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1. 发明授权

US07846085B2 Kit for forming implants in wall of gastrointestinal tract 失效
标题翻译：用于在胃肠道壁形成植入物的试剂盒
公开(公告)号：US07846085B2
公开(公告)日：2010-12-07
申请号：US10785713
申请日：2004-02-23
申请人： David E. Silverman , Alan Stein , Edward J. Gough
发明人： David E. Silverman , Alan Stein , Edward J. Gough
IPC分类号： A61F2/00
CPC分类号： A61F2/04 , A61B1/00089 , A61B17/3478 , A61B2017/00269 , A61B2017/306 , A61F5/0069
摘要： A kit for treating a gastrointestinal tract of a mammal and including a package and a tubular needle, an end piece and a container of an implant-forming material carried within the package. The end piece has an outer surface provided with at least one recess and an internal passageway communicating with the recess. The end piece is mounted on the distal extremity of an elongate probe member and introduced into the upper portion of the gastrointestinal tract. A portion of the wall of the gastrointestinal tract is drawn into the recess and the tubular needle is extended through the elongate probe member and the internal passageway into the portion of the wall in the recess. Material from the container is loaded into the tubular needle and injected into the portion of the wall to form an implant in the wall.
摘要翻译：一种用于治疗哺乳动物的胃肠道并且包括在包装内携带的植入物形成材料的包装和管状针，端部件和容器的套件。端件具有设置有至少一个凹部的外表面和与凹部连通的内部通道。端件安装在细长的探针构件的远端上并被引入胃肠道的上部。胃肠道壁的一部分被拉入凹槽中，并且管状针通过细长的探针构件和内部通道延伸到凹部中壁的部分中。将来自容器的材料装入管状针中并注入壁的部分以在壁中形成植入物。

2. 发明授权

US06358197B1 Apparatus for forming implants in gastrointestinal tract and kit for use therewith 有权
标题翻译：用于在胃肠道中形成植入物的装置和用于其的试剂盒
公开(公告)号：US06358197B1
公开(公告)日：2002-03-19
申请号：US09538863
申请日：2000-03-29
申请人： David E. Silverman , Alan Stein , Edward J. Gough
发明人： David E. Silverman , Alan Stein , Edward J. Gough
IPC分类号： A61F200
CPC分类号： A61F2/04 , A61B1/00089 , A61B17/3478 , A61B2017/00269 , A61B2017/306 , A61F5/0069
摘要： An apparatus comprising an elongate probe member having proximal and distal extremities for use with a suction source to treat a portion of a wall forming a cavity in a body having a natural body opening for accessing the cavity. The elongate probe member has a length so that when the distal extremity is in the vicinity of the portion of the wall the proximal extremity is outside of the body. The distal extremity of the elongate probe member has an outer surface and is provided with at least one recess opening onto the outer surface and an internal passageway communicating with the recess. When the suction source is coupled to the apparatus a suction is created in the recess by means of the passageway to draw the portion of the wall into the recess. A hollow needle is slidably disposed in the elongate probe member and has a distal end portion. The needle is actuatable from outside the body for movement from a retracted position in which the distal end portion of the needle is out of the recess and an extended position in which the distal end portion of the needle extends into the recess. The needle can be extended into the portion of the wall drawn into the recess so as to introduce a material into the portion of the wall and form an implant in the portion of the wall.
摘要翻译：一种装置，包括具有近端和远端的细长探针构件，用于与抽吸源一起使用，以处理形成具有用于进入空腔的自然体开口的主体中的空腔的壁的一部分。细长的探针构件具有这样的长度，使得当远端在壁的部分附近时，近端在身体外部。细长探针构件的远端具有外表面，并且在外表面上设置有至少一个凹口，以及与凹部连通的内部通道。当抽吸源联接到设备时，通过该通道在凹槽中产生吸力以将壁的一部分拉入凹槽中。空心针可滑动地设置在细长探针构件中并且具有远端部分。针可从身体外部致动，以从针头的远端部分脱离凹部的缩回位置和针的远端部分延伸到凹部中的延伸位置移动。针可以延伸到被拉入凹部的壁的部分中，以将材料引入壁的部分中并在壁的部分中形成植入物。

3. 发明授权

US06695764B2 Apparatus for treating wall of body cavity 有权
标题翻译：用于治疗体腔壁的装置
公开(公告)号：US06695764B2
公开(公告)日：2004-02-24
申请号：US10066155
申请日：2002-01-31
申请人： David E. Silverman , Alan Stein , Edward J. Gough
发明人： David E. Silverman , Alan Stein , Edward J. Gough
IPC分类号： A61F200
CPC分类号： A61F2/04 , A61B1/00089 , A61B17/3478 , A61B2017/00269 , A61B2017/306 , A61F5/0069
摘要： An apparatus for treating a wall of a body cavity comprising an elongate probe member having a distal extremity with an outer surface and at least one recess opening onto the outer surface. When a suction source is coupled to the apparatus, a suction is created in the recess to draw a portion of the wall into the recess. A needle is slidably disposed in the elongate probe member and actuatable from outside the body for movement from a retracted position to an extended position in which the distal end portion of the needle extends into the recess whereby the needle can be extended into the portion of the wall drawn into the recess.
摘要翻译：一种用于处理体腔的装置，包括具有远端的细长探针构件，其具有外表面和在外表面上开口的至少一个凹部。当抽吸源联接到设备时，在凹部中产生吸力以将壁的一部分拉入凹部。针可滑动地设置在细长的探针构件中并且可从身体的外部致动，用于从缩回位置移动到延伸位置，在该位置，针的远端部分延伸到延伸位置，由此针可以延伸到墙被拉入凹槽。

