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1. 发明授权

US07084272B2 Process for the preparation of azoxystrobin and analogues thereof 有权
标题翻译：嘧菌酯及其类似物的制备方法
公开(公告)号：US07084272B2
公开(公告)日：2006-08-01
申请号：US10480863
申请日：2002-05-03
申请人： David Anthony Jackson , James Peter Muxworthy , Mark Robert Sykes
发明人： David Anthony Jackson , James Peter Muxworthy , Mark Robert Sykes
IPC分类号： C07D239/52
CPC分类号： C07D239/52
摘要： A process for the preparation of a compound of the general formula (I): wherein R1 is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and R2 is any group which can be transesterified to form a methyl ester, which comprises treating a compound of general formula (II): wherein R1 and R2 have the meanings given above, with a formylating agent and subsequently treating the formylated product with a methylating agent
摘要翻译：制备通式（I）化合物的方法：其中R 1是在6-位被卤素取代的4-嘧啶基环，羟基，2-氰基苯氧基，2,6- 二氟苯氧基，2-硝基苯氧基或2-硫代羧酰胺基苯氧基和R 2是可以酯交换形成甲酯的任何基团，其包括处理通式（II）的化合物：其中R 1和R 2具有上述含义，与甲酰化剂接触，随后用甲基化剂处理甲酰化产物

2. 发明授权

US07244737B2 Process for the preparation of azoxystrobin and analogues thereof 有权
标题翻译：嘧菌酯及其类似物的制备方法
公开(公告)号：US07244737B2
公开(公告)日：2007-07-17
申请号：US11425173
申请日：2006-06-20
申请人： David Anthony Jackson , James Peter Muxworthy , Mark Robert Sykes
发明人： David Anthony Jackson , James Peter Muxworthy , Mark Robert Sykes
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D239/02
CPC分类号： C07D239/52
摘要： The present invention relates to a compound of the general formula: wherein R1 is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and wherein R2 is any group which can be transesterified to form a methyl ester. The present invention is also directed to a process of preparing said compound.
摘要翻译：本发明涉及以下通式的化合物：其中R 1是在6位被卤素取代的4-嘧啶基环，羟基，2-氰基苯氧基，2,6-二氟苯氧基，2 - 硝基苯氧基或2-硫代羧酰氨基苯氧基，其中R 2是可以酯交换形成甲酯的任何基团。本发明还涉及制备所述化合物的方法。

3. 发明授权

US08735600B2 Process for purification of 1-methylpyrazole-4-carboxylic acid esters 有权
标题翻译：纯化1-甲基吡唑-4-羧酸酯的方法
公开(公告)号：US08735600B2
公开(公告)日：2014-05-27
申请号：US13320730
申请日：2010-04-20
申请人： Graham McDougald , James Peter Muxworthy , Beverley Ann Wilde
发明人： Graham McDougald , James Peter Muxworthy , Beverley Ann Wilde
IPC分类号： C07D231/14 , C07D409/12
CPC分类号： C07D231/14
摘要： The present invention relates to improvements in processes towards the production 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid, which is a useful intermediate in fungicide production. In particular, the invention relates to a process for treating a compound of formula III, wherein R1 is C1-C6 alkyl and R2 is CF3, CF2H or CFH2, comprising the steps of a) contacting a compound of formula III with base, and b) separating the compound of formula III and the base.
摘要翻译：本发明涉及生产3-二氟甲基-1-甲基-1H-吡唑-4-羧酸的方法的改进，其是杀真菌剂生产中的有用中间体。特别地，本发明涉及一种用于处理式III化合物的方法，其中R 1是C 1 -C 6烷基，R 2是CF 3，CF 2 H或CFH 2，包括以下步骤：a）使式III化合物与碱反应，b ）分离式III化合物和碱。

4. 发明授权

US5952531A Nitration process 失效
标题翻译：硝化过程
公开(公告)号：US5952531A
公开(公告)日：1999-09-14
申请号：US960924
申请日：1997-10-30
申请人： Ian Jeffrey Grassham Priestley , James Peter Muxworthy , John Heathcote Atherton , Martin Lennon , Stephen Martin Brown
发明人： Ian Jeffrey Grassham Priestley , James Peter Muxworthy , John Heathcote Atherton , Martin Lennon , Stephen Martin Brown
IPC分类号： C07B43/02 , C07C201/08 , C07C205/38 , C07C205/59 , C07C231/12 , C07C235/44 , C07C303/40 , C07C311/51 , C07C43/00 , C07C29/00 , C07C205/00
CPC分类号： C07C303/40 , C07B43/02 , C07C201/08
摘要： A process for the nitration of an aromatic or heteroaromatic compound with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids, characterised in that nitration is performed in a solvent comprising at least 50% v/v of a C.sub.1 -C.sub.6 alkyl ester of a C.sub.1 -C.sub.4 carboxylic acid. The process is of particular use for the nitration of diphenyl ethers to give compounds which are useful as herbicides or as intermediates in the synthesis of herbicides.
摘要翻译：一种用包含硝酸或硝酸和硫酸的混合物的硝化剂硝化芳族或杂芳族化合物的方法，其特征在于，在包含至少50％v / v的C 1 -C 6烷基的溶剂中进行硝化酯的C 1 -C 4羧酸。该方法特别用于二苯醚的硝化，得到可用作除草剂的化合物或作为除草剂合成中的中间体。

