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1. 发明申请

US20080027145A1 Therapeutic Molecules and Methods for Generating and/or Selecting Same 审中-公开
标题翻译：用于产生和/或选择相同的治疗分子和方法
公开(公告)号：US20080027145A1
公开(公告)日：2008-01-31
申请号：US10588687
申请日：2005-02-03
申请人： David C. S. Huang , Peter M. Colman , Catherine L. Day , Jerry M. Adams , Lin Chen , Simon N. Willis , Andrew Wei , Brian J. Smith , Mark G. Hinds
发明人： David C. S. Huang , Peter M. Colman , Catherine L. Day , Jerry M. Adams , Lin Chen , Simon N. Willis , Andrew Wei , Brian J. Smith , Mark G. Hinds
IPC分类号： A61K35/00 , A61P35/00 , G01N33/48 , G01N33/53
CPC分类号： C07K14/4747
摘要： The present invention relates generally to therapeutic molecules useful for inducing apoptosis of particular cells such as, but not limited to, cancer cells and methods for generating and/or selecting same. The present invention further provides methods for inducing apoptosis of cells such as cancer cells and pharmaceutical compositions useful for same. The present invention further provides methods for generating or selecting therapeutic agents capable of inducing apoptosis of particular cells by the selective inhibition of pro-survival proteins. The present invention further provides a computational approach to therapeutic molecule design based on structure-binding characteristics.
摘要翻译：本发明一般涉及用于诱导特定细胞凋亡的治疗分子，所述特定细胞例如但不限于癌细胞，以及用于产生和/或选择癌细胞的方法。本发明还提供诱导细胞凋亡的方法，例如癌细胞和对其有用的药物组合物。本发明还提供了通过选择性抑制前体存活蛋白来产生或选择能够诱导特定细胞凋亡的治疗剂的方法。本发明还提供了基于结构结合特征的治疗分子设计的计算方法。

2. 发明申请

US20120245866A1 METHOD AND SYSTEM FOR PROVIDING ISOLATED DETAIL INFORMATON ABOUT STATIONS WHICH ARE SIMULTANEOUSLY ACTIVE IN AN IRRIGATION SYSTEM 有权
标题翻译：关于在灌溉系统中同时活动的站点的隔离细节信息的方法和系统
公开(公告)号：US20120245866A1
公开(公告)日：2012-09-27
申请号：US13490659
申请日：2012-06-07
申请人： David Hunts , Brian J. Smith
发明人： David Hunts , Brian J. Smith
IPC分类号： G06F19/00
CPC分类号： A01G25/167
摘要： A method provides information about stations in an irrigation system which are simultaneously active. An irrigation flow curve image is displayed which summarizes flow information for an irrigation system. The method interacts with a user to receive an indication from a user interface pointing device of a position within a flow curve area of the irrigation flow curve image on the display. The method retrieves detail information for stations in the irrigation system which are simultaneously active at a time indicated by the position of the user interface pointing device. Detail information is displayed isolating the stations in the irrigation system which are simultaneously active at the time indicated by the position of the user interface pointing device, wherein the detail information further individually indicates irrigation activity for stations which are simultaneously active at the time indicated by the position of the user interface pointing device.
摘要翻译：一种方法提供了灌溉系统中同时有效的站点的信息。显示灌溉流量曲线图，其汇总灌溉系统的流量信息。该方法与用户相互作用以从用户界面指示装置接收在显示器上的冲洗流曲线图像的流曲线区域内的位置的指示。该方法检索在由用户界面指示装置的位置指示的时间同时活动的灌溉系统中的站的详细信息。显示详细信息，隔离在由用户界面指示装置的位置指示的时间同时活动的灌溉系统中的站，其中详细信息还单独地指示在由所述用户界面指示装置指示的时间同时活动的站的灌溉活动用户界面指点设备的位置。

