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1. 发明申请

US20050245596A1 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin k inhibitors for the treatment of bone loss 失效
标题翻译： 1-（氧代氨基乙酰基）戊基氨基甲酸酯的衍生物作为组织蛋白酶k抑制剂用于治疗骨丢失
公开(公告)号：US20050245596A1
公开(公告)日：2005-11-03
申请号：US10510469
申请日：2003-04-01
申请人： David Barrett , John Catalano , David Deaton , Aaron Miller , John Ray , Vicente Samano
发明人： David Barrett , John Catalano , David Deaton , Aaron Miller , John Ray , Vicente Samano
IPC分类号： A61K31/341 , A61K31/365 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/404 , A61K31/4155 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61P19/00 , A61P19/10 , A61P43/00 , C07D207/12 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/48 , C07D307/20 , C07D307/33 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D43/02 , C07D45/02
CPC分类号： C07D207/27 , C07D207/12 , C07D207/273 , C07D207/48 , C07D307/20 , C07D307/33 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
摘要翻译：式（I）的杂环取代的酮酰胺衍生物，其中取代基A，D，A和R如权利要求中所定义，其可用作组织蛋白酶K抑制剂。所描述的发明还包括制备这种杂环取代的酮酰胺衍生物的方法以及在制备用于治疗与骨吸收和形成之间不平衡的疾病（包括骨质疏松症）相关的药物的药物的方法，其可最终导致骨折。

2. 发明授权

US09799070B1 System and method for aggregating and presenting financial information 有权
公开(公告)号：US09799070B1
公开(公告)日：2017-10-24
申请号：US13027067
申请日：2011-02-14
申请人： David Barrett , Witold Stankiewicz
发明人： David Barrett , Witold Stankiewicz
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00
摘要： Disclosed herein is a system and method for managing financial information. According to an embodiment, electronic purchase data is received from an electronic payment source. The received electronic purchase data is generated into one or more visual representation formats using a transformation server. Once the visual representation has been generated, the visual representation format is rendered using a display device.

3. 发明申请

US20080100022A1 VEHICLE STEP WITH HINGED PEDESTAL MOUNT 有权
标题翻译：带有铰链式安装的车辆步骤
公开(公告)号：US20080100022A1
公开(公告)日：2008-05-01
申请号：US11962625
申请日：2007-12-21
申请人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
发明人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
IPC分类号： B60R3/02
CPC分类号： B60R3/02
摘要： A vehicle step assembly uses hinged pedestals, attitude links and an energy storage device to position step stringers and an attached step beam in a generally horizontal and elevated deployed position, while permitting a space-saving tucked-in stowed position.
摘要翻译：车辆步进组件使用铰接的基座，姿态连杆和能量存储装置来将步进桁条和附接的步进梁放置在大致水平和升高的展开位置，同时允许节省空间的收起位置。

4. 发明申请

US20050004014A1 New compound 审中-公开
标题翻译：新化合物
公开(公告)号：US20050004014A1
公开(公告)日：2005-01-06
申请号：US10860508
申请日：2004-06-04
申请人： Takahiro Matsuya , Hiroaki Mizuno , Takashi Tojo , Hiroshi Matsuda , David Barrett
发明人： Takahiro Matsuya , Hiroaki Mizuno , Takashi Tojo , Hiroshi Matsuda , David Barrett
IPC分类号： A61K38/00 , C07K7/56 , A61K38/12 , C07K7/64
CPC分类号： C07K7/56 , A61K38/00
摘要： This invention relates to new lipopeptide compound represented by the following general formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由以下通式（I）表示的新的脂肽化合物：其中R 1，R 2，R 3，R 4和R 5如说明书中所定义或其具有抗微生物活性（特别是抗真菌活性），对β-1,3-葡聚糖合酶的抑制活性，其制备方法，包含其的药物组合物，以及预防和/或治疗方法的感染性疾病，包括人或动物中的卡氏肺囊虫感染（例如肺孢子虫肺炎）。

5. 外观设计

USD321884S Antenna 失效
公开(公告)号：USD321884S
公开(公告)日：1991-11-26
申请号：US353520
申请日：1989-05-16
申请人： David Barrett
设计人： David Barrett

6. 发明申请

US20200255990A1 APPARATUS AND METHOD OF KNITTING MATERIAL INTO A CIRCULAR TUBE 审中-公开
公开(公告)号：US20200255990A1
公开(公告)日：2020-08-13
申请号：US16274208
申请日：2019-02-12
申请人： Andrew Bennett , Silas Hughes , Kristin Draper , David Barrett
发明人： Andrew Bennett , Silas Hughes , Kristin Draper , David Barrett
IPC分类号： D04B15/88 , D04B15/32
摘要： The field of the present invention relates, in general, to apparatus and methods of knitting a material into a tubular form, where the length of such tubular form is not dictated by conventional distances between the knitting areas and the catch basins of integrated machines. In short, this invention increases the distal relationship between the needle-equipped element, which performs the knitting function, and the basin that catches the resulting tubular form of the material. The basin rotates synchronized with the rotation of the resulting tubular form. The separation facilitates the continuous production of a length of the resulting tubular form of the material. The tubular form thus can be longer than such length where, as taught in the prior art, the catch basin is fixed—as part of integrated machines—in close proximity with the element that performs the knitting. As an inventive method, the steps include (A) feeding such material into the proximity of a needle-equipped element; (B) knitting such material with such needle-equipped element to produce such resulting tubular form; (C) catching such resulting tubular form in a basin that is physically disconnected from the needle-equipped element and distanced therefrom to produce a desirably longer length of the resulting tubular form; and (D) electronically controlling such feeding step, such knitting step, and such catching step (synchronizing the catching with the rotation of resulting tubular form), whereby the rates of the feeding, knitting and catching produce such resulting tubular form that is unbuckled.