5. 发明申请

US20120065407A1 PROCESS FOR PURIFICATION OF 1-METHYLPYRAZOLE-4-CARBOXYLIC ACID ESTERS 有权
标题翻译： 1-甲基吡唑-4-羧酸酯的纯化方法
公开(公告)号：US20120065407A1
公开(公告)日：2012-03-15
申请号：US13320730
申请日：2010-04-20
申请人： Graham McDougald , James Peter Muxworthy , Beverley Ann Wilde
发明人： Graham McDougald , James Peter Muxworthy , Beverley Ann Wilde
IPC分类号： C07D231/14 , C07D409/12
CPC分类号： C07D231/14
摘要： The present invention relates to improvements in processes towards the production 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid, which is a useful intermediate in fungicide production. In particular, the invention relates to a process for treating a compound of formula III, wherein R1 is C1-C6 alkyl and R2 is CF3, CF2H or CFH2, comprising the steps of a) contacting a compound of formula III with base, and b) separating the compound of formula III and the base.
摘要翻译：本发明涉及生产3-二氟甲基-1-甲基-1H-吡唑-4-羧酸的方法的改进，其是杀真菌剂生产中的有用中间体。特别地，本发明涉及一种用于处理式III化合物的方法，其中R 1是C 1 -C 6烷基，R 2是CF 3，CF 2 H或CFH 2，包括以下步骤：a）使式III化合物与碱反应，b ）分离式III化合物和碱。

6. 发明授权

US07285678B2 Purification of 2-nitro-4-methylsulphonylbenzoic acid 有权
标题翻译： 2-硝基-4-甲基磺酰基苯甲酸的纯化
公开(公告)号：US07285678B2
公开(公告)日：2007-10-23
申请号：US10472962
申请日：2002-03-25
申请人： Kambiz Javdani , Gilbert Rodriguez , James Peter Muxworthy
发明人： Kambiz Javdani , Gilbert Rodriguez , James Peter Muxworthy
IPC分类号： C07C315/06
CPC分类号： C07C315/06 , C07C317/44
摘要： A method for removing impurities from 2-nitro-4-methylsulfonylbenzoic acid which comprises at least two of the following steps, in any order, (a) dissolving 2-nitro-4-methylsulfonylbenzoic acid in water at a pH of about 2 to 10, followed by filtration; (b) contacting an aqueous solution of 2-nitro-4-methylsulfonylbenizoic acid with activated carbon at a pH of about 2 to 10; (c) treating an aqueous solution of 2-nitro-4-methylsulfonylbenzoic acid with sufficient base to hydrolyze undesired nitro and dinitro substituted impurities; followed by maintaining the resulting aqueous solution comprising 2-nitro-4-methylsulfonylbenzoic acid at a temperature of up to about 95° C., and adjusting the pH of said solution to about a pH which is sufficient to effect crystallization of 2-nitro-4-methylsulfonylbenzoic acid upon cooling.
摘要翻译：一种从2-硝基-4-甲基磺酰基苯甲酸中除去杂质的方法，该方法包括至少两个以下步骤，以任何顺序，（a）将2-硝基-4-甲基磺酰基苯甲酸溶于约2至10的pH下的水中，然后过滤; （b）将2-硝基-4-甲基磺酰基二十八碳酸的水溶液与约2至10的pH下的活性炭接触; （c）用足够的碱处理2-硝基-4-甲基磺酰基苯甲酸的水溶液以水解不希望的硝基和二硝基取代的杂质; 然后将所得到的包含2-硝基-4-甲基磺酰基苯甲酸的水溶液在高至约95℃的温度下保持，并将所述溶液的pH调节至足以使2-硝基-4-甲基磺酰基苯甲酸结晶的pH值， 4-甲基磺酰基苯甲酸。

7. 发明授权

US06790991B2 Process for the preparation of diphenyl ether compounds 失效
标题翻译：二苯醚化合物的制备方法
公开(公告)号：US06790991B2
公开(公告)日：2004-09-14
申请号：US10168611
申请日：2002-06-20
申请人： Stephen Martin Brown , Brian David Gott , James Peter Muxworthy
发明人： Stephen Martin Brown , Brian David Gott , James Peter Muxworthy
IPC分类号： C07C30300
CPC分类号： C07C201/08 , C07C303/40 , C07C311/51 , C07C205/59
摘要： A process for producing fomesafen from acifluorfen comprises the steps of (a) converting acifluorfen to its acid chloride, (b) coupling the acid chloride so formed with methanesulphonamide to form crude fomesafen and (c) purifying the crude fomesafen, characterized in that each of the steps is carried out in a single common solvent, which is preferably a chloroalkane. Preferably the steps are telescoped together so that there is no isolation of the product for any step until fomesafen is obtained.
摘要翻译：从氟锁草醚生产福莫斯芬的方法包括以下步骤：（a）将氟锁草醚转化为酰氯，（b）将形成的酰氯与甲磺酰胺反应形成粗制甲磺酸盐，（c）纯化粗制物，其特征在于，该步骤在单一的普通溶剂中进行，其优选为氯代烷烃。优选地，这些步骤被伸缩在一起，使得在获得fomesafen之前，没有任何步骤的产品被隔离。

