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1. 发明授权

US4235083A Method and apparatus for producing patterned effect on knitted fabric 失效
标题翻译：用于在针织物上产生图案效果的方法和装置
公开(公告)号：US4235083A
公开(公告)日：1980-11-25
申请号：US963310
申请日：1978-11-24
申请人： David Dale , Robert C. Barksdale
发明人： David Dale , Robert C. Barksdale
IPC分类号： D04B27/12
CPC分类号： D04B27/12
摘要： An attachment for a warp knitting machine is disclosed. The attachment produces a patterned effect on fabric knitted by the warp knitting machine. The warp knitting machine includes at least one warp beam, a thread separating mechanism, a knitting mechanism, and a first tensioning mechanism positioned between the warp beam and the knitting mechanism. The attachment includes a moveable supplemental tensioning mechanism operatively connected to the knitting machine for cyclically varying the tension on first and second groups of threads disposed on opposite sides of the supplemental tensioning mechanism. A mechanism is provided for cyclically moving the supplemental tensioning mechanism in first and second directions about a neutral position to alternately tension the first and second groups of threads.
摘要翻译：公开了一种经编机的附件。附件在经编机上编织的织物上产生图案效果。经编机包括至少一个经轴，分离机构，编织机构以及位于经线和编织机构之间的第一张紧机构。附件包括可操作地连接到针织机的可动辅助张紧机构，用于循环地改变设置在辅助张紧机构的相对侧上的第一组和第二组螺纹上的张力。提供了一种用于在第一和第二方向围绕中立位置周期性地移动补充张紧机构以交替地拉紧第一组和第二组螺纹的机构。

2. 发明授权

US4382371A Method and apparatus for producing patterning effect on knitted fabric 失效
标题翻译：针织物制作图案效果的方法和装置
公开(公告)号：US4382371A
公开(公告)日：1983-05-10
申请号：US185191
申请日：1980-09-08
申请人： David Dale , Robert C. Barksdale
发明人： David Dale , Robert C. Barksdale
IPC分类号： D04B27/12 , D04B27/14
CPC分类号： D04B27/14 , D04B21/06 , D04B27/12
摘要： An attachment for a warp knitting machine is disclosed. The attachment produces a patterned effect on fabric knitted by the warp knitting machine. The warp knitting machine includes at least one warp beam, a thread separating mechanism, a knitting mechanism, and a first tensioning mechanism positioned between the warp beam and the knitting mechanism. The attachment includes a moveable supplemental tensioning mechanism operatively connected to the knitting machine for cyclically varying the tension on first and second groups of threads disposed on opposite sides of the supplemental tensioning mechanism. A mechanism is provided for cyclically moving the supplemental tensioning mechanism in first and second directions about a neutral position to alternately tension the first and second groups of threads.
摘要翻译：公开了一种经编机的附件。附件在经编机上编织的织物上产生图案效果。经编机包括至少一个经轴，分离机构，编织机构以及位于经线和编织机构之间的第一张紧机构。附件包括可操作地连接到针织机的可动辅助张紧机构，用于循环地改变设置在辅助张紧机构的相对侧上的第一组和第二组螺纹上的张力。提供了一种用于在第一和第二方向围绕中立位置周期性地移动补充张紧机构以交替地拉紧第一组和第二组螺纹的机构。

3. 发明申请

US20080063624A1 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 有权
标题翻译：移动原核细胞/干细胞的方法
公开(公告)号：US20080063624A1
公开(公告)日：2008-03-13
申请号：US11841837
申请日：2007-08-20
申请人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald Macfarland , Gary Calandra , Hal Broxmeyer , David Dale
发明人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald Macfarland , Gary Calandra , Hal Broxmeyer , David Dale
IPC分类号： A61K31/395 , A61K31/4427 , A61K38/19 , A61P9/00
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 其中A包含含有至少一个N的单环或双环稠环体系，B是H或1-20个原子的有机部分，Z'可以以上述Z所定义的形式实施，或者可以是式 <？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR 2）N < 其中每个R独立地为H或直链，支链或环状烷基（1-6C），n为1或2，X为芳环，包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

4. 发明申请

US20060193826A1 Methods to mobilize progenitor/stem cells 有权
标题翻译：调动祖细胞/干细胞的方法
公开(公告)号：US20060193826A1
公开(公告)日：2006-08-31
申请号：US11269773
申请日：2005-11-08
申请人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
发明人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
IPC分类号： A61K38/19 , A61K31/551 , A61K31/33
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula N wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 或Z具有式N，其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以Z所定义的形式实施，或者可以具有公式<？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR 2 2 N）n 其中每个R独立地为H或直链，支链或环状的烷基（1-6C），n为1，其中每个R独立地为H或直链，支链或环状的烷基（1-6C）或2，X是芳环，包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

5. 外观设计

USD741782S1 Extended vehicular armrest 有权
标题翻译：延长的车辆扶手
公开(公告)号：USD741782S1
公开(公告)日：2015-10-27
申请号：US29497339
申请日：2014-07-23
申请人： David Dale
设计人： David Dale

6. 发明申请

US20060223180A1 Methods to mobilize progenitor/stem cells 审中-公开
标题翻译：调动祖细胞/干细胞的方法
公开(公告)号：US20060223180A1
公开(公告)日：2006-10-05
申请号：US11446390
申请日：2006-06-02
申请人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
发明人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
IPC分类号： A61K31/33 , C12N5/08
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 或Z具有下式：其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以上述Z所定义的形式实施，或可替代地可以是公式<？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR <2> 其中每个R独立地是H或直链，支链或环状的烷基（1-6C），n是1或者 2，X为芳环，包括杂芳环，或为硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

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