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1. 发明申请

US20050047793A1 Scheme for reducing low frequency components in an optical transmission network 审中-公开
标题翻译：降低光传输网络中低频分量的方案
公开(公告)号：US20050047793A1
公开(公告)日：2005-03-03
申请号：US10651158
申请日：2003-08-28
申请人： David Butler , Kurt Schuder
发明人： David Butler , Kurt Schuder
IPC分类号： H04B10/155 , H04B10/18 , H04B10/12
CPC分类号： H04B10/5055 , H04B10/25137 , H04B10/516
摘要： A system and method for reducing undesirable components in optical signals in an optical transmission network. A block coding scheme is implemented that is matched to the spectral characteristics of one or more optical components of a transmission path, e.g., filters, optical media, et cetera, whereby the source data is encoded for shifting the power density spectra of the optical signals.
摘要翻译：一种用于减少光传输网络中的光信号中不期望的分量的系统和方法。实现了与传输路径的一个或多个光学部件（例如滤波器，光学介质等）的光谱特性匹配的块编码方案，由此对源数据进行编码以便移动光信号的功率密度谱。

2. 发明申请

US20170282661A1 UTILITY SLED 审中-公开
公开(公告)号：US20170282661A1
公开(公告)日：2017-10-05
申请号：US15475387
申请日：2017-03-31
申请人： David Butler
发明人： David Butler
IPC分类号： B60F3/00 , B62B3/02 , B63B35/73 , B62B5/06
CPC分类号： B60F3/0092 , B60F3/0007 , B62B15/003 , B62B15/007 , B62B15/008 , B62B2202/402 , B62B2202/42 , B63B35/73 , B63B2035/738
摘要： A utility sled is formed from a lightweight material and includes a handle flexibly attached to the front end thereof. The handle includes a hook that is seated within a small opening of the utility sled when not in use. A pair of retractable wheels is attached to an exterior of each sidewall of the utility sled. The sidewalls are biased outward when no load is present. When loaded, the sidewalls advantageously tend to straighten vertically. The formed bottom of the sled includes a plurality of ribs which both add strength to the sled as well as function as sled runners when the wheels are retracted. The ribs operate to reduce friction between the sled bottom and the underlying surface.

3. 发明授权

US09687550B2 Compositions for nucleic acid delivery 有权
公开(公告)号：US09687550B2
公开(公告)日：2017-06-27
申请号：US13514352
申请日：2010-12-07
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Mamta Kapoor , Rajesh Kumar Kainthan
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Mamta Kapoor , Rajesh Kumar Kainthan
IPC分类号： C07C229/12 , A61K47/18 , C07C217/08 , C07C219/08 , C07C251/40 , C07C271/12 , C07C271/20 , C07C323/25 , C07D317/28 , C07D317/44 , C07D317/72 , C07D491/10 , C12N15/88 , A61K31/7105 , A61K31/713 , A61K47/22
CPC分类号： A61K47/18 , A61K31/7105 , A61K31/713 , A61K47/186 , A61K47/22 , C07C217/08 , C07C219/08 , C07C229/12 , C07C251/40 , C07C271/12 , C07C271/20 , C07C323/25 , C07C2601/02 , C07D317/28 , C07D317/44 , C07D317/72 , C07D491/10 , C12N15/88
摘要： The present invention is based, in part, upon the discovery of charged lipids that provide advantages when used in lipid particles for the in vivo delivery of a therapeutic agent. As such, described herein are compounds useful for delivering a nucleic acid to a cell.

