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1. 发明授权

US06358228B1 Vasoocclusive device including asymmetrical pluralities of fibers 有权
标题翻译：血管收缩装置包括不对称的多个纤维
公开(公告)号：US06358228B1
公开(公告)日：2002-03-19
申请号：US09286774
申请日：1999-04-06
申请人： David E. Tubman , Thomas A. Osborne
发明人： David E. Tubman , Thomas A. Osborne
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/0057 , A61B17/12131 , A61B17/1215 , A61B17/12181 , A61B90/39 , A61B2017/00575 , A61B2017/1205
摘要： A vasoocclusive device 10 is adapted for introduction into a vessel of a human or veterinary patient and occluding flow through the vessel. The device 10 includes a radiopaque member 12 (such as a metallic coil 14) having a proximal end 16 and a distal end 18, the distal end 18 being introduced first into the vessel. The member 12 is about 1.5 mm to about 3.0 mm long and no more than about 2.7 mm wide, preferably about 0.25 to 0.4 mm wide. The device 10 also includes a distal plurality 20 of fibers having an average distal fiber length, associated with and extending away from the distal end 18 of the member 12, as well as a proximal plurality 24 of fibers having an average proximal fiber length, associated with and extending away from the proximal end 16 of the member 12. The average proximal fiber length is about two to about five times the average distal fiber length. The average distal fiber length is preferably about 4 to 8 mm, while the average proximal fiber length is preferably about 9 to 15 mm. The distal and proximal pluralities 20 and 24 of fibers each preferably include 8 to 10 individual fibers composed of polyester, nylon or silk of about 40 denier. The vasoocclusive device 10 is particularly advantageous in that it can be used in vessels which are significantly narrower than those in which prior devices could be used, yet its asymmetric arrangement of the distal and proximal pluralities 20 and 24 of fibers allows it to enjoy significantly improved lodging in such narrow vessels.
摘要翻译：血管收缩装置10适于引入人或兽医患者的血管并阻塞通过血管的流动。装置10包括具有近端16和远端18的不透射线构件12（例如金属线圈14），远端18首先被引入容器。构件12的长度为约1.5mm至约3.0mm，宽度不大于约2.7mm，优选为约0.25至0.4mm宽。装置10还包括具有与构件12的远端18相关联并远离构件12的远端纤维长度的平均远端纤维长度的远端多个纤维20以及具有平均近端纤维长度的近端多个纤维24，其具有相关联的远离构件12的近端16并且远离构件12的近端16.平均近端纤维长度为平均远端纤维长度的约2至约5倍。平均末端纤维长度优选为约4至8mm，而平均近纤维长度优选为约9至15mm。纤维的远端和近端多个20和24各自优选包括由约40旦尼尔的聚酯，尼龙或丝组成的8至10个单独纤维。血管闭塞装置10是特别有利的，因为它可以用于明显比可以使用现有装置的容器窄的容器，但是其纤维的远端和近端多个20和24的不对称布置允许其显着改善住在这样狭窄的船只。

2. 发明授权

US09498271B2 Coaxial needle cannula with distal spiral mixer and side ports for fluid injection 有权
标题翻译：同轴针套管与远端螺旋混合器和侧面端口用于注射液体
公开(公告)号：US09498271B2
公开(公告)日：2016-11-22
申请号：US12914167
申请日：2010-10-28
申请人： Thomas A. Osborne , Jeffry S. Melsheimer , Christopher D. Bosel
发明人： Thomas A. Osborne , Jeffry S. Melsheimer , Christopher D. Bosel
IPC分类号： A61B17/88 , A61M5/315 , B01F5/06 , A61M5/19
CPC分类号： A61J1/20 , A61B17/8816 , A61B17/8822 , A61B18/06 , A61B2017/8838 , A61M5/19 , A61M5/31581 , B01F5/0473 , B01F5/0614 , B01F5/0615 , B01F2215/0029
摘要： Disclosed is a multi-lumen mixing device that includes a first and second lumen constructed and arranged to separately pass a first and second reagent to a mixing chamber in the device, where the mixing chamber includes a mixing feature that mixes the first and second reagents. The disclosed multi-lumen mixing device may also include a port in fluid communication with the reaction mixing to permit the product of the combined reagents to be injected into a patent.
摘要翻译：公开了一种多腔混合装置，其包括构造和布置成将第一和第二试剂分开地通过装置中的混合室的第一和第二腔，其中混合室包括混合第一和第二试剂的混合特征。所公开的多腔混合装置还可以包括与反应混合流体连通的端口，以允许将组合试剂的产物注入专利。

3. 发明授权

US08246672B2 Endovascular graft with separately positionable and removable frame units 有权
标题翻译：血管内移植物具有单独定位和可拆卸的框架单元
公开(公告)号：US08246672B2
公开(公告)日：2012-08-21
申请号：US12339596
申请日：2008-12-19
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/013 , A61F2/07 , A61F2/89 , A61F2002/016 , A61F2002/065 , A61F2002/9534 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/008 , A61F2230/0093
摘要： A device for repairing a vessel body including a plurality distinct and independently positionable, expandable frame units disposed within a tubular graft. The independent frame units are capable of being positioned, repositioned, or removed to conform the tubular graft to the anatomy of the vessel body.
摘要翻译：一种用于修理容器主体的装置，包括设置在管状移植物内的多个不同且可独立定位的可扩展框架单元。独立的框架单元能够定位，重新定位或移除以使管状移植物符合血管体的解剖结构。

4. 发明授权

US08197534B2 Valve device with inflatable chamber 有权
标题翻译：带充气室的阀门装置
公开(公告)号：US08197534B2
公开(公告)日：2012-06-12
申请号：US11394303
申请日：2006-03-30
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