3. 发明申请

US20110051703A1 Mobile router device 有权
标题翻译：移动路由器设备
公开(公告)号：US20110051703A1
公开(公告)日：2011-03-03
申请号：US12807549
申请日：2010-09-07
申请人： John C. Fulknier , Brian J. Smith
发明人： John C. Fulknier , Brian J. Smith
IPC分类号： H04W84/02 , H04W4/00
CPC分类号： H04W40/00 , H04L45/00 , H04L45/60 , H04W4/80 , H04W24/08 , H04W28/08 , H04W48/18 , H04W76/15 , H04W84/12 , H04W84/18 , H04W88/10 , H04W88/16
摘要： A wireless mobile router (140) includes wireless network interfaces (202) and (218) attached to a network controller (142). The wireless network interface (202) communicates with a cellular network (110) to access cellular network services. The wireless network interface (218) and the network controller (142) comprise a WLAN (170) or PAN (180) and a network router hosting a plurality of client devices. Each client device may access a wide area network, WAN over the cellular network. The wireless mobile router (140) is configured to exchange various cellular network signals with various WLAN and PAN networks. The wireless mobile router (140) is particularly suitable for use in a vehicle or at locations where WAN access is not readily available.
摘要翻译：无线移动路由器（140）包括附接到网络控制器（142）的无线网络接口（202）和（218）。无线网络接口（202）与蜂窝网络（110）通信以接入蜂窝网络服务。无线网络接口（218）和网络控制器（142）包括WLAN（170）或PAN（180）和托管多个客户端设备的网络路由器。每个客户端设备可以通过蜂窝网络访问广域网WAN。无线移动路由器（140）被配置为与各种WLAN和PAN网络交换各种蜂窝网络信号。无线移动路由器（140）特别适用于车辆或WAN接入不容易获得的位置。

4. 发明授权

US07813314B2 Mobile router device 有权
标题翻译：移动路由器设备
公开(公告)号：US07813314B2
公开(公告)日：2010-10-12
申请号：US11497892
申请日：2006-08-02
申请人： John C. Fulknier , Brian J. Smith
发明人： John C. Fulknier , Brian J. Smith
IPC分类号： H04W4/00
CPC分类号： H04W40/00 , H04L45/00 , H04L45/60 , H04W4/80 , H04W24/08 , H04W28/08 , H04W48/18 , H04W76/15 , H04W84/12 , H04W84/18 , H04W88/10 , H04W88/16
摘要： A wireless mobile router (140) includes wireless network interfaces (202) and (218) attached to a network controller (142). The wireless network interface (202) communicates with a cellular network (110) to access cellular network services. The wireless network interface (218) and the network controller (142) comprise a WLAN (170) or PAN (180) network router hosting a plurality of client devices. Each client device may access a wide area network, WAN over the cellular network. The wireless mobile router (140) is configured to exchange various cellular network signals with various WLAN and PAN networks. The wireless mobile router (140) is particularly suitable for use in a vehicle or at locations where WAN access is not readily available.
摘要翻译：无线移动路由器（140）包括附接到网络控制器（142）的无线网络接口（202）和（218）。无线网络接口（202）与蜂窝网络（110）通信以接入蜂窝网络服务。无线网络接口（218）和网络控制器（142）包括托管多个客户端设备的WLAN（170）或PAN（180）网络路由器。每个客户端设备可以通过蜂窝网络访问广域网WAN。无线移动路由器（140）被配置为与各种WLAN和PAN网络交换各种蜂窝网络信号。无线移动路由器（140）特别适用于车辆或WAN接入不容易获得的位置。

5. 发明授权

US07778230B2 Mobile router device 有权
标题翻译：移动路由器设备
公开(公告)号：US07778230B2
公开(公告)日：2010-08-17
申请号：US11650634
申请日：2007-01-06
申请人： John C. Fulknier , Brian J. Smith
发明人： John C. Fulknier , Brian J. Smith
IPC分类号： H04W4/00
CPC分类号： H04L45/00 , H04L45/60
摘要： A wireless mobile router (300) includes a CPU (222) and one or more network interfaces for hosting locally reachable devices. The router (300) includes one or more cellular network interface devices (316) configured to make a network connection with a cellular network. The router (300) operates to translate data packets received from locally reachable devices and to direct the translated data packets to public IP address over the cellular network. In addition, a stack of mobile routers (400) includes two or more mobile routers (300) interfaced together to make two or more network connections with a cellular network for increasing bandwidth and for load balancing network traffic passing from the router (300) to the cellular network. The wireless mobile router (300) and the stack (400) are suitable for use in a moving vehicle.
摘要翻译：无线移动路由器（300）包括CPU（222）和用于托管本地可到达设备的一个或多个网络接口。路由器（300）包括配置成与蜂窝网络进行网络连接的一个或多个蜂窝网络接口设备（316）。路由器（300）操作以转换从本地可达设备接收的数据分组，并且通过蜂窝网络将转换的数据分组引导到公共IP地址。另外，一组移动路由器（400）包括两个或更多个移动路由器（300），其连接在一起以与蜂窝网络进行两个或更多个网络连接，用于增加带宽并且用于负载平衡从路由器（300）传递到蜂窝网络。无线移动路由器（300）和堆栈（400）适用于移动车辆。