4. 发明授权

US07691087B2 Injection device 失效
标题翻译：注射装置
公开(公告)号：US07691087B2
公开(公告)日：2010-04-06
申请号：US10723476
申请日：2003-11-25
申请人： Edward J. Gough , Alan Stein
发明人： Edward J. Gough , Alan Stein
IPC分类号： A61F2/00
CPC分类号： A61M25/0084 , A61B5/14546 , A61B5/1459 , A61B5/6848 , A61B17/00491 , A61B2017/00269 , A61M2025/0089
摘要： An injection device for use with tissue of a mammalian body comprising a first tubular member and a second tubular member slidably disposed in the first tubular member. The first and second tubular members have respective proximal and distal extremities. The distal extremity of the second tubular member is provided with a needle that is extendable from the distal extremity of the first tubular member. The proximal extremity of the second tubular member is lockable relative to the proximal extremity of the first tubular member. The second tubular member has a column strength when locked within the first tubular member for limiting retraction of the second tubular member relative to the first tubular member during puncture of the tissue by the needle.
摘要翻译：一种用于哺乳动物主体的组织的注射装置，包括可滑动地设置在第一管状构件中的第一管状构件和第二管状构件。第一和第二管状构件具有相应的近端和远端。第二管状构件的远端设置有可从第一管状构件的远端延伸的针。第二管状构件的近端可相对于第一管状构件的近端被锁定。第二管状构件在锁定在第一管状构件内时具有柱强度，用于在通过针穿刺组织期间限制第二管状构件相对于第一管状构件的缩回。

5. 发明授权

US08545478B2 Injection device 有权
标题翻译：注射装置
公开(公告)号：US08545478B2
公开(公告)日：2013-10-01
申请号：US12652148
申请日：2010-01-05
申请人： Edward J. Gough , Alan Stein
发明人： Edward J. Gough , Alan Stein
IPC分类号： A61M31/00
CPC分类号： A61M25/0084 , A61B5/14546 , A61B5/1459 , A61B5/6848 , A61B17/00491 , A61B2017/00269 , A61M2025/0089
摘要： An injection device for use with tissue of a mammalian body comprising a first tubular member and a second tubular member slidably disposed in the first tubular member. The first and second tubular members have respective proximal and distal extremities. The distal extremity of the second tubular member is provided with a needle that is extendable from the distal extremity of the first tubular member. The proximal extremity of the second tubular member is lockable relative to the proximal extremity of the first tubular member. The second tubular member has a column strength when locked within the first tubular member for limiting retraction of the second tubular member relative to the first tubular member during puncture of the tissue by the needle.
摘要翻译：一种用于哺乳动物主体的组织的注射装置，包括可滑动地设置在第一管状构件中的第一管状构件和第二管状构件。第一和第二管状构件具有相应的近端和远端。第二管状构件的远端设置有可从第一管状构件的远端延伸的针。第二管状构件的近端可相对于第一管状构件的近端被锁定。第二管状构件在锁定在第一管状构件内时具有柱强度，用于在通过针穿刺组织期间限制第二管状构件相对于第一管状构件的缩回。

6. 发明申请

US20100174162A1 INJECTION DEVICE 有权
标题翻译：注射装置
公开(公告)号：US20100174162A1
公开(公告)日：2010-07-08
申请号：US12652148
申请日：2010-01-05
申请人： Edward J. Gough , Alan Stein
发明人： Edward J. Gough , Alan Stein
IPC分类号： A61M5/31 , A61M5/315 , A61B5/1459
CPC分类号： A61M25/0084 , A61B5/14546 , A61B5/1459 , A61B5/6848 , A61B17/00491 , A61B2017/00269 , A61M2025/0089
摘要： An injection device for use with tissue of a mammalian body comprising a first tubular member and a second tubular member slidably disposed in the first tubular member. The first and second tubular members have respective proximal and distal extremities. The distal extremity of the second tubular member is provided with a needle that is extendable from the distal extremity of the first tubular member. The proximal extremity of the second tubular member is lockable relative to the proximal extremity of the first tubular member. The second tubular member has a column strength when locked within the first tubular member for limiting retraction of the second tubular member relative to the first tubular member during puncture of the tissue by the needle.
摘要翻译：一种用于哺乳动物主体的组织的注射装置，包括可滑动地设置在第一管状构件中的第一管状构件和第二管状构件。第一和第二管状构件具有相应的近端和远端。第二管状构件的远端设置有可从第一管状构件的远端延伸的针。第二管状构件的近端可相对于第一管状构件的近端被锁定。第二管状构件在锁定在第一管状构件内时具有柱强度，用于在通过针穿刺组织期间限制第二管状构件相对于第一管状构件的缩回。

