , Kester Batchelor , William Colon
发明人： David Francischelli , Mark Stewart , Daniel Cheek , Brian Ross , Paul Rothstein , Scott Klein , Asif Hameed , Doug Crowe , Kester Batchelor , William Colon
IPC分类号： A61B18/12
CPC分类号： A61B18/1402 , A61B5/0422 , A61B18/1492 , A61B2017/00053 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61N1/06 , A61N1/36017
摘要： A system for ablating tissue and electrically interfacing with a heart including an electrosurgical instrument, an energy source, and a controller. The instrument includes a shaft maintaining first and second electrodes at a distal section. The electrodes are electrically isolated from one another. The controller controls delivery of energy from the energy source, and monitors electrical signals at the electrodes. The controller is programmed to operate in a monopolar mode and a bipolar mode. In the monopolar mode, the first and second electrodes are electrically uncoupled, and energy from the energy source is delivered to the first electrode in performing an ablation procedure. In the bipolar mode, first and second electrodes are electrically coupled and serve as opposite polarity poles to apply energy to a tissue target site, detect electrical signals at a tissue target site, or both.
摘要翻译：一种用于消融组织并与包括电外科器械，能量源和控制器的心脏电接口的系统。仪器包括轴，其在远端部分保持第一和第二电极。电极彼此电隔离。控制器控制能量从能源的传递，并监测电极处的电信号。控制器被编程为在单极模式和双极模式下工作。在单极模式中，第一和第二电极是电耦合的，并且来自能量源的能量在执行消融过程时被传送到第一电极。在双极模式中，第一和第二电极被电耦合并且用作相反的极性极以将能量施加到组织靶位点，检测组织靶位置处的电信号，或者两者。

7. 发明申请

US20120123400A1 METHODS AND DEVICES FOR CONTROLLING ENERGY DURING ABLATION 审中-公开
标题翻译：在排除过程中控制能量的方法和装置
公开(公告)号：US20120123400A1
公开(公告)日：2012-05-17
申请号：US13104483
申请日：2011-05-10
申请人： David Francischelli , Catherine R. Condie , Jinback Hong
发明人： David Francischelli , Catherine R. Condie , Jinback Hong
IPC分类号： A61B18/12 , A61B18/18 , A61B18/02
CPC分类号： A61B18/12 , A61B18/1492 , A61B34/10 , A61B2018/00291 , A61B2018/00642 , A61B2018/00648 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2034/101
摘要： System and method for ablating tissue of a heart of a patient. The tissue is characterized, then a predetermined ablation procedure is selected based on the characterization, ablation energy is delivered according to procedure with the ablation device, and a temperature of the tissue and an impedance of the tissue are determined. Delivery of ablation energy is ceased at a time based, at least in part, on when at least one of an accumulated effective temperature of the tissue over time exceeds a thermal dose threshold and an accumulated effective energy of the tissue over time exceeds an effective energy threshold. Else, the ablation energy delivered is modified by adjusting the energy level based, at least in part, on at least one of the temperature being outside of a predetermined temperature range and the impedance being outside of an impedance range.
摘要翻译：用于烧蚀患者心脏的组织的系统和方法。表征组织，然后基于表征选择预定的消融程序，根据消融装置的程序递送消融能量，并且确定组织的温度和组织的阻抗。至少部分地基于时间上的组织的累积有效温度中的至少一个超过热剂量阈值并且随着时间的推移，组织的积累的有效能量超过有效能量时，消除能量的递送停止阈。否则，通过至少部分地基于至少一个温度在预定温度范围之外并且阻抗在阻抗范围之外来调节能量水平来改变所传送的消融能量。

8. 发明申请

US20070043397A1 Cardiac mapping instrument with shapeable electrode 审中-公开
标题翻译：具有可塑电极的心脏测绘仪
公开(公告)号：US20070043397A1
公开(公告)日：2007-02-22
申请号：US11586112
申请日：2006-10-25
申请人： Jon Ocel , Roderick Briscoe , David Francischelli , Scott Jahns , James Keogh , Katherine Jolly , Matthew Bonner
发明人： Jon Ocel , Roderick Briscoe , David Francischelli , Scott Jahns , James Keogh , Katherine Jolly , Matthew Bonner
IPC分类号： A61N1/362
CPC分类号： A61B5/042 , A61B5/7475 , A61B18/14 , A61B2017/2927 , A61B2018/1472 , A61N1/056
摘要： An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.
摘要翻译：公开了一种包括细长轴和非导电手柄的仪器。轴限定近端部分和远端部分。远侧部分形成导电尖端。此外，轴适于从直状态转变到第一弯曲状态。轴能够独立地保持与直线状态和第一弯曲状态相关联的不同形状。手柄刚性地联接到轴的近端部分。该仪器可用于心脏起搏和/或心脏在心脏跳动中临时起搏的作用，以优化用于治疗患有充血性心力衰竭和心室异常不适和/或用于外科手术切除手术的患者的心室导线的位置。