6. 发明申请

US20090297995A1 Mechanical Acoustic Noise Generator System for Scramjet Engine 失效
标题翻译：机械声学噪声发生器系统
公开(公告)号：US20090297995A1
公开(公告)日：2009-12-03
申请号：US12131248
申请日：2008-06-02
申请人： Kevin D. Kennedy , Brian J. Smith
发明人： Kevin D. Kennedy , Brian J. Smith
IPC分类号： F02K7/10
CPC分类号： F02K7/10 , F05D2240/127
摘要： A noise generator system is provided with each noise generator being pivotally mounted to a mounting surface associated with the air intake of a turbineless jet engine. Each noise generator is positioned so as to convert a laminar or transitional air stream into a turbulent air stream such that a turbulent air-fuel mixture is realized in the combustion section of the engine to achieve more efficient operation.
摘要翻译：提供了一种噪声发生器系统，每个噪声发生器枢转地安装到与无头喷气发动机的进气口相关联的安装表面。每个噪声发生器被定位成将层流或过渡空气流转换成湍流空气流，使得在发动机的燃烧部分中实现湍流空气 - 燃料混合物以实现更有效的操作。

7. 发明授权

US07246346B2 System and method for persisting dynamically generated code in a directly addressable and executable storage medium 有权
标题翻译：在直接可寻址和可执行的存储介质中持久化动态生成的代码的系统和方法
公开(公告)号：US07246346B2
公开(公告)日：2007-07-17
申请号：US10245994
申请日：2002-09-17
申请人： Seth M. Demsey , Brian J. Smith , Scott M. Corbin , Michael D. Smith , W. Michael Zintel
发明人： Seth M. Demsey , Brian J. Smith , Scott M. Corbin , Michael D. Smith , W. Michael Zintel
IPC分类号： G06F9/45 , G06F3/06 , G06F12/00
CPC分类号： G06F9/45516
摘要： The present invention is directed at a virtual machine environment operating on portable devices with limited resources. The virtual machine environment includes a method for compiling an intermediate language into native code wherein the native code is stored in a directly addressable and executable storage medium, such as flash memory. A portion of the native code is written to a cache resident in volatile memory during compiling. The cache is written to the directly addressable and executable storage medium. The cache may be sized in relation to a block size associated with the directly addressable and executable storage medium. A metadata map is maintained and associates a physical address at which the native code is stored in the storage medium with the method. The native code is persisted by storing the metadata map in the storage medium and associating the metadata map with the method.
摘要翻译：本发明涉及在有限资源的便携式设备上运行的虚拟机环境。虚拟机环境包括用于将中间语言编译成本地代码的方法，其中本地代码存储在直接可寻址和可执行的存储介质（诸如闪存）中。在编译期间，本地代码的一部分被写入驻留在易失性存储器中的缓存。缓存被写入直接可寻址和可执行的存储介质。高速缓存可以相对于与直接可寻址和可执行的存储介质相关联的块大小来定尺寸。维护元数据图并将存储介质中的本地代码的物理地址与该方法相关联。通过将元数据映射存储在存储介质中并将元数据映射与该方法相关联来保持本地代码。