5. 发明授权

US08043302B2 Implant retrieval assembly and method for retrieving an implant 有权
标题翻译：植入物检索组件和用于检索植入物的方法
公开(公告)号：US08043302B2
公开(公告)日：2011-10-25
申请号：US11708235
申请日：2007-02-20
申请人： Jeffry S. Melsheimer , Thomas A. Osborne
发明人： Jeffry S. Melsheimer , Thomas A. Osborne
IPC分类号： A61B17/26
CPC分类号： A61B17/221 , A61B17/32056 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/2919
摘要： An implant retrieval frame for advancement of a retrieval device to snare an implant is disclosed. The frame comprises a first arm and a second arm. The first arm has a first handle end and a first pivot end. The second arm has a second handle end and a second pivot end. The second pivot end is connected to the first pivot end to define a pivot axis about which the first and second arm pivotally move. The frame further comprises a connector to which the retrieval device is attached. The connector is configured to cooperate with the first and second arms to translate pivotal movement of one of the first and second arms to linear movement of the retrieval device relative to the pivot point.
摘要翻译：公开了一种用于推进提取装置以圈套植入物的植入物检索框架。框架包括第一臂和第二臂。第一臂具有第一手柄端和第一枢转端。第二臂具有第二手柄端和第二枢转端。第二枢转端连接到第一枢转端以限定枢转轴线，第一和第二臂枢转运动。该框架还包括一个连接器，拾取装置附接到该连接器。连接器构造成与第一和第二臂配合以将第一和第二臂之一的枢转运动转换成相对于枢转点的线性运动。

6. 发明申请

US20100063577A1 METHOD OF IMPLANTING A PROSTHETIC VALVE 审中-公开
标题翻译：植入预制阀的方法
公开(公告)号：US20100063577A1
公开(公告)日：2010-03-11
申请号：US12621214
申请日：2009-11-18
申请人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
发明人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.
摘要翻译：提供了将人造瓣植入人体容器中的方法。第一可膨胀框架构件被输送到身体容器中并在其处处被部署。第二可膨胀框架构件被输送到处理点。第二可膨胀框架构件具有附接的移植构件，其形成适于允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体容器。在展开第一可膨胀框架构件之后，第二可膨胀框架构件在处理点处展开，使得第二框架构件位于所述主体容器内的第一框架构件的径向内侧以形成人造瓣膜。

7. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

8. 发明授权

US07625390B2 Removable vena cava filter 有权
标题翻译：可移动的腔静脉过滤器
公开(公告)号：US07625390B2
公开(公告)日：2009-12-01
申请号：US11108255
申请日：2005-04-18
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/008
摘要： The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut includes an arcuate segment having a first tensile strength. The arcuate segment extends from the first end to an anchoring hook. The anchoring hook is integral with the arcuate segment and having the first thickness and first tensile strength. The filter further comprises a plurality of secondary struts freely spaced between the primary struts and having connected ends attached together along the longitudinal axis. Each secondary strut freely extends from the connected end to a free end avoiding contact with other secondary struts and primary struts. Each secondary strut has a second tensile strength.
摘要翻译：本发明提供一种用于在血管中捕获血栓的可移除的腔静脉过滤器。过滤器包括多个主支柱，其具有沿着纵向轴线连接在一起的第一端。每个主支柱包括具有第一拉伸强度的弓形段。弧形段从第一端延伸到锚钩。锚定钩与弓形段成一体，具有第一厚度和第一拉伸强度。过滤器还包括多个辅助支柱，其在主支柱之间自由间隔开并且具有沿着纵向轴线连接在一起的连接端。每个辅助支柱从连接端自由延伸到自由端，避免与其他辅助支柱和主支柱接触。每个辅助支柱具有第二拉伸强度。

9. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

10. 发明授权

US07595082B2 Wire guide 有权
标题翻译：导线导轨
公开(公告)号：US07595082B2
公开(公告)日：2009-09-29
申请号：US10813423
申请日：2004-03-30
申请人： John J. Connors, III , Kurt J. Tekulve , Thomas A. Osborne
发明人： John J. Connors, III , Kurt J. Tekulve , Thomas A. Osborne
IPC分类号： B05D3/12 , A61M25/09 , A61M31/00
CPC分类号： A61M25/09 , A61M25/01 , A61M2025/09133 , A61M2025/09175
摘要： A wire guide includes a mandrel that has a proximal portion and a distal portion. A first coating with a low coefficient of friction is disposed on the proximal portion of the mandrel. A second coating is disposed on the distal portion of the mandrel, where the second coating provides a sub-structure. A third coating is disposed on the second coating, where the third coating comprises a surface that allows for easy maneuverability of the wire guide. The first coating on the proximal portion provides enough lubricity to keep the wire guide from becoming bound or stuck in a catheter or medical device while still allowing a user to have a good grip of the wire guide. The second coating on the distal portion provides lubricity for the wire guide, which allows the user to easily maneuver the wire guide through a vascular anatomy.
摘要翻译：线引导件包括具有近端部分和远端部分的心轴。具有低摩擦系数的第一涂层设置在心轴的近端部分上。第二涂层设置在心轴的远端部分上，其中第二涂层提供子结构。第三涂层设置在第二涂层上，其中第三涂层包括允许导线器易于操作的表面。近端部分上的第一涂层提供足够的润滑性以保持线引导件不会被粘合或卡在导管或医疗装置中，同时仍然允许使用者具有良好的电线导向器的抓地力。远端部分上的第二涂层为线引导件提供润滑性，其允许使用者容易地通过血管解剖结构操纵线引导件。

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