9. 发明申请

US20080045898A1 TRANS-SEPTAL CATHETER WITH RETENTION MECHANISM 有权
标题翻译：带有保持机构的TRANS-SEPTAL CATHETER
公开(公告)号：US20080045898A1
公开(公告)日：2008-02-21
申请号：US11923320
申请日：2007-10-24
申请人： Mark Stewart , David Francischelli , James Skarda
发明人： Mark Stewart , David Francischelli , James Skarda
IPC分类号： A61M25/04 , A61M29/02
CPC分类号： A61B17/00234 , A61B2017/00252 , A61M25/10
摘要： A trans-septal guide catheter for providing access through the septum separating a first heart chamber from a second heart chamber that includes an elongated guide catheter body extending between guide catheter proximal and distal ends. A distal segment of the guide catheter is adapted to be inserted through the septum to locate the distal segment of the guide catheter within one of the first heart chamber and the second heart chamber. The catheter body encloses a guide catheter lumen adapted to provide access into the one of the first heart chamber and the second heart chamber through a guide catheter lumen proximal end opening and a guide catheter lumen distal end opening. A retention mechanism engages the septum and maintains the distal segment of the guide catheter extending into the one of the first heart chamber and the second heart chamber.
摘要翻译：一种反间隔导引导管，用于提供通过将第一心室与第二心室隔开的隔膜的通路，该第二心室包括在引导导管近端和远端之间延伸的细长引导导管主体。引导导管的远侧部分适于插入穿过隔膜以将引导导管的远侧部分定位在第一心室和第二心室之一内。导管主体包围引导导管内腔，其适于通过引导导管内腔近端开口和引导导管内腔远端开口提供通向第一心室和第二心室之一的通路。保持机构接合隔膜并且保持引导导管的远端段延伸到第一心室和第二心室中的一个。

10. 发明申请

US20070244473A1 Method of surgical dissection and/or guidance of other medical devices into body 审中-公开
标题翻译：手术解剖和/或其他医疗器械进入体内的方法
公开(公告)号：US20070244473A1
公开(公告)日：2007-10-18
申请号：US11698764
申请日：2007-01-26
申请人： Mark Thompson , Darrin Dickerson , Brett Bowman , Christopher Kelly , William Malecki , David Francischelli , Mark Stewart , Thomas Daigle , Douglas Gubbin , David Kim , Paul Rothstein , Adam Podbelski , Christopher Plott , Benjamin Yaffe
发明人： Mark Thompson , Darrin Dickerson , Brett Bowman , Christopher Kelly , William Malecki , David Francischelli , Mark Stewart , Thomas Daigle , Douglas Gubbin , David Kim , Paul Rothstein , Adam Podbelski , Christopher Plott , Benjamin Yaffe
IPC分类号： A61B18/18
CPC分类号： A61B17/00234 , A61B1/0055 , A61B17/0218 , A61B18/1482 , A61B90/30 , A61B2017/003 , A61B2017/00367 , A61B2017/320044 , A61B2090/0811
摘要： A method of surgical dissection of tissue with a dissector comprising: an elongate shaft comprising a proximal portion and a distal portion, wherein the distal portion comprises a plurality of segments that articulate with respect to one another and the plurality of segments includes a distal segment having a distal end; and a handle attached to the proximal portion of the shaft, wherein the handle comprises controls for articulating the plurality of segments of the distal portion of the shaft with respect to one another, comprising the steps of: positioning the distal end of the dissector in a body; advancing the distal end through the body to dissect tissue; and simultaneously articulating the plurality of segments with respect to one another. A method of surgical dissection of tissue and guiding a second device to a desired physiological location with a first device.
摘要翻译：一种用分离器手术解剖组织的方法，包括：细长轴，其包括近端部分和远侧部分，其中所述远端部分包括相对于彼此铰接的多个部分，并且所述多个部分包括远侧部分，远端以及附接到所述轴的所述近端部分的手柄，其中所述手柄包括用于将所述轴的远侧部分的所述多个段相对于彼此铰接的控制器，包括以下步骤：将所述解剖器的远端定位在身体; 将远端推进穿过身体解剖组织; 并且同时相对于彼此铰接多个段。一种手术切割组织并用第一装置将第二装置引导到所需生理位置的方法。

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