4. 发明授权

US09249671B2 Method and a device of tangentially biasing internal cooling on nozzle guide vanes 有权
标题翻译：方法和在喷嘴导向叶片上切向偏置内部冷却的装置
公开(公告)号：US09249671B2
公开(公告)日：2016-02-02
申请号：US13393304
申请日：2009-09-04
申请人： David Butler
发明人： David Butler
IPC分类号： F01D5/18 , F01D9/04
CPC分类号： F01D5/186 , F01D9/041 , F05D2240/12 , F05D2240/126 , F05D2250/51
摘要： A deflector for guiding a cooling fluid to a blade device of a turbine is provided. The deflector includes a first opening region with a first opening shape and a second opening region with a second opening shape. The deflector is connectable to a first blade device and to a second blade device in such a way that the cooling fluid is streamable through the first opening region into the first blade device and the cooling fluid is streamable through the second opening region into the second blade device. The first opening shape differs from the second opening shape for achieving a predetermined first mass flow of the cooling fluid into the first blade device and a predetermined second mass flow of the cooling fluid into the second blade device at predetermined installation locations of the first blade device and the second blade device.
摘要翻译：提供了用于将冷却流体引导到涡轮机的叶片装置的偏转器。偏转器包括具有第一开口形状的第一开口区域和具有第二开口形状的第二开口区域。导流器可连接到第一叶片装置和第二叶片装置，使得冷却流体可流过第一开口区域进入第一叶片装置，并且冷却流体可流过第二开口区域进入第二叶片设备。第一开口形状与第二开口形状不同，用于在第一刀片装置的预定安装位置处实现冷却流体进入第一刀片装置的预定的第一质量流量和冷却流体进入第二刀片装置的预定的第二质量流量和第二刀片装置。

5. 发明授权

US09220683B2 Lipids and compositions for the delivery of therapeutics 有权
标题翻译：用于递送治疗剂的脂质和组合物
公开(公告)号：US09220683B2
公开(公告)日：2015-12-29
申请号：US13128253
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Jayaprakash K. Narayanannair , Muthusamy Jayaraman , Laxmab Eltepu
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Jayaprakash K. Narayanannair , Muthusamy Jayaraman , Laxmab Eltepu
IPC分类号： A61K39/12 , A61K9/127 , A61K39/00 , C12N15/11
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures: (Formula (I) or (XXXV)).
摘要翻译：本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构的脂质：（式（I）或（XXXV））。

6. 发明申请

US20140200257A1 PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY 有权
标题翻译：聚乙二醇脂及其用于药物递送的用途
公开(公告)号：US20140200257A1
公开(公告)日：2014-07-17
申请号：US13979336
申请日：2012-01-11
申请人： Kallanthottathil G Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
发明人： Kallanthottathil G Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
IPC分类号： A61K47/18 , C07D207/12 , C07D307/20 , C07C271/16 , C07C235/06
CPC分类号： A61K47/18 , A61K47/6911 , C07C235/06 , C07C271/16 , C07D207/12 , C07D207/14 , C07D307/12 , C07D307/20 , C08G65/329 , C08L2203/02
摘要： The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.
摘要翻译：本发明提供用于药物递送的聚（乙二醇）脂质缀合物。

7. 发明申请

US20130209217A1 PLATFORM SEGMENT FOR SUPPORTING A NOZZLE GUIDE VANE FOR A GAS TURBINE AND NOZZLE GUIDE VANE ARRANGEMENT FOR A GAS TURBINE 有权
标题翻译：用于支持气体涡轮的喷嘴导向件的平台部分和用于气体涡轮的喷嘴导向器叶片装置
公开(公告)号：US20130209217A1
公开(公告)日：2013-08-15
申请号：US13703643
申请日：2011-05-31
申请人： David Butler , Anthony Davis , Charlotte Poole , Paul Matthew Walker
发明人： David Butler , Anthony Davis , Charlotte Poole , Paul Matthew Walker
IPC分类号： F01D9/02
CPC分类号： F01D9/023 , F01D9/041 , F05D2240/127 , F05D2240/81 , F05D2260/201 , F05D2260/2212
摘要： A platform segment for supporting a nozzle guide vane for a gas turbine is provided. The platform segment includes a gas passage surface arranged to be in contact with a streaming gas exhausted from a combustor, wherein the streaming gas streams along the gas passage surface in a streaming direction, a cooling surface, opposite to and thermally connected to the gas passage surface and arranged to be in contact with a cooling fluid, a wall protruding from the cooling surface and extending at least partially in the streaming direction, wherein the wall is arranged circumferentially between positions, at which adjacent guide vanes are to be provided, such that cooling fluid is channeled by the wall for cooling a downstream portion of the cooling surface, and a further wall protruding from the cooling surface and extending at least partially in the streaming direction.
摘要翻译：提供了一种用于支撑用于燃气轮机的喷嘴导向叶片的平台段。所述平台段包括气体通道表面，其布置成与从燃烧器排出的流动气体接触，其中所述流动气体沿流动方向沿所述气体通道表面流动，冷却表面与所述气体通道相对并热连接表面并布置成与冷却流体接触，壁从冷却表面突出并且至少部分地沿流动方向延伸，其中壁在周向上布置在相邻导向叶片的位置之间，使得冷却流体由壁引导，用于冷却冷却表面的下游部分，以及从冷却表面突出并在流动方向上至少部分延伸的另一壁。