7. 发明授权

US08177707B2 Method for treating tissue with an implant 有权
标题翻译：用植入物治疗组织的方法
公开(公告)号：US08177707B2
公开(公告)日：2012-05-15
申请号：US12825095
申请日：2010-06-28
申请人： David E. Silverman , Alan Stein
发明人： David E. Silverman , Alan Stein
IPC分类号： A61F2/00
CPC分类号： B01J21/066 , B01J37/036 , B01J37/20 , C07C5/31 , C07C2521/06 , C07C13/28
摘要： A method for forming a valve-like mechanism in a body of a mammal having an esophagus extending through a lower esophageal sphincter to a stomach and formed by a wall having a muscle layer and a mucosal layer. The method comprises the step of forming at least one implant in the muscle layer of the wall in the vicinity of the lower esophageal sphincter. The at least one implant inhibits opening of esophagus at the lower esophageal sphincter and causes the mucosal layer to appose in the vicinity of the implants.
摘要翻译：一种用于在具有延伸穿过下食道括约肌到胃并且由具有肌肉层和粘膜层的壁形成的具有食道的哺乳动物体内形成阀状机构的方法。该方法包括在下食管括约肌附近在壁的肌肉层中形成至少一种植入物的步骤。所述至少一个植入物抑制食管下端括约肌的食道开放并使粘膜层附着在植入物附近。

8. 发明授权

US07364591B2 Method for treating morbid obesity 有权
标题翻译：治疗病态肥胖的方法
公开(公告)号：US07364591B2
公开(公告)日：2008-04-29
申请号：US11435462
申请日：2006-05-16
申请人： David E. Silverman , Alan Stein
发明人： David E. Silverman , Alan Stein
IPC分类号： A61F2/00
CPC分类号： A61F5/0069 , A61B17/00234 , A61B17/00491 , A61B17/04 , A61B17/0469 , A61B17/064 , A61B17/12 , A61B17/12099 , A61B17/12186 , A61B2017/00827 , A61F2/0036 , A61F5/0079 , A61F5/0083 , A61F5/0086 , A61F2002/044
摘要： A method for treating morbid obesity in a body of a mammal having a gastrointestinal tract extending through a stomach and a pyloric sphincter and a wall forming the stomach and pyloric sphincter. At least one implant is formed in the wall in the vicinity of the pyloric sphincter to inhibit emptying of the stomach.
摘要翻译：一种用于治疗哺乳动物身体中的病态肥胖的方法，所述哺乳动物具有延伸穿过胃和幽门括约肌的胃肠道以及形成胃和幽门括约肌的壁。在幽门括约肌附近的壁中形成至少一个植入物以抑制胃的排空。

9. 发明授权

US06802868B2 Method for treating morbid obesity 失效
标题翻译：治疗病态肥胖的方法
公开(公告)号：US06802868B2
公开(公告)日：2004-10-12
申请号：US10386241
申请日：2003-03-10
申请人： David E. Silverman , Alan Stein
发明人： David E. Silverman , Alan Stein
IPC分类号： A61F200
CPC分类号： A61F5/0069 , A61B17/00234 , A61B17/00491 , A61B17/04 , A61B17/0469 , A61B17/064 , A61B17/12 , A61B17/12099 , A61B17/12186 , A61B2017/00827 , A61F2/0036 , A61F5/0079 , A61F5/0083 , A61F5/0086 , A61F2002/044
摘要： A method for treating morbid obesity in a body of a mammal having a gastrointestinal tract extending through a stomach and a pyloric sphincter and a wall forming the stomach and pyloric sphincter. At least one implant is formed in the wall in the vicinity of the pyloric sphincter to inhibit emptying of the stomach.
摘要翻译：一种用于治疗哺乳动物身体中的病态肥胖的方法，所述哺乳动物具有延伸穿过胃和幽门括约肌的胃肠道以及形成胃和幽门括约肌的壁。在幽门括约肌附近的壁中形成至少一个植入物以抑制胃的排空。

10. 发明授权

US06595910B2 Method for treating fecal incontinence 失效
公开(公告)号：US06595910B2
公开(公告)日：2003-07-22
申请号：US09882522
申请日：2001-06-15
申请人： David E. Silverman , Alan Stein
发明人： David E. Silverman , Alan Stein
IPC分类号： A61F200
CPC分类号： A61F2/0009 , A61B17/00491 , A61B17/12022 , A61B17/12036 , A61B17/12099 , A61B17/12186 , A61B17/3478 , A61B2017/00495 , A61F2/0036 , A61M5/31593
摘要： A method for treating fecal incontinence in a body of a mammal having a rectum formed by a rectal wall extending to an anus wherein the rectal wall includes a sphincter muscle surrounding the anus. At least one nonaqueous solution is introduced into the rectal wall in the vicinity of the anus. A nonbiodegradable solid is formed in the rectal wall from the at least one nonaqueous solution.

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