7. 发明授权

US08839593B2 Pre-cast blocks for use in column construction 有权
标题翻译：用于柱施工的预制块
公开(公告)号：US08839593B2
公开(公告)日：2014-09-23
申请号：US13030021
申请日：2011-02-17
申请人： David Barrett , Derek Zimmerman , David Jacobson , Randy Quaintance , John C Purvis
发明人： David Barrett , Derek Zimmerman , David Jacobson , Randy Quaintance , John C Purvis
IPC分类号： E04C3/34 , E04B1/04 , E04B1/02 , E04H12/12
CPC分类号： E04C3/34 , E04H12/12
摘要： A decorative column comprising a rigid center post, a plurality of pre-cast pieces with each piece having a hole extending therethrough so the pre-cast piece slides onto the center post and remains in place on the center post. Each pre-cast piece being stacked upon another pre-cast piece, the pre-cast pieces being of a predefined shape, and a compressible center core liner filling a portion of the hole of the pre-cast piece. The compressible center core including a cutout shape consistent with the cross sectional shape of the rigid center post thereby allowing passage of the center post through the compressible center core.
摘要翻译：一种装饰柱，包括刚性中心柱，多个预铸件，其中每个件具有穿过其中的孔，使得预铸件滑动到中心柱上并保持在中心柱上的适当位置。每个预铸件堆叠在另一个预铸件上，预铸件具有预定形状，以及填充预制件的孔的一部分的可压缩中心芯衬套。可压缩中心芯具有与刚性中心柱的横截面形状一致的切口形状，从而允许中心柱通过可压缩中心芯。

8. 发明授权

US08034058B2 Tibial cement skirt assembly 有权
标题翻译：胫骨水泥裙组装
公开(公告)号：US08034058B2
公开(公告)日：2011-10-11
申请号：US11378834
申请日：2006-03-17
申请人： David Barrett , Andrew New , John Ewans , Rick Kowalski
发明人： David Barrett , Andrew New , John Ewans , Rick Kowalski
IPC分类号： A61F2/38
CPC分类号： A61B17/8808 , A61F2/38 , A61F2/389 , A61F2002/30387 , A61F2002/30476 , A61F2002/30507 , A61F2002/3895 , A61F2220/0025
摘要： An assembly for use in fixing a first component of a joint prosthesis, having a bone facing surface and an exposed surface which faces towards a second component of the joint prosthesis when implanted on a patient's bone. The assembly includes a skirt which can be temporarily fixed to the edge of the first component extending along the edge thereof from a remote portion of the edge to an accessible portion of the edge. The skirt provides at least one opening through which cement located between the bone facing surface of the component and the surface of the bone can be displaced. The opening is located so that cement is prevented from being displaced at the remote portion of the edge and is instead displaced at the accessible portion of the edge.
摘要翻译：一种用于固定关节假体的第一部件的组件，其具有面向骨的表面和当植入患者骨骼时面向关节假体的第二部件的暴露表面。该组件包括裙部，该裙部可以暂时地固定到沿其边缘延伸的第一部件的边缘，从边缘的远端部分延伸到边缘的可接近部分。裙部提供至少一个开口，通过该开口，位于组件的面向骨的表面和骨表面之间的水泥可以通过该开口移位。开口被定位成使得防止水泥在边缘的偏远部分移位，而是在边缘的可接近部分移位。

9. 发明授权

US07823896B2 Articulated step system for automotive vehicle 有权
标题翻译：车辆铰接步进系统
公开(公告)号：US07823896B2
公开(公告)日：2010-11-02
申请号：US11421902
申请日：2006-06-02
申请人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
发明人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
IPC分类号： B60R3/02
CPC分类号： B60R3/02
摘要： An articulated step system for an automotive vehicle includes a step housing attached to the vehicle frame by means of at least one standoff bracket and a tension strut extending generally downwardly from a first end attached to a vehicle body to a second end attached to the step housing. The articulated step has a stowed position generally underlying the body, and a deployed position extending generally outwardly from the body. Movement of the step may be either translational or rotational with respect to the step housing. In one embodiment, the step extends for the full length of the cab of the vehicle, and partially under a load carrying body at the rear of the vehicle.
摘要翻译：一种用于机动车辆的关节式步进系统包括：通过至少一个支架支架和一个大致向下延伸的从第一端部连接到车身延伸到第二端部的台架壳体，其连接到车架上的台阶壳体。铰接步骤具有通常位于身体下方的收起位置，以及从身体大致向外延伸的展开位置。台阶的移动可以相对于台阶外壳平移或旋转。在一个实施例中，该步骤延伸到车辆的驾驶室的整个长度，并且部分地在车辆后部的负载承载体下方。

10. 发明授权

US07740260B2 Vehicle step with hinged pedestal mount 有权
标题翻译：带铰链底座的车步
公开(公告)号：US07740260B2
公开(公告)日：2010-06-22
申请号：US11681358
申请日：2007-03-02
申请人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
发明人： Michael VanBelle , Louis Caballero , Sven Sauerwein , David Barrett
IPC分类号： B60R3/02
CPC分类号： B60R3/02
摘要： A vehicle step assembly uses hinged pedestals and attitude links to position step stringers and an attached step beam in a generally horizontal and elevated deployed position, while permitting a space-saving tucked-in stowed position.
摘要翻译：车辆步进组件使用铰接的基座和姿态连杆将步进桁条和附接的阶梯梁放置在大致水平和升高的展开位置，同时允许节省空间的收起位置。

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