8. 发明申请

US20130026868A1 Electric Machine With Enhanced Cooling 有权
标题翻译：增强冷却电机
公开(公告)号：US20130026868A1
公开(公告)日：2013-01-31
申请号：US13194133
申请日：2011-07-29
申请人： Leon Klafter , David C. Wideman , David Butler
发明人： Leon Klafter , David C. Wideman , David Butler
IPC分类号： H02K9/06
CPC分类号： H02K9/06
摘要： An electric machine includes a casing have a first end plate and a second end plate, the first end plate having an air inlet and the second end plate having an air outlet; an outer rotor positioned inside the casing; a stator positioned inside the outer rotor; a hub positioned inside the stator; a fan positioned within the casing, the fan drawing air from the air inlet and exhausting air out the air outlet.
摘要翻译：一种电机，包括具有第一端板和第二端板的壳体，所述第一端板具有空气入口，所述第二端板具有空气出口; 位于壳体内部的外转子; 位于外转子内的定子; 定位在定子内部的毂; 定位在壳体内的风扇，风扇从空气入口抽出空气并排出空气出口。

9. 发明申请

US20120058144A1 LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS 有权
标题翻译：用于输送治疗药物的脂肪和组合物
公开(公告)号：US20120058144A1
公开(公告)日：2012-03-08
申请号：US13128363
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Marco A. Ciufolini
IPC分类号： A61K39/00 , C07D211/46 , C07D207/12 , C07D317/28 , C07C217/52 , C07C291/04 , A61K47/18 , A61K47/28 , A61K47/22 , A61K48/00 , A61K31/713 , C12N5/00 , A61K39/12 , A61K39/02 , A61P31/12 , A61P31/04 , A61P33/00 , A61P35/00 , A61P37/04 , C07C229/46
CPC分类号： A61K31/7088 , A61K9/1272 , A61K31/7105 , A61K39/00 , A61K2039/55561 , A61K2039/6018 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/32 , C12N2310/3521 , C12N2310/3533
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII.
摘要翻译：本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构XIV或XVII的脂质。

10. 发明授权

US08102256B2 Apparatus and method for determining location and tracking coordinates of a tracking device 有权
标题翻译：用于确定跟踪装置的位置和跟踪坐标的装置和方法
公开(公告)号：US08102256B2
公开(公告)日：2012-01-24
申请号：US11969905
申请日：2008-01-06
申请人： Joseph F. Scalisi , David Butler , Roger B. Anderson , Desiree Mejia , Michael L. Beydler
发明人： Joseph F. Scalisi , David Butler , Roger B. Anderson , Desiree Mejia , Michael L. Beydler
IPC分类号： G08B1/08
CPC分类号： G08C17/02 , G01C21/165 , G01S19/19 , G01S19/34 , G01S19/49 , H04M1/72572 , H04M2250/10 , H04M2250/12
摘要： An apparatus to monitor location coordinates of an electronic tracking device. The apparatus includes a transceiver, a signal processor, an accelerometer, and an antenna. The antenna communicates signal strength to the signal processor associated with the electronic tracking device. In response to signal strength, a battery power monitor controls battery usage by electronic circuitry associated with the electronic tracking device. An accelerometer provides a supplemental location tracking system to improve tracking accuracy of a primary location tracking system of the electronic tracking device.
摘要翻译：一种用于监视电子跟踪装置的位置坐标的装置。该装置包括收发器，信号处理器，加速度计和天线。天线将信号强度传送到与电子跟踪装置相关联的信号处理器。响应于信号强度，电池电力监视器通过与电子跟踪装置相关联的电子电路控制电池使用。加速度计提供补充位置跟踪系统，以提高电子跟踪装置的主要位置跟踪系统的跟踪精度。

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