8. 发明授权

US06341311B1 Directing data object access requests in a distributed cache 失效
标题翻译：在分布式缓存中定向数据对象访问请求
公开(公告)号：US06341311B1
公开(公告)日：2002-01-22
申请号：US09087330
申请日：1998-05-29
申请人： Brian J. Smith , Vinod V. Valloppillil , Hans Hurvig
发明人： Brian J. Smith , Vinod V. Valloppillil , Hans Hurvig
IPC分类号： G06F1300
CPC分类号： H04L67/1095 , G06F17/30902 , H04L29/06 , H04L67/2814 , H04L67/2842 , H04L67/288 , H04L69/329
摘要： A method, computer program product, and system for routing URL data object requests in a proxy server array. A URL data object request is received at one proxy server of the array while the desired URL data object resides in the local cache of another proxy server in the array. The receiving proxy server will deterministically identify the residing proxy server based on information residing thereon without resorting to expensive query-response transactions, such as those that occur in proxy server arrays using ICP. An array membership list containing array membership information is available at each and every proxy server and is used in conjunction with the URL as the information for identifying the correct proxy server where the URL data object resides. First, a deterministic hash value is computed for each proxy server name and the URL. Next, a combined hash value is computed that combines the URL hash value with each proxy server hash value. Finally, the proxy server with the highest “score” or combined hash value is identified as the proxy server where the desired URL data object should reside in local cache storage. Since the array membership list, the URL, and the hashing algorithm are the same at each proxy server, the same proxy server will be identified as having the URL data object regardless of which proxy server originally receives the URL data object request.
摘要翻译：用于在代理服务器阵列中路由URL数据对象请求的方法，计算机程序产品和系统。在阵列的一个代理服务器处接收URL数据对象请求，而所需的URL数据对象驻留在阵列中另一个代理服务器的本地缓存中。接收代理服务器将基于驻留在其上的信息来确定性地识别驻留的代理服务器，而不诉诸昂贵的查询 - 响应事务，例如使用ICP在代理服务器阵列中发生的事务。包含数组成员身份信息的数组成员资格列表可在每个代理服务器上使用，并与URL一起用作标识URL数据对象所在的正确代理服务器的信息。首先，为每个代理服务器名称和URL计算确定性哈希值。接下来，计算将URL哈希值与每个代理服务器哈希值组合的组合哈希值。最后，具有最高“分数”或组合哈希值的代理服务器被识别为代理服务器，其中期望的URL数据对象应驻留在本地高速缓存存储器中。由于阵列成员关系列表，URL和散列算法在每个代理服务器上是相同的，所以相同的代理服务器将被标识为具有URL数据对象，而不管哪个代理服务器最初接收到URL数据对象请求。

9. 发明授权

US4318953A Transfer materials 失效
标题翻译：转移材料
公开(公告)号：US4318953A
公开(公告)日：1982-03-09
申请号：US115709
申请日：1980-01-28
申请人： Brian J. Smith , Geoffrey R. Taylor
发明人： Brian J. Smith , Geoffrey R. Taylor
IPC分类号： B41M3/12 , B44C1/16 , B44C1/17 , B32B3/18
CPC分类号： B44C1/1725 , B41M3/12 , B44C1/162 , B44C1/1712 , Y10S428/913 , Y10S428/914 , Y10T428/24843 , Y10T428/24876 , Y10T428/24901 , Y10T428/2826 , Y10T428/2848
摘要： Transfer materials are described which are of particular value in sign making applications. The materials consist of a carrier sheet, indicia thereon, usually formed by printing from a printing ink composition and adhesive over the indicia. The dry transfer material may be used in the usual way to assemble a desired legend on a temporary carrier sheet using the pulling power of the adhesive optionally assisted by the "stretch release" technique if the carrier sheet and indicia are appropriately formulated. According to the invention, the indicia are formulated so that following their transfer to build up the desired legend, they may be adhered under the action of heat and pressure without plastic deformation to the surface of a transparent or translucent rigid sign sheet made of polymethylmethacrylate, polyvinylchloride or cellulose triacetate.
摘要翻译：描述了在签字应用中特别有价值的转移材料。这些材料由载体片，其上的标记组成，通常通过印刷油墨组合物和粘合剂在标记上印刷形成。如果载体片和标记被适当配制，干燥转印材料可以以通常的方式用于使用任选由“拉伸释放”技术辅助的粘合剂的拉力在临时载体片上组装所需的图例。根据本发明，标记被配制为使得在其转移以建立期望的图例之后，它们可以在没有塑性变形的热和压力的作用下粘附到由聚甲基丙烯酸甲酯制成的透明或半透明的刚性标志牌的表面，聚氯乙烯或三醋酸纤维素。

10. 发明授权

US09463178B2 Ophthalmic solution for absorbing ultraviolet radiation and method for absorbing ultraviolet radiation 有权
公开(公告)号：US09463178B2
公开(公告)日：2016-10-11
申请号：US14809881
申请日：2015-07-27
申请人： Brian J. Smith
发明人： Brian J. Smith
IPC分类号： A61K31/12 , A61K31/216 , A61K31/4184 , A61K47/24 , A61K31/277 , A61K31/618 , A61K45/06 , A61K9/00 , A61K31/675 , A61K47/10 , A61K47/26
CPC分类号： A61K31/216 , A61K9/0048 , A61K31/12 , A61K31/277 , A61K31/4184 , A61K31/618 , A61K31/675 , A61K45/06 , A61K47/10 , A61K47/24 , A61K47/26 , A61K2300/00
摘要： An ophthalmic solution is provided. The ophthalmic solution includes an ultraviolet-A absorber and an ultraviolet-B absorber. The ophthalmic solution has a viscosity of between about 1 and 100 cps. The ophthalmic solution can be used to absorb ultraviolet radiation in the eye.

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