8. 发明授权

US6054613A Process for the production of sulphonamides 失效
标题翻译：磺酰胺生产工艺
公开(公告)号：US6054613A
公开(公告)日：2000-04-25
申请号：US308742
申请日：1999-05-24
申请人： Brian David Gott , James Peter Muxworthy , Stephen Martin Brown
发明人： Brian David Gott , James Peter Muxworthy , Stephen Martin Brown
IPC分类号： C07C303/38 , C07C303/44 , C07C311/03
CPC分类号： C07C303/38
摘要： A process for the preparation of a sulfonamide of formula:RSO.sub.2 NR.sup.1 R.sup.2wherein R represents C.sub.1 -C.sub.10 alkyl; andR.sup.1 and R.sup.2 independently represent hydrogen, C.sub.1 -C.sub.10 alkyl or C.sub.6 -C.sub.10 aryl; which comprises reacting the corresponding alkane- or arenesulfonyl halide of formula:RSO.sub.2 Halwherein Hal represents halogen; with the corresponding compound of formula:NHR.sup.1 R.sup.2in an aqueous solvent and extracting the sulfonamide from the resulting mixture into a polar organic solvent.
摘要翻译： PCT No.PCT / GB97 / 03272 Sec。 371日期1999年5月24日 102（e）1999年5月24日PCT 1997年11月27日PCT公布。公开号WO98 / 25890 日期1998年6月18日制备下式的磺酰胺的方法：其中R代表C1-C10烷基; 并且R 1和R 2独立地表示氢，C 1 -C 10烷基或C 6 -C 10芳基; 其包括使相应的式：RSO 2 Hal的烷烃或芳烃磺酰卤反应，其中Hal表示卤素; 与相应的式NHR1R2化合物在水溶剂中反应，并将所得混合物中的磺酰胺萃取到极性有机溶剂中。

9. 发明授权

US6028219A Process for the nitration of diphenylethers 失效
标题翻译：硝基二苯醚的工艺
公开(公告)号：US6028219A
公开(公告)日：2000-02-22
申请号：US901545
申请日：1997-07-28
申请人： John Heathcote Atherton , Stephen Martin Brown , James Peter Muxworthy , Martin Lennon
发明人： John Heathcote Atherton , Stephen Martin Brown , James Peter Muxworthy , Martin Lennon
IPC分类号： C07B43/02 , C07C201/08 , C07C205/38 , C07C205/59 , C07C205/60 , C07C303/40 , C07C311/51 , C07C205/06
CPC分类号： C07C201/08 , C07C303/40
摘要： A process for the preparation of a compound of general formula I: ##STR1## wherein: R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl, any of which may optionally be substituted with one or more substituents selected from halogen and OH; or COOR.sup.4, COR.sup.6, CONR.sup.4 R.sup.5 or CONHSO.sub.2 R.sup.4 ;R.sup.4 and R.sup.5 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl optionally substituted with one or more halogen atoms;R.sup.6 is a halogen atom or a group R.sup.4 ;R.sup.2 is hydrogen or halo;R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl, any of which may optionally be substituted with one or more halogen atoms; or halo;the process comprising reacting a compound of general formula II: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined for general formula I; with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids in the presence of an organic solvent and in the presence of acetic anhydride, characterized in that the molar ratio of acetic anhydride to compound of general formula II is from about 1:1 to 3:1.
摘要翻译：一种制备通式I化合物的方法：其中：R 1是氢或C 1 -C 6烷基，C 2 -C 6烯基或C 2 -C 6炔基，其中任何一个可以被一个或多个选自卤素和哦; 或COOR4，COR6，CONR4R5或CONHSO2R4; R 4和R 5各自独立地为氢或任选被一个或多个卤素原子取代的C 1 -C 4烷基; R6是卤素原子或基团R4; R2是氢或卤素; R 3是C 1 -C 4烷基，C 2 -C 4烯基或C 2 -C 4炔基，其中任何一个可以任选被一个或多个卤素原子取代; 或卤素; 所述方法包括使通式II的化合物：其中R 1，R 2和R 3如通式I所定义; 与硝酸和硝酸和硫酸的混合物在有机溶剂的存在下和在乙酸酐存在下的硝化剂，其特征在于乙酸酐与通式II的化合物的摩尔比为约1： 1到